Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis by Yuan Xu, Hongfei He, Haiyang Li

“…Given tacrolimus's immunosuppressive impact, the gene expression matrix data obtained from dataset GSE1010 was submitted to CIBERSORT to assess immune cell infiltration outcomes. Finally, we examined the regulatory network of screened key genes that interact with RNA-binding proteins, potential drugs, small-molecule compounds, and transcription factors. …”
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Energy-Saving Metro Train Timetable Optimization Method Based on a Dynamic Passenger Flow Distribution by Jingshuang Li, Fuquan Pan, Hailiang Tang, Sen Tong, Lixia Zhang, Xinguang Li, Xiaoxia Yang

“…The PSO-GA structure has PSO as the main body and integrates the chromosome crossover and mutation operations of the GA into the iterative process to improve the search efficiency of the algorithm. Finally, the proposed method and model are tested based on the actual data of a metro line in Qingdao, China. …”
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Association between Gastroesophageal Reflux Disease and Elastographic Parameters of Liver Steatosis and Fibrosis: Controlled Attenuation Parameter and Liver Stiffness Measurements by Ivana Mikolasevic, Goran Poropat, Tajana Filipec Kanizaj, Nadija Skenderevic, Marko Zelic, Marija Matasin, Luka Vranic, Andrea Kresovic, Goran Hauser

“…Furthermore, a significant positive association with hiatal hernia was obtained for BMI and CAP. Finally, a significant positive association with hiatal hernia was obtained with CAP in multivariate analysis. …”
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Conservation networks do not match the ecological requirements of amphibians by Matutini, Florence, Baudry, Jacques, Fortin, Marie-Josee, Pain, Guillaume, Pithon, Josephine

“…Then, to identify spatial continuity in suitable habitats at the regional scale, we defined species and multi-species core habitats to perform a connectivity analysis using Circuitscape theory. Finally, we compared different suitability maps with existing conservation networks to assess conservation coverage and efficiency. …”
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Simulation of Flow Around a Finite Rectangular Prism: Influence of Mesh, Model, and Subgrid Length Scale by Xutong Zhang, Maxime Savoie, Mark K. Quinn, Ben Parslew, Alistair Revell

“…In general, front-body separation and reattachment exhibited greater sensitivity to mesh refinement than wake resolution. Finally, in order to correlate the observed DDES mesh requirements with the observations from the converged RANS solutions, an approximation for the Taylor microscale was explored as a potential tool for mesh sizing.…”
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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…Feature selection methods such as LASSO, SVM-RFE and random forest algorithm were applied to localize possible therapeutic target genes. Finally, We analyzed the molecular pathways of CXCR4 in DFUs by Gene set enrichment analysis (GSEA).ResultsWe identified a total of 751 differential genes, of which 409 genes were significantly upregulated and 342 genes were downregulated in diabetic foot ulcer tissues. …”
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Factors accounting for limited sexual reproduction in a long-lived unisexual plant species by Irene Bisang, Flavien Collart, Flavien Collart, Alain Vanderpoorten, Lars Hedenäs

“…Topography and climatic conditions at 1-km resolution were employed to measure niche overlap between (i) sex-expressing and non-expressing and (ii) male and female specimens. We finally modelled sex expression and sporophyte production depending on these topo-climatic predictors.ResultsAmong the 63% of reproductive samples across the entire latitudinal gradient, females outnumbered males by a factor 5.6, and 8% of the female samples bore sporophytes. …”
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Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…These findings suggest that CAA modulates mitochondrial function and autophagy by regulating the Nrf2 signalling pathway to mitigate the toxic damage. Finally, the effect of the autophagy inhibitor, 3-MA, on PC12 cells suggests that CAA promotes mitophagy by participating in the Nrf2 pathway, thereby preventing CPF-induced oxidative stress damage.…”
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Diversity and Conservation Status of Large Mammals in Ghamot National Park, Azad Jammu and Kashmir, Pakistan by Muhammad Jahangeer, Siddique Muhammad, Muhammad Shakeel, Mir Muhammad Saleem, Ali Usman, Hussain Abid

“…The forest and riparian zone had the greatest similarity in species composition, both between and among seasons. Finally, our findings show that GNP has an essential influence in Pakistan mammal conservation. …”
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Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…Mean per-patient indirect cost was €4089 (moderate HA), €797 (moderate HB), €8633 (severe HA) and €8049 (severe HB). Finally, the mean total cost (direct and indirect) for moderate and severe patients were €91 017 (HA) and €163 924 (HB). …”
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Depression Detection and Diagnosis Based on Electroencephalogram (EEG) Analysis: A Systematic Review by Kholoud Elnaggar, Mostafa M. El-Gayar, Mohammed Elmogy

“…Additionally, integrating Internet of Things (IoT) devices with EEG for continuous mental health monitoring and distinguishing between different types of depression are identified as critical research areas. Finally, the review emphasizes improving the reliability and predictability of computational intelligence-based models to advance depression diagnosis. …”
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MUNet: a novel framework for accurate brain tumor segmentation combining UNet and mamba networks by Lijuan Yang, Lijuan Yang, Qiumei Dong, Da Lin, Chunfang Tian, Xinliang Lü

“…Additionally, we design the SD-Conv structure, which reduces feature redundancy without increasing model parameters, further enhancing computational efficiency. Finally, we propose a new loss function that combines mIoU loss, Dice loss, and Boundary loss, which improves segmentation overlap, similarity, and boundary accuracy from multiple perspectives. …”
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Proceso del cuidado enfermero aplicado al adulto mayor con insuficiencia respiratoria por neumonía by Gladis Villanueva Cadenas, Edith Telma Meza Martel, Yulissa Novalí Collantes Vilchez, María del Pilar Medina Siesquén

“…Resultados: La evolución del paciente geriátrico fue favorable, la saturación de oxígeno aumentó a 96 %, con menos porcentaje de oxígeno, pasando de un 90 % por máscara de reservorio a 32 % en cánula binasal, mejorando la ventilación y la permeabilidad de la vía aérea. …”
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Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish by Sunil Sharma, Alfredo Rojas, Abhishek Gour, Rosemaria Serradimigni, Connor Leong, Abhisheak Sharma, Subham Dasgupta

“…We then assessed global DNA methylation using a combination of whole-mount immunohistochemistry and ELISA for 5-methylcytosine (5-mC) and showed significant IPP-induced hypermethylation within whole embryo in situ. Finally, we focused on eye and brains as targets. …”
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Efficacy and safety of immune checkpoint inhibitors in patients with advanced intrahepatic cholangiocarcinoma by Ziting Peng, Jianhui Dong, Shuyao Tang, Jiaxu Shi, Tongdong Shi

“…The Kaplan-Meier method was employed to plot survival curves, and differences between groups were assessed using log-rank tests.Results96 patients diagnosed with ICC were included, comprising 60 males (62.50%) and 36 females (37.50%). 85 patients exhibited disease progression, 22 patients succumbed, and 38 patients were lost to follow-up finally. Those who initiated immunotherapy promptly following first-line antitumor treatment exhibited a notably prolonged PFS compared to those experiencing tumor progression (5.63 months (95%CI: 3.12~8.14) vs 2.50 months (95%CI: 1.83~3.17), P=0.002). …”
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Interactions et transactions identitaires d'immigrés noirs dans l'espace public et les centres de santé au Maroc by Annélie Delescluse

“…We will see that the domination felt by the latter towards medical staff, and towards the Moroccan population more generally, also triggers and sustains a set of tense behaviours and refusals that lead to perilous situations, particularly when they abandon the care prescribed in Morocco and return to their countries of origin. Finally, the article looks at three possible reactions to these processes of othering: victimisation, the reversal of stigma and racialisation in return. …”
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Improving doublet cell removal efficiency through multiple algorithm runs by Yong She, Chaoye Wang, Qi Zhao

“…Subsequently, in simulated datasets, we proved that the multi-round removal strategy was more effective in removing doublets than a single removal, with cxds showing the best results when applied twice, and the ROC of the four methods during the two rounds of removal improved by at least 0.05 compared to single removal. Finally, compared to running the algorithm once, we found that the MRDR strategy was more beneficial for differential gene expression analysis and cell trajectory inference when using default analysis parameters. …”
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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis by Li Q, Li D, Tian C, Liu X, Wang H, Liu H

“…The therapeutic effect of Baji capsule was evaluated by high-resolution micro-computed tomography (Micro-CT) and tissue section staining, serum inflammatory factor levels were assessed by ELISA, serum oxidative stress-related marker levels were determined by kits, and finally the mechanism was explored by network pharmacology and then verified by immunohistochemistry.Results: Micro-CT results showed that Baji capsule attenuated LPS-induced inflammatory bone loss.Baji capsule also reduced serum inflammatory factor levels and oxygen free radical production. …”
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Application of ANSYS software package for electromagnetic and thermal analysis of the electric motor of the pilger mill drive seamless pipe manufacturing technology by B. I. Kosimov

“…The analysis system confirms the accuracy of the calculation using simplified optimization methods and finally removes technical risks before manufacturing an industrial design. …”
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Conventional Mercury Penetration and Constant Velocity Mercury Penetration Experiments Are Used to Quantitatively Characterize the Difference in Micropore Structure in Low Permeabi... by Kaitao Yuan, Yan Li, Tiaotiao Shi, Husheng Huang, Yanfei Li, Minglei He

“…Taking C 6 and C 7 reservoirs in Ordos Basin as an example, a total of 13 representative pairs of samples were selected to analyze the difference in capillary pressure curve shape and pore throat distribution characteristics between the two experiments and to clarify the reasons for the difference in microscopic pore characteristic parameters measured by the two experiments. Finally, the correlation between the microscopic pore characteristic parameters and the movable fluid saturation parameters is analyzed. …”
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