Severe central nervous system injury in 9 children with COVID-19 by Peipei Zhang, Meiyun Xin, Yingge Bai, Xueyun Ren, Na Li

“…Most of the children had elevated interleukin-6 (100%), lactic acid (100%), alanine transaminase (87.5%), aspartate transaminase (87.5%), creatine kinase MB (87.5%), and lactate dehydrogenase (85.7%) levels. …”
Get full text

Carcass Traits, Physicochemical Characteristics, Fatty Acid, and Protein Profile of Khiew Phalee, Pradu Hang Dam and Broiler Chicken Meat by S. Phromnoi, W. Chumngoen, T. Puangmalee, W. Nuchchanart

“…Protein profile analysis found three different protein bands based on SDS-PAGE and LC-MS/MS analysis between three different chicken breeds, including 70 kDa proteins (heat shock 70 kDa and albumin OS) and 110 kDa protein (pyruvate kinase PKM) in KP and PHD with higher intensity than CBR. …”
Get full text

Human Platelets Take up Anti-VEGF Agents by B. Sobolewska, B. Fehrenbacher, P. Münzer, H. Kalbacher, S. Geue, Konstantinos Stellos, M. Schaller, F. Ziemssen

“…The role of actin filaments and clathrin-coated vesicles in the transport of ranibizumab, aflibercept, and bevacizumab was evaluated by two pharmacologic inhibitors: staurosporine (protein kinase C inhibitor) and cytochalasin D. Results. All three anti-VEGF agents were taken up by platelets and colocalized with VEGF. …”
Get full text

Very first real-world data on zongertinib use in non-small cell lung cancer patients with HER2 mutations: A brief report by Oliver Illini, Anna Sophie Lang-Stöberl, Hannah Fabikan, Christoph Weinlinger, Arschang Valipour, Maximilian J. Hochmair

“…New agents, including zongertinib, a HER2-selective tyrosine kinase inhibitor (TKI), are being investigated in clinical trials. …”
Get full text

Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study by Kazuyuki Hirooka, Eri Nitta, Yoshiaki Kiuchi, Masaki Tanito, Shunsuke Nakakura, Tetsuya Baba, Hideaki Okumichi, Aisyah Muhlisah, Ariyanie Nurtania, Hiromitsu Onoe, Yotaro Matsuoka

“…Background To investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.Methods This prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent trabeculectomy or trabeculectomy combined with cataract surgery followed by 3-month postoperative ripasudil treatments. …”
Get full text

CGH, cDNA and Tissue Microarray Analyses Implicate FGFR2 Amplification in a Small Subset of Breast Tumors by Mervi Heiskanen, Juha Kononen, Maarit Bärlund, Joachim Torhorst, Guido Sauter, Anne Kallioniemi, Olli Kallioniemi

“…A cDNA microarray survey of 588 genes showed >40‐fold overexpression of FGFR2. Finally, a tissue microarray based FISH analysis of 750 uncultured primary breast cancers demonstrated in vivo amplification of the FGFR2 gene in about 1% of the tumors. …”
Get full text

Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats by Jiawei Wang, Yunxiao Zhao, Fengque Zheng, Nana Ma, Rongyan Qin, Weili Qin, Bo Liu, Aiping Qin

“…The combined transplantation of HucMSCs and ucPRP resulted in more stem cells being retained in the ovaries of POF rats, the estrus cycle of the POF rats being restored, the levels of serum E2, AMH, and FSH improving, and damaged follicles beginning to grow. Finally, we confirmed that the potential mechanism of the combination of HucMSCs and ucPRP to rescue the ovarian function of POF rats is to promote ovarian angiogenesis and to promote the proliferation and reduce the apoptosis of ovarian granulosa cells. …”
Get full text

Anti‐retinal Autoantibodies in Hydroxychloroquine Eye Toxicity by Samuel D. Good, Grazyna Adamus, Michael B. Gorin, Jordan Jacquez, Jennifer Grossman, Isao Matsuura, Ashira Hasan, Brian Skaggs, Maureen McMahon

“…Results Patients with HCQ retinal toxicity had a higher likelihood of testing positive for anti‐arrestin AAbs (60.7% vs 30.6%, P = 0.001) and anti–pyruvate kinase M2 AAbs (46.4% vs 28.1%, P = 0.05). Patients with HCQ eye toxicity also had a higher number of total anti‐retinal AAbs (mean 3.0 ± 2.40 vs 2.04 ± 1.7, P = 0.01). …”
Get full text

Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…Using the MTT Assay, the dose-dependent response of FV-CNPs against HepG2 cells was determined, and an IC50 value of 59.41 µg/mL was obtained. Finally, the toxicity test conducted on zebrafish eggs revealed that bending bodies only became visible at levels exceeding 100 μg/mL. …”
Get full text

Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study by Guangming Dai, Yajuan Ran, Jiajia Wang, Xingru Chen, Junnan Peng, Xinglong Li, Huojin Deng, Min Xiao, Tao Zhu

“…A total of 643 AECOPD patients were enrolled in this multicenter cross-sectional study. Finally, 455 were included, 214 in the normal-eosinophil AECOPD (NEOS-AECOPD) group, 63 in the mild increased-eosinophil AECOPD (MEOS-AECOPD) group, and 138 in the severe increased-eosinophil AECOPD (SEOS-AECOPD) group. …”
Get full text

Clinical Consultation in the Workplace: Are There Implications for Response Attitudes? by Bárbara Gonzalez, Rosa F. Novo, Maria João Afonso, Matilde Fernandes, Ana Vieira

“…Comparing participants with under-reporting in each sample, the COS had lower clinical profiles, and tended to present excessively low psychopathology and symptomology values, suggesting higher defensiveness. Finally, the fact that 33% of the COS present biased response attitudes (i.e., 15% presented under-reporting and 18% presented over-reporting) has implications for both clinical and career decision making processes. …”
Get full text

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky [version 2; peer review: 1 approved, 2 approved with reservations] by Pamela Klaassen, Mark Booth, Thomas Stanke, Evanthia Hatziminaoglou, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen, John Orlowski-Scherer, Tomasz Kamiński, Joe Bright, Atul Mohan, Michael Koss, Sigurd Næss, Francisco Miguel Montenegro-Montes, Paola Severgnini, Claudio Ricci, Jochen Greiner, Cristian Vignali

“…We make theoretical predictions for the instrumental and observatory properties required to significantly contribute to these science cases, and compare them to the projected AtLAST capabilities. Finally, we consider the unique ways in which transient science cases constrain the observational strategies of AtLAST, and make prescriptions for how AtLAST should observe in order to maximize its transient science output without impinging on other science cases.…”
Get full text

Phosphorylation of histone H3Ser10 in plant cell division by D. B. Loginova, O. G. Silkova

“…We discuss the participation of currently known candidate kinases and phosphatases in the dynamics of H3Ser10 phosphorylation. …”
Get full text

Validation of SOC Estimation Using OC and EC Concentration in PM2.5 Measured at Seoul by Ha Young Yoo, Ki Ae Kim, Yong Pyo Kim, Chang Hoon Jung, Hye Jung Shin, Kwang Ju Moon, Seung Myung Park, Ji Yi Lee

“…We compared the (OC/EC)pri ratio from 1-h data with 24-h data and revealed that (OC/EC)pri estimated from 24-h data had twice larger than 1-h data due to the low time resolution of sampling. We finally confirmed that the most appropriate value of (OC/EC)pri is that calculated by a regression analysis of 1-h data and estimated SOC values at PM2.5 of the Seoul atmosphere.…”
Get full text

Retrieval of Land Surface Temperature From Passive Microwave Observations Using CatBoost-Based Adaptive Feature Selection by Yang Dai, Yingbao Yang, Xin Pan, Penghua Hu, Xiangjin Meng, Fanggang Li, Zhenwei Wang

“…Next, for each group, we ranked the feature sets according to their importance and employed the recursive feature elimination (RFE) method for feature selection. Finally, the optimized feature sets were used in the CatBoost algorithm to construct the PMW-LST retrieval model. …”
Get full text

The Impact of Onchocerciasis Elimination Measures in Africa: A Systematic Review by Policarpo Ncogo, Christine Giesen, María Jesús Perteguer, Maria P. Rebollo, Rufino Nguema, Agustín Benito, Zaida Herrador

“…Results: A total of 63 articles met the inclusion criteria and were finally selected. Publications were found from 19 out of 31 African endemic countries. …”
Get full text

Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Ly294002, a selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed the β-catenin/TCF4 complex activation and EMT through blocking Akt-mediated GSK-3β inactivation in the ''disruption complex'' in chronic NaAsO2 exposed DU145 and PC-3 cells. …”
Get full text

Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…CAPN1, LIMA1, ANXA6, HUWE1, PARP1 or PARP4 proteins could be potential cell targets for conotoxins and serve as biomarkers in MPM. Finally, we found that both conotoxins reduced the tumor mass in MPM xenografts; s-cal14.1b reached statistical significance. …”
Get full text

Emerging Risk Management in Industry 4.0: An Approach to Improve Organizational and Human Performance in the Complex Systems by F. Brocal, C. González, D. Komljenovic, P. F. Katina, Miguel A. Sebastián

“…Under this complex context, we expose the concept considering the current models of risk management. Finally, we discuss how enhancing human and organizational performance can be achieved through risk management in complex systems linked to Industry 4.0. …”
Get full text

Assessing survey design changes of long-term fishery-independent groundfish trawl surveys in the Gulf of Mexico by Adam G. Pollack, Eric R. Hoffmayer, Theodore S. Switzer, David S. Hanisko, Jill M. Hendon, John Mareska, Fernando Martinez-Andrade, Jeff Rester, Zachary C. Zuckerman, Gilmore Pellegrin

“…Overall, the design changes and spatial expansion have been beneficial from a stock assessment standpoint, resulting in an increase in the number of indices used for single-species stock assessments and the utility of survey data in support of ecosystem modeling efforts. Finally, a discussion around the lesson learned (i.e., the critical need for overlap of survey designs), emphasizing the potential impacts of these changes on the overall time series concerning stock assessments, is presented.…”
Get full text