Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Sign... by Jingjing Ye, Wei Ai, Fenglin Zhang, Xiaotong Zhu, Gang Shu, Lina Wang, Ping Gao, Qianyun Xi, YongLiang Zhang, Qingyan Jiang, Songbo Wang

“…Moreover, Ca2+o-induced promotion of pBMSCs proliferation, the changes of proliferative genes expression levels, and the activation of ERK1/2 signaling pathway were effectively blocked by U0126, a selective ERK kinase inhibitor. In conclusion, our findings provided evidence that the enhanced pBMSCs proliferation in response to Ca2+o was associated with the activation of CaSR and ERK1/2 signaling pathway, which may be useful for the application of pBMSCs in future clinical studies aimed at tissue regeneration and repair.…”
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Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation by John S. Wang, Omar Elghawy, Brett R. Kurpiel, Michael G. Douvas

“…After clinical progression, he was treated with sorafenib, a multiprotein kinase inhibitor more commonly used in the treatment of hepatocellular and renal cell carcinoma due to its off target FLT3 inhibition. …”
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An Improved Hierarchical Optimization Framework for Walking Control of Underactuated Humanoid Robots Using Model Predictive Control and Whole Body Planner and Controller by Yuanji Liu, Haiming Mou, Hao Jiang, Qingdu Li, Jianwei Zhang

“…Meanwhile, a whole body control (WBC) strategy refines ground reaction forces and joint trajectories under full-body dynamics and contact wrench cone (CWC) constraints, guaranteeing physically realizable interactions with the environment. Finally, a position–velocity–torque (PVT) controller integrates feedforward torque commands with the desired trajectories for robust execution. …”
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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. …”
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Study on the Characteristics of Self-Stabilizing Height Distribution for Deep Foundation Pit Vertical Sidewall in Binary Strata of Upper Soil and Lower Rock by Zhang Ziguang, Yihang Li, Jiesheng Zhang, Tao Xu, Guangyong Cao, YiKang Xu

“…The spatial distribution map of the self-stabilizing height for deep foundation pit vertical sidewall in upper soil and lower rock binary stratum has been constructed, and the mathematical fitting equation between Hr0 and Hs has been obtained. Finally, combined with the implementation effect of the deep foundation pit project of Ningxia Road Station for Qingdao Metro Line 3, the rationality of the conclusions is verified. …”
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Radio frequency energy harvesting-combined collaborative energy-saving computation offloading mechanism by Bei TANG, Qian WANG, Siguang CHEN

“…In order to fit the differentiated energy demands in vertical markets and ensure that internet of things (IoT) devices can hold an efficient and sustainable operation mode, a radio frequency energy harvesting-combined collaborative energy-saving computation offloading mechanism was studied.Specifically, a system energy consumption minimization problem was formulated under the joint optimization consideration of computation offloading decision, uplink bandwidth resource allocation, downlink bandwidth resource allocation and base station power splitting.Meanwhile, by combining the concept of penalty function, a new evaluation index was introduced, and then an adaptive particle swarm optimization-based collaborative energy saving computation offloading (APSO-CESCO) algorithm was proposed to solve the problem.The proposed algorithm constructed dynamic inertia weight and linearly adjusted penalty factor, which could alternate the spatial distribution density of the particle community in real-time during the iterative search process, and the optimal computation offloading policy with tolerable punishment could be well-generated.Furthermore, to prevent particles from exceeding exploration range, the velocity boundary was introduced which could also reduce the generation probability of invalid solutions and improve the actual exploration effectiveness.Finally, the simulation results show that the proposed algorithm can achieve higher convergence efficiency and solution accuracy, and compared with other common benchmark schemes, the system energy consumption can be reduced by 34.09%, 14.72%, and 6.86%, respectively.…”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The dataset was constructed using pIC50 values of various compounds targeting the inhibition of leucine-rich repeat kinase 2 (LRRK2). The best ensemble model showed exceptional predictive performance, with five-fold cross-validation and external validation metrics exceeding 0.8 (Q2cv = 0.864 and Q2ext = 0.873). …”
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Incoherent Integration Detection Method of Airborne Phased Array Radar in a Multipath Environment by Yili Hu, Yongbo Zhao, Sheng Chen

“…In essence, the proposed method makes full use of multipath energy to improve the detection capability of airborne PAR in the multipath environment. Finally, the detection probability of the proposed method is given, and the detection performance is analyzed.…”
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The Enigmatic Upper Ordovician of the Naturtejo UNESCO Global Geopark (Portugal) by Sofia Pereira, Jorge Colmenar, Cristiana Esteves, Ícaro Dias da Silva, Miguel Pires, Carlos Neto de Carvalho

“…In the Vila Velha de Ródão Syncline, the Barroca da Senhora stream fossil site constitutes a new geosite within the protected area of Portas de Ródão Natural Monument, presenting the most complete Upper Ordovician sequence of this structure. Finally, the stratigraphic and paleontologic record of the Vale Feitoso estate offers all the conditions to propose a new theme geotrail, diversifying the tourism in the Monfortinho village (Penha Garcia Syncline).…”
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Experimental and Thermal Investigation on Powder Mixed EDM Using FEM and Artificial Neural Networks by Venkata N. Raju Jampana, P. S. V. Ramana Rao, A. Sampathkumar

“…Further, back propagated neural network (BPNN) with feed forward architecture with analysis of variance (ANOVA) is used to find the best fit and approximate solutions to optimization and search problems. Finally, confirmation test results of experimental MRR are compared using the values of MRR obtained using FEM and ANN. …”
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One-Pot Synthesis of W-TiO2/SiO2 Catalysts for the Photodegradation of p-Nitrophenol by Ulises Arellano Sánchez, Lifang Chen, Jin An Wang, Luis Enrique Noreña, Maximiliano Asomoza, Silvia Solis, Xiaolong Zhou, Yueqin Song, Jing Liu

“…Under UV irradiation, p-nitrophenol was initially photodegraded into hydroquinone and benzosemiquinone intermediates, which were further degraded into smaller fragments such as organic carboxylic acids and finally completely mineralized. A proposed photoreaction mechanism was presented based on the key roles of the surface hydroxyl species and superoxide radicals such as O2- and ⋅OH, together with W6+/W5+ couples and e-/h+ pairs in the catalysts in the p-nitrophenol photodegradation. …”
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Perioperative infarction during coronary bypass surgery: an attempt to refine the diagnostic criteria using data from a retrospective case–control study by Lars Niclauss, Liam-Kani Roulet, Piergiorgio Tozzi, Filip Dulguerov, Ziyad Gunga, Anna Nowacka, Matthias Kirsch

“…An enzyme activity increase alone is of limited diagnostic value for perioperative MI, which is associated with greater mortality. Finally, the use of a higher threshold for hs-cTnT (>45 × URL) may increase its specificity for graft failure.…”
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Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice by Yanyan Zhang, Yaxi Du, Hong Yu, Yongchun Zhou, Feng Ge

“…Rhabdomyolysis was monitored using creatine kinase (CK) level. Oxidative stress was determined using kidney tissue glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) levels. …”
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The experience economy of the largest walking event in the world: The case of the Nijmeegse Vierdaagse by Thijs Glaap, Polina Ermolaeva

“…Lastly, only small relevance was found in becoming a different person and experiencing a completely different world through escapism. Finally, practically all participants expressed their wish to re-attend the event considering it successful.…”
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Effects of Resveratrol on Liver Function Tests in Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials by P. Ebrahimpour, M. Karamian, A. Sharifi

“…The effect was presented as a mean difference and 95 % confidence interval (CI) in a random-effects model.Results. Finally, six eligible randomized controlled trials consisting of 256 patients were found. …”
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Clustering by Hybrid K-Means-Based Rider Sunflower Optimization Algorithm for Medical Data by A. Jaya Mabel Rani, A. Pravin

“…In this research, initially, the data preprocessing phase has been carried out to clean the current input medical data, and then in the second phase, important features are chosen with the help of the Tversky index with holoentropy. Finally, medical data clustering has been carried out by using hybrid K-means-based rider sunflower optimization (RSFO) algorithm. …”
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State of Charge Estimation of Lithium-Ion Battery Considering Operating Conditions and Aging Degree by WU Jiang, ZHANG Yan, LIU Zelong, CHENG Gang, LEI Dong, JIAO Chaoyong

“…Thus, an adaptive dual extended Kalman filter (ADEKF) algorithm is formed. Finally, algorithm verifications are performed with testing data and public datasets. …”
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Chordoma Spontaneous Regression After COVID-19 by Luis Fernando Moura da Silva Junior, Gyl Eanes Barros Silva, Marcos Adriano Garcia Campos, Antonio Augusto Lima Teixeira Júnior, Ramon Moura Santos, Orlando José dos Santos, Natalino Salgado Filho

“…Six months after COVID-19, she finally came back for endoscopic endonasal resection of the tumor and pre-operative MRI surprisingly showed 98.9% regression of the tumor volume. …”
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Application of Peaks Over Threshold Method in Flood Frequency Analysis in Seyhan Basin by Gülay Onuşluel Gül, Ali Gül

“…Uncertainty analysis was performed by determining the parameters of the Generalized Pareto distribution and the confidence intervals over the calculated flood flows of 2, 5, 10, 25, 50 100, 200, 500 and 1000 years. Finally, flood quantities with the recurrence intervals of 2, 5, 10, 25, 50, 100, 200, 500 and 1000 years were computed and compared to the corresponding quantities obtained from the annual maximum series. …”
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Analysis of the Impact of Different Forecasting Techniques on the Inventory Bullwhip Effect in Two Parallel Supply Chains with a Competition Effect by Xigang Yuan, Xiaoqing Zhang, Dalin Zhang

“…We constructed the quantity model of the bullwhip effect and the inventory bullwhip effect. Finally, we analyzed the impact of different forecasting techniques and market share on the inventory bullwhip effect. …”
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