Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatmentResearch in context by Haritha Desu, Renaud Balthazard, Audrey Daigneault, Sandra Da Cal, Wendy Klément, Jennifer Yu, Marie-Laure Clénet, Clara Margarido, Annie Levert, Canisius Fantodji, Olivier Tastet, Jean-Marc Girard, Pierre Duquette, Alexandre Prat, Gabrielle Macaron, Marie-Claude Rousseau, Nathalie Arbour, Catherine Larochelle

“…Samples associated with distinct DMTs exhibited specific profiles for age-sensitive immune markers. Finally, lower levels of IL-6, TNF, IL-10, and β-NGF were observed at baseline in PwMS who subsequently experienced clinical failure after DMTs initiation. …”
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TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway by Yun Zhang, Hong-Mei Tang, Chun-Feng Liu, Xie-Fang Yuan, Xiao-Yun Wang, Ning Ma, Guo-Feng Xu, Song-Ping Wang, Jun Deng, Xing Wang

“…The inhibition of ROS generation by N-Acetyl-L-cysteine (NAC) resulted in a decrease in mucus expression and autophagy activity in vivo as well as in vitro. Finally, TGF-β3-neutralizing antibody significantly reduced the ROS generation, mucus expression, and autophagy activity and also decreased the phosphorylation of Smad2 and Smad3. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…We assessed the predictive performance of our model for distinguishing the enrichment of exceptional longevity among long-lived individuals in two replication cohorts (the Scripps Wellderly cohort and the Medical Genome Reference Bank (MRGB)) and showed that the median lifespan in the highest decile of our composite prognostic index is up to 4.8 years longer. Finally, using the proteomic correlates of iLGS, we identified protein markers associated with exceptional longevity irrespective of chronological age and prioritized drugs with repurposing potentials for gerotherapeutics. …”
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Design and testing of a posture-adjusting precision metering device for high-speed maize planting by Jianxin Dong, Xiaojun Gao, Zhouzhou Zheng, Pengfei Zhao, Yubin Bi, Yuxiang Huang, Yuxiang Huang, Yuxiang Huang

“…Secondly, the influences of the seed posture adjusting efficiency and seed flow distribution characteristics on the seed-filling effect were clarified by the EDEM simulation. Finally, the high-speed metering performance was optimized and validated using bench testing.ResultsThe experiment demonstrated that the type A groove had the highest seed posture adjusting efficiency, a more uniform seed flow distribution, and a superior seed-filling effect as compared to the other groove types. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…When comparing all possible biomarker combinations, the tripartite combination of MRI, OCT and blood biomarkers achieved the highest discriminative accuracy. Finally, predictive causal modeling identified that LV mediates significant parts of the effect of GMV and sNfL on disability progression.ConclusionMultimodal biomarkers, i.e. different major surrogates for pathology derived from MRI, OCT and blood, inform about different parts of the disease pathology leading to clinical progression.…”
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The Instant Effects of Continuous Transcutaneous Auricular Vagus Nerve Stimulation at Acupoints on the Functional Connectivity of Amygdala in Migraine without Aura: A Preliminary S... by Wenting Luo, Yue Zhang, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Yongsong Ye, Hui Li, Bo Liu

“…Each participant attended two kinds of eight-minute stimulations, taVNS and sham-taVNS (staVNS), separated by seven days in random order. Finally, 27 of them were included in the analysis of seed-to-voxel FC with the left/right amygdala as seeds. …”
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Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment by Yu Luo, Fangmin Zhang, Lidan Zhu, Jianfeng Ye, Hong-ye Pan, Xiaoyan Lu, Xiaohui Fan

“…Results The combination of BBP and CF (STDP without BBP) significantly reduced AMI-induced infarction size, pathological alterations of cardiac tissues, and serum lactate dehydrogenase and creatine kinase levels in rats, compared with CF or BBP treatment alone. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…Laboratory tests revealed that patients who died had higher creatinine, lactate, activated partial thromboplastin time, thrombin time, interleukin (IL)-6, IL-10, creatine kinase, and D-dimer than survivors. Imaging examinations predominantly revealed symmetrical lesions in the thalamus. …”
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miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting by Yilan Xu, Danyang Li, Na Wang, Bei Ge, Chen Meng, Min Zhao, Zihan Lin, Min Li, Yigang Yuan, Yue Cai, Liuzhi Shi, Shenmeng Gao, Haige Ye

“…Moreover, the median OS and LFS were longer in AML patients with miR-182 promoter hypermethylation than AML with hypomethylation. Finally, the area under the curve (AUC) for 1-year mortality was 0.831, for 2-year was 0.788, and for 3-year was 0.800. …”
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Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway by Lu Cao, Wenchao Ding, Yashuo Feng, Chong Guan, Li Liu, Hongyu Xie, Kewei Yu, Dongyan Xu, Lijuan Zhao, Xuan Sha, Xiaoman Deng, Santian Wu, Yangrui Wang, Yi Wu, Tingting Zhang, Nianhong Wang

“…In addition, the EA group exhibited a significant reduction in cerebral infarct volume and impairment of neurobehavioral function, an increase in cerebral blood flow and microvascular diameter on the ischemic side, and significantly higher expression levels of FNDC5, brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), protein kinase B (Akt), and endothelial nitric oxide synthase (eNOS). …”
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A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein by Juan José Valenzuela-Fuenzalida, Benjamín Rodríguez-Osorio, Cristian Salgado-Torres, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandro Bruna-Mejías, Roberto Avila-Sepulveda, Álvaro Becerra-Farfán, Macarena Rodríguez-Luengo, Juan Sanchis-Gimeno, Guinevere Granite, Héctor Gutiérrez-Espinoza

“…About the right anterior portal vein variant originating from the left portal vein, it was 4% (CI = 1-6%). Finally, the prevalence of the isolated variants was 2% (CI = 1-3%). …”
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Factorial invariance of the generalized anxiety disorder scale (GAD-7) in Latin America and the Caribbean by Norman López, Norman López, Juan-Carlos Coronado, Daniela Ripoll-Córdoba, Nicole Caldichoury, César Quispe-Ayala, Breiner Morales-Asencio, Raúl Quincho-Apumayta, Cesar Castellanos, Juan Martínez, Juan Cárdenas-Valverde, Luis Mario Castellanos-Alvarenga, David Salazar, Irina Flores-Poma, Jorge Herrera-Pino, Wendy Bada, Yuliana Flórez, Karen Alcos-Flores, Boris Zurita-Cueva, Elsa Muñoz Romero, Cristian Romo, Regulo Antezana, Claudio Avila Saldaña, Pascual A. Gargiulo

“…Additionally, the factor structure showed measurement invariance between genders and countries, with adequate fit indices at all levels (configural, metric, scalar, and strict), suggesting that the measurements are equivalent in both contexts. Finally, the internal consistency of the GAD-7 was high, with a McDonald’s Omega coefficient of 0.91.ConclusionsThe GAD-7 exhibits a factor structure that is equivalent across genders and countries, demonstrating its validity and reliability for the rapid detection of GAD symptoms in different countries within the region.…”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…Tusc5 expression was not induced appreciably in liver preparations overexpressing PPARs, suggesting that tissue-specific factors regulate PPARγ responsiveness of the TUSC5 gene. Finally, we observed no differences in Tusc5 WAT expression or prevalence of coding region SNPs in lean versus obese human subjects. …”
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Pretreatment with AM1241 Enhances the Analgesic Effect of Intrathecally Administrated Mesenchymal Stem Cells by Junran Xie, Jinxuan Ren, Na Liu, Chengwei Wu, Dongju Xiao, Huanyu Luo, Jingxian Du

“…Moreover, CCI-induced upregulation of the phosphorylated extracellular signal-regulated kinase (ERK) 1/2 (p-ERK1/2) was inhibited following i.t. injection of AM1241-treated mesenchymal stem cells and this inhibition was noticeably higher compared to injection with untreated mesenchymal stem cells. …”
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Catálogo de las Licofitas (Lycopodiopsida) y Helechos (Polypodiopsida) nativos de Chile by Javian G. Gallardo-Valdivia, Marcelo D. Arana, Gloria I. Rojas, Paulette I. Naulin

“…Las Lycopodiopsida (licófitas) y Polypodiopsida (helechos), conocidos clásicamente como “pteridofitos”, juntos representan los primeros linajes vivientes de plantas con un sistema vascular en el esporofito. …”
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Donkey milk supplementation alleviates renal fibrosis of chronic kidney disease by enhancing anti-inflammatory ability by Cui Huimin, Wang Peng, Chen Man, Lin Hong, Zhao Yuxin, Pu Zhiyu, Yang Jianjun

“…However, donkey milk supplementation activated miR-223-3p, thereby inhibiting the expression of inhibitor of kappa-B kinase (IKKα) and nuclear factor kappa-B (NF-κB) proteins. …”
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Pharmacovigilance imbalance analysis of VEGFR-TKI-related taste and smell disorders by Zhong-hua Fu, Chenglong Zhao, Yaqin Wang, Lei Zhang, Lei Wang

“…The advent of targeted drugs such as vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) has significantly extended the survival time of cancer patients, and thus widely used in clinical practice. …”
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Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) by Nuwadatta Subedi, Sunita Ranabhat, Sanjib Mani Regmi, Mukesh Mallik, Dela Singh, Shree Krishna Shrestha, Bandana Gurung, Arjun Bhattarai, Madan Prasad Baral, Sudhir Raman Parajuli, Ramchandra Bastola, Junu Shrestha, Sahisnuta Basnet, Eva Gauchan, Sabita Paudel

“…The “Cause of Death Panel” will finalize MITS informed cause of death following the customized protocol for the project and the cause so derived will be compared with that obtained by the review of deaths by the MPDSR committees of the hospitals. …”
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor by Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan

“…Knockdown of MR eliminated the increased ENaC expression in primary IMCD cells isolated from KO mice. Finally, BP was significantly decreased in Ang II-infused KO mice after treatment of MR antagonist spironolactone and the difference between LC and KO mice was abolished. …”
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SCUBADive. I. JWST+ALMA Analysis of 289 Submillimeter Galaxies in COSMOS-web by Jed McKinney, Caitlin M. Casey, Arianna S. Long, Olivia R. Cooper, Sinclaire M. Manning, Maximilien Franco, Hollis Akins, Erini Lambrides, Elaine Gammon, Camila Silva, Fabrizio Gentile, Jorge A. Zavala, Aristeidis Amvrosiadis, Irham Andika, Malte Brinch, Jaclyn B. Champagne, Nima Chartab, Nicole E. Drakos, Andreas L. Faisst, Seiji Fujimoto, Steven Gillman, Ghassem Gozaliasl, Thomas R. Greve, Santosh Harish, Christopher C. Hayward, Michaela Hirschmann, Olivier Ilbert, Boris S. Kalita, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Vasily Kokorev, Daizhong Liu, Georgios Magdis, Henry Joy McCracken, Jason Rhodes, Brant E. Robertson, Margherita Talia, Francesco Valentino, Aswin P. Vijayan

“…In a preliminary morphology analysis we find that  ∼10% of the members of our sample exhibit spiral arms and 5% host stellar bars, with one candidate bar found at z  > 3. Finally, we find that the clustering of JWST sources within 10″ of a submillimeter galaxy is a factor of 2 greater than what is expected based on either random clustering or the distribution of sources around any red galaxy irrespective of a submillimeter detection.…”
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