Comparison of different developmental stages of jujube (Ziziphus jujuba) fruit and identification of Hub genes by Li Yalan, Ren Tian, Qu Siyu, Hao Qing, Fan Dingyu, Alimire Alimu

“…The relationships among DEGs within each group were assessed and hub genes were identified using the degree algorithm of Cytohubba. Finally, the expression levels of these hub genes were compared across the four stages. …”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…The c-Jun N-terminal kinase (JNK) pathway plays a crucial role in response to dietary stressors, and it was demonstrated that the inhibition of the JNK pathway could potentially be used in the treatment of MAFLD. …”
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Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers by Ruohua Li, Cuixia Zhou, Kejun Ye, Haihui Chen, Mengjia Peng

“…Key differentially expressed genes included CRH(Corticotropin-Releasing Hormone), LEP(Leptin), PDK4(Pyruvate Dehydrogenase Kinase Isozyme 4), SPP1(Secreted Phosphoprotein 1), and SST(Somatostatin). …”
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Gut microbiota and quantitative traits divergence at different altitude of long-tailed dwarf hamsters, Cricetulus longicaudatus by Yue Ren, Mengfan Tao, Xiaoliang Wang, Xinsheng Pu, Guangtong Guo, Kuiyou Chen, Bingyu Zhao, Yu Hou, Xin'gen Yang, Yumei Xu

“…And Providencia had significant correlation with body size. Finally, functional analysis of the gut microbiota showed changes in metabolic function that depended on elevation, and collinear network analysis showed how the gut microbiota interacts with each other. …”
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Cellular and genetic analysis of wound healing in Drosophila larvae. by Michael J Galko, Mark A Krasnow

“…During this time, the Jun N-terminal kinase (JNK) pathway is activated in a gradient emanating out from the wound, and the epidermal cells spread along or through the wound plug to reestablish a continuous epithelium and its basal lamina and apical cuticle lining. …”
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PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway by Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang

“…In addition, the associations of PDE4 and Epac1 with A-kinase anchor protein 95, connexin 43, cyclin D1, and cyclin E1 were evaluated. …”
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Fiber length distribution characterizes the brain network maturation during early school-age by Yanlin Yu, Qing Cai, Longnian Lin, Chu-Chung Huang

“…Meta-analytic decoding revealed that the widespread decrease in length median occurred in regions responsible for sensory processing, whereas a more localized increase in length median was observed in regions involved in memory and cognitive control. Finally, simulation tests on healthy adults further supported that the decrease in long-range connections and increase in short-range connections contributed to enhanced network segregation and integration, respectively. …”
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Global metabolome changes induced by environmentally relevant conditions in a marine-sourced Penicillium restrictum by Le, Van-Tuyen, Bertrand, Samuel, Brandolini-Bunlon, Marion, Gentil, Emmanuel, Robiou du Pont, Thibaut, Rabesaotra, Vony, Wielgosz-Collin, Gaëtane, Mossion, Aurélie, Grovel, Olivier

“…This study also provides insight into the P. restrictum adaptation to marine salinity through fatty acids alteration and shows that lipid metabolism is far more altered in an OSMAC approach than the specialized metabolism. This study finally highlights the need for using environment-mimicking culture conditions to reveal the metabolic potentialities of marine microbes.…”
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Research on refined UAV inspection method of wind/solar power stations based on YOLOv8 by Jieyi Pu, Qifeng Zhang, Wenbo Zhao, Wei Zhang, Zengren Qin, Yumeng Zhang

Subjects: “…Wind/solar power stations…”
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Tunnel Back Analysis Based on Differential Evolution Using Stress and Displacement by Joon-Sang An, Kyung-Nam Kang, Ju-Young Choi, Won-Suh Sung, Vathna Suy, Ki-Il Song

“…However, the conventional displacement-based back analysis is unsuitable for a segment-lined tunnel after construction because of its trivial internal displacement since the average error is greater than 32% and the evolutionary calculation is finalized due to the maximum iteration criteria. The average error obtained from the proposed back analysis algorithm using both stress and displacement ranged within approximately 6–8%. …”
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A hybrid stochastic-interval Mean–CVaR model for the wind-storage system offering strategy under uncertainties by Ziang Wang, Xiuli Wang, Zhicheng Wang, Jing Huang, Xiancheng Ren, Mengfu Tu

Subjects: “…Wind-storage system…”
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Water phase distribution and its dependence on internal structure in soaking maize kernels: a study using low-field nuclear magnetic resonance and X-ray micro-computed tomography by Baiyan Wang, Baiyan Wang, Shenghao Gu, Juan Wang, Guangtao Wang, Xinyu Guo, Chunjiang Zhao, Chunjiang Zhao

“…This indicates that water might penetrate the embryo through the pedicel and vitreous endosperm through the pericarp during soaking.DiscussionFinally, we suggested that the proportion of semi-bound water could be a robust indicator to predict moisture content in maize kernels. …”
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Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity by Sung-Soo Jang, Sara E. Royston, Gunhee Lee, Shuwei Wang, Hee Jung Chung

“…Here we show that a single episode of electroconvulsive seizures (ECS) increased protein expression of membrane-associated STriatal-Enriched protein tyrosine Phosphatase (STEP61) and decreased tyrosine-phosphorylation of its substrates N-methyl D-aspartate receptor (NMDAR) subunit GluN2B and extracellular signal regulated kinase 1/2 (ERK1/2) in the rat hippocampus at 2 days following a single ECS. …”
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Effect of Selected Nanospheres on the Mechanical Strength of Lime-Stabilized High-Plasticity Clay Soils by Ali Ghorbani, Hadi Hasanzadehshooiili, Mostafa Mohammadi, Fariborz Sianati, Mahdi Salimi, Lukasz Sadowski, Jacek Szymanowski

“…The same trend was achieved in the CBR test, in which the CBR value for the optimal mixtures containing nano-ZnO and nano-SiO2 was 14.8 and 16.6 times higher than that of high-plasticity clay soil, respectively. Finally, the results obtained from scanning electron microscopy (SEM) analysis revealed that the nanospheres caused a dense and compact matrix to form in the soil, which led to the enhancement of the mechanical strength of the treated samples.…”
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Set of 15 SNP-SNP Markers for Detection of Unbalanced Degraded DNA Mixtures and Noninvasive Prenatal Paternity Testing by Ranran Zhang, Yu Tan, Li Wang, Hui Jian, Jing Zhu, Yuanyuan Xiao, Mengyu Tan, Jiaming Xue, Fan Yang, Fan Yang, Weibo Liang

“…In addition, the panel successfully genotyped degraded DNA from single and mixed samples. Finally, 15 SNP-SNPs were applied to 26 trios. All samples displayed positive results with at least one marker to detect cffDNA. …”
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Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins. by Jessica R Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee

“…Compared to that for IBa, VDF of ICa was less sensitive to an inhibitor of Gα proteins (GDP-β-S) and an inhibitor of Gβγ (C-terminal construct of G-protein coupled receptor kinase 2). While insensitive to high intracellular Ca2+ buffering, VDF of ICa that remained in GDP-β-S was blunted by reductions in PIP2. …”
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Insulator–metal transition in VO2 film on sapphire studied by broadband dielectric spectroscopy by Arsenii A. Gavdush, Vladislav A. Zhelnov, Kirill B. Dolganov, Alexander A. Bogutskii, Sergey V. Garnov, Maria G. Burdanova, Dmitry S. Ponomarev, Qiwu Shi, Kirill I. Zaytsev, Gennadii A. Komandin

“…By studying $$\hbox {VO}_2$$ at different substrate temperatures and atmosphere pressures, we show that IMT appears to be pressure-dependent, which we attribute to the different thermostatic conditions of a sample. Finally, we estimate somewhat optimal thickness and temperature of the $$\hbox {VO}_2$$ film in metallic phase for the THz optoelectronic applications. …”
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Towards Reliable Participation in UAV-Enabled Federated Edge Learning on Non-IID Data by Youssra Cheriguene, Wael Jaafar, Halim Yanikomeroglu, Chaker Abdelaziz Kerrache

“…Through experiments, we assess the effectiveness of our scheme in resisting different attack scenarios, in terms of convergence and achieved model accuracy. Finally, we demonstrate the performance superiority of the proposed approach compared to baseline methods.…”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Consistent with this, N82L and N82W mutations abolish ORF3a-mediated water permeation. Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. …”
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Hypoxia Inducible Factor-1α Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin α4 by Jong Ho Choi, Yun Bin Lee, Jieun Jung, Seong Gyu Hwang, IL-Hoan Oh, Gi Jin Kim

“…The expression of integrin α4 was decreased in BM-MSCs by increased HIF-1α under hypoxia, whereas the expression of Rho-associated kinase 1 (ROCK1) and Rac1/2/3 was increased. After downregulation of HIF-1α by YC-1, which is an inhibitor of HIF-1α, BM-MSC migration was decreased via upregulation of integrin α4 and downregulation of ROCK1 and Rac1/2/3. …”
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