Identifying households with children who have complex needs: a segmentation model for integrated care systems by Roberta Piroddi, Andrea Astbury, Wesam Baker, Kostantinos Daras, Joe Rafferty, Iain Buchan, Benjamin Barr

“…We then used individual and household linked data across multiple health and social care services to identify these households, providing an algorithm to be used in a case finding interface. Finally, to understand the needs of this segment, and to identify unmet need, to tailor support, we used descriptive statistics and Poisson regression to profile the segment and compare them with the rest of the population. …”
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Prognostic model and immune-infiltrating cell landscape based on differentially expressed autophagy-related genes in TP53-mutated multiple myeloma by Yan-Hua Zheng, Hong-Yuan Shen, Xiang Chen, Juan Feng, Guang-Xun Gao

“…Results Three differentially expressed ARGs (CASP8, MAPK8, RB1CC1) were finally incorporated to construct the risk model. …”
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Hydrochemical Characteristics and Evolution Mode of Cold Seeps in the Qiongdongnan Basin, South China Sea by Zhifeng Wan, Chongmin Chen, Jinqiang Liang, Wei Zhang, Wei Huang, Pibo Su

“…The cold seep fluxes changed from large to small before finally disappearing, showing a close connection with gas hydrate formation and decomposition, and influenced the local topography and ecosystems.…”
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Exploration of the Mountainous Urban Rail Transit Resilience Under Extreme Rainfalls: A Case Study in Chongqing, China by Chenhui Liu, Xue Su, Zhichun Wu, Yingjun Zhang, Cuizhu Zhou, Xiangguo Wu, Yong Huang

“…Additionally, risk levels for landslide and flood-prone areas are classified using the K-means algorithm, based on rainfall, elevation, and slope data, identifying high-risk stations. Finally, the node recovery sequence and strategies for high-risk nodes affected by landslides and floods are examined. …”
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Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database by Hanzhang Yuan, Jingsheng Cheng, Jun Xia, Zeng Yang, Lixin Xu

“…Moreover, the decreased expression of the biomarkers was also verified in glioma patient samples. Finally, we confirmed that these 3 genes might promotes glioma proliferation and migration in vitro. …”
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Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Subsequently, the obtained data were subjected to further network pharmacological analysis to explore the potential key active compounds, core target genes, and biological processes (BPs) associated with the effect of ZJP against GERD. Finally, the prediction results of NP were validated by MD, and MDS of the optimal core protein-ligand for each component obtained by MD were performed using Gromacs 2020 software. …”
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Influence of Mine Earthquake Disturbance on the Principal Stress of the Main Roadway near the Goaf and Its Prevention and Control Measures by Penghui Guo, Jiazhuo Li, Xiqing Hao, Heng Cui, Lihua Tian, Wenhao Xie, Jiaqi Chu

“…In the later stage of mine earthquake disturbance, the principal stress directions in the surrounding rock reverse rotation, and the reverse rotation angle of the principal stress direction in the roof is the largest. Finally, the asymmetric distribution characteristics of principal stress rotation are verified by using the asymmetric deformation phenomenon on both sides of roadway surrounding rock. …”
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Structure-Based Virtual Screening, Docking, ADMET, Molecular Dynamics, and MM-PBSA Calculations for the Discovery of Potential Natural SARS-CoV-2 Helicase Inhibitors from the Tradi... by Ahmed M. Metwaly, Alaa Elwan, Abdul-Aziz M. M. El-Attar, Sara T. Al-Rashood, Ibrahim H. Eissa

“…Interestingly, the MD simulation studies for compound 533, the one with the highest docking score, over 100 ns showed its correct binding to SARS-CoV-2 helicase with low energy and optimum dynamics. Finally, MM-PBSA studies showed that 533 bonded favorably to SARS-CoV-2 helicase with a free energy value of −83 kJ/mol. …”
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Assessing routine childhood vaccination acceptance, hesitancy and refusal in Cape Town, Western Cape, South Africa: a mixed-method study protocol by Charles Shey Wiysonge, Lindi Mathebula, Moleen Zunza, Sara Cooper

“…For phase II of the study, we will explore the behavioural and social drivers of childhood vaccination from the perspective of caregivers of children aged 0–2 years using a purposively selected sample of 20–25 participants from phase I. Finally, for phase III of the study, we will explore the behavioural and social drivers of childhood vaccination from the perspective of 20–25 healthcare workers providing vaccinations to children aged 0–2 years purposively sampled from primary healthcare facilities.Ethics and dissemination Ethical approval was obtained from Stellenbosch University (S23/10/232). …”
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Stability Analysis of TBM Tunnel Undercrossing Existing High-Speed Railway Tunnel: A Case Study from Yangtaishan Tunnel of Shenzhen Metro Line 6 by Mingji Zhao, Yun Cheng, Zhanping Song, Tong Wang, Yuwei Zhang, Yitong Gong, Yuncai Song

“…At the top of the existing tunnel segment, convergence settlement was 3.09 mm and settlement rate was slow first which was accelerated, then stabilized, and finally slowed down again which was opposite to the uplift development trend of the bottom of tunnel segment. …”
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Prevalence of Intestinal Parasites and Gastrointestinal Carriage of Pathogenic Gram Negative Enteric Bacteria among Apparently Healthy Food Handlers of Public Hospitals, Addis Abab... by Tegegn Belhu, Kinfe Fissehatsion, Abraham Tesfaye, Dr Yohannes Woldekidan, Kassu Desta

“…For bacterial identification culture, biochemical tests and antimicrobial sensitivity (Kirby-Baure disk diffusion method) have been performed. Finally, validated data were analyzed using statistical package for social science version 20 (SPSS). …”
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Machine Learning for the Early Prediction of Delayed Cerebral Ischemia in Patients With Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis by Haofuzi Zhang, Peng Zou, Peng Luo, Xiaofan Jiang

“…During the analysis, we discussed the performance of different models in the training and validation sets. ResultsWe finally included 48 studies containing 16,294 patients with SAH and 71 ML models with logistic regression as the main model type. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…To evaluate changes in serum TMAO levels, targeted metabolomics was performed. Finally, the study looked at the intrinsic relationships among modifications in the intestinal flora, metabolite profile changes, and the targets of SMI compounds to clarify how they might be used to treat H-HF. …”
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Looking for the origins of the human brain: The role of South Africa in the history of palaeoneurology by Amélie Beaudet, Edwin de Jager, Mirriam Tawane, Brendon Billings

“…Additionally, we examine how the use of digital replicas of fossil hominin endocasts and the need to study extant human brains to form a comparative platform might raise questions about research practices (e.g. study and exhibition of fossil and extant human brains) and management of such invaluable heritage resources (e.g. data sharing). We finally consider how our view of human brain evolution, and in particular the putative uniqueness of the hominin brain, has changed over the last century. …”
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Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis by Zheng Wu, Ying Lin, Li-Min Liu, Yan-Li Hou, Wei-Ting Qin, Lei Zhang, Shu-Heng Jiang, Qin Yang, Yong-Rui Bai

“…Significant positive correlations were noticed between cGAS-STING score and TIICs, including activated CD8+ T cells, activated CD4+ T cells, monocytes, and mast cells. Finally, the cGAS-STING score was revealed to be an independent prognostic factor for KIRC patients and possessed a strong predictive power for the prognostic evaluation of KIRC and KIRP patients. …”
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Significance of Combining Bronchoalveolar Lavage Fluid With Targeted Next‐Generation Sequencing in the Pathogen Detection‐Based Diagnosis of Pulmonary Infections by Jiangbo Liu, Bo Yang, Yu Wu, Guihong Yang, Xiaojiu Zha, Wei Jiang

“…Results The data of a total of 169 patients (78 in the tNGS group and 91 in the mNGS group) were collected, and 145 patients (67 in the tNGS group and 78 in the mNGS group) were finally diagnosed with lung infections. The comprehensive positive pathogen detection‐based diagnosis rate for tNGS was 86.6%, with a single‐pathogen lung infection diagnosis rate of 85.7% and a mixed‐pathogen pulmonary infection diagnosis rate of 88.0%. …”
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Resilience-oriented passenger subsidy design for taxi travel under pandemic control by Lei Xia, Zhengfeng Huang, Gao Gao, Pengjun Zheng

“…Secondly, using the travel resilience calculation formula, we evaluate the taxi travel resilience levels under different pandemic control measures and analyze other factors (such as virus characteristics) on taxi travel resilience through regression models. Finally, we construct a taxi travel resilience improvement model. …”
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Research on the Performance of a Liquid–Solid Triboelectric Nanogenerator Prototype Based on Multiphase Liquid by Wei Wang, Jin Yan, Xianzhang Wang, Hongchen Pang, Chengqi Sun, Yin Sun, Lijun Wang, Dapeng Zhang

“…COMSOL Multiphysics 6.0 software was used to investigate the material transport mechanism and formation of oil–water two-phase and gas–oil–water three-phase. Finally, this study presents the power generation performance of ML-TENG Pro in the extreme state of gas–oil–water three-phase “emulsification”. …”
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Bioinformatics screening and clinical validation of CircRNA and related miRNA in male osteoporosis by Jiayi Li, Sijia Guo, Qingyun Sun, Ning An, Jisheng Lin, Qi Fei

“…PPI networks of shared mRNAs were constructed and the hub genes in the PPI networks were identified with CytoHubba, a plugin in Cytoscape software (3.10.1). Finally, a ceRNA network of four circRNAs derived from three hub genes was constructed. …”
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3D-augmentation of 2D ultrasound for appendicitis diagnosis: A cross-sectional pilot study by Rebecca G. Theophanous, Elias Jaffa, Matthew R. Morgan, Carl D. Herickhoff, Erica Peethumnongsin, Joao Ricardo Nickenig Vissoci, Joshua S. Broder

“…Mean 3DUS pixels were 320.5 PPI depth, 388 PPI width, mean total frame number 344, and field of view 78.8°. Finally, we demonstrated two appendicitis complications on 3DUS: abscess and a dilated noncompressible appendix with appendicoliths. …”
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