Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…In particular, we emphasize that there is complex lipid metabolism connections between TAMs and distinct tumors, which influences TAM to bias from M1 to M2 phenotype in tumor progression, and ultimately promotes tumor occurrence and development. Finally, we discuss the existing issues on therapeutic strategies by reprogramming TAMs based on lipid metabolism regulation (or increasing the ratio of M1/M2-like TAMs) that could be applied in the future to clinical tumor treatment.…”
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Looking at Infrared Background Radiation Anisotropies with Spitzer: Large-scale Anisotropies and Their Implications by A. Kashlinsky, Richard G. Arendt, M. L. N. Ashby, J. Kruk, N. Odegard

“…Out of these, the model where the CIB fluctuation excess originates from the granulation power due to LIGO-observed primordial black holes as dark matter appears most successful in accounting for all observations related to the measured CIB power amplitude and spatial structure, including the measured coherence between the CIB and unresolved cosmic X-ray background (CXB). Finally we point out the use of the data to probe the CIB-CXB cross power to new scales and higher accuracy. …”
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Synergistic Activations of REG Iα and REG Iβ Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells by Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa

“…Promoter assay revealed that a signal transducer and activator of transcription- (STAT-) binding site in each promoter of REG Iα (TGCCGGGAA) and REG Iβ (TGCCAGGAA) was essential for the IL-6+Dx-induced promoter activation. A Janus kinase 2 (JAK2) inhibitor significantly inhibited the IL-6+Dx-induced REG Iα and REG Iβ transcription. …”
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DIAGNÓSTICO, MORTE BIOLÓGICA E/OU SOCIAL COMO HORIZONTE EM PESSOAS QUE VIVEM COM HIV/AIDS // DIAGNOSIS, BIOLOGICAL AND/OR SOCIAL DEATH AS A HORIZON IN PEOPLE LIVING WITH HIV/AIDS by Talita Miranda Pitanga Barbosa Cardoso, Ana Beatriz Ferreira Barros da Silva, Marcia Cristina Graça Marinho, Marcio Costa de Souza

“…Assim, é possível perceber o quanto a sociabilidade, apoio mútuo e amparo estatal permitem a reescrita da vida. Considerações finais: o medo do diagnóstico decorrente do estigma, preconceito e discriminação ainda é presente, e afasta do processo de cuidar. …”
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Assessment and enhancement of transfer capability for large-scale renewable generation base transmitted by voltage source converter based high voltage direct current system by Shiyuan Chen, Shunjiang Lin, Yuerong Yang, Kaiyun Jiang, Mingbo Liu

“…To solve the bi-level optimal power flow model, the Kriging surrogate model is used to obtain the relationship between the transfer capability and the types and sizes of the reactive power compensation devices at the anticipated installation buses, and the inner-layer transfer capability assessment model is replaced with equality constraints, thereby transforming the original bi-level optimal power flow model into a single-layer mixed-integer nonlinear programming model for direct resolution. Finally, the effectiveness of the proposed model and solution method is validated using a real transmission system in South China.…”
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Assessing the Safety Level of Hospitalized Patients: Analyzing Patient Activities by Sayedeh Somayyeh Mousavipour, Mousa Jabbari, Mahnaz Saremi, Abbas Ebadi, Ehsan Shariat Bahadori, Davoud Khorasani Zavareh

“…Experts' opinions were used to rank the risk, and finally the risk level of the identified hazards was determined before and after the control measures. …”
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ROCK Inhibitor-Induced Promotion of Retinal Pigment Epithelial Cell Motility during Wound Healing by Hiroyuki Kamao, Atsushi Miki, Junichi Kiryu

“…The aim of this study is to evaluate the effect of Rho-associated coiled-coil containing kinase (ROCK) inhibitor Y27632 on retinal pigment epithelial (RPE) cell motility during wound healing. …”
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A multi-task model for failure identification and GPS assessment in metro trains by Pratik Vinayak Jadhav, Sairam V. A, Siddharth Sonkavade, Shivali Amit Wagle, Preksha Pareek, Ketan Kotecha, Tanupriya Choudhury

“…The local interpretable model agnostic explanations (LIME) technique was used to provide explanations for the model predictions. Finally, a dashboard was developed for the same application consisting of the best-trained algorithm for decision-making, along with trend visualizations and explanations. …”
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Analysis of Overburden Structure and Pressure-Relief Effect of Hard Roof Blasting and Cutting by Hao Liu, Jin Dai, Jinquan Jiang, Pu Wang, Jiqiang Yang

“…Moreover, the optimal roof-cutting position (5 m) and angle (15°) are obtained with the specific mining conditions. Finally, on-site monitoring of the anchor-cable force and support force in panel 5312 of the Jining no. 3 coal mine is used to verify the pressure-relief effect after roof blasting and cutting. …”
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How do various strategies for returning residues change microbiota modulation: potential implications for soil health by Nan Jiang, Nan Jiang, Zhenhua Chen, Zhenhua Chen, Yi Ren, Shichang Xie, Zimeng Yao, Zimeng Yao, Dongqi Jiang, Yulan Zhang, Yulan Zhang, Lijun Chen, Lijun Chen

“…Moreover, the residue additions resulted in the accumulation of ARGs, while only SC caused an increase in certain pathogens. Finally, through analyzing the correlation network among indices that exhibited active responses to residue additions, potential indicators for functional changes in response to residue additions were identified. …”
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Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…Transcription factor analysis and developmental trajectory analysis reveal the potential role of fibroblasts in GC development. Finally, prognosis analysis and gene mutation analysis using TCGA-STAD data indicate an adverse prognosis associated with the key gene set in GC.ConclusionThis study provides new insights into the association between AF and GC and offers novel clues for understanding its impact on the pathogenesis and therapeutic strategies of GC.…”
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Spatiotemporal dynamics and driving mechanism of eco-environmental quality in piedmont-oasis-desert ecotone based on long-term harmonized remote sensing ecological index- take Korl... by Junling He, Xifeng Ju, Chuqiao Han, Liming Liu, Haidong Zhang, Saitiniyazi Adilai, Chongbo Li

“…Secondly, the spatial patterns were identified by trend analysis, coefficient of variation, and spatiotemporal migration model. Finally, the explanatory power was quantified, and the evolution trend was further discussed. …”
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Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis by LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun

“…HRW exerts anti-inflammatory effects by regulating the nuclear factor erythroid 2-related factor 2 and mitogen-activated protein kinase pathways, which are closely associated with inflammation. …”
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Real-time detection of road surface friction coefficient: A new framework integrating diffusion model and Transformer in Transformer algorithms by Zhangcun Yan, Lishengsa Yue, Wang Luo, Jian Sun

“…Second, we used a diffusion model to enhance the dataset, increasing sample diversity. Finally, we trained a TNT model on the extended dataset to recognize friction coefficients. …”
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Primary cutaneous gamma–delta T cell lymphoma presenting as a leg ulcer in a kidney transplant recipient on hemodialysis: a case report with a literature review by Yuki Oba, Hiroki Mizuno, Shigekazu Kurihara, Daisuke Ikuma, Masayuki Yamanouchi, Tatsuya Suwabe, Katsuyuki Miki, Kei Kono, Kennichi Ohashi, Aya Nishida, Atsushi Wake, Yuki Nakamura, Yoshifumi Ubara, Naoki Sawa

“…Although he decided to undergo amputation of his right leg finally, he died following postoperative cytomegalovirus meningitis. …”
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Integrating phylogeographic and phenotypic evidence to delimit deep evolutionary lineages in the Dryophytes japonicus species complex, with an assessment of their conservation need... by Amaël Borzée, Yikweon Jang, Siti N. Othman, Jordy Groffen, Irina V. Maslova, Zoljargal Purevdorj, Kiyomi Yasumiba, Tomohiko Shimada, Yoonjung Yi, Natalya Alekseevna Schepina, Desiree Andersen, Yoonhyuk Bae, Ikuo Miura, Christophe Dufresnes

“…Phenotypic differentiation between populations was only partly linked to their phylogenetic relationships. Finally, despite the relatively narrow ranges of many lineages, none crosses the threshold to be currently listed as threatened. …”
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Transcriptional and Posttranscriptional Regulations of the HLA-G Gene by Erick C. Castelli, Luciana C. Veiga-Castelli, Layale Yaghi, Philippe Moreau, Eduardo A. Donadi

“…We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3′UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region.…”
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Comparative Study of Fuel and Greenhouse Gas Consumption of a Hybrid Vehicle Compared to Spark Ignition Vehicles by Edgar Vicente Rojas-Reinoso, Michael Anacleto-Fernández, Jonathan Utreras-Alomoto, Carlos Carranco-Quiñonez, Carmen Mata

“…The numerical model compared the values of fuel consumption measured with those calculated on all the routes with the highest traffic, finally indicating which vehicle with the smallest cylinder capacity is optimal, with an average consumption of 14 km/l on each route compared to a hybrid vehicle with an average consumption of 8.5 km/l per route, for better fuel performance within the Metropolitan District of Quito, in heavy traffic conditions. …”
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A novel adaptive droop-based SoC balancing control strategy for distributed energy storage system in DC microgrid by Liangliang Guo, Xinrui Liu, Xinyu Li, Rui Wang, Hanwen Ren, Zhiliang Wang, Qiuye Sun

“…In addition, the stability analysis of the proposed control strategy is carried out to ensure the stable operation of the system in theory. Finally, the control method proposed in this paper is evaluated comprehensively on MATLAB/Simlink simulation platform and hardware-in-the-loop (HIL) experimental platform. …”
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The microbiome of Total Suspended Particles and its influence on the respiratory microbiome of healthy office workers by Giulia Solazzo, Sabrina Rovelli, Simona Iodice, Matthew Chung, Michael Frimpong, Valentina Bollati, Luca Ferrari, Elodie Ghedin

“…Indoor TSP exposure was negatively associated with commensal bacteria and positively associated with Staphylococcus aureus relative abundance. Finally, a correlation between the relative abundance of respiratory bacteria identified in the indoor TSP and the upper respiratory microbiome was found, suggesting a potential interaction between TSP and the upper airways.…”
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