Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…Similar inhibition was seen by blocking phosphoinositide 3 kinase signaling, which is required for microbial phagocytosis. …”
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Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles by Qunjun Liang, Zhifeng Zhou, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu

“…The loading weight in CCA showed that dynamics in transmodal networks contributed the most to the correlation in the subtypes characterized by typical depression symptoms, whereas unimodal networks contributed the most to subtypes characterized by anxiety and insomnia. Finally, gene expression underlying the CCA model, along with its biological encoding process, performed using a postmortem gene expression atlas revealed distinct gene enrichments for different subtypes. …”
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Study on Inhibitory Effect of Cavity on Gas Explosion Propagation by Zhuo Yan, Shujie Yuan, Zhongqing Li, Shicheng Gu, Chaomin Mu

“…The dual cavity further improves the suppression performance and attenuates the shock wave overpressure by 28.88%. Finally, by simulating the propagation process of the gas explosion shock wave and flame in the cavity, the mechanism of inhibiting gas explosion propagation by the cavity structure is analyzed.…”
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Empowering Security Operation Center With Artificial Intelligence and Machine Learning—A Systematic Literature Review by Mohamad Khayat, Ezedin Barka, Mohamed Adel Serhani, Farag Sallabi, Khaled Shuaib, Heba M. Khater

“…Moreover, this systematic review emphasizes the benefits of these technologies for enhancing security operations. Finally, a case study is presented to describe the function of ML- and AI-powered SOC components to achieve optimum security. …”
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Comprehensive evaluation of pure and hybrid collaborative filtering in drug repurposing by Clémence Réda, Jill-Jênn Vie, Olaf Wolkenhauer

“…Moreover, in drug repurposing, the ability of a model to extrapolate beyond its training distribution is crucial and should also be assessed. Finally, we identified a subcategory of collaborative filtering that seems efficient and robust to distribution shifts. …”
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Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation by Guang Yang, Minghui Wang, Mulan Qahar, Jinqing He, Zhiwei Lai, Sanmu Li, Dehua He, Xuefei Yan, Zuying Xiong, Zibo Xiong, Thu H. Le

“…Subsequently, the investigation focused on assessing the effects of activated macrophages on podocytes. Finally, the study evaluated the effectiveness of dexamethasone in mitigating the impacts of burns on the kidneys. …”
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Berberine-induced browning and energy metabolism: mechanisms and implications by Aslıhan Alpaslan Ağaçdiken, Zeynep Göktaş

“…While the precise mechanisms behind this effect remain unclear, the adenosine monophosphate-activated protein kinase (AMPK) pathway is known to play a crucial role. …”
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KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis by Xiaonan Zhou, Peng Jiang, Huangqi Tan, Yanfang Wang, Lunhao Bai

“…KLF9 mediated the transcription of G protein-coupled receptor kinase 5 (GRK5) by directly targeting the GRK5 promoter. …”
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Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants by Wenying Qiao, Jiashuo Li, Lijia Luo, Wenjuan Peng, Xi Wang, Ronghua Jin, Junnan Li

“…It further highlighted significant mediation effects of TG, with the mediated proportion ranging from 10.4 % to 42.9 %. Finally, sensitivity and stratified analyses were performed, confirming the reliability of these findings. …”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. …”
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Latent profile analysis and influence factors study of nurses’ job performance by Zhenfan Liu, Xiaoting Yan, Guifang Xie, Jing Lu, Zhitong Wang, Cui Chen, Jijun Wu, Wei Qing

“…Latent profile analysis of nurses’ job performance were analyzed, and logistic regression was used to analyze the factors influencing different categories of nurses’ job performance.Results390 nurses were finally included. Nurses job performance score was (45.05 ± 6.55). …”
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Identification and prioritization of factors affecting the saffron supply chain and selection strategies during the pandemic crisis based on the ANP-SWOT method by Farshid Riahi Dorcheh, Misagh Rahbari

“…Subsequently, the weights of the criteria, sub-criteria, and priorities of the presented strategies are computed using the AHP-SWOT and ANP-SWOT methods. Finally, data were acquired through the systematic collection of expert opinions using the Delphi method.FindingsAccording to the prioritization of saffron export development strategies during the COVID-19 pandemic based on the AHP-SWOT method, “Performing marketing research in universities” and “Creating international associations and using anti-COVID-19 tools” were identified as the most important strategies. …”
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Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…Our model is able to describe changes in the ratio of pathogenic T cells and regulatory T cells after the appearance of islet antibodies in the pancreas. Finally, we discuss the robustness of the model and its ability to assist experimentalists in designing studies to test complicated theories about the disease.…”
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Generation of barcoded plasmid libraries for massively parallel analysis of chromatin position effects by M. O. Lebedev, L. A. Yarinich, A. V. Ivankin, A. V. Pindyurin

“…We also compare different approaches to check the quality of barcoded plasmid libraries. Finally, we briefly describe alternative approaches that can be used for the generation of such libraries. …”
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Security protection method based on mimic defense and Paillier encryption for smart IoT terminals by GU Tiansheng, ZENG Fukang, SHAO Sisi, NIE Yijun, JI Zongkai, ZHENG Yulu, SHI Yuchen, LIU Shangdong, JI Yimu

“…It also effectively supported the efficient and reliable transmission of data of the intelligent IoT devices. Finally, taking the mimic smart IoT system as an application scenario, the proposed method was theoretically analyzed and experimentally validated for its improved performance and security.…”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…It is caused by bi-allelic mutations impacting a gene encoding a serine/threonine kinase ATM (Ataxia Telangiectasia Mutated), which plays a crucial role in DNA repair and maintenance of genomic stability. …”
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Investigation of Theoretical Models, Pumping-Recharge Well Arrangements and System Performance of Abandoned Mine Water Source Heat Pump by Zhiqiang Zhang, Wenchao Zu, Wenke Zhang, Kexun Wang, Xueqing Ma, Ping Cui

“…The influences of different recharge temperatures, pumping and recharging flow rates, well spacings, hydraulic gradients, aquifer thicknesses, porosities and other factors on the pumping temperature are studied according to the selected pumping and recharging well arrangement scheme. Finally, by choosing a residential building as the analysis object, a simulation model of the abandoned mine water source heat pump heating system is constructed, which is compared with a gas boiler heating system, revealing the energy savings and environmental protection benefits of the abandoned mine water source heat pump system. …”
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Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells by Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

“…Moreover, SelS overexpression regulates TNF-α-induced inflammatory factors including interleukin-1β, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 and attenuates the TNF-α-induced activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. …”
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Key Transmission Section Search Based on Graph Theory and PMU Data for Vulnerable Line Identification in Power System by Miao Yu, Shouzhi Zhang, Fang Shi, Jianqun Sun, Jingjing Wei, Yixiao Wu, Jingxuan Hu

“…The fast localization of transmission cross sections associated with vulnerable lines is realized. Finally, the critical transmission cross sections are screened according to the line outage distribution factor and line safety margin. …”
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Analysis and Evaluation of Ecological Environment Monitoring Based on PIE Remote Sensing Image Processing Software by Xiaofeng Wang, Zhengran Wang

“…Secondly, the composition of PIE remote sensing image processing technology system and its application advantages were described, the common indicators and analysis methods of ecological environment monitoring were given, and the index system and model of ecological environment comprehensive evaluation were established. Finally, through the analysis of experimental cases, the results showed that the ecological environment monitoring analysis and evaluation method proposed in this paper was feasible. …”
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