3D/4D printed bio-composites reinforced by bamboo charcoal and continuous flax fibres for superior mechanical strength, flame retardancy and recoverability by Mahdi Bodaghi, Kaveh Rahmani, Mohammadreza Lalegani Dezaki, Callum Branfoot, Jon Baxendale

“…Shape memory tests under cold/hot programming protocols demonstrated efficient shape fixation with shape recovery ratios reaching up to 98.9 % for pure PLA and 89 % for PLA/BC/CFF for hot programming. Finally, a conceptual meta-bio-composite was 4D printed, showcasing key achievements such as quasi-zero stiffness, constant force behaviour, enhanced energy absorption/dissipation, and excellent recoverability and reusability. …”
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Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…The induction of CAFs can be abolished using a neutralizing antibody to TGFβ1 as well as by pretreatment of the hASCs with SB431542, a TGFβ1 receptor kinase inhibitor. Additionally, we found that these hASC-derived CAF-like cells exhibit functional properties of CAFs, including the ability to promote tumor cell invasion in an in vitro invasion assay, as well as increased expression of stromal-cell-derived factor 1 (SDF-1) and CCL5. …”
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VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment by Cheng Cheng, Qingrui Zha, Linmao Sun, Tianming Cui, Xinyu Guo, Changjian Xing, Zhengxiang Chen, Changyong Ji, Shuhang Liang, Shengwei Tao, Junhui Chu, Chenghui Wu, Qi Chu, Xuetian Gu, Ning Zhang, Yumin Fu, Shumin Deng, Yitong Zhu, Jiabei Wang, Yao Liu, Lianxin Liu

“…The accumulated G3P diffuses into the TME and directly interacts with SRC-family tyrosine kinase LCK, a critical component of the T-cell receptor (TCR) signaling pathway in CD8+T cells. …”
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Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and... by Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky, Amera O. Ibrahim

“…KEGG analysis indicated that the drug combination might work through pathways like PI3K-Akt signaling, microRNAs in cancer, and EGFR tyrosine kinase inhibitor resistance. Conclusions Combining cisplatin with R. dentatus L. may be a promising approach for treating tongue carcinoma by affecting multiple pathways, providing a new perspective for developing more effective treatments for OSCC.…”
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Exploring Multi-Pathology Brain Segmentation: From Volume-Based to Component-Based Deep Learning Analysis by Ioannis Stathopoulos, Roman Stoklasa, Maria Anthi Kouri, Georgios Velonakis, Efstratios Karavasilis, Efstathios Efstathopoulos, Luigi Serio

“…In the first case, a dice score coefficient (DSC), sensitivity, and precision of 0.76, 0.78, and 0.82, respectively, were found, while in the second case the model detected and segmented correct (True positives) the 48.8% (DSC ≥ 0.5) of abnormal components, partially correct the 27.1% (0.05 > DSC > 0.5), and missed (False Negatives) the 24.1%, while it produced 25.1% False Positives. Finally, we present an extended analysis between the True positives, False Negatives, and False positives versus their position inside the brain, their intensity at three MRI modalities (FLAIR, T2, and T1ce) and their volume.…”
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Evaluating Executive Functions in Patients with Juvenile Myoclonic Epilepsy Using Frontal Assessment Battery by Hossein Sanjari Moghaddam, Masoud Doost Hoseini, Mohammad Reza Khaleghi, Abbas Tafakhori, Mahsa Dolatshahi, Shayan Pourmirbabaei, Elmira Agah, Shakila Meshkat, Vajiheh Aghamollaii

“…We found significant associations between disease duration and conceptualization, mental flexibility, inhibitory control, and total FAB score only in JME patients with recent seizure. Finally, receiver operating characteristic (ROC) analysis showed area under the curve (AUC) of 0.971 (95% confidence interval (CI): 0.947–0.994) for FAB total score, 0.933 for conceptualization (95% CI: 0.973-894), and 0.836 for mental flexibility (95% CI: 0.921-751). …”
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Analysis of GAA Junction Less NS FET Towards Analog and RF Applications at 30 nm Regime by Asisa Kumar Panigrahy, Sudheer Hanumanthakari, Shridhar B. Devamane, Shruti Bhargava Choubey, M. Prasad, D. Somasundaram, N. Kumareshan, N. Arun Vignesh, Gnanasaravanan Subramaniam, Durga Prakash M, Raghunandan Swain

“…A detailed investigation has also been done into the P-type device response for the same device. Finally, the proposed GAA nanosheet device is used in the inverter model. …”
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Fuzzy Random Characterization of Pore Structure in Frozen Sandstone: Applying Improved Niche Genetic Algorithm by Yao Ya-feng, Lin Jian, Ge Jian, Peng Shi-long, Yin Jian-chao, Ouyang Li-na

“…In addition, the improved niche genetic algorithm effectively overcomes the shortcomings of the traditional genetic algorithm, such as low effectiveness, slow convergence, and weak controllability, which provides an effective way for parameter inversion in the section of frozen geotechnical engineering. Finally, based on the T2 spectrum test of frozen sandstone, the fuzzy random characterization of frozen sandstone pore distribution is carried out by using this transformation method. …”
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Multiscale Adaptively Spatial Feature Fusion Network for Spacecraft Component Recognition by Wuxia Zhang, Xiaoxiao Shao, Chao Mei, Xiaoying Pan, Xiaoqiang Lu

“…Second, the multi-scale adaptively spatial feature fusion module within the Multi-ASFFD cascades four adaptively spatial feature fusion blocks to fuse low-level, middle-level, and high-level features at various scales to enrich the semantic information for different spacecraft components. Finally, a compound loss function comprising the cross-entropy and boundary losses is presented to guide the MASFFN better focus on the unclear component edge. …”
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Stability of GaN HEMT Device Under Static and Dynamic Gate Stress by Linfei Gao, Ze Zhong, Qiyan Zhang, Xiaohua Li, Xinbo Xiong, Shaojun Chen, Longkou Chen, Huaibao Yan, Anle Zhang, Jiajun Han, Wenrong Zhuang, Feng Qiu, Hsien-Chin Chiu, Shuangwu Huang, Xinke Liu

“…The positive gate shift <inline-formula> <tex-math notation="LaTeX">$(\Delta V_{\mathrm{ TH}})$ </tex-math></inline-formula> of 0.4 V is observed with increasing voltage from 3 V to 8 V; <inline-formula> <tex-math notation="LaTeX">$\Delta V_{\mathrm{ TH}}$ </tex-math></inline-formula> initially drops smoothly after release stresses by external capacitance discharge. Finally, integrated passive components and <inline-formula> <tex-math notation="LaTeX">${p}$ </tex-math></inline-formula>-GaN gate HEMT circuit are recommended to mitigate the <inline-formula> <tex-math notation="LaTeX">$V_{\mathrm{ TH}}$ </tex-math></inline-formula> instability for E-mode HEMT.…”
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Time Course of Muscle Damage and Inflammatory Responses to Resistance Training with Eccentric Overload in Trained Individuals by Bernardo Neme Ide, Lázaro Alessandro Soares Nunes, René Brenzikofer, Denise Vaz Macedo

“…Four subjects presented significant changes for creatine kinase at P2, and another two at P13; six for C-reactive protein at P2, and three at P11; two for neutrophils at P2, P4, and P13, respectively; and only one for white blood cells at P2, P4, P7, and P9, for lymphocyte at P7, P9, and P13, and for platelet at P4. …”
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EGFR-TKIs or EGFR-TKIs combination treatments for untreated advanced EGFR-mutated NSCLC: a network meta-analysis by Ao Liu, Xiaoming Wang, Lian Wang, Han Zhuang, Liubo Xiong, Xiao Gan, Qian Wang, Guanyu Tao

“…Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and EGFR-TKI combination treatments have become the standard first-line treatments for EGFR-mutated non-small cell lung cancer (NSCLC) patients. …”
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Chemical structure–property relationships of photocurable monomers/macromers: Potential binder candidates for ceramic/metal vat photopolymerization by Setareh Zakeri, Antonia Ressler, Piie Konnunaho, Teemu Sandblom, Joshua Cunningham, Milla Rinne, Matti Järveläinen, Anastasia Elias, Erkka J. Frankberg, Erkki Levänen

“…Furthermore, it was observed that methacrylate-containing resins shrank more compared to their acrylate-containing counterparts. Finally, five potential candidates were proposed for ceramic/metal VPP.…”
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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…The intracellular iron overload with downregulation of ferritin was strongly related to macrophage polarization that was exaggerated at 72 h. Finally, early introduced therapy to target free iron during sepsis is a proposed novel solution for protecting the renal tissue from acute injury due to macrophage activation that may end up with chronic kidney injury, if not mortality.…”
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Succinate Supplement Elicited “Pseudohypoxia” Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells by Huimin Mao, Andi Yang, Yunhe Zhao, Lang Lei, Houxuan Li

“…The succinate supplement enhanced hPDLC proliferation, migration, and osteogenesis with decreased succinate dehydrogenase (SDH) expression and activity, as well as increased hexokinase 2 (HK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), suggesting metabolic reprogramming from oxidative phosphorylation to glycolysis in a normal oxygen condition. …”
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How to transform cultivated land protection on the Northeast Tibetan Plateau？ A multifunctional path exploration by Rongrong Ma, Yuhan Huang, Wei Zhou, Jun Ren, Hongyu Wang, Zeyu Shi, Juan Wang

“…The K-means clustering algorithm is utilized to identify the alignment between the supply and demand of multiple CL functions and determine dominant and deficient CL functions. Finally, a comprehensive zoning approach is employed to enhance the dominant functions of CL, and transformation zones and the corresponding directions of these functions are identified, along with proposed countermeasures. …”
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Solid‐Solution Limits and Thorough Characterization of Bulk β‐(AlxGa1‐x)2O Single Crystals Grown by the Czochralski Method by Zbigniew Galazka, Andreas Fiedler, Andreas Popp, Palvan Seyidov, Saud Bin Anooz, Roberts Blukis, Jana Rehm, Kornelius Tetzner, Mike Pietsch, Andrea Dittmar, Steffen Ganschow, Arub Akhtar, Thilo Remmele, Martin Albrecht, Tobias Schulz, Ta‐Shun Chou, Albert Kwasniewski, Manuela Suendermann, Thomas Schroeder, Matthias Bickermann

“…Further, Ir incorporation into the crystals decreases with [Al], wherein Ir4+ Raman peak disappears already at [Al] ≥ 15 mol%. Finally, thermal conductivity measurements on β‐(AlxGa1‐x)2O3 crystals show a drastic decrease of its values with [Al], to about 1/3 of the β‐Ga2O3 value at [Al] = 30 mol%.…”
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Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management by Bhargav Shreevatsa, Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur

“…The AXL gene, which codes for a receptor tyrosine kinase, has emerged as a promising therapeutic target due to its involvement in neuroinflammation and oligodendrocyte dysfunction. …”
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Aqueous foams in microgravity, measuring bubble sizes by Pasquet, Marina, Galvani, Nicolo, Pitois, Olivier, Cohen-Addad, Sylvie, Höhler, Reinhard, Chieco, Anthony T., Dillavou, Sam, Hanlan, Jesse M., Durian, Douglas J., Rio, Emmanuelle, Salonen, Anniina, Langevin, Dominique

“…The temporal evolution of the average bubble radii deduced from DTS and of the same average radii of the bubbles measured at the sample surface is the same (to a factor probably close to one) throughout the coarsening. Finally, ground experiments were performed to compare bubble size distributions in a bulk wet foam and at its surface at times so short that diffusive gas exchange is insignificant. …”
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Comparison of plasma start-up with high Z and low Z first wall in WEST by C. Guillemaut, K. Afonin, G. Bodner, J. Bucalossi, Y. Corre, P. Devynck, A. Diallo, M. Diez, N. Fedorczak, A. Gallo, B. Guillermin, V. Lapleigne, R. Lunsford, P. Maget, J. Morales, Ph. Moreau, the WEST Team, the EUROfusion Tokamak Exploitation Team

“…Since W seems to be the main cause for core radiation, correlation between outer limiter W sources and other impurity sources are investigated. Finally, analysis of the legacy of B powder drops on a number of start-up plasmas suggests that it is less effective at reducing radiated power when the first wall is covered with W.…”
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