Real-world assessment to estimate multiple attributes related to treatment cost driver for mantle cell lymphoma in Japan by econometric modeling by Saaya Tsutsué, Shinichi Makita, Hiroya Asou, Anila Mathew, Yuki Kado, Koki Idehara, Seok-Won Kim, Dilinuer Ainiwaer

“…SEM analysis revealed Bruton tyrosine kinase inhibitor-based treatment as a cost driver (β: 0.398 [0.340; 0.457], p < 0.001). …”
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Imagem de loja: proposição de escala para o segmento varejista farmacêutico by Ronaldo Barbosa de Souza, José Edson Lara

“…Para o desenvolvimento do trabalho, foi escolhida a população de clientes de farmácias de um importante município de Minais Gerais. As amostras coletadas dessa população foram os clientes de uma rede de farmácias desse município e após o tratamento estatístico dos dados amostrais evidenciou-se a importância da imagem de loja para as farmácias. …”
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Study on the Adsorption Mechanism of Hydrophobic SiO2 Nanoparticles: A Molecular Dynamics Study by Runnan Zhou, Yuyuan Wang, Dong Zhang, Peng Ye, Jianguang Wei

“…Nanoparticles can only break through the first adsorption layer to absorb on the layer. Finally, wetting angle tests were conducted which indicated that SiO2 nanoparticles can be adsorbed on the surface and have a good wetting reversal effect. …”
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A framework for quantifying the multisectoral burden of animal disease to support decision making by Sara Lysholm, Sara Lysholm, Gemma L. Chaters, Gemma L. Chaters, Carlotta Di Bari, Carlotta Di Bari, Ellen C. Hughes, Ellen C. Hughes, Ben Huntington, Ben Huntington, Jonathan Rushton, Jonathan Rushton, Lian Thomas, Lian Thomas

“…It then discusses how these estimates can be combined to generate multisectoral estimates of the impacts of animal diseases on human societies and the environment using monetary values. Finally this paper explores how this framework can support the evaluation of interventions from a One Health perspective though SCBA. …”
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Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…In addition, single-cell analysis displayed the cell types, the subcellular localization of prognostic genes, and the cellular interaction to reveal the potential molecular communication mechanism of anoikis resistance. Finally, in vitro experiments confirmed the critical role of CRABP2 in STAD. …”
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Influence of Cord Parameters on the Load Characteristics of Airbags by Yu-Ru Li, Shou-Ne Xiao, Jun-Ke Xie, Tao Zhu, Bing Yang, Guang-Wu Yang, Shi-De Xiao

“…Second, the validity of the model was verified by the test data of the vertical force and cavity pressure of the airbag. Finally, based on the gas-solid coupling model proposed, the influence of the cord parameters on the vertical force characteristics was studied. …”
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Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

“…Here, we investigated if allopregnanolone attenuates extracellular signal-regulated kinase (ERK) and its downstream prostaglandin E2 (PGE2) expression in the dorsal spinal cord concomitant with neuropathic pain relief in paclitaxel (PTX)-induced neuropathic pain model rats. …”
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Classifying Sunn Pest Damaged and Healthy Wheat Grains Across Different Species with YOLOV8 and Vision Transformers by Melike Çolak, Özgü Özkan, Ali Berkol, Nergis Pervan Akman, Murat Ardıç, Okan Sezer, Nazife Gözde Ayter Arpacıoğlu, Zekiye Budak Başçiftçi, Murat Olgun

“…Moreover, this study employs a combination of augmentation techniques, implying that two separate augmentation techniques, texture-based and one morphological, were applied to the same image. Finally, no study in the available literature uses a vision transformer to classify healthy and sunned pest-damaged wheat grains. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…In conclusion, we propose future research directions including conducting more high-quality randomized controlled trials to optimize application strategies for probiotics alongside other treatments while considering variations based on age and health conditions among pediatric populations. Finally, in summary although probiotics exhibit promising benefits in preventing and treating RRTIs in children; additional studies are necessary to refine their application strategies ensuring both safety and effectiveness.…”
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Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation by Michele Barone, Maria Principia Scavo, Raffaele Licinio, Michele Piombino, Nicola De Tullio, Rosanna Mallamaci, Alfredo Di Leo

“…Moreover, the number of WT-Tx-Apc mice with a high-grade dysplastic polyps significantly decreased as compared to Apc-Tx-Apc mice. Finally, at 4 and 7 weeks after transplantation, WT-Tx-Apc mice showed a progressive significant increase of Y+/Cdx2+ cells in “normal” mucosa, whereas, in the adenomatous tissue, Y+/Cdx2+ cells remained substantially unvaried. …”
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Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats by Liangrong Wang, Feifei Chen, Yafei Pan, Lina Lin, Xiangqing Xiong

“…S1P lyase (S1PL), sphingosine kinase (SphK) 1, and SphK2 mRNA expressions, wet/dry weight (W/D), and polymorphonuclear/alveolus (P/A) in lung tissues were detected, and the lung injury score was evaluated. …”
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Emission Characteristics of Volatile Organic Compounds from Typical Coal Utilization Sources: A Case Study in Shanxi of Northern China by Yang Xu, Hualong Yu, Yulong Yan, Lin Peng, Rumei Li, Cheng Wang, Zhiyong Li

“…Additionally, the VOC profiles for power plants employing the same coal source or combustion technology exhibited strong similarities, although the BTEX ratios varied more between plants using different coal sources than those using different combustion technologies. Finally, alkenes were primarily responsible for the ozone formation (73.1%, 59.0%, and 87.6% for the power plants, steel plants, and residential stoves, respectively), whereas aromatics were primarily responsible for the SOA formation (more than 94.0% for all four coal-utilizing sources).…”
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Comprehensive identification, characterization and expression analyses of the class III POD gene family in water lily (Nymphaea colorata) by Wasi Ullah Khan, Wasi Ullah Khan, Latif Ullah Khan, Noor Muhammad Khan, Ji Zhang, Wang Wenquan, Wang Wenquan, Fei Chen, Fei Chen

“…The analysis of promoter cis-acting elements indicated the presence of regulatory elements associated with various responses such as ABA, MeJA, light responsiveness, anaerobic conditions, and drought inducibility. Finally, the RT-qPCR based expression and enzymes activity of ten NcPOD genes depicted the dynamically differential response to NaCl, heat, cold, and heavy metals (CuSO4 and CdCl2) stresses. …”
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Exogenous dopamine application ameliorates chilling injury and preserves quality of kiwifruit during cold storage by Morteza Soleimani Aghdam, Zeinab Asle-Mohammadi, Amin Ebrahimi, Farhang Razavi

“…By 150 µM dopamine application, higher SUMO E3 ligase (SIZ1) and target of rapamycin (TOR) genes expression accompanied by lower poly(ADP-Ribose) polymerase 1 (PARP1) and sucrose non-fermenting 1-related kinase 1 (SnRK1) genes expression was associated with higher salicylic acid, ATP, NADPH and proline accumulation in kiwifruits during storage at 1 °C for 120 days. …”
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The prevention opportunities of retinopathy in diabetic patients – position paper endorsed by the Polish Lipid Association by Maciej Banach, Stanisław Surma, Grzegorz Dzida, Jacek Jóźwiak, Bogusław Okopień, Jacek Rysz, Konrad Szosland, Andrzej Grzybowski

“…In this Position Paper by the Polish Lipid Association (PoLA) we have reviewed the current stage of knowledge on possible mechanisms by which fenofibrate may contribute to retinopathy prevention, available data on safety and efficacy, to finally recommend administering fenofibrate in prevention of this dangerous diabetic complication, which significantly affects quality of life and disability-adjusted life-years (DALY). …”
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Does the transfer of knowledge from the pioneer generation to the second‐generation speed‐up the learning curve of robot‐assisted partial nephrectomies? TRANSFER trial (UroCCR n°83... by Louis Vignot, Zine‐Eddine Khene, Adil Mellouki, Arnoult Morrone, Jean‐Christophe Bernhard, Karim Bensalah, Daniel Chevallier, Nicolas Doumerc, Morgan Roupret, Francois‐Xavier Nouhaud, Cédric Lebacle, Jean‐Alexandre Long, Pierre Pillot, Xavier Tillou, Brannwel Tibi, Matthieu Durand, Younes Ahallal, Imad Bentellis

“…The learning speed for WIT was explored graphically by polynomial regression after cubic splines. Finally, CUSUM charts were obtained. Results There were 1203 RAPN in the pioneer group and 119 performed by second‐generation surgeons. …”
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Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…Abstract Sevenless, the Drosophila homologue of ROS1 (University of Rochester Sarcoma) (herein, dROS1) is a receptor tyrosine kinase (RTK) essential for the differentiation of Drosophila R7 photoreceptor cells. …”
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Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells by Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara

“…While CD19-targeted CAR-T cells and Janus kinase (JAK) inhibitors have independently shown efficacy against certain B-cell leukemias, such as Philadelphia chromosome-like acute lymphoblastic leukemia, the concurrent use of JAK1/2 inhibitors, such as ruxolitinib, has been implicated in reducing CAR-T cell potency by inhibiting the JAK1-dependent T cell activation pathway. …”
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Hot deformation physical mechanisms and a unified constitutive model of a solid solution Ti55511 alloy deformed in the two-phase region by Huijie Zhang, Y.C. Lin, Gang Su, Yongfu Xie, Wei Qiu, Ningfu Zeng, Song Zhang, Guicheng Wu

“…Material constants are determined using a genetic algorithm (GA), and the experimental data align well with the predicted data. Finally, process parameters are optimized based on the model to achieve favorable microstructures.…”
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In-situ/operando study of Cu-based nanocatalysts for CO2 electroreduction using electrochemical liquid cell TEM by Jiawei Wan, Jiawei Wan, Qiubo Zhang, Ershuai Liu, Ershuai Liu, Yi Chen, Yi Chen, Jiana Zheng, Jiana Zheng, Amy Ren, Walter S. Drisdell, Walter S. Drisdell, Haimei Zheng, Haimei Zheng

“…Using the multimodal characterization toolbox, we provide the opportunity to correlate the structure of a working catalyst with its performance. Finally, we discuss advancements as well as the remaining gap in elucidating the structural-performance relationship of working catalysts. …”
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