A Fully Coupled Hydromechanical Model for CO2 Sequestration in Coal Seam: the Roles of Multiphase Flow and Gas Dynamic Diffusion on Fluid Transfer and Coal Behavior by Rui Yang, Weiqun Liu, Tianran Ma, Junhe Xie, Yang Hu, Rui Zhou, Yongjie Yang

“…Additionally, through the model application for long-term CO2 sequestration, we found that the stored CO2 molecules are mainly in an adsorbed state at the early injection stage, while with the continuous injection of gas, the stored CO2 molecules are mainly in a free state. Finally, the roles of multiphase flow and gas dynamic diffusion on fluid transfer and coal behavior were analyzed. …”
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Parent-implemented early intervention design for improving speech and language skills among Mandarin-speaking infants and toddlers with cleft lip and/or palate by Sha Lai, Li Lu, Zhongliang Zhou, Chi Shen, Binting Yang, Binting Yang, Zhanping Ren, Zhanping Ren, Siwei Ma, Siwei Ma, Siwei Ma

“…Second, according to the problem diagnosis, the logical model of parent–child interaction behavior change was constructed. Finally, the health outcomes were transformed into intervention goals at three levels (i.e., infants and toddlers with CL/P, parents and environment), and a set of early intervention programs were designed by integrating various intervention techniques.ResultsThe diagnosis of parent–child interaction problems showed that 40.91% of parents and children often use electronic media together; in parent–child interaction, 41.67% of parents presented ‘lack of waiting’, 29.55% overcorrected pronunciation errors. …”
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Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men by Carla Basualto-Alarcón, Paola Llanos, Gerardo García-Rivas, Mayarling Francisca Troncoso, Daniel Lagos, Genaro Barrientos, Manuel Estrada

“…Expression of SHBG is controlled by peroxisome proliferator-activated receptor γ (PPARγ) and AMP-activated protein kinase (AMPK). AMPK/PPAR interaction is critical to regulate hepatocyte nuclear factor-4 (HNF4), a prerequisite for SHBG upregulation. …”
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Impact of dietary Spirulina on performance, antioxidant status, carcass traits and pathological alteration in broilers exposed to ochratoxin A stress by Ayman S. Salah, Mahmoud S. El-Tarabany, Marwa Mostafa, Rania Samir Zaki, Mahmoud M. Azzam, Omnia I. El Euony, Mahmoud Alagawany, Antonia Lestingi, Ahmed A. Elolimy, Mahmoud Madkour, Ahmed Fotouh

“…Antioxidant activity (superoxide dismutase, catalase, total antioxidant capacity, and glutathione peroxidase) of broilers exposed to OTA was significantly increased by Spirulina supplementation. Finally, supplementing Spirulina platensis in broiler chickens fed on OTA contaminated diet attenuated the harmful effects of OTA, while improving the growth performance, antioxidant activity, lipid profile, and immune response of broiler chickens.…”
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A Study on Multi-Scale Behavior Recognition of Dairy Cows in Complex Background Based on Improved YOLOv5 by Zheying Zong, Zeyu Ban, Chunguang Wang, Shuai Wang, Wenbo Yuan, Chunhui Zhang, Lide Su, Ze Yuan

“…The C3 module of the model was enhanced by incorporating Deformable convolution (DCNv3), which improves the accuracy of cow behavior characteristic identification. Finally, the original detection head was replaced with a Dynamic Detection Head (DyHead) to improve the efficiency and accuracy of cow behavior detection across different scales in complex environments. …”
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Risk Factors Associated with Leishmaniasis in the Most Affected Provinces by Leishmania infantum in Morocco by Maryam Hakkour, Asmae Hmamouch, Mohamed Mahmoud El Alem, Abdelhakim Bouyahya, Abdelaali Balahbib, Abdelhak EL Khazraji, Hajiba Fellah, Abderrahim Sadak, Faiza Sebti

“…As for socioeconomic factors, poverty was the only factor that influences the spread of VL. Finally, the distance from endemic foci showed significance for both VL and LC (P<0.05). …”
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Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. Finally, the esophageal microbiome could be the protagonist to be investigated, deepening our understanding of the subtle association between the host microbiota and tumor development.…”
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Evaluation of 3D-CRT Radiotherapy Treatment Planning with Radiobiological Effects in Patient-Specific 3D Printed Anthropomorphic Phantom Postmastectomy Breast Cancer Axillary Metas... by Endarko Endarko, Aditya Hariyanto, Siti Aisyah, Nandia Kavilani, Ahmad Syafi&#039;i

“…Normal tissue complication probability for OARs has values below 5%, while the smallest value was obtained for the left lung. Finally, the point dose verification between planning and measurement using TLD100 and EBT3 film indicated an average difference of 9.14% and 4.34%, respectively, with no significant difference. …”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. …”
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Features of diagnosis and treatment of gastrointestinal stromal tumors by N. I. Bogomolov, T. V. Burdinskaya, M. A. Goncharova, A. G. Goncharov, N. N. Tomskikh

“…Targeted therapy by tyrosine kinase inhibitors was carried out for 14 patients. …”
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A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia by Li Wang, Si-yu Chen, Jian-wei Yang, Kang-yu Wang, Kun-peng Li, Shun Wan, Xiao-ran Li, Li Yang

“…Gene Expression Omnibus (GEO) analysis explores the differential expression of genes. Finally, The GeneMANIA tool was utilized to further understand the functional roles of these susceptibility genes. …”
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Diversidade na formação em saúde: vivências de estudantes de graduação de uma universidade federal by Caroline Izabela Silva, Natália Sevilha Stofel, Flávio Adriano Borges, Irai Maria de Campos Teixeira, Natália Rejane Salim

“…Um dos pontos evidenciados é a presença da diversidade no espaço universitário como forma de mobilização e mudanças no ensino. CONSIDERAÇÕES FINAIS: O estudo mostrou a necessidade da elaboração de estratégias que garantam a discussão das temáticas de diversidade na formação em saúde de forma institucionalizada, bem como parte integrante do projeto mais amplo da universidade. …”
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Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei by Haitao Fan, Xin Zhang, Yanan Yin, Lefei Jiao

“…The gene expression of cellular energy sensor AMP-activated protein kinase was up-regulated in muscle and hepatopancreas. …”
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Life cycle greenhouse gas emissions of hydrogen imported by maritime transportation: A South Korean case study by Gyuna Kwak, Juha Lee, Yujin Jung, Wonjae Choi

“…Importing ammonia is generally more advantageous than liquid hydrogen, unless the grid electricity emissions are exceptionally low, specifically below 332.1 g-CO2-eq./kWh. Finally, hydrogen requires emissions below 8.55 and 11.89 kg-CO2-eq.…”
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Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation by Nico Hartmann, Lena Preuß, Belal A. Mohamed, Moritz Schnelle, Andre Renner, Gerd Hasenfuß, Karl Toischer

“…Methods and results We therefore analysed the activation of classical cardiac signal pathways [mitogen‐activated protein kinases (MAPKs) (ERK, p38, and JNK) and Akt‐GSK3β] in in vitro of mechanical overload (ejecting heart model, rabbit and human isolated muscle strips). …”
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Potential and costs required for methane removal to compete with BECCS as a mitigation option by Yann Gaucher, Katsumasa Tanaka, Daniel J A Johansson, Olivier Boucher, Philippe Ciais

“…We show that to totally replace bioenergy based CDR with MR, the MR potential should reach at least 180–290 MtCH _4 per year, i.e. between 50% and 90% of current anthropogenic methane emissions, with maximum unit cost between 11 000 and 69 000 $/tCH _4 , depending on the climate target. Finally, we found that replacing CDR by MR reshapes the intergenerational distribution of climate mitigation efforts by delaying further the mitigation burden.…”
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PhyIndBC: Development of a machine learning tool for screening of potential breast cancer inhibitors from phytochemicalsGitHub by Agneesh Pratim Das, Subhash M. Agarwal

“…NPs predicted as actives were further screened via ensemble virtual screening (eVS) technique against erb-b2 receptor tyrosine kinase 2 (HER2), to identify high-affinity molecules against this breast cancer drug target. …”
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Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres by David Young, Sohail Rahmany, Deborah Taylor, Emma Davis, Michael Colwill, Sonia Kalyanji Mehta, Roisin Campbell, Karl Hazel, Karishma Sethi-Arora, Susan Ritchie, Ashley I Heinson, Helen Moyses, Keith Bodger, Emma Johnston, Lucy Hicks, Anjan Dhar, Jimmy Limdi, Rachel Cooney, John Paul Seenan, Kamal Patel, Alissa Walsh, Fraser Cummings

“…Background: Filgotinib, an oral Janus kinase 1 preferential inhibitor, has been shown to be an effective treatment for ulcerative colitis (UC) in pre-registration studies. …”
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The relationship between thiamin, folic acid and cognitive function in a rat model of uremia by Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu

“…In summary, we applied a uremic rat model and proved that uremia causes serum thiamin and folic acid deficiency, homocysteine elevation, along with neuron reduction and severe oxidative stress in hippocampus, finally leading to CI.…”
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Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…After conducting correlation analysis between phenotypic features and shiitake mushroom caps weight, four most correlated phenotypic features were identified: Area, Perimeter, External rectangular width, and Long axis; they were divided into four groups based on their correlation rankings. Finally,M3 group using GWO_SVM algorithm achieved optimal performance among six mainstream machine learning models tested with an R²value of 0.97 and RMSE only at 0.038 when comparing predicted values with true values. …”
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