TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…Oxidative stress-related factors, mitochondrial dysfunction-related indicators in each group were measured; the levels of inflammatory factors in serum and kidney tissue of rats were examined. Finally, the expression of proteins related to the TLR4/NF-κB signaling pathway was observed by western blot.Results Compared with the CLP + vehicle and CLP + TAK-242 groups, the CLP + TAK-242 group reduced blood urea nitrogen (BUN), creatinine (Cr), cystatin-C (Cys-C), reactive oxygen species (ROS), malondialdehyde (MDA), and inflammatory factors levels (p < 0.01), as well as increased superoxide dismutase (SOD) activity of CLP rats (p < 0.01). …”
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Ultrasonic-assisted adsorption of methylene blue using shrimp shells as a low-cost adsorbent: Evaluation on the adsorption isotherm, kinetics, and thermodynamics by Erni Misran, Wahyu Pratama, Kanzi Insan Kasyidi Napitupulu, Muhammad Dani Supardan, Dewi Agustina Iryani, Viqry Pramananda

“…The adsorption kinetics study revealed that the experimental data for all three adsorbents conformed well to the Pseudo-Second Order model, with R2 values ranging from 0.99998 to 1.0000. Finally, the thermodynamic assessment demonstrated that ultrasonic-assisted MB adsorption with the three adsorbents was spontaneous, with ΔG° values of -1,542, -10,669, and -10,680 kJ/mol, ΔS° values of 62.845, 150.900, and 162.260 kJ/mol.K, and ΔH° values of 17,347, 35,088, and 38,339 kJ/mol for A1, A2, and A3, respectively.…”
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Effect of different clay additions to concrete on its ultrasonic acoustic parameters and compressive strength by Wenxiang Wu, Shunchao Chen, Yong Wu, Xiangyang Zhang, Debiao Kong, Jifeng Wen

“…Subsequently, the acoustic parameters and compressive strength were tested for concrete specimens with different mud contents cast on site. Finally, the effects of concrete mud content on wave velocity, sound time, amplitude, frequency and strength were analyzed according to the measured acoustic parameters, and the relational equations of mud content on acoustic parameters were verified, which provided a reference for evaluating the defective degree of concrete mud content. …”
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Seven Immune-Related Genes’ Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma by Rui Mu, Yuehong Shen, Chuanbin Guo, Xinyun Zhang, Hongyu Yang, Huijun Yang

“…The protein-protein interaction (PPI) network and functional enrichment pathway investigations were utilized to explore possible potential molecular mechanisms. Finally, the hub gene’s differential mRNA expression levels were evaluated by means of the Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA) was utilized for the validation of their translational levels. …”
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The Fake History: Soviet Totalitarianism and the Memory of the Guerrilla War by Bernardas Gailius

“…Later, the critical narratives appear that challenge the tradition. Finally, the genetic narratives help to grasp the changes in the tradition itself. …”
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From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment by Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

“…The technical challenges include efficient and targeted delivery to tumor sites without affecting healthy tissue; biological, such as potential toxicity, immune system activation, or resistance mechanisms; economic, involving high production and scaling costs; and regulatory, requiring rigorous testing for safety, efficacy, and long-term effects to meet stringent approval standards. Finally, we have explored emerging trends, the potential for personalized medicine, and the ethical and social implications of this transformative technology. …”
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Multiscale study on the compressive performance of diverse solid waste backfill bodies by Hang Yin, Jiepeng Liu, Xuhong Zhou, Hongtuo Qi, Shuxian Liu, Shuai Pang

“…Material strength difference mechanisms were characterized using SEM–EDS and XRD microscopic techniques. Finally, discrete element numerical simulation was utilized for analyzing the evolution of sample failure. …”
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Management of Irritable Bowel Syndrome: Novel Approaches to the Pharmacology of Gut Motility by Carmelo Scarpignato, Iva Pelosini

“…Besides decreasing colonic sensitivity to distension, these drugs prolong intestinal transit and may be particularly useful in diarrhea-predominant IBS. Finally, when administered in small pulsed doses, octreotide, besides reducing the perception of rectal distension, accelerates intestinal transit, although other evidence disputes such an effect.…”
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Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity by Nouh AH, Elgendy FM, Gobran FA, Zhuravlova MS

“…It typically presents as sparse hair at birth with a coarse texture, followed by regrowth during childhood then, finally, gradual hair loss at puberty, resembling pattern of androgenetic alopecia.Case Presentation: The study describes two cases from different unrelated families presenting with recalcitrant alopecia resembling female pattern hair loss, with dermoscopic findings consistent with pili torti and yellow dots. …”
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Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment. by Mariagiovanna Cantone, Manuela Pennisi, Giuseppe Lanza, Raffaele Ferri, Francesco Fisicaro, Francesco Cappellani, Emanuele David, Vito Nicosia, Klizia Cortese, Giovanni Pennisi, Valentina Puglisi, Rita Bella

“…When focused to younger patients (<65 years), we confirmed the significant worsening of both MoCA and StroopT but not HDRS, as well as the significant changes in PI and RI. Finally, considering the differences (D) between baseline and follow-up, the following significant correlations emerged, although with a small-to-medium effect size for all of them: positive correlation between MBFV-D and MoCA-D and between RI-D and STROOP-D, and a negative significant correlation between RI-D and MoCA-D.…”
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Rural–urban and age differences in association between depression and suicidal attempt: a large retrospective clinical sample study in China by Yong Xia, Dandan Ge, Zhonghua Zhang

“…Subgroup analyses were carried out to assess the relationship between age, region and SA in depressed patients, after excluding non-depressed patients, and to inspect the interaction of age and region. Finally, further comparisons of the disparities in suicide patterns among different age groups and regional groups were made.Results Among 7593 patients (3630 males), 655 (8.6%) patients with SA were observed. …”
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Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents by Albratty Mohammed, El-Sharkawy Karam Ahmed, Alhazmi Hassan Ahmed

“…Products 9a,b underwent cyclization to produce pyridazine derivatives 10a,b. Finally, 1,3,4-oxadiazole derivative 1 was directed toward reaction with hydrazine derivatives, bromoacetophenone and ethylchloroacetate affording compounds 11a,b, 12 and 13, resp. …”
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DeepGenMon: A Novel Framework for Monkeypox Classification Integrating Lightweight Attention-Based Deep Learning and a Genetic Algorithm by Abdulqader M. Almars

“…Next, the CNN is employed to process the visual input and extract hierarchical features for classifying the input data into multiple classes. Finally, the CNN’s hyperparameters are adjusted using a genetic algorithm to enhance the model’s robustness and classification accuracy. …”
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Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized... by Azizeh Farshbaf-Khalili, Alireza Ostadrahimi, Mojgan Mirghafourvand, Khatereh Ataei-Almanghadim, Sara Dousti, Amir Mehdi Iranshahi

“…Eighty-one participants completed the trial and were finally analyzed. There were no statistically significant differences in demographic characteristics and dietary intake of participants (except for vitamin C intake, P=0.023) between the groups at baseline. …”
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Secondary Subtalar Arthrodesis: Surgical Outcome and Predictors of Functional Outcome and Quality of Life After Bone Block Distraction vs In Situ Technique by Robin Eelsing BSc, Sally Al-Sheikh MD, Jens A. Halm MD, PhD, Tim Schepers MD, PhD

“…Multiple regression revealed that a higher Böhler angle before the initial fracture reconstruction significantly improved the AOFAS score, whereas the FFI significantly improved by an initial conservative treatment and implant removal after arthrodesis. Finally, increasing age significantly improved the EQ5D index. …”
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Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral hea... by Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo

“…Subsequently, the effect of exosomal miR-122 on the osteogenic differentiation ability of BMSCs was detected, including cell proliferation, expression of osteogenic-related genes (RUNX2, BMP2, OPN, ALP), and calcium nodule formation. Finally, the therapeutic effect of M2-Exo was analyzed in a rat model of AIONFH, and bone repair and pathological damage were evaluated by Micro-CT, RT-qPCR, HE, Masson staining, and immunohistochemistry (COL I). …”
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A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition? by Grazia Bossi, Maria Sole Prevedoni Gorone, Luca Lungarotti, Francesco Pelillo, Amelia Mascolo, Matteo Naso, Daniele Veraldi, Francesca Olivero, Costanza Chirico, Maria Vittoria Marino, Cristina Dutto, Gian Luigi Marseglia

“…Because the diseases’ onset is seldom simultaneous, patients with CNO and IBD deserve a properly extended follow-up. Finally, the analysis of the relationship between CNO and autoimmune intestinal diseases provides a unique opportunity to understand the pathophysiological pro-inflammatory network underlying both types of disorders and it is necessary to make the most suitable therapeutic choice.…”
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Inclusive educational process at the university: Theoretical and experimental model of teachers' psychological readiness by V. Z. Kantor, Yu. L. Proekt

“…The following stages are determined: from providing basic methodological readiness in the framework of professional development through the creation of internal conditions for readiness for inclusive education, examining the experiences and psychological difficulties in interacting with people with disabilities, and, finally, to accompanying the actual inclusive teaching practice.…”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Subsequently, we employed weighted gene co-expression network analysis (WGCNA) to identify differentially expressed genes (DEGs) within each cluster and utilized the “GSVA” and “GSEABase” software packages to examine variations in gene sets enriched across various CRG clusters. Finally, we selected the best-performing machine learning model to predict genes associated with AS. …”
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Le flirt à Rabat au Maroc : Engagements des corps et arrangements socio-spatiaux by Chadia Arab, Christophe Guibert

“…The couples behave like “teams”, as Erving Goffman (1973) formulates it, operating jointly a strict control of their gestures, representations, body distances and finally of the glances coming from outside. Complicity within the couple therefore, but also between couples in the same place. …”
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