Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…CTSB further induced ferroptosis via spermidine/spermine-N1-acetyltransferase (SAT1)-mediated lipid peroxidation, mitochondrial damage and mitogen-activated protein kinase (MAPK) signalling pathway activation, eventually affecting the function of HSFs. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…We integrated MR findings with clinical trial evidence from several drug gene related databases to identify drugs with repurposing potential. Finally, we developed a tier system and identified immune-cell-based prioritized drug targets for COVID-19. …”
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The new HFA/ICOS risk assessment tool to identify patients with chronic myeloid leukaemia at high risk of cardiotoxicity by Daniela Di Lisi, Cristina Madaudo, Giulia Alagna, Marco Santoro, Ludovico Rossetto, Sergio Siragusa, Giuseppina Novo

“…Abstract Aims Tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukaemia (CML) can cause cardiovascular adverse events. …”
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Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…This study investigated the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a pivotal regulator of glycolysis, in PARPi resistance and explored its potential as a therapeutic target to overcome PARPi resistance. …”
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Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…The anti-IAP antibody inhibited IGF-I-stimulated SHPS-1, p52Shc, MAP kinase phosphorylation, and proliferation in endothelial cells. …”
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AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis by Wuping Tan, Yijun Wang, Siyi Cheng, Zhihao Liu, Mengjie Xie, Lingpeng Song, Qinfang Qiu, Xiaofei Wang, Zeyan Li, Tianyuan Liu, Fuding Guo, Jun Wang, Xiaoya Zhou

“…AdipoRon, orally active synthetic adiponectin receptor agonist, could upregulate AdipoR1/2 (independently of adiponectin) and reduce lipid droplet accumulation, and alleviate fibrosis to restore HFpEF phenotypes. Finally, AdipoRon primarily exerted its effects through restoring the balance of myocardial fatty acid intake, transport, and oxidation via the downstream AMPKα or PPARα signaling pathways. …”
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Developing an automatic treatment record review system for quality assurance of patient treatment delivery in radiation therapy by Peng Huang, Yingjie Xu, Fukui Huan, Yanxin Zhang, Min Ma, Kuo Men, Jianrong Dai

“…As a result, for each daily treatment record, a reviewed flag (pass, failure, warning, and N/A) is assigned by the TRRS. Finally, this system is evaluated by 6 months patient treatment records collected in our institute and compared to the manual process on the same data. …”
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Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model by Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Luca Boldrini, Agnese Latorre, Deniz Can Guven, Serena Iacovelli, Tiziana Talienti, Alessandro Rizzo, Francesco Alfredo Zito, Raffaella Massafra

“…Discussion As far as we know, our research is the first proposal using ViTs on DCE‐MRI exams to monitor pCR over time during NAC. Conclusion Finally, the changes in DCE‐MRI at pre‐ and mid‐treatment could affect the accuracy of pCR prediction to NAC.…”
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Multiresidue Pesticides Analysis of Vegetables in Vietnam by Ultrahigh-Performance Liquid Chromatography in Combination with High-Resolution Mass Spectrometry (UPLC-Orbitrap MS) by Nam Vu-Duc, Trung Nguyen-Quang, Thuy Le-Minh, Xuyen Nguyen-Thi, Tri Manh Tran, Hai Anh Vu, Lan-Anh Nguyen, Tien Doan-Duy, Bui Van Hoi, Cam-Tu Vu, Dung Le-Van, Lan-Anh Phung-Thi, Hong-An Vu-Thi, Dinh Binh Chu

“…Experimental results demonstrated that the ionization suppression or enhancement was the main contribution on the overall recoveries of target analytes. Finally, the in-house validated method was applied to pesticides screening in vegetables samples in local villages in Hanoi, Vietnam. …”
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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

“…Aim This study aimed to investigate the effects of different intensities of endurance training on kidney function and inflammation in a rat model of lithium-induced nephropathy, focusing on the expression of aquaporin 2 (AQP2), glycogen synthase kinase 3-beta (GSK-3β), and SIRT1. Methods Thirty-five male Wistar rats were divided into five groups: control, lithium-only, lithium with low-intensity exercise (LIT), lithium with medium-intensity exercise (MIT), and lithium with high-intensity exercise (HIT). …”
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The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorpholog... by Pinxian Yang, Haijiao Wang, Lei Ma, Haoran Yin, Zhanying Zhu, Cong Liu, Wei Huang, Zhiyu Zhou, Xiaoyi Wu, Sehrish Taj

“…The Phe 13.3 group had lower expression of S6 kinase 1 (S6K1) and target of rapamycin (TOR) than other groups. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. …”
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A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Thereafter, morphological changes of E. coli O157:H7 cells were monitored by electron microscopy technologies. Finally, the potential application of zp39 in controlling EHEC in food was tested with spinach juice and the Galleria mellonella larvae model was employed to assess the in vivo efficacy. …”
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Regularidades de la superación profesional sobre fibrilación auricular en la Atención Primaria de Salud by Maribel Sandrino Sánchez, Ileana María Hernández Rodríguez, Martha María Pérez Martín, Mailin Silva Borroto, Nitza Hernández Suárez, Liz Yuliet Hernández Castillo

“…<br /><strong>Objetivo:</strong> identificar las regularidades de la superación profesional sobre fibrilación auricular en el Policlínico Turcios Lima de Pinar del Río.<br /><strong>Métodos:</strong> estudio descriptivo de corte transversal realizado de diciembre de 2019 a febrero del 2020. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…However, we also find increased astrocytic TSPO expression in chronic-appearing lesions with astrogliosis. Finally, we find expression of TSPO in a subset of neurons, most frequently GLS2 + glutamatergic neurons. …”
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UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…Mechanistically, UBE2T directly interacts with CDC42, promoting its K48-linked polyubiquitination and proteasomal degradation, thereby inhibiting CDC42 from degrading CD276 via the autophagy-lysosomal pathway, indirectly upregulating CD276 and thereby impairing the CD8+ T cells function, ultimately mediating tumor immune escape and BrM. Finally, animal experimental results also showed that inhibition of UBE2T elevated the TNBC sensitivity to immune checkpoint CD276 blockade and inhibited BrM of TNBC.Conclusions In conclusion, our results indicate a new mechanism whereby UBE2T-mediated ubiquitination positively controls the UBE2T/CDC42/CD276 axis to upregulate tumor cell expression of CD276 and thereby impair CD8+ T cells function, ultimately leading to tumor cell immune escape and BrM.…”
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Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits.…”
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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage by Shan Tian, Ruixue Li, Jiao Li, Jinhui Zou

“…Exposure to PS-NPs activated the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway both in the AOM/DSS mouse model and cellular model. …”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…Compared with HFD control mice, PCM supplementation increased phosphorylation of AMP-activated protein kinase (AMPK). Peroxisome proliferator-activated receptor (PPAR) α was significantly increased by PCM administration. …”
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Neuroprotective Effects of Metformin and Berberine in Lipopolysaccharide-Induced Sickness-Like Behaviour in Mice by Triveni Kodi, Sharanya Praveen, Sravan Kumar Paka, Runali Sankhe, Adarsh Gopinathan, Nandakumar Krishnadas, Anoop Kishore

“…Activation of AMP-activated protein kinase (AMPK) is reported to regulate inflammation in conditions such as Alzheimer and traumatic brain injury. …”
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