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20721
Host-symbiont-gene phylogenetic reconciliation
Published 2023-05-01“…Then we show in a aphid enterobacter system that some reliable transfers detected by our method, are invisible to classic 2-level reconciliation. We finally evaluate different hypotheses on human population histories in the light of their coevolving Helicobacter pylori symbionts, reconciled together with their genes. …”
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20722
Research progress on the antiviral immune regulation of ubiquitin ligase F-box family
Published 2025-01-01“…FBPs can form the SCF complex by binding with S-phase kinase-associated protein 1 (SKP1), cullin 1 (CUL1), and ring-box 1 (Rbx1), functioning as E3 ubiquitin ligase. …”
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20723
Teleconnections detection of land use carbon emissions beyond geographical proximity promotes the construction of cross-city networks
Published 2025-01-01“…Then a complex network model is used to construct the spatial correlation strength, network structure, and network clustering among cities to identify spatial associations between cities within the YRDUA. Finally, the CatBoost machine learning regression model is used to analyze the factors influencing LUCE. …”
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20724
Evaluation of the potential value of artificial intelligence (AI) in public health using fluoride intake as the example
Published 2025-02-01“…These hypotheses were then evaluated independently by three evaluators. Finally, summaries were made through group discussions among all the authors. …”
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20725
Blood biochemistry changes in a minipig infarction model
Published 2025-01-01“…Aspartate transaminase (AST), alanine aminotransferase (ALT), creatine kinase (CK), lactate dehydrogenase (LDH), and high-sensitivity troponin I were determined.ResultsWhile the parameters measured at baseline remained within physiological ranges, a notable elevation was seen in comparison with the results observed on day 30. …”
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20726
Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status
Published 2019-01-01“…Four studies examined VOCs in gastric and colorectal tumors showing a change in metabolic biomarkers of cancer patients compared to the control group. Finally, the study of VOCs in breast milk has improved the understanding of the potential health risks of exposure of children to chemical pollutants. …”
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20727
Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation
Published 2025-01-01“…Moreover, it will investigate various aspects, including the safety and efficacy of a new third‐generation EGFR tyrosine kinase inhibitor (TKI), lazertinib, approved for both first‐ and second‐line treatments. …”
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20728
Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China
Published 2024-02-01“…Results Although trapped BMSB numbers were generally low across all traps tested, the black corflute trap was found to attract the highest average number of BMSB males and females, followed by the wooden-made trap, the bee-hive box and finally the wooden-made locked trap, which attracted the lowest numbers of BMSB. …”
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20729
Histone Arginine Methylation-Mediated Epigenetic Regulation of Discoidin Domain Receptor 2 Controls the Senescence of Human Bone Marrow Mesenchymal Stem Cells
Published 2019-01-01“…Further, we found through knockdown and overexpression approaches that coactivator-associated arginine methyltransferase 1 (CARM1) regulated the expression level of DDR2 and the senescence of hBM-MSCs. Finally, chromatin immunoprecipitation analysis confirmed direct binding of CARM1 to the DDR2 promoter region with a high level of H3R17 methylation in early-passage hBM-MSCs, and inhibition of CARM1-mediated histone arginine methylation decreased DDR2 expression and led to cellular senescence. …”
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20730
Comparative transcriptome analysis reveals potential regulatory mechanisms in response to changes in physiological functions in Oreochromis aureus under salinity stress
Published 2025-03-01“…On the basis of GO, KEGG and STEM analyses, the data enabled the development of a mechanistic model that details how O. aureus adapts to salinity stress by regulating physiological changes. Finally, RT-qPCR assays verified the accuracy and reliability of the high-throughput sequencing results. …”
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20731
Camrelizumab-Related Lethal Arrhythmias and Myasthenic Crisis in a Patient with Metastatic Thymoma
Published 2022-01-01“…Workups on admission indicated dramatically elevated transaminase, troponin I, creatine kinase, and a new-onset conduction abnormality on electrocardiography. …”
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20732
Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria
Published 2018-04-01“…Other proteins that might be interesting were annexin D8 and D1, protein kinase interacting with calcinerin B, actin-binding protein profilin, GTP-binding protein Ran1. …”
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20733
Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma
Published 2025-01-01“…Differentially expressed genes (DEGs) between the high and low SLC3A2 expression groups were primarily involved in cytokine-cytokine receptor interaction and immune response. Finally, in vitro experiments demonstrated that SLC3A2 stimulates tumor cell proliferation and migration. …”
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20734
Sudden Vision Loss Secondary to Optic Nerve Infiltration as a Presenting Symptom of Metastatic Lung Adenocarcinoma
Published 2022-01-01“…Further investigation into the role of tyrosine kinase inhibitors and radiation therapy in treating intraocular metastasis involving the optic nerve is needed.…”
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20735
Fatigue in patients with chronic obstructive pulmonary disease: protocol of the Dutch multicentre, longitudinal, observational FAntasTIGUE study
Published 2018-04-01“…Additional assessments will be conducted following hospitalisation due to an exacerbation of COPD that occurs between baseline and 12 months. Finally, at 18 and 24 months the participants will be followed up on their fatigue, number of exacerbations, exacerbation-related hospitalisation and survival.Ethics and dissemination This protocol was approved by the Medical research Ethics Committees United, Nieuwegein, the Netherlands (NL60484.100.17).Trial registration number NTR6933; Pre-results.…”
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20736
Dynamic alterations in spontaneous neural activity in patients with attention-deficit/hyperactivity disorder: A resting-state fMRI study
Published 2025-03-01“…We investigated the relationship between clinical and dynamic indicators, and additionally performed voxel-based functional connectivity (FC) analysis. Finally, we developed an auxiliary diagnosis model. …”
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20737
The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats
Published 2025-06-01“…At the end of the experiment, rats were euthanized by cervical dislocation, and blood and the collected tissue samples were collected to measure creatinine kinase (CKM), malondialdehyde (MDA), total antioxidant capacity (TAOC), inducible nitric oxide synthase-2 (iNOS2), and aldolase. …”
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20738
Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur
Published 2025-01-01“…The impact of PSCP on HCC was assessed in vitro and in vivo, focusing on the expression and activity of p53 and AMP-activated protein kinase (AMPK), as well as mitochondrial function. …”
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20739
Cetacean feeding modelling using machine learning: A case study of the Central-Eastern Mediterranean Sea
Published 2025-05-01“…These differences in predictive performance might reflect the distinct trophic niches of the studied odontocetes. Finally, simulated predictive maps of Risso's dolphin feeding habitats for summer months were realized in the Gulf of Taranto, providing actionable insights for conservation and sustainable management. …”
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20740
Internal Dosimetry in Patients Undergoing Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-[DOTA0-Tyr3] Octerotate: A Single-Center Experience
Published 2025-01-01“…Models of time-activity were established for different organs. Finally, using absorbed dose formulation and IDIAC-Dosage software, the mean absorbed dose in the organs was determined. …”
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