The Effects of Six Weeks of Endurance Training and CGRP Inhibition on Nrf2 and AKT Expression in the Hippocampal Tissue of Male Wistar Rats by Maryam Zare, Shila Nayebifar, Soheil Aminizadeh, Majid Vahidian-Rezazadeh

“…To study the effects of a six-week endurance training protocol and calcitonin gene-related peptide (CGRP) inhibition on the nuclear factor erythroid 2-related factor 2 (Nrf2) and protein kinase B (PKB) or AKT expression in the hippocampal tissue of male Wistar rats. …”
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Design and Verification of a Deep Rock Corer with Retaining the In Situ Temperature by Zhiqiang He, Heping Xie, Mingzhong Gao, Ling Chen, Bo Yu, Yunqi Hu, Jianping Yang

“…Moreover, a heat transfer model that considered multiple heat dissipation surfaces was established, which can provide theoretical guidance for engineering applications. Finally, a verification test of the integrated active and passive thermal insulation system (graphene heating material and C1) was carried out. …”
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Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review by Vanessa Bertolucci, André Felipe Ninomiya, Giovanna Barbarini Longato, Luisa Oliveira Kaneko, Nilson Nonose, Pedro Paulo Menezes Scariot, Leonardo Henrique Dalcheco Messias

“…In summary, these compounds modulate signaling pathways, including nuclear factor kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial growth factor, and reactive oxygen species. …”
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Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing by Xinyi Feng, Yu Zhang, Jun Feng, Zhongjun Li, Zhi Zhang, Lin Zhu, Ruoyu Zhou, Haibo Wang, Xiaojun Dai, Yanqing Liu

“…Then, 16S rDNA sequencing was performed on fecal samples to study the differential intestinal microbiota in gastric cancer patients. Finally, conduct a correlation analysis between them. …”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…Quantitative PCR analysis further validated 9 important genes, and the results were well consistent with our transcriptomic data. Finally, 5 important transcription factors including WRI1, ABI3, FUS3, PKL and VAL1 were identified, and their main regulatory genes might contain ACCase, KASⅡ, LACS, FAD3 and LPAAT which were determined through correlation analysis of expression levels for 27 walnut samples. …”
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From Nasion to Sellion: repositioning landmarks for radioprotection-tailored 3D cephalometric analysis by Marco Serafin, Benedetta Baldini, Elisa Boccalari, Salvatore Bocchieri, Sergio Sambataro, Chiarella Sforza, Giuseppe Baselli, Gianluca Martino Tartaglia, Alberto Caprioglio

“…Pearson test revealed highly significant correlations for all the tested variables; the highest coefficient was found between N^Me^Go vs Se^Me^Go (r = 0.989, p < 0.001) while the lowest among SNA vs SSeA (ρ = 0.814, p < 0.001). Finally, linear regression provided the new norm range values for the Sellion-based measurements.Conclusion Pearson’s coefficients between Sellion- and Nasion-related measurements exhibited significantly high levels of correlation, suggesting the potential use of Sellion-based measurements for innovative cephalometric analyses. …”
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Multi-channel spatio-temporal graph attention contrastive network for brain disease diagnosis by Chaojun Li, Kai Ma, Shengrong Li, Xiangshui Meng, Ran Wang, Daoqiang Zhang, Qi Zhu

“…Moreover, temporal dependencies across windows are captured by integrating feature embeddings through a self-attention mechanism, and the inter-window recurrent contrastive constraint is devised to extract higher-order spatio-temporal topological features. Finally, a multi-layer perceptron (MLP) is used to classify the brain networks. …”
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Dimensional control of interface coupling-induced ferromagnetism in CaRuO3/SrCuO2 superlattices by Li Zhe, Shi Wenxiao, Zhang Jine, Zheng Jie, Wang Mengqin, Zhu ZhaoZhao, Han Furong, Zhang Hui, Xie Liming, Yunzhong Chen, Fengxia Hu, Baogen Shen, Yuansha Chen, Jirong Sun

“…Along with the thickness-driven structural transition of the SrCuO2 layers, the interfacial FM order gradually deteriorates and finally disappears. As shown by the X-ray absorption results, the charge transfer at the CaRuO3/chain-SrCuO2 and CaRuO3/plane-SrCuO2 interfaces are different, resulting in dimensional control of the interfacial magnetic state. …”
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Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers by Taylor N. Takla, Jennie Feldpausch, Erin M. Edwards, Shuo Han, Peter A. Calabresi, Jerry Prince, Kathleen M. Zackowski, Nora E. Fritz

“…Volumetric differences seen between the PwMS and controls were primarily driven by the MS fallers. Finally, functional performance on motor and cognitive tasks was associated with cerebellar volumes. …”
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A Transcriptomic Analysis Reveals Diverse Regulatory Networks That Respond to Cold Stress in Strawberry (Fragaria×ananassa) by Yong Zhang, Yunting Zhang, Yuanxiu Lin, Ya Luo, Xiaorong Wang, Qing Chen, Bo Sun, Yan Wang, Mengyao Li, Haoru Tang

“…Functional enrichment analysis showed that DEGs were significantly (adjusted P value < 0.05) overrepresented in six pathways including plant hormone signal transduction, flavonoid biosynthesis, mitogen-activated protein kinase (MAPK) signaling, starch and sucrose metabolism, circadian rhythm, and alpha-linolenic acid metabolism. …”
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Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Gene... by Elena V. Tchetina, Karina A. Maslova, Mikhail Y. Krylov, Valery A. Myakotkin

“…OP registered by low BMD indices in late postmenopausal patients was associated with a significant upregulation of autophagy protein ULK1, cyclin-dependent kinase inhibitor p21, and metalloproteinase MMP-9 gene expression in the blood compared to the healthy controls and in a significant downregulation of mTOR (mammalian target of rapamycin), RUNX2, and ALPL gene expression, while expression of cathepsin K, caspase-3, transforming growth factor (TGF)β1, interleukin- (IL-) 1β, and tumor necrosis factor α (TNFα) was not significantly affected. …”
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Composite Study of Relationships Between the Characteristics of Atlantic Cold Tongue: Onset, Duration, and Maximum Extent by Dianikoura Ibrahim Koné, Adama Diawara, Benjamin Komenan Kouassi, Fidele Yoroba, Kouakou Kouadio, Assi Louis Martial Yapo, Touré Dro Tiemoko, Mamadou Diarrassouba, Foungnigué Silué, Arona Diedhioune

“…In addition, 63% of years with a short duration of ACT have a cold tongue with a low maximum extent, while 83% of years with a long duration of ACT have a cold tongue with a greater maximum extent. Finally, 78% of early ACT onset years are associated with the coldest SST tongue in the eastern equatorial Atlantic Ocean. …”
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Nuclear Intron Sequence Variation of the <i>Bulinus globosus</i> Complex (Mollusca: Planorbidae): Implications for Molecular Systematic Analyses by Chairat Tantrawatpan, Kotchaphon Vaisusuk, Chrysantus M. Tanga, Warayutt Pilap, Naruemon Bunchom, Ross H. Andrews, Tongjit Thanchomnang, Wanchai Maleewong, Weerachai Saijuntha

“…Genetic variation, heterozygosity, and DNA recombination in <i>B. globosus</i> were examined using the mitochondrial cytochrome c oxidase subunit 1 (<i>COI</i>) and the intron 3 region of the arginine kinase gene (AkInt3). A total of 81 <i>B. globosus</i> snails were collected from three different localities in Kwale County, Kenya. …”
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Geological Conditions and Sedimentary Models of Oligocene and Eocene Effective Source Rocks in the Northern Yinggehai Basin by Jianxiang Pei, Gaowei Hu, Zhipeng Huo, Zhihong Chen, Yabing Chen, Xiaofei Fu, Weihong Wang, Haiyu Liu, Yanan Wang, Jingshuang Luo, Guofei Chen

“…Based on the analogy with the Hanoi Depression in Vietnam and the Yacheng District in the Qiongdongnan Basin and the comprehensive analysis of self-geological conditions, the development conditions of Eocene and Oligocene source rocks in the northern Yinggehai Basin are examined, focusing on tectonic evolution, sedimentary facies, and the paleoenvironment. Finally, the sedimentary models for the effective source rocks are established. …”
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An optimized lightweight real-time detection network model for IoT embedded devices by Rongjun Chen, Peixian Wang, Binfan Lin, Leijun Wang, Xianxian Zeng, Xianglei Hu, Jun Yuan, Jiawen Li, Jinchang Ren, Huimin Zhao

“…In addition, it provides a detection frame rate of up to 33 Frames Per Second (FPS), satisfying the real-time requirement. Finally, an intelligent production line system based on FRYOLO is implemented, which not only provides robust technical support for the efficient operation of fruit production processes but also demonstrates the availability of the proposed network model in practical IoT applications.…”
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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Ci... by Alexander A. Pugovkin, Aleksandr G. Markov, Sergey V. Selishchev, Leonie Korn, Marian Walter, Steffen Leonhardt, Leo A. Bockeria, Olga L. Bockeria, Dmitry V. Telyshev

“…Furthermore, this study expands the information on LV-LVAD interaction, which leads to the optimization of the RBP speed rate control in clinics for adult and pediatric patients suffering from heart failure. Finally, we show that the implementation of control algorithms using the modulation of the RBP speed in order to open the aortic valve and unload the LV more efficiently is necessary and will be content of further research.…”
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Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia by Neetu Pandey, Geeta Yadav, Rashmi Kushwaha, Shailendra Prasad Verma, Uma Shankar Singh, Ashutosh Kumar, Prabhaker Mishra

“…Imatinib inhibits BCR-ABL tyrosine kinase produced due to reciprocal translocation t(9;22) in neoplastic CML cells. …”
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Returns to scale in decision-making units with integer-valued or mixed inputs and integer-valued or real outputs using radial models in data envelopment analysis by Zeinab Tavassoli, Mohsen Rostami-MalKhalifeh, Farhad Hosseinzadeh Lotfi, Tofigh allahVieanloo

“…Purpose: The current paper tries to determine the type of returns to scale in a decision-making unit under the condition that integer-valued inputs or outputs are present.Methodology: This paper introduces radial models for determining the value and type of Returns to Scale (RTS) in 4 scenarios, including single integer-valued input – single real output (scenario one), mixed inputs – exclusively real outputs (scenario two), exclusively integer-valued inputs – exclusively real outputs (scenario three), and exclusively integer-valued inputs – exclusively integer-valued outputs (scenario four); in each scenario, the values of the left RTS and right RTS are determined, and the RTS type is then determined on that basis. Finally, by presenting three examples based on two scenarios, namely single integer-valued input – single real output and single integer-valued input – single integer-valued output, the new method is compared with previous methods using GAMS software, and the conclusions are provided.Findings: The type of returns to scale differs when integer-valued inputs or outputs are present as compared with the case where the inputs and outputs are assumed to have real values.Originality/Value: This study focuses on the value and type of returns to scale for integer-valued data. …”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

“…Significant enrichment in DNA repair pathways in feline FSA correlate with aggressive clinical behavior in human soft-tissue sarcoma. Finally, we leverage the molecular profiles to identify vulnerabilities, including sensitivity to ATR and PARP inhibition as potential treatment for feline FSA. …”
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