Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…In the developing limbs, LRP1 partially colocalises with Wnt5a and its deficiency alters abundance and distribution of Wnt5a and Vangl2. Finally, using Xenopus as a model system, we show the regulatory role for LRP1 in Wnt/PCP signalling. …”
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Real-world outdoor air exposure effects in a model of the human airway epithelium – A comparison of healthy and asthmatic individuals using a mobile laboratory setting by Pavel Rossner, Helena Libalova, Tereza Cervena, Michal Sima, Zuzana Simova, Kristyna Vrbova, Antonin Ambroz, Zuzana Novakova, Fatima Elzeinova, Anezka Vimrova, Lubos Dittrich, Michal Vojtisek, Martin Pechout, Michal Vojtisek-Lom

“…We measured lactate dehydrogenase (LDH) and adenylate kinase (AK) production and transepithelial electrical resistance (TEER), analyzed 15-F2t-isopostane (IsoP) and a panel of 20 cytokines/chemokines/growth factors. …”
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Challenges and Prospects of Digital Core-Reconstruction Research by Linqi Zhu, Chong Zhang, Chaomo Zhang, Xueqing Zhou, Zhansong Zhang, Xin Nie, Weinan Liu, Boyuan Zhu

“…The progress related to these various stochastic reconstruction methods, the characteristics of constructed 3D digital cores, and the potential of these methods are analysed and discussed in detail. Finally, reasonable prospects are presented based on the current state of this research area. …”
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HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy by Ting-I Lee, Yu-Hsun Kao, Wen-Chin Tsai, Cheng-Chih Chung, Yao-Chang Chen, Yi-Jen Chen

“…Moreover, control and MPT0E014-treated DM rats had lower concentrations of 5′ adenosine monophosphate-activated protein kinase 2α, PPAR-γ coactivator 1α, phosphorylated acetyl CoA carboxylase, cluster of differentiation 36, diacylglycerol acyltransferase 1 (DGAT1), DGAT2, tumor necrosis factor-α, and interleukin-6 protein than DM rats. …”
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A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus by G. V. Kochneva, A. A. Grazhdantseva, G. F. Sivolobova, A. V. Tkacheva, A. N. Shvalov, A. Yu. Unusova, E. I. Ryabchikova, S. V. Netesov

“…We used the attenuated recombinant vaccinia virus (VACV) VVdGF-GFP2 of the L-IVP strain (GenBank accession number KP233807), with deletion of two virulence genes: the virus growth factor and thymidine kinase, with the gene for the green fluorescent protein (GFP2) inserted in an area of the latter. …”
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Biocompatibility, Degradation Behavior, and Mechanical Properties of Magnesium Alloy Plates In Vivo by Yongping Wang, Qingqing Qin, Xiaorong Liu, Qiangqiang Li, Huaibin Zhang, Dubin Yang, Yao Jiang

“…The concentrations of serum alanine transaminase, creatinine (CREA), creatine kinase (CK), and magnesium ion were measured before and 1 day, 1, 2, 4, 8, and 16 weeks after operation, respectively, to evaluate the biocompatibility of magnesium alloy plates. …”
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Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT by Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren

“…The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. …”
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Integrative proteomic-transcriptomic analysis revealed the lifestyles of Lactobacillus paracasei H4-11 and Kluyveromyces marxianus L1-1 under co-cultivation conditions by Na Liu, Likang Qin, Haiying Zeng, Anyan Wen, Song Miao

“…In L. paracasei H4-11, L-lactate dehydrogenase, phosphoglucomutase, acetate kinase, alcohol dehydrogenase and acetyl-CoA were up-regulated and D-lactate dehydrogenase and N-Acetyltransferase were down-regulated. …”
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The effects of Fraxini cortex and Andrographis herba on Escherichia coli-induced diarrhea in chicken by Yunying Wang, Zhenwei Sheng, Huicong Li, Xuewen Tan, Yingqiu Liu, Weimin Zhang, Wuren Ma, Lin Ma, Yunpeng Fan

“…In this study, the model of chicken diarrhea induced by E. coli was established, and different TCM formulas were used for treatment, and finally the formula with the best effect was screened out. …”
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Efficacy And Safety Of Low Dose Tofacitinib As Induction Therapy In Moderate To Severe Ulcerative Colitis: A Pilot Study by Sadia Ahmed, Muhammad Umar, Muhammad Kamran, Misbah Noureen, Iqra Ashraf, Javeria Khan

“…Tofacitinib, an orally administered micromolecule, blocks the Janus kinase (JAK) signal transducer pathway, thereby reducing mucosal inflammation. …”
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Circulating Regulatory T-Cells in Monoclonal Gammopathies of Uncertain Significance and Multiple Myeloma: In Search of a Role by Giovanni D’Arena, Giovanni Rossi, Luca Laurenti, Teodora Statuto, Fiorella D’Auria, Luciana Valvano, Vittorio Simeon, Aldo Giudice, Idanna Innocenti, Vincenzo De Feo, Rosanna Filosa, Pellegrino Musto

“…With respect to MM patients and after a median follow-up of 33 months, Tregs did not show any significant correlation with main clinical and laboratory characteristics. Finally, from a functional point of view, Tregs displayed an effective suppressor function, irrespective of disease status. …”
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Successful Use of Negative Pressure Wound Therapy for Abdominal Wall Necrosis Caused by a Perforated Ascending Colon Using the ABThera System by Kouki Imaoka, Takuya Yano, Yasuhiro Choda, Ko Oshita, Yuma Tani, Tetsushi Kubota, Michihiro Ishida, Daisuke Satoh, Masanori Yoshimitsu, Kanyu Nakano, Masao Harano, Hiroyoshi Matsukawa, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima

“…A reduction was observed in the size of the open wound with visible granulation tissue. The defect was finally covered with a mesh split-thickness skin graft and anterolateral thigh flap. …”
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Accurate estimation of Jujube leaf chlorophyll content using optimized spectral indices and machine learning methods integrating geospatial information by Nigela Tuerxun, Sulei Naibi, Jianghua Zheng, Renjun Wang, Lei Wang, Binbin Lu, Danlin Yu

“…Support vector regression (SVR), random forest regression (RFR), and geographically weighted least squares support vector regression (GWLS-SVR) were then used to assess the prediction accuracy. Finally, the optimal variables and regression model were identified. …”
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Application Analysis of Intelligent Robot Inspection System at Offshore Step-up Substation by Dengke ZHOU, Long CHENG, Yaping ZHANG, Peng TANG, Sheng GU, Kaiyuan ZHENG, Junsheng HE, Xue ZHANG

“…[Objective] The offshore step-up substation serves as the central hub for power collection in offshore wind farms, and its inspection, operation and maintenance are crucial to ensuring safe production and improving efficiency. …”
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Association of dust exposure with anxiety and depression in the occupational population: The important role of sleep duration by Zhuoheng Shen, Yue Sun, Yang Li, Qi Zhang, Yifei Liu, Jiyan Han, Jiafei Yang, Jiangping Li, Zhiyun Ha, Yaowen Yang, Zhihong Liu, Suzhen Guan, Jian Sun

“…After a series of screening 1274 valid subjects were finally included. Binary logistic regression was used to explore the association of dust exposure with anxiety and depression. …”
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Techno-economic optimization of hybrid power systems for sustainable energy in remote communities of Iraq by Mohammed A. Qasim, Salam J. Yaqoob, Mohit Bajaj, Vojtech Blazek, Adel A. Obed

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Ecological risk assessment and response prediction caused by LUCC in the central Yunnan Province by Yongdong Zhang, Zisheng Yang, Renyi Yang, Fuhua Liu, Yimei He, Linlin Cao, Jinrong Yang, Jiayi Zhang

“…In short, the future ERs of CYP have decreased, and the ERs corresponding to various ecosystem services (ESs) interact with each other, causing a ripple effect. Finally, this study proposes policy recommendations to alleviate ERs in the CYP.…”
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Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI by Fei Peng, Jiaxiang Xia, Fandong Zhang, Shiyu Lu, Hao Wang, Jiashu Li, Xinmin Liu, Yao Zhong, Jiahuan Guo, Yonghong Duan, Binbin Sui, Chuyang Ye, Yi Ju, Shuai Kang, Yizhou Yu, Xin Feng, Xingquan Zhao, Rui Li, Aihua Liu

“…The ability of the hybrid model to predict aneurysm instability was compared with baseline models: PHASES (population, hypertension, age, size, earlier rupture, and site) LR, ELAPSS (earlier subarachnoid hemorrhage, location, age, population, size, and shape) LR, aneurysm wall enhancement (AWE) LR, and Radiomics using the area under the curve (AUC) with Delong's test. Finally, the Hybrid Model was further validated in the validation cohort (patients enrolled between December 2021 to May 2022). …”
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Predictive method for poultry carcass visceral dimensions using 3D point cloud and Genetic Algorithm-based wavelet neural network by Zhengwei Zhu, Yan Chen, Lu Cai, Jinzhou Yang, Ke Wen, Jingjing Bao, Zhigang Hu, Dandan Fu

“…By comparing the prediction results and analyzing Mean Absolute Percentage Error (MAPE) and Root Mean Square Error (RMSE) of the six models, it was determined that the GA-WNN model had the best prediction results. Finally, in order to verify the generalizability of the method, generalizability experiments were conducted on different breeds of poultry, which proved that the method of this study had superior generalizability ability. …”
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Immunotherapy in metastatic renal cell carcinoma: Insights from a Dutch nationwide cohort by Hilin Yildirim, Anke Richters, Adriaan D. Bins, Arnoud W. Postema, Maureen J.B. Aarts, Martijn G.H. van Oijen, Patricia J. Zondervan, Katja K.H. Aben

“…Targeted therapy with tyrosine kinase inhibitors (TKIs) was the standard of care for metastatic renal cell carcinoma (mRCC) until recently, when new first-line combinations with immuno-oncology (IO) agents were approved. …”
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