Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…Baoyue Ding,1,2,* Mingjuan Li,2,* Jie Zhang,2,* Xiaojuan Zhang,2 Huan Gao,2 Jianqing Gao,3 Chunyan Shen,4 Yan Zhou,4 Fanzhu Li,5 Ailin Liu1 1Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, People’s Republic of China; 3Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 People’s Republic of China; 4Jiaxing Institute for Food, Drug and Product Quality Control, Jiaxing, Zhejiang, People’s Republic of China; 5Zhejiang Chinese Medical University, School of Pharmaceutical Science, Hangzhou, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanzhu Li; Ailin Liu, Email lifanzhu@zcmu.edu.cn; ailinliu@mail.fjmu.edu.cnPurpose: The incidence of malignant melanoma (MM) has risen over the past three decades, and despite advancements in treatment, there is still a need to improve treatment modalities. …”
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Le mobilier en cuir antique et médiéval du boulevard Dr Henri-Henrot à Reims/Durocortorum by Martine Leguilloux

“…The models are categorized by the shape of the soles: those with a rounded cut in the front, those with an anatomical cut, taking on the shape of one or more toes and finally, those with a very flared shape in the front portion of the shoe, at toe level, presenting a rectilinear cut. …”
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De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…On the eastern terrace, the complex included two semi-detached buildings, to the north of a theater building and, finally, double imperial-style thermal baths at the bottom of the valley. …”
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Supercharged nanoadhesive through co-assembly of recombinant protein and tetrahedral DNA for corneal transplantation by Jing Zhao, Feng Zhang, Zhe Zhang, Zhenhua Li, Yanze Yu, Bingqing Sun, Binghong Yu, Yong Ma, Xuan Ding, Liyin Wang, Lifei Zheng, Wenguo Cui, Xingtao Zhou

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Effect of Sucrose Spray on some Phytochemical Characteristics of Stevia (Stevia rebaudiana Bertoni) under Field Conditions by Vahid Akbarpour, Hossein Aruei, Kambiz Mashayekhi, Majid Azizi Arani, Mohammad Ali Bahmanyar

“…The occurrence of these biochemical phenomena caused by the consumption of intermediate substances ultimately increases the photosynthetic efficiency and improves the accumulation of photosynthetic substances, as well as the synthesis of secondary metabolites. Finally, it can be concluded that the application of sucrose with its appropriate solvent (methanol) could decrease or replace the absolute requirement for carbon source in the environment.…”
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Film Recommender System Menggunakan Metode Neural Collaborative Filtering by Ni’mah Khoiriyah Ayyiyah, Retno Kusumaningrum, Rismiyati Rismiyati

“…Keinginan untuk menikmati hiburan dalam media digital mendorong pengguna internet lain untuk mengunjungi situs-situs yang menawarkan film tertentu, sehingga meningkatkan minat mereka terhadap website yang menawarkan hiburan digital. …”
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Immunisation schedule of the Pediatric Spanish Association: 2024 recommendations by Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, Elisa Garrote Llanos, Lucía López Granados, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Ignacio Salamanca de la Cueva, Pepe Serrano Marchuet, Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, María Garcés-Sánchez, Elisa Garrote Llanos, Abián Montesdeoca Melián, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Pepe Serrano Marchuet

“…., adelantar la segunda dosis de vacuna frente a varicela a los dos años.Debido al muy importante aumento de casos de tosferina desde finales del 2023 y especialmente en 2024, recomendamos adelantar la dosis de Tdpa en la adolescencia a los 10-12 años.Para completar la protección frente a los meningococos en la adolescencia, recomendamos la vacunación frente al MenB a los 12 años.Consideramos que la vacunación frente a gripe debe ser sistemática hasta los 18 años, pero dadas las decepcionantes coberturas en los niños entre 6–59 meses, creemos prioritario actualmente aumentar dichas coberturas, y una vez conseguido este objetivo, ampliar la vacunación a niños y adolescentes entre 5–18 años.Se mantienen respecto al calendario 2024, entre otras, las tablas de inmunización sistemática para personas sanas y la de grupos de riesgo, el uso de las nuevas vacunas conjugadas de valencia ampliada frente al neumococo, la vacunación sistemática a los 4 meses de edad con MenACWY, y la vacunación frente al SARS-CoV-2 para personas mayores de 6 meses con factores de riesgo.…”
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Pierre et carrières dans la Saintonge antique : identification, usages et diffusion by Jacques Gaillard, Egle Conforto

“…The port town of Barzan, on the edge of the Gironde estuary, relied on a strategically placed road, specially created to link it to Saintes, its capital, with the Thénac quarry conveniently located along the route. Finally, this study reveals a rubble trade that is generally under studied, as is the case for the quarries of Marcamps, which supplied the second phase of the reconstruction of Barzan. …”
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Hameaux et villages paysans de la période romaine en plaine d’Alsace by Antonin Nüsslein, Pascal Flotté, Mathias Higelin, Muriel Roth-Zehner

“…A role that undoubtedly benefited the army present in Strasbourg, at the outlet of the Bruche plain. Finally, the last part of the article presents the initial hypotheses on the origin of the phenomenon of the strong presence of villages and hamlets in the plain of Alsace between the 2nd and the 4th c. …”
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Alteration, mineralization, geochemistry and fluid inclusion investigations in Joftrud prospect area, southwest of Birjand by Omid Shareipour, Azadeh Malekzadeh Shafaroudi, Maryam Javidi Moghaddam

“…The purpose of this research is the geology, examine the geochemical and fluid inclusion data, and finally discus mineralization model of occurrence of ore veins in the Joftrud prospect area. …”
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Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling by Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan, Bo Fang

“…This study aims to investigate the regulation of transient receptor potential vanilloid 1 (TRPV1) and cyclin-dependent kinase 5 (CDK5) expression levels by miR-142-5p as a common upstream molecule, and to delve into the mature process of miR-142-5p from the perspective of N 6-methyladenosine (m6A) modification. …”
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戶外教育課程評估指標建構之研究 Indicators for Evaluating Outdoor Education Curricula by 鄭智明 Chi Meng Cheang, 陳美燕 Mei-Yen Chen, 郭雄軍 Husing-Chun Kuo

“…Fourth, it leverages social resources. Finally, safety and risk management mechanisms are consistently embedded throughout the curriculum of outdoor education. …”
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Value-creating factors in the professional relationship between the auditor and the employer in the auditing profession by Alireza Vaziri, keihan Azadi, Mojtaba Maleki choubari

“…Incentives such as entering new markets, improving research and development and obtaining new technologies, economic savings due to scale and globalization, the need for expertise in the industry due to the complexity of business owners' activities and maintaining or increasing market share, and finally, the personality characteristics of auditors have played a significant role in the entry of audit institutions into marketing issues. …”
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Identifying factors affecting the commercialization of products of knowledge-based companies based in science and technology parks and growth centers by yousef sofi, Vahid Reza Mirabi, Rahim Sarvar

“…Recognizing the needs of the consumer market, creating ideas, conducting research and studying for the development of technology and finally its commercialization are the inevitable stages of the birth and creation of a new technology (Cooper, 2019). …”
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Perceived effects of the hidden curriculum of return to entrepreneurship with the mediation of goal orientation by Ahmad KarimiDashtaki, Mohammadbagher Akbarpour Zangalani

“…In other words, goal orientation expresses a coherent pattern of a person's beliefs, which causes a person to approach situations in different ways, engage in activities in that field, and finally provide an answer (Ames, 1992). One of the topics that is unfortunately neglected in the research related to entrepreneurial tendencies is the study of the role of students' perceptions of the hidden curricula of academic environments. …”
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Jean-Philippe Luis, L’ivresse de la fortune. A.M. Aguado, un génie des affaires by Claude Morange

“…La otra cara del personaje la constituyen las inversiones que realizó en el mundo industrial o en proyectos de fomento: minas del Creusot, ferrocarril de París a Dieppe, y, en España, minas de plomo de la sierra de Gador, saneamiento de las marismas del Guadalquivir y minas de carbón de Asturias. …”
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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

“…Better training for doctors is needed, that is more supportive of young people, making sure they are listened to, respected and believed. Finally, the National Health Service needs to positively influence current debates and challenge false and misleading information about transgender people. …”
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Modeling the relationship between the moral charter derived from Islamic teachings and performance with the mediating variable of employees' perception by leila jahantigh, Abbas Babaeenezhad, Mohsen Zayandehroudi, saeed sayadi

“…With the rich culture of Islam and the useful experiences of the ancient Iranian civilization, Iranian business organizations can play an important role in promoting global ethics in business; the Islamic code of ethics makes organizations better deal with economic, political and cultural crisis; ethical organizations in Islamic business insist on respecting the rights of employees in addition to the rights of customers, and based on their rights, they begin to formulate their ethical duties. Finally, it helps the organizational personnel to achieve organizational goals by simplifying their work with greater effectiveness.…”
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Developing an effective teaching model in order to improve the educational level of schools by Mehdi Mohammadi, fardin Abdollahy, Rafigh Hasani

“…The facilities and physical space of the classroom, the use of multimedia in teaching, the use of lesson presentation software (PowerPoint and Parzi), creating a positive learning environment, using warm and soothing colors for the classroom, having workshops and laboratories for special courses are some of these tools and equipment. Finally, it is suggested that the school administrators help the teacher to improve the quality of teaching by providing a healthy atmosphere and adequate educational materials. …”
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Presenting the model of customer participation with brands in social media with emphasis on cultural differences by Hamed Saghafian, Samad Aali, morteza mahmoodzadeh

“…Meanwhile, brand trust has a positive and significant effect on brand loyalty, and brand trust and loyalty also have a positive and significant effect on brand co-creation. Finally, brand trust moderates the relationship between customer involvement and brand loyalty. …”
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