Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell by Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan

“…Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. …”
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Naturally russeted and wound russeted skins of mango (cv. ‘Apple’) show no differences in anatomy, chemical composition or gene expression by Jannis Straube, Thomas O. Athoo, Viktoria Zeisler-Diehl, Kiran Suresh, Lukas Schreiber, Moritz Knoche

“…Compared with cuticles, periderms showed decreased expressions of cuticle-related genes (MiSHN1, MiGPAT6, MiCUS1, MiCER1, MiWCB11) and increased expressions of periderm-related genes (MiMYB93, MiNAC058, MiCYP86A1, MiCYP86B1, MiGPAT5, MiABCG20). …”
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Exploration of Digital Twin Design Mechanism of the Deep in Situ Rock Insulation Coring Device by Bo Yu, Heping Xie, Ling Chen, Wu Zhao, Zhiqiang He

“…This digital twin to help users participate in product design and understand the product design process. Finally, the TOPSIS evaluation model was used to calculate the user’s score on the design scheme, which increased by 27.64%, which improves the overall efficiency of product design. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Furthermore, synergistic effects between amphiregulin and FGF19 within HepLPC-secretomes were identified, contributing to HSC apoptosis and exerting antifibrotic effects via activation of the janus kinase-STAT1 pathway. Conclusions:. HepLPCs have the potential to ameliorate liver cirrhosis by inducing STAT1-dependent apoptosis in HSCs. …”
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Solar energy driven photocatalytic membrane modules for water reuse in agricultural and food industries. Pre-industrial experience using s-triazines as model molecules by Ignazio Renato Bellobono, Franca Morazzoni, Riccardo Bianchi, Emilia Simona Mangone, Rodica Stanescu, Cristina Costache, Paola Maria Tozzi

“…Quantum yields, as indicative of catalytic and photocatalytic mechanisms, were evaluated satisfactorily: they are discussed, and compared with those of previous studies on the same substrates, carried out in the same module, but in conditions of practically monochromatic irradiation (254 nm) within the range of optical absorption of semiconductor. Finally, in order to compare effectiveness of composite photocatalytic membranes, described above, prepared by photografting, either in the presence or in the absence of an added photopromoter, as well as that of metallic membranes, onto which the semiconductor without any photopromoter was present as a 3–4 μm thick surface layer, directly produced on the nanotechnologically treated surface, with those of other commercial materials, parallel experiments were carried out, by using commercial sheets in which the semiconductor was immobilised, by a method based substantially on glueing by colloidal silica. …”
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Study of height-spread sporadic-E layers observed in the South American Magnetic Anomaly by Juliano Moro, Juliano Moro, Jiyao Xu, José Valentin Bageston, Lígia Alves da Silva, Lígia Alves da Silva, Laysa Cristina Araújo Resende, Laysa Cristina Araújo Resende, Clezio Marcos De Nardin, Vânia Fátima Andrioli, Vânia Fátima Andrioli, Angela Machado Santos, Angela Machado Santos, Giorgio Arlan da Silva Picanço, Hui Li, Liu Zhengkuan, Chi Wang, Nelson Jorge Schuch

“…Most HSEs layers lasted between 1 h and 3 h 30 min, with a peak incidence during November, December, and January. Finally, the study discusses the most likely mechanisms responsible for HSEs layer formation, considering the geomagnetic conditions and time of their detection on ionograms.…”
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TDCN: A novel temporal depthwise convolutional network for short-term load forecasting by Mingping Liu, Chenxu Xia, Yuxin Xia, Suhui Deng, Yuhao Wang

“…However, with the growing integration of renewable energy sources like wind power and photovoltaics, load data have become increasingly complex and nonlinear, making accurate forecasting a challenging task in modern power systems. …”
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Rapid estimation method of lithium battery state of health based on novel health feature by DONG Xiaohong, DONG Jinbo, WANG Mingshen, ZENG Fei, PAN Yi

“…Next, by analyzing the oxford battery aging dataset and the random usage dataset of lithium ion batteries used by NASA, the method traverses the constant current charging voltage range in steps of 0.01 V and determines the optimal starting voltage of the lithium battery by maximizing the Pearson correlation coefficient. Finally, considering different time intervals, the method uses the ordinary least squares (OLS) regression analysis method to determine the optimal time interval parameter of the lithium battery. …”
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Evaluation and Optimization Research on the Spatial Distribution of Automated External Defibrillators Based on a Genetic Algorithm: A Case Study of Central Urban District of Nanjin... by Ge Shi, Jiahang Liu, Chuang Chen, Jingran Zhang, Jinghai Xu, Yu Chen, Jiaming Na, Wei Chen

“…Subsequently, a coverage model is constructed to simulate the coverage capacity of potential emergency needs for new facilities, and a genetic algorithm is utilized to solve it. Finally, an AED site selection experiment is conducted, and the site selection results are discussed and analyzed in conjunction with practical conditions. …”
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Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids by Mohamed A. Abdellah, Sotiris K. Hadjikakou, Nick Hadjiliadis, Maciej Kubicki, Thomas Bakas, Nikolaos Kourkoumelis, Yannis V. Simos, Spyros Karkabounas, Mirela M. Barsan, Ian S. Butler

“…The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value. …”
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Cross-Cultural Adaptation and Validation of “Malocclusion Impact Questionnaire” into Moroccan Arabic by Farid Bourzgui, Samir Diouny, Hadam Mkhantar, Zineb Serhier, Mohamed Bennani Othmani

“…The objective of this study was to translate and culturally adapt the malocclusion impact questionnaire (MIQ) into Moroccan Arabic and to assess its reliability and validity among a sample of young Moroccan teenagers. The PIDAQ was cross-culturally adapted into Malay version by forward- and backward-translation processes, followed by psychometric validation. …”
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Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents by Bianca de Luca, Pedro Xavier-Elsas, Mônica Barradas, Ricardo A. Luz, Túlio Queto, Carla Jones, Maria Augusta Arruda, Thiago Mattar Cunha, Fernando Queiroz Cunha, Maria Ignez Gaspar-Elsas

“…This effect was (a) paralleled by induction of iNOS in eosinophils; (b) duplicated by sodium nitroprusside, isoproterenol, and cAMP-inducing/mimetic agents; (c) prevented by protein kinase A inhibition. NO was produced through iNOS by dibutyryl-cAMP-stimulated bone-marrow. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Then, data augmentation was performed within each category using simplified molecular input line entry system (SMILES) enumeration combined with structural similarity expansion. Finally, by training the optimal quantitative structure–retention relationship (QSRR) models for each category of compounds and selecting the best-fitting model for prediction via discriminant analysis during the prediction period, a novel and universal high-throughput retention time prediction model was established. …”
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Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…The insertion of exogenous genes has increasingly been used to develop new oncolytic HSV-1 variants. Finally, we discuss limitations associated with oncolytic virotherapy at the conclusion of this review. …”
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Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A D₂O Exchange and Freeze-Drying Study by Tan Guo, Dina Moazamian, Arya A. Suprana, Saeed Jerban, Eric Y. Chang, Yajun Ma, Michael Carl, Min Chen, Jiang Du

“…Later, the samples were lyophilized for over 40 h and then sealed in tubes. Finally, the samples were brought to room temperature and visualized using the identical 3D ZTE and UTE sequences. …”
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ASD-YOLO: a lightweight network for coffee fruit ripening detection in complex scenarios by Baofeng Ye, Baofeng Ye, Renzheng Xue, Renzheng Xue, Haiqiang Xu, Haiqiang Xu

“…In addition, we introduce SPD-Conv into backbone and head to enhance the detection of occluded small objects and low-resolution images. Finally, we replaced upsampling in our model with DySample, which requires less computational resources and is able to achieve image resolution improvements without additional burden. …”
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The Calicophoron daubneyi genome provides new insight into mechanisms of feeding, eggshell synthesis and parasite-microbe interactions by Shauna M. Clancy, Mark Whitehead, Nicola A. M. Oliver, Kathryn M. Huson, Jake Kyle, Daniel Demartini, Allister Irvine, Fernanda Godoy Santos, Paul-Emile Kajugu, Robert E. B. Hanna, Sharon A. Huws, Russell M. Morphew, J. Herbert Waite, Sam Haldenby, Mark W. Robinson

“…We reveal that C. daubneyi eggshell proteins lack L-DOPA typically required for eggshell crosslinking in trematodes and propose that C. daubneyi employs atypical eggshell crosslinking chemistry that produces eggs with greater stability. Finally, although extracellular digestion of rumen ciliates occurs within the C. daubneyi gut, unique ultrastructural and biochemical adaptations of the gastrodermal cells suggest that adult flukes also acquire nutrients via uptake of volatile fatty acids from rumen fluid. …”
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ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…We investigated a novel pathway, namely extracellular signal regulated kinase 5 (ERK5) mediated signaling, in modulating glucose-induced vascular endothelial growth factor (VEGF) expression. …”
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The spectrum-efficacy correlation of Kai-Xin-San for cognition of Aβ42 transgenic Drosophila and verification of its active ingredients by Jinfu Wu, Hang Sun, Yiyang Zhao, Lian Lian, Hongsheng Bian, Yong Guo, Dan Li, Lili Huang

“…Subsequently, the effects of the 15 batches of KXS were assessed in an olfactory escape memory experiment, utilizing Aβ42 transgenic drosophila as a model. Finally, the spectrum-effect relationship between the KXS fingerprint and memory improvement was analyzed, with the active ingredients subjected to validation testing.ResultsThe results identified seventeen common peaks in the fingerprint, and eight active components were determined: polygalaxanthone III, 3-6-disinapoylsucrose, ginsenoside Rg1, ginsenoside Rb1, β-asarone, α-asarone, dehydrotumulosic acid, and dehydropachymic acid. …”
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Impact of Synthetic Porous Medium Geometric Properties on Solute Transport Using Direct 3D Pore-Scale Simulations by Paolo Roberto Di Palma, Nicolas Guyennon, Andrea Parmigiani, Christian Huber, Falk Heβe, Emanuele Romano

“…Our findings suggest that the advective transport is primarily affected by the specific surface area and the mean curvature of the porous medium, while the effective diffusion coefficient scales as the inverse of the tortuosity squared. Finally, the possibility of estimating the hydrodynamic dispersion coefficient knowing only the geometric properties of porous media and the applied pressure gradient has been tested, within the range of tested porous media, against advection-diffusion simulations at low Reynolds (<10-1) and Peclet numbers ranging from 101 to 10-2.…”
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