A novel high-resolution eco-functional vegetation mapping of coastal dunes by Michele Innangi, Mirko Di Febbraro, Marco Balsi, Ginevra Colonna, Michele Finizio, Federica Pontieri, Maria Laura Carranza

“…The first class, situated near the drift-line, included Thinopyrum junceum, a species adapted to wind and sand movement. The second class bridged dynamic foredune and more stable areas, featuring ruderal species like Scabiosa atropurpurea. …”
Get full text

Elevation gradient effects on grassland species diversity and phylogenetic in the two-river source forest region of the Altai Mountains, Xinjiang, China by Jing Che, Jing Che, Mao Ye, Mao Ye, Qingzhi He, Qingzhi He, Guoyan Zeng, Guoyan Zeng, Miaomiao Li, Miaomiao Li, Weilong Chen, Weilong Chen, Xiaoting Pan, Xiaoting Pan, Jiaorong Qian, Jiaorong Qian, Yexin Lv, Yexin Lv

“…The species diversity along the elevation gradient exhibits a bimodal trend, with an initial increase, followed by a decrease, another increase, and finally a decline as the elevation rises. In contrast, phylogenetic diversity shows a unimodal pattern, characterized by an initial increase followed by a decline with increasing elevation. …”
Get full text

Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. …”
Get full text

Behavior of non-Transmissible Chronic Diseases in Elder Adults by Raidel González Rodríguez, Juan Cardentey García

“…<strong> <br />Methods:</strong> a cross descriptive retrospective study was done at the medical office no2 belonging to the Pedro Borrás Astorga polyclinic at Pinar del Río during 2016. The universe of study was 348 elder adults with the diagnosis of non-transmissible chronic disease. …”
Get full text

The Stress and Adversity Inventory for Adults (Adult STRAIN) in Korean: Initial Validation and Associations with Psychiatric Disorders by Eun Soo Kim, Yun Tae Kim, Kang-Seob Oh, Young Chul Shin, Sang-Won Jeon, Dong-Won Shin, Sung Joon Cho, George M. Slavich, Junhyung Kim

“…Each domain of Korean-style stress, based on the timing, type, life domain, and sociopsychological characteristics of stress exposure, showed a different distribution of lifetime psychiatric diagnosis probabilities (odds ratios = 1.20–4.85). Finally, the test–retest reliability for total lifetime stressor count and severity over four weeks was high. …”
Get full text

Examining Internal and External Consent in Consensual and Non-Consensual Contexts in Women by Nieves Moyano, Antonio Rafael Hidalgo-Muñoz, María del Mar Sánchez-Fuentes, Kristen Jozkowski, Reina Granados

“…Further, those who experienced nonconsensual sex in an unknown setting (vs. known) reported feeling less safety and readiness in term of internal consent. Finally, women who experienced sexual coercion (vs. sexual assault) indicated greater use of borderline pressure. …”
Get full text

Combining a Standardized Growth Class Assessment, UAV Sensor Data, GIS Processing, and Machine Learning Classification to Derive a Correlation with the Vigour and Canopy Volume of... by Ronald P. Dillner, Maria A. Wimmer, Matthias Porten, Thomas Udelhoven, Rebecca Retzlaff

“…Model overall performance metrics were optimized with grid search-based hyperparameter tuning and repeated-k-fold-cross-validation. Finally, ML-based growth class prediction results were extensively discussed and evaluated for overall (accuracy, f1-weighted) and growth class specific- classification metrics (accuracy, user- and producer accuracy).…”
Get full text

Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study by Xiao'ao Xue, Weichu Tao, Qianru Li, Yi Li, Yiran Wang, Le Yu, Xicheng Gu, Tian Xia, Rong Lu, Ru Wang, He Wang, Yinghui Hua

“…Then, the two-sample Mendelian randomization (MR) analysis was applied based on the genetically predicated ankle-foot sprains from FinnGen to validate causal relationship. Finally, genetically predicated cerebellar neuroimaging features were used to explore the mediating role of maladaptive neuroplasticity between ankle-foot sprains and falls by two-step MR analyses. …”
Get full text

Evaluation of Digital PCR as a Technique for Monitoring Acute Rejection in Kidney Transplantation by Hyeseon Lee, Young-Mi Park, Yu-Mee We, Duck Jong Han, Jung-Woo Seo, Haena Moon, Yu-Ho Lee, Yang-Gyun Kim, Ju-Young Moon, Sang-Ho Lee, Jong-Keuk Lee

“…Our results further showed that autosomal, sex-specific, and mitochondrial SNPs were suitable markers for identifying donor cfDNA. Finally, we found that donor-derived cfDNA measurement by dPCR was not sufficient to predict a patient's clinical condition. …”
Get full text

IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…In order to simultaneously consider node weights and information updates, a dual-channel method combining Graph Attention Network (GAT) and Graph Convolutional Network (GCN) is adopted. Finally, the extracted features from both channels are merged for the classification of IL-6-inducing peptides. …”
Get full text

Update on the Treatment of Diabetic Retinopathy by Jennifer L. Wilkinson-Berka, Antonia G. Miller

“…This review examines evidence from preclinical and clinical studies that shows that targeting inhibition of the renin-angiotensin system, vascular endothelial growth factor, corticosteroids, protein kinase C, growth hormone, and advanced glycation end-products are potential treatments for DR.…”
Get full text

The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…We also outline the main antifungal resistance mechanisms identified in planktonic cells of these yeast species. Finally, we explore the impact of biofilm formation, a classical virulence attribute of fungi, on antifungal resistance, highlighting the resistance mechanisms associated with this complex microbial structure that have been uncovered to date.…”
Get full text

Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats by Xiaohong Wang, Guoxiong Zhou, Chun Liu, Ronglong Wei, Shunxing Zhu, Yuefen Xu, Mengjie Wu, Qing Miao

“…Serum amylase levels were determined by ELISA; protein and mRNA expression levels of nucleus nuclear factor kappa B (NF-κB) p65, light chain 3II (LC3-II), and Beclin-1 and mRNA expression levels of Class III phosphatidylinositol 3-kinase (PI3K-III) in pancreas tissue were detected by Western blot and quantitative real-time PCR, respectively; mortality and pathological change of the pancreas were observed at 3, 12, and 24 h after operation. …”
Get full text

Effect of Modulating Spin-Coating Rate of TiO2 Precursor for Mesoporous Layer on J-V Hysteresis of Solar Cells with Polar CH3NH3PbI3 Perovskite Thin Film by Qi Li, Xiaoping Zou, Yuanyuan Li, Yaxian Pei, Shuangxiong Zeng, Dongdong Guo

“…Thirdly, a weak polar hysteresis loop relation for CH3NH3PbI3 film was observed. Finally, the hysteresis index for the 1500 rpm mesostructured solar cell shows relatively low J-V hysteresis compared with the 3000 rpm mesostructured and the planar-structured solar cell. …”
Get full text

Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy by S. Rossi, R. Maisto, C. Gesualdo, M. C. Trotta, F. Ferraraccio, M. K. Kaneva, S. J. Getting, E. Surace, F. Testa, F. Simonelli, P. Grieco, F. Merlino, M. Perretti, M. D’Amico, C. Di Filippo

“…Similar changes were quantified with respect to Ki-67 staining. Finally, application of MC3-MC4 agonist/antagonists resulted to be inactive with respect to all parameters under assessment.…”
Get full text

Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

“…By using ML-7, a selective inhibitor of myosin light-chain kinase (MLCK), the beneficial effect of L. reuteri LR1 on contents of ZO-1 and occludin was shown to be dependent on the MLCK pathway. …”
Get full text

Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer by Martina Duca, Nadia Malagolini, Michela Pucci, Virginie Cogez, Anne Harduin-Lepers, Fabio Dall’Olio

“…Deletion experiments of the putative FOXD1 binding sites in the ~ 2800 bp sequence upstream of the B4GALNT2 transcriptional start site cloned in frame with the luciferase reporter gene, confirmed the regulatory role of FOXD1. Finally, FOXD1 knock down in the non-B4GALNT2 expresser cell line SW948 stimulated B4GALNT2. …”
Get full text

High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. Finally, significant correlations were found between obesity-related phenotypes and gut microbiota through correlation analysis.ConclusionOur findings suggest that the potential mechanism by which high-dose thiamine supplementation alleviated HFFD-induced obesity might involve reshaping gut microbiota and restoring the intestinal barrier, thereby ameliorating gut microbiota-related endotoxemia.…”
Get full text

Gastrointestinal Bleeding due to Pancreatic Disease-Related Portal Hypertension by Kexin Zheng, Xiaozhong Guo, Ji Feng, Zhaohui Bai, Xiaodong Shao, Fangfang Yi, Yongguo Zhang, Rui Zhang, Han Liu, Fernando Gomes Romeiro, Xingshun Qi

“…One elderly patient with metastatic pancreatic cancer underwent endoscopic variceal treatment as a rescue therapy but finally died of refractory gastrointestinal (GI) bleeding; another younger patient with chronic pancreatitis died of massive GI bleeding; and the remaining three patients survived at their last follow-up. …”
Get full text

Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori by Tieshan Feng, Ping Lin, Jiao Gong, Dong Cheng, Xi Yang, Quan Zhang, Tingcai Cheng

“…The upregulated genes in the midgut were mainly involved in peptidoglycan catabolic process and tyrosine kinase signaling pathway, whereas the downregulated genes were mainly involved in chitin metabolic pathways. …”
Get full text