Atrial Arrhythmias in Patients with Severe COVID-19 by Kai-Yue Han, Qi Qiao, Ye-Qian Zhu, Xin-Guang Chen, Xing-Xing Kang, Gao-Feng Zhang, Xun-Chao Cai, Yong Du, Jing Jin, Ruo-Min Di, Chen-Xi Yang, Feng-Xiang Zhang, Ying-Jia Xu

“…Patients with severe COVID-19 (severe and critical type diseases) developed more atrial arrhythmias compared with those with nonsevere symptoms. Plasma creatine kinase isoenzyme (CKMB) levels (P=0.01) were higher in the severe group than in the nonsevere group, and there were more deaths in the severe group than in the nonsevere group (6 (15%) vs. 3 (2.30%); P=0.05). …”
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Health system financing fragmentation and maternal mortality transition in Mexico, 2000–2022 by Edson Serván-Mori, Carlos Pineda-Antúnez, Diego Cerecero-García, Laura Flamand, Alejandro Mohar-Betancourt, Christopher Millett, Thomas Hone, Rodrigo Moreno-Serra, Octavio Gómez-Dantés

“…We compared the distribution of individual attributes and place of residence between deceased women with and without social security to identify overrepresented demographic profiles. Finally, we mapped state disparities in MMR by health insurance for the last four political administrations. …”
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Soft computing approaches of direct torque control for DFIM Motor's by Zakariae Sakhri, El-Houssine Bekkour, Badre Bossoufi, Nicu Bizon, Mishari Metab Almalki, Thamer A.H. Alghamdi, Mohammed Alenezi

“…Optimization approaches such as DTC-GA, DTC-ACO, and DTC-RTO contribute to reducing switching losses and improving energy efficiency, a crucial aspect for large-scale applications. Finally, P-DTC offers excellent dynamics and precise speed tracking, making it ideal for rapid response systems. …”
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Long-term effect of island industrial construction on groundwater health risk by Yong Huang, Daqing Wang, Haoli Xu, Zhao Lu, Zijian Cheng, Zhibin Ding, Yi Wang, Yue Shi, Huiru Cui, Xiaoying Lian

“…However, the health risk in the center of the park reached Level 1 and above, and the risk area of Level 2 and above covered an area of up to 94,613 m2, accounting for 0.0039 of the entire study area. Finally, Monte Carlo simulations were used to conduct uncertainty and sensitivity analyses to reflect the objective reality of groundwater health risks under the combined influence of various uncertainty factors. …”
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Discovery of Novel Diagnostic Biomarkers for Common Pathogenic <i>Nocardia</i> Through Pan-Genome and Comparative Genome Analysis, with Preliminary Validation by Chaohong Wang, Xinmiao Jia, Ming Wei, Jun Yan, Qing Sun, Sibo Long, Maike Zheng, Yiheng Shi, Guanglu Jiang, Yan Zhao, Hairong Huang, Xinting Yang, Li Gu, Guirong Wang

“…Comparative genome analysis of these core genes with the validation-set gene sequences was then performed using BLAT, with a threshold of 30% amino acid coverage and identity, in order to distinguish specific core genes. Finally, candidate gene-specific primers were designed using Snapgene software and DNA samples were obtained from clinical <i>Nocardia</i> strains and closely related species for validation. …”
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Outburst mechanism and hazard prevention technique of limestone aquifer under isolated island panels by Wei Wang, Wei Wang, Wei Wang, Yanjun Wu, Yanjun Wu, Yanjun Wu, Yongli Shi, Yongli Shi, Yongli Shi, Jingzhong Zhu

“…The maximum stress of the panel floor is greater than that of mining without isolated islands. (2) The special drilling structures, stepwise gradient pressurization, and segmented sequential downward grouting technique are proposed to ensure the grouting effect under goaf. (3) Finally, the limestone water disaster regional treatment and control for the isolated island shaft is carried out and validated. …”
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DESAIN KOMIK DIGITAL CERITA RAKYAT DESA ARJOWILANGUN by Prisca Amelia, Harijati Purwaningsih

“…Banyak cara untuk melestarikan cerita rakyat dengan menarik minat generasi muda, salah satunya adalah cerita rakyat tersebut dijadikan sebuah komik. …”
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Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…Further, the top 2 moieties – Djh1 and Djh2 were selected after MMGBSA analysis and target selectivity prediction towards kinase. Further induced fit docking (IFD) analysis, DFT analysis, and MD simulation were employed to establish that – Djh1 and Djh2 could act as potential hit molecules for selective inhibition of PI3Kα. …”
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex by A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova

“…All PHF10 isoforms are degraded by β-TrCP ubiquitin ligase but PHF10-S isoforms contain a cluster of serins (X-cluster) for multiple phosphorylation by casein kinase I. This phosphorylation protects the β-TrCP degron from β-TrCP recognition and subsequently stabilizes the PHF10-S isoforms. …”
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An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene by Fayeza Sadia Laskar, Md. Nazmul Islam Bappy, Md. Sowrov Hossain, Zenifer Alam, Dilruba Afrin, Sudeb Saha, Kazi Md. Ali Zinnah

“…Mesenchymal–epithelial transition (MET) factor is a proto-oncogene encoding tyrosine kinase receptor with hepatocyte growth factor (HGF) or scatter factor (SF). …”
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Effects of Ghrelin on Triglyceride Accumulation and Glucose Uptake in Primary Cultured Rat Myoblasts under Palmitic Acid-Induced High Fat Conditions by Lingling Han, Jia Li, Ying Chen, Wei Wang, Dan Zhang, Guoliang Liu

“…The glucose transporter 4 (GLUT4), AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), and uncoupling protein 3 (UCP3) were assessed by RT-PCR and western blot. …”
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Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer by Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker

“…We perform GµF of blood from orthotopic ovarian cancer mouse models and characterize the morphological features of scCTCs and cCTCs, and the expression of molecular markers for aggressiveness. Finally, we analyze blood from 17 epithelial ovarian cancer patients with either localized or metastatic disease, and from 13 colorectal cancer liver metastasis patients. …”
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Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro by Ting Li, Ting Fang, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Xiaochen Yu, Bei Sun, Liming Chen

“…The autophagy inhibitor (3-methyladenine, 3-MA) and AMP-activated protein kinase (AMPK) activator (AICAR)/inhibitor (Compound C) were used to determine the involvement of AMPK and autophagy in the regulation of lipid accumulation by empagliflozin. …”
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A EFICÁCIA DE PLANTAS MEDICINAIS NO TRATAMENTO DE DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS by Luis Roberto Gomes Mohana, Rodolfo Francisco, Hálmisson D’Árley Santos Siqueira, Caroline Jordana Azevedo dos Santos, Josemeire da Costa Ximenes, Nair Portela Silva Coutinho, Jéssica Maria Silva Ribeiro, Jacqueline Martins Cantanhede, Renata Pinheiro Pedra Fernandes, Rodolfo Ritchelle Lima dos Santos

“…Resultados: Ao todo foram incluídos 12 estudos considerados elegíveis para compor a síntese de evidências, na qual destacou-se que existe um grande acervo de plantas medicinais, ainda pouco explorado, mas que vem sendo desbravadas ao longo dos anos, sendo incluídas como terapias alternativas e complementares podendo ser usadas no tratamento de múltiplas doenças crônicas, com diferentes formas e usos, apresentam também um baixo teor de toxicidade sendo consideradas com potencial eficácia e segurança. Considerações Finais: ressalta-se que o uso de plantas medicinais deve ser feito sobre orientação profissional da saúde e que ainda são necessários mais estudos que enfatizem sobre dosagem, segurança e reais efeitos das plantas medicinais no tratamento de doenças crônicas não transmissíveis.  …”
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Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations by Ashley E. Tessnow, Rodney N. Nagoshi, Robert L. Meagher, Todd M. Gilligan, Ben M. Sadd, Yves Carrière, Holly N. Davis, Shelby J. Fleischer, Kelly Richers, John C. Palumbo, Patrick Porter, Jose Carlos Verle Rodrigues, Gregory A. Sword

“…We provide the first evidence for nuclear genomic differentiation between the two major overwintering populations of fall armyworm in the US. Finally, our data reveal population-specific patterns of selection on genomic regions containing putative insecticide resistance alleles, which could relate to their biogeography. …”
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Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…The mechanisms through which TI-076 acts seem to involve the modulation of several genes associated with inflammation (Il1b, Nlrp3, Pparα and Pparγ), white adipose and liver metabolism (Cartpt, Mgll, Ramp3, Faah, Cck, Clps, Pparα and Pparγ), liver damage and fibrosis (Creb1, Col1a1 and Col3a1). Finally, TI-076 did not interact with CYP3A4 in vivo and proved to be safe. …”
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A Lightweight Network for Ship Detection in SAR Images Based on Edge Feature Aware and Fusion by Yuming Li, Jin Liu, Xingye Li, Xiliang Zhang, Zhongdai Wu, Bing Han

“…Furthermore, a lightweight feature fusion network, Filter-Pruned Bi-directional Feature Pyramid Network (FP-BiFPN), is carefully designed, which can not only suppresses background information, but also accentuates ship targets. Finally, we propose a selective quantization algorithm based on a bit-width selection mechanism to reduce model memory usage without compromising performance. …”
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Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages by Yuan Li, Yanping Chen, Yuan Meng, Meng Shen, Fan Yang, Xiubao Ren

“…Objective: The combination of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) leads to an increased incidence of severe immune-related adverse events (irAEs). …”
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ReliefF guided variable spiral tuna swarm optimization algorithm with somersault foraging for feature selection by Yu-Cai Wang, Jie-Sheng Wang, Min Zhang, Hao-Ming Song, Jia-Ning Hou, Yu-Liang Qi, Yu-Wei Song

“…In the second set of experiments, RReTSO CY is compared with other binary swarm intelligence optimization algorithms, with results indicating that the proposed method effectively reduces the feature subset size, improves classification accuracy and achieves the lowest average fitness value. Finally, the Wilcoxon rank-sum tests were conducted to statistically validate the effectiveness of the proposed algorithm.…”
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A Fine-Grained Aircraft Target Recognition Algorithm for Remote Sensing Images Based on YOLOV8 by Xiao-Nan Jiang, Xiang-Qian Niu, Fan-Lu Wu, Yao Fu, He Bao, Yan-Chao Fan, Yu Zhang, Jun-Yan Pei

“…Subsequently, a focus modulation mechanism is employed to enhance the network&#x0027;s interactive understanding of local and global features, thereby improving the recognition accuracy for small and challenging targets. Finally, a multitype feature fusion is designed, which optimizes the generation of feature maps by integrating local features, high-level semantic information, and low-level texture information, enhancing the accuracy of fine-grained target recognition. …”
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