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22821
Single-step retrosynthesis prediction via multitask graph representation learning
Published 2025-01-01“…., reaction sites, synthons, and LGs). Finally, case studies demonstrate that the retrosynthesis routes inferred by Retro-MTGR are promising for single-step synthesis reactions. …”
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22822
Field Monitoring-Based and Theoretical Analysis of Baota Mountain Landslide Stability
Published 2021-01-01“…The theoretical factor of safety was also calculated for the landslide. Finally, the theoretical results were validated by monitoring data in the field. …”
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22823
Analysis on Elastohydrodynamic Lubrication in Grease-lubricated Ball Bearings Considering Film Thickness Correction
Published 2024-01-01“…Then, a modified film thickness formula proposed in this study, based on the Hamrock-Dowson approach, is applied to calculate and adjust the film thickness within the model. Finally, the model is solved numerically using a direct iteration method to analyze the effects of different rheological indices, ellipticity, entrainment speeds, and loads on the film thickness and pressure of the grease. …”
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22824
Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis
Published 2021-01-01“…Furthermore, the mRNA transcription levels of α-smooth muscle actinn (α-SMA), desmin, and two MMPs (MMP2 and MMP9) were reduced and the expression levels of transforming growth factor β1 (TGF-β1), p- small mother against decapen-taplegic protein (Smad)1/2 and p-extracellular signal-regulated kinases (ERK)1/2 in the liver tissue down-regulated dramatically. …”
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22825
Common variable immunodeficiency: An uncommon cause of bronchiectasis, granulomatous disease, chronic liver disease, and enteropathy – Case report and review of literature
Published 2020-01-01“…Herein, we describe the case of a 48-year-old female, who initially presented to our hospital with recurrent bouts of upper and LRTI, along with small-bowel diarrhea, and progressively developed generalized lymphadenopathy and ascites, before being finally diagnosed by the rheumatologist, as a case of CVID, with associated CVID-related enteropathy, granulomatous disease, and chronic liver disease. …”
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22826
A Multi-Source Domain Adaptation Method for Bearing Fault Diagnosis with Dynamically Similarity Guidance on Incomplete Data
Published 2025-01-01“…The similarity between source and target domain data is calculated based on features extracted by a shared-weight network, dynamically adjusting the contribution of different source domain data to minimize distribution differences. Finally, matched source and target domain samples are mapped to the same feature space for fault diagnosis. …”
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22827
ASD: Interaction and socialisation through an adapted social network
Published 2025-02-01“…Furthermore, usability inspections were conducted using automated tools, identifying x issues, as described in the text. Finally, a test with an ASD specialist was conducted, whose considerations indicate good clinical use prospects for the tool, which are detailed in this article. …”
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22828
A lead-free KNN-based, co-fired multilayered piezoceramic energy harvester with a high output current and power
Published 2025-03-01“…The inherent advantages of multilayered ceramics enable the PEH to achieve a peak-to-peak output current of up to 1.48 mA and a peak-to-peak output power of 2.19 mW under a harmonic force load of 6 kN at 14 Hz. Finally, the PEH is tested to validate its practical application in real road environments, demonstrating its promising for the use of self-powered monitoring sensors for collecting traffic data.…”
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22829
InSAR-YOLOv8 for wide-area landslide detection in InSAR measurements
Published 2025-01-01“…We also replace the original C2f module with the lighter C2f_Faster module to process information more efficiently, making the model lighter and more efficient. Finally, the SIoU loss function replaces the CIoU loss function to improve the bounding box regression and enhance detection accuracy. …”
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22830
Functional state of the nigrostriatal system of Krushinsky – Molodkina rats during audiogenic seizure expression
Published 2016-05-01“…In the current work, we studied the role of extracellular signal-regulated kinase (ERK1/2) in the regulation of the nigrostriatal glutamate, GABA and dopamine neurons of Krushinsky – Molodkina rats at clonus-tonus and ataxia stages of audiogenic seizure. …”
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22831
Sliding Mode Control for Variable-Speed Trajectory Tracking of Underactuated Vessels with TD3 Algorithm Optimization
Published 2025-01-01“…Moreover, an adaptive law is designed to estimate the upper bound of the unknown disturbances, ensuring system stability even in the presence of asymptotic observation errors. Finally, the Twin-Delayed Deep Deterministic Policy Gradient (TD3) algorithm is employed for real-time controller parameter tuning. …”
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22832
Study on the Method of Automatically Drawing Multiscale Engineering Geotechnical (Geological) Sections Step by Step of Engineering Layers including Lenses
Published 2022-01-01“…Firstly, the spatial information of the top and bottom boundaries of any borehole layer were extracted, and then based on the stratigraphical column, the borehole layer was studied by a step-by-step coarsen from the finest stratigraphical column to the coarsest stratigraphical column, and the occupation relationship among layers was distinguished; secondly, from the coarsest stratigraphical column to the finest level stratigraphical column step-by-step and taking the radial basis function (RBF) interpolation as an example, top and bottom boundaries were interpolated, respectively, by following the order of current stratigraphical column; next, topological relationship among engineering layers was processed according to contact relationship of strata, and strata boundaries with 0 thickness were deleted; and finally, auxiliary information such as scaler and legend were added in section to complete the drawing of multiscale sections. …”
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22833
Resilient Performance of Self-Centering Hybrid Rocking Columns: Theory, Experiment, and Numerical Simulation
Published 2022-01-01“…The design method and process for the RED-HRC were finally developed. A typical hysteretic response with “double-flag shape” characteristics was obtained. …”
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22834
Long-Term Statistical Analysis of Severe Weather and Climate Events in Greece
Published 2025-01-01“…The main results show that between 2010 and 2023, Greece experienced: nearly one heatwave per summer; heavy rainfall events, most common in winter and autumn, showing a significant increase, particularly in the eastern Aegean and western continental Greece; dry spells, which are longest in southern Greece; thunderstorm and hail events peaking in spring and summer; fire weather conditions and risk peaking in southern Greece. Finally, societal impacts from weather hazards have increased in Greece over the past 14 years, with flash floods being the most frequent and damaging events, while public preparedness and effective risk communication remain low.…”
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22835
Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor
Published 2020-07-01“…Additionally, the working range of the tested units was established, and the limits of detection and quantification were found to be 5 and 15 µg m−3, respectively. Finally, in order to serve as an alternative to the gravimetric method, these instruments must be accredited for PM measurement in accordance with standards such as ISO 17025.…”
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22836
COGNITIVE GRAMMAR IN AN ENGLISH CLASSROOM, OR, HOW TO MAKE LIFE FOR RUSSIAN STUDENTS EASIER
Published 2013-12-01“…It's a bit different with prepositions: even though there are prepositions in Russian, their number and usage in English very often cause confusion. Finally, as far as the so-called tenses go – which are, in fact, tense-aspect forms – many students experience difficulties in developing necessary skills for a simple reason. …”
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22837
Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model
Published 2015-01-01“…Decreased production of proinflammatory cytokines, such as IFN-γ, IL-2, and IL-17, and increased secretion of regulatory cytokines such as TGF-β, IL-4, IL-10, and IL-13 by stimulated splenocytes were also shown in response to islet lysate or PHA stimulants (P<0.05). Finally, we demonstrated that AT-MSCs could effectively sustain viability as well as insulin secretion potential of pancreatic islets in the presence of reactive splenocytes (P<0.05). …”
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22838
Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L
Published 2025-02-01“…Consequently, this interaction disrupted the binding between STING and TANK-binding kinase 1 (TBK1), thereby inhibiting downstream signaling including phosphorylation of TBK1, STING and IRF3 for antiviral signaling. …”
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22839
Or else, or so or what? A few Examples of the Staging of the Implicit in English
Published 2012-03-01“…Second their usage is considered in context, with a view to providing finally a unified theorisation of such constructions.…”
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22840
Quantum-Ordering Ambiguities in Weak Chern—Simons 4D Gravity and Metastability of the Condensate-Induced Inflation
Published 2025-01-01“…On matching our results with the inflationary phenomenology, we fix the quantum-ordering ambiguities, and obtain an order-of-magnitude constraint on the String-Mass-Scale-to-Planck-Mass ratio, consistent with previous estimates by the authors in the framework of a dynamical-system approach to linear-axion RVM inflation. Finally, we examine the role of periodic modulations in the axion potential induced by non-perturbative effects on the slow-roll inflationary parameters, and find compatibility with the cosmological data.…”
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