The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…Moreover, overexpression of proteolytically inactive tPA in tPA Ala-BAC mice leads to increased neuroinflammation and neurodegeneration compared to mice expressing normal levels of tPA, suggesting a tPA dose response. Finally, treatment of mice with glunomab, a neutralizing antibody that selectively blocks tPA binding to the N-methyl-D-aspartate receptor-1 (NMDAR1) without affecting NMDAR1 ion channel function, identifies the tPA interaction with NMDAR1 as necessary for tPA-mediated neuroinflammation and neurodegeneration in response to α-synuclein-mediated neurotoxicity. …”
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Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review by Siligato R, Gembillo G, De Giorgi A, Di Maria A, Scichilone LM, Capone M, Vinci FM, Nicoletti S, Bondanelli M, Malaventura C, Storari A, Santoro D, Dionisi S, Fabbian F

“…For patients with kidney disease, FT represents a significant burden, both through the direct costs of disease management and treatment and through indirect costs such as the loss of income due to missed work and expenses for transportation and accommodations near outpatient clinics. Finally, it should be noted that in different countries, it is difficult for people with kidney disease to obtain health insurance coverage. …”
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Loose cigarette purchase and adolescent smoking in Indonesia: a mixed-methods study by Vid Adrison, Dian Kusuma, Gea Melinda, Fariza Zahra Kamilah, Syifa Rizki Amelia, Sofwatun Nida

“…Students reported the extensive selling of loose cigarettes and such a situation persuaded them to buy tobacco products more frequently, thus spending at least half of their weekly allowance on tobacco products, ranging from 30 000 to 200 000 Indonesian rupiah or equivalent to US$2–13 per week. Finally, our study highlighted that only a few students in this study either had to show their identity card or were denied when purchasing loose cigarettes in informal retailers.Conclusion Our study demonstrates that students purchasing loose cigarettes is significantly associated with non-daily smoking, consuming five or fewer sticks per day, and lower addiction which could be interpreted as smokers in the experimental phase. …”
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EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles by Noha Elsherbini, Dong Hyun Kim, Richard J. Payne, Thomas Hudson, Véronique-Isabelle Forest, Michael P. Hier, Alexandra E. Payne, Marc P. Pusztaszeri

“…While 55% of thyroid nodules were benign at the time of surgery, the possible malignant transformation of these nodules, had they not been resected, is unknown. Finally, 13% of the nodules with EIF1AX mutations were aggressive with a significant PDTC component. …”
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Gravitational wave luminosity distance for Starobinsky gravity in viscous cosmological models by Jia-nan Chi, Ya-Bo Wu, Yu Sang, Xue Zhang, Yi-liang Hu, Wen-zhong Liu, Bo-hai Chen

“…Meanwhile, the EM signals change from strong to weak earlier than GW signals do. Finally, we confirm that $$\delta (z)$$ δ ( z ) and $$d_L^{GW}(z)$$ d L GW ( z ) of our model meet the constraints imposed by the standard siren GW170817 and its electromagnetic companion GRB170817A.…”
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Construction of a Practical Oriented Tool for Evaluating the Ability of Community Medical Staff to Provide Hospice Care Services and Its Reliability and Validity by SHA Jingjing, JING Limei, DING Tongjiu, XIN Yurong, TANG Lan, LI Shuijing

“…The Delphi expert consultation method invited a total of 15 authoritative experts in Shanghai who study and carry out hospice services, in which the expert authority coefficient was 0.87, and the Kendall harmony coefficient of the overall index system was 0.624 (P<0.01), and the evaluation tools for the 50 entries were finally formed after two rounds of Delphi expert consultation. …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Our findings suggest that patients with high metabolic scores have poorer prognoses, and the metabolic score serves as an independent prognostic factor. Finally, RNA stability experiments confirmed CKB, RRM2, NME1, PKM, and UXS1 as specific metabolic target genes affected by NC/IGF2BP3, displaying reduced RNA half-life post IGF2BP3 downregulation. …”
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Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat (<i>Fagopyrum tataricum</i> (L.) Gaertn.) by Juan Huang, Fei Liu, Jieqiong Zhang, Bin Tang, Jiao Deng, Taoxiong Shi, Liwei Zhu, Hongyou Li, Qingfu Chen

“…A protein–protein interaction network was constructed and co-expression was analyzed based on the gene expression patterns of the <i>FtGBSSs</i>, and the identified TFs, belonging to bZIP, ERF, bHLH, and MADS-box TF families, were identified within this network, and their expression patterns were significantly correlated to the expression patterns of two seed-specific <i>FtGBSS</i> genes (<i>FtGBSS-3</i> and <i>FtGBSS-5</i>). Finally, <i>FtGBSS1-5</i> was successfully transformed into rice through transgenic manipulation, and the <i>FtGBSS1-5</i> overexpression lines showed an increase in amylose content accompanied by a reduction in amylopectin and total starch contents compared with WT. …”
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How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center by Xiangyi Kong, Zhiqiang Liu, Chunyu Huang, Xiuyu Hu, Meilan Mo, Hongzhan Zhang, Yong Zeng

“…Subsequently, the validation set was applied to verify the validity of the model. Finally, for a more intuitive assessment of the CLBR more intuitively for clinicians and patients, a Nomogram model was established based on predictive model. …”
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أسلوب التعامل مع الخلافات الفقهية: مراجعة كتاب الموافقات للإمام الشاطبي. دار الكتب العلمية، ٢٠٠٥، ٥٨٠ صفحة، ISBN: ٢-٧٤٥١-١٥٣٠-٨، (غلاف صلب)... by Muhammad Najib Abdullah, Muhammad Nazir Alias, Syaryanti Hussin, Ibrahim Zakariyya Moosa

“…This work is found to be beneficial and deserving of further scholarly attention to address the reprehensible differences in the Muslim world. Finally, this research provides a valuable contribution to the international scholarship on Islamic jurisprudence and legal theory, by shedding light on a critical and timely issue of sectarian divisions, and highlighting the constructive approach proposed by a prominent Islamic scholar, Imam al-Shatibi, to address this challenge.   …”
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Effectiveness of shared decision-making for glycaemic control among type 2 diabetes mellitus adult patients: A systematic review and meta-analysis. by Edosa Tesfaye Geta, Dufera Rikitu Terefa, Wase Benti Hailu, Wolkite Olani, Emiru Merdassa, Markos Dessalegn, Miesa Gelchu, Dereje Chala Diriba

“…The sensitivity analysis was performed using a leave-one-out meta-analysis to quantify the impact of each study on the overall effect size in mean difference HbA1c%. Finally, the statistically significant MD of HbA1c% between the intervention groups engaged in SDM and control groups received usual care was declared at P ˂0.05, using a 95% confidence interval (CI).…”
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Application of failure mode and effect analysis combined with risk assessment tracking in the management of arthroscopy day surgery instruments (失效模式与效应分析联合风险评估追踪在关节镜日间手术器械管理中的应用)... by NI Ting (倪婷), BI Yaxi (毕雅晞), GONG Ronghua (龚荣花)

“…Conclusion The application of FMEA combined risk assessment and tracking in the arthroscopic day surgical instrument management process can effectively reduce the potential risks, ensure the normal operation of the arthroscopic day surgical instruments, and finally improve the operation efficiency. (目的 探讨失效模式与效应分析 (FMEA) 联合风险评估追踪在关节镜日间手术器械管理中的应用效果。…”
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The pattem of the conquest of the Polabian Slavs and Western Baltic lands from the point of view of Christianization of the Baltic tribes by Marius Ščavinskas

“…The nobility of the Western Baltic tribes (Prussian, Curonian, Semgallian and finally Ugric Livonian tribes in Livonia), contrary to the nobility of the Polabian tribes, were not granted any political rights. …”
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Novel predictive biomarkers for atonic postpartum hemorrhage as explored by proteomics and metabolomics by Jiangxue Qu, Hai Jiang, Huifeng Shi, Nana Huang, Jiawen Su, Yan Zhang, Lian Chen, Yangyu Zhao

“…Furthermore, we verified that concentrations of histidine (350.85 ± 207.87 vs. 648.33 ± 400.87) and DPYD (4.01 ± 2.56 vs. 10.96 ± 10.71), and immune cell-related proteins such as CD163 (0.29 ± 0.19 vs. 1.51 ± 0.83) and FGL2 (5.98 ± 4.23 vs. 11.37 ± 9.42) were significantly lower in the PPH group. Finally, the AUC for independent prediction of PPH using CD163, histidine, DPYD, and FGL2 are 0.969 (0.897-1), 0.722 (0.536–0.874), 0.719 (0.528–0.864), and 0.697 (0.492–0.844), respectively. …”
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Gender differences in efficiency of the telemedicine care of heart failure patients. The results from the TeleEduCare-HF study by Agata Bielecka-Dąbrowa, Dariusz Trzmielak, Agata Sakowicz, Kamil Janikowski, Maciej Banach

“…The questionnaire was conducted in all patients at baseline after enrollment to the study and after 3 months of telemonitoring and extensive educational process. Results The study finally included 140 men with an average age of 66 years (SD: 56–71) and 163 women with an average age of 64 years (58–72). …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…After 12 weeks of surgery, the efficacy of 4-OI treatment on PTOA in mice was evaluated using MRI, micro-CT, histological analysis, and quantitative real-time polymerase chain reaction. Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. …”
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Perancangan Perangkat Audit Internal untuk Sistem Keamanan Informasi pada Organisasi XYZ by Arif Rahman Hakim, Rizky Aditya Pratama Wijaya

“…The results of implementation trials, assessment, and finalization of our audit tool shows that our audit tool has been consistent with the needs of XYZ organization. …”
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Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa by George G Zhanel, Vibhu Vishisht, Ed Tam, Daryl J Hoban, James A Karlowsky

“…CONCLUSION: The present study found that individual antipseudomonal antimicrobial agents tested against 12 clinical isolates of P aeruginosa had eight- to greater than 32-fold higher MPCs than MICs, that combining doripenem or meropenem with a second active antipseudomonal agent with a different mechanism of action was more effective at preventing resistance selection than the two agents used individually, and finally, that doripenem was less likely than both imipenem and meropenem to select for spontaneous resistance mutants of P aeruginosa.…”
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Review and Prospect of Research on Urban Walking Safety and Environmental Influencing Factors Thereof by Lin LI, Yu YE, Yong CHEN

“…Especially in the field of data mining regarding urban form and walkers’ psychological perception, new technologies are helpful for in-depth analysis of the influence of built environment factors on walking safety. Finally, the research trend of walking safety is reflected in three aspects: Research object, content and method. …”
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Harnessing Big Heterogeneous Data to Evaluate the Potential Impact of HIV Responses Among Key Populations in Sub-Saharan Africa: Protocol for the Boloka Data Repository Initiative by Refilwe Nancy Phaswana Mafuya, Edith Phalane, Amrita Rao, Kalai Willis, Katherine Rucinski, K Alida Voet, Amal Abdulrahman, Claris Siyamayambo, Betty Sebati, Mohlago Seloka, Musa Jaiteh, Lerato Lucia Olifant, Katharine Journeay, Haley Sisel, Xiaoming Li, Bankole Olatosi, Neset Hikmet, Prashant Duhoon, Francois Wolmarans, Yegnanew A Shiferaw, Lifutso Motsieloa, Mashudu Rampilo, Stefan Baral

“…The data transfer agreement between the Pan African Centre for Epidemics Research and the Perinatal HIV Research Unit was finalized (October 2024), and we are anticipating receiving data by (December 2024). …”
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