Remote Mapping of Bedrock for Future Cosmogenic Nuclide Exposure Dating Studies in Unvisited Areas of Antarctica by Jonathan R. Adams, Philippa J. Mason, Stephen J. Roberts, Dylan H. Rood, John L. Smellie, Keir A. Nichols, John Woodward, Joanne S. Johnson

“…Supervised classification results indicate WV-3 performs well at differentiating felsic and mafic rock types and that ASTER, while coarser, could also achieve satisfactory results and be used in concert with more targeted WV-3 image acquisitions. Finally, we present a revised felsic–mafic geological map for Mt Murphy. …”
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The frequency of mutations in advanced thyroid cancer in Japan: a single-center study by Soji Toda, Hiroyuki Iwasaki, Yoichiro Okubo, Hiroyuki Hayashi, Mei Kadoya, Hiroyuki Takahashi, Tomoyuki Yokose, Yukihiko Hiroshima, Katsuhiko Masudo

“…Of the 81 patients with differentiated thyroid carcinoma (DTC) and PDTC, 88.9% were radioactive iodine-refractory, and 32.7% of all cases had previously been treated with multiple kinase inhibitors. Of ATC cases, 52.9% had BRAF mutations, and 5.9% had RET fusion. …”
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Investigation of Anti-Friction Properties of MoS₂ and SiO₂ Nanolubricants Based on the Friction Pairs of Inconel 718 Superalloy and YG6 Carbide by Lijie Ma, Fengnan Li, Shijie Ba, Zunyan Ma, Xinhui Mao, Qigao Feng, Kang Yang

“…Then, the viscosity, wettability, and tribological properties of the nanolubricants were measured and analyzed with a rotary viscometer, a contact angle measuring instrument, and a friction tester. Finally, the action mechanism of two nano-additives was explained based on the energy spectrum test results of the abrasion surface. …”
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Vegetation height estimation based on machine learning model driven by multi-source data in Eurasian temperate grassland by Wuhua Wang, Jiakui Tang, Na Zhang, Xuefeng Xu, Anan Zhang, Yanjiao Wang, Kaihui Li, Yidan Wang

“…The first Eurasian temperate grassland vegetation height dataset was finally generated. The results highlighted the superior performance of the Random Forest with an R2 of 0.54, RMSE of 7.39 cm, and MPAE of 49.25 %. …”
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Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location by Christopher Wills, Katie Watts, Amy Houseman, Timothy S. Maughan, David Fisher, Nada A. Al-Tassan, Richard S. Houlston, Valentina Escott-Price, Jeremy P. Cheadle

“…We investigated the relationship between Phosphatidylinositol 4-Kinase Type 2 Beta (PI4K2B) expression in colorectal tumours and survival in 597 patients from The Human Protein Atlas (THPA). …”
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Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells by Marilena Celano, Valentina Maggisano, Saverio Massimo Lepore, Marialuisa Sponziello, Valeria Pecce, Antonella Verrienti, Cosimo Durante, Marianna Maranghi, Piernatale Lucia, Stefania Bulotta, Giuseppe Damante, Diego Russo

“…In this translational study, we analyzed in vitro the effects of leptin on the growth and migration of thyroid cancer cells (TPC-1 and K1), the molecular mechanisms underlying leptin’s action, and the influence of prolonged leptin exposure on cell response to a protein kinase inhibitor lenvatinib. The expression levels of OB-R mRNA and protein were also investigated in vivo in a series of aggressive PTCs divided into two groups based on the presence of the BRAF mutation. …”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…In contrast, the conditioned medium from senescent fibroblasts that upregulated NF-κB activity altered deoxycytidine kinase levels in drug-untreated CRC cells and abrogated DAC effect on degradation of DNA methyltransferase 1. …”
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Fatigue life prediction of asphalt binders under variable loading levels based on dissipated pseudo-strain energy by Chenze Fang, Hui Li, Zhenxia Li, Yuanzhao Chen, Tengteng Guo

“…Furthermore, the evolution law and increment process of fatigue damage for the tested binders were analyzed using the fatigue damage characterized by dissipated pseudo-strain energy (DPSE). Finally, a binder fatigue life prediction model considering the sequence and interaction of variable loading levels according to damage equivalent criterion. …”
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Impact of Organic Agriculture on the Quality of Grapes (Syrah and Tempranillo) Harvested in Guanajuato, Mexico: Relationship Between Soil Elemental Profile and Grape Bioactive Prop... by Fabio Macías-Gallardo, Tannia Alexandra Quiñones-Muñoz, Raúl Miranda-Avilés, Luis Felipe Ramírez-Santoyo, Gabriela Ana Zanor, César Ozuna

“…The second component showed positive correlations between OM, silt, soil oxides, antioxidant capacity, and phenols in grape skin and seed. Finally, the edaphic conditions of the ORG vineyard allowed for one to obtain optimal grapes for winemaking due to their higher phenol content.…”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…The effects of CCG-257081 on proliferation (Ki67) and caspase-3 activation were assessed in resistant YUMMER_R tumors in vivo. Finally, two CCG-257081 enantiomers were tested for pirin binding, inhibition of the Rho/MRTF-mediated activation of ACTA2 gene expression in fibroblasts, and the prevention of Vem resistance development by YUMMER_P cells.ResultsVem reduced growth of parental but not resistant cells, while CCG-257081 inhibited both. …”
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Clinical efficacy of a virtual reality tool for the treatment of obesity: study protocol of a randomised controlled trial by Dimitra Anastasiadou, Jose Antonio Ramos-Quiroga, Mel Slater, Bernhard Spanlang, Desiderio Cano Porras, Marta Comas, Andreea Ciudin, Gemma Parramon Puig, Julia Vázquez-De Sebastián, Pilar Lusilla-Palacios

“…Readiness to change, BMI, eating habits and physical activity, psychological well-being, body image satisfaction, quality of life in relation to body image, and weight bias internalisation will be assessed at baseline, post intervention, 1-week and 4-week follow-up. Finally, variables related to adherence and satisfaction with the VR tool will be evaluated for the experimental groups.Ethics and dissemination This study was approved by the Research Projects Committee of the Vall d’Hebron University Hospital. …”
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Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia by Qi Zhou, Yongyu Guan, Pingping Zhao, Huiyuan Chu, Yaming Xi

“…Gilteritinib treats acute myeloid leukemia (AML) with the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. …”
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Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2 by Siyao Li, Mingdan You, Chengjie Chen, Jingqi Fu, Yuanyuan Xu, Jingbo Pi, Yi Wang

“…We also created Nrf2 knockdown (KD) BV2 microglia to investigate the role of cell-specific Nrf2 in Cd-induced microglial activation. Finally, we developed co-culture systems of either Nrf2-KD or Scramble microglia and primary neurons or HT22 neurons to study the effects of Nrf2-regulated microglial activation on synaptic damages induced by Cd. …”
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Advanced process control in laser-based powder bed fusion–Smart Fusion feedback-loop control as a path to uniform properties for complex structures? by Florian Nahr, Tobias Novotny, Dominik Kunz, Ulrich Kleinhans, Lova Chechik, Dominic Bartels, Michael Schmidt

“…In MS1, the open-loop lead to signs of in-situ precipitation resulting in a significant local hardness increase in comparison to the feedback-loop control. Finally, the complex MS1 part could be built without minimum exposure times and uniform hardness of 350 HV0.5.…”
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Access to Diagnostics and Treatment for People With Metastatic EGFR-Positive NSCLC: Lessons From Project PRIORITY by Jill Feldman, MA, Ivy Elkins, MBA, Zofia Piotrowska, MD, Bellinda L. King-Kallimanis, PhD, Tendai Chihuri, MD, Carly Johnson, BS, Alecia Clary, PhD, Teri Kennedy, MA, Upal Basu Roy, PhD, MPH

“…In addition, 89% reported receiving at least one tyrosine kinase inhibitor (TKI); osimertinib was the most prescribed first-line TKI for stage IV participants diagnosed after 2017. …”
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Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…Exercise significantly upregulated phosphoinositide 3 kinase (PI3K) docking site phosphorylation and downregulated the negative IRS1 phosphorylations thereby increasing the glucose transporter (GLUT) expressions and reducing the lactate accumulation. …”
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Validation of deep-learning accelerated quantitative susceptibility mapping for deep brain nuclei by Ying Zhou, Ying Zhou, Lingyun Liu, Shan Xu, Yongquan Ye, Ruiting Zhang, Minming Zhang, Jianzhong Sun, Peiyu Huang

“…QSM values from 7 deep brain nuclei were extracted and agreements between images with different Afs were assessed. Finally, the correlations between age and QSM values in the selected deep brain nuclei were evaluated.Results59 participants were recruited. …”
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Human Action Recognition Using Difference of Gaussian and Difference of Wavelet by Gopampallikar Vinoda Reddy, Kongara Deepika, Lakshmanan Malliga, Duraivelu Hemanand, Chinnadurai Senthilkumar, Subburayalu Gopalakrishnan, Yousef Farhaoui

“…Linear Discriminant Analysis (LDA), a widely used dimensionality reduction technique, is also used to eliminate duplicate data. Finally, a closest neighbor method is used to classify the dataset. …”
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Nicotine is associated with smoking dependence and vascular inflammation through cotinine: A mediation analysis by Kumboyono Kumboyono, Indah N. Chomsy, Nadya N. Shalshabilla, Hidayat Sujuti, Arie Srihardyastutie, Cholid T. Tjahjono, Teuku Heriansyah, Titin A. Wihastuti

“…This study aimed to evaluate the relationship between NO levels and cotinine through the expression of nAChRs that mediate the nicotine dependence mechanism and Tie2 (Tyrosine Kinase 2) expression. Methods A cross-sectional study was conducted with 200 participants grouped into two groups based on their smoking status: 100 smokers and 100 non-smokers. …”
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Advancement of Pt and Pd-based catalysis for green, sustainable energy and bio-medical applications by Nithyadharseni Palaniyandy, Sekhosana Kutloano, Lakshmi Devaraj, Xolile Fuku, Sathish Sundar Dhilip Kumar

“…Additionally, the unique attributes of metal nanoclusters for biomedical sensing and imaging applications are discussed. Finally, a personal outlook is given to highlight the challenges and opportunities for the development of novel electrocatalysts suitable for a wide range of commercial applications in fostering advancements in sustainable technologies and materials.…”
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