Object-Level Contrastive-Learning-Based Multi-Branch Network for Building Change Detection from Bi-Temporal Remote Sensing Images by Shiming Li, Fengtao Yan, Cheng Liao, Qingfeng Hu, Kaifeng Ma, Wei Wang, Hui Zhang

“…Second, an object-level contrastive learning loss is designed and jointly optimized with a pixel-level similarity loss to ensure the global consistency of buildings. Finally, an attention-based discriminative feature generation and fusion block is designed to enhance the representation of multi-scale change features. …”
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ErbB4 as a Potential Molecular Target in the Treatment of Esophageal Squamous Cell Cancers by Ke Zhao, Bao-Jun Chen, Zhi-Guo Chen

“…ErbB4 is an important member of ErbB subfamily of tyrosine kinases receptor with overexpression in several tumors; however its biological role in esophageal cancer is poorly understood till date. …”
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Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats by D. Saul, J. H. Kling, R. L. Kosinsky, D. B. Hoffmann, M. Komrakova, M. Wicke, B. Menger, S. Sehmisch

“…In M. longissimus, we observed a shift to type IIa fibres. Serum creatine kinase levels were significantly lower in highest baicalein concentration group. …”
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Reconstruction of climatic events from the 16th century in Transylvania: interdisciplinary analysis based on historical sources by Ovidiu Răzvan Gaceu, Tudor Caciora, Ștefan Baias, Cezar Morar, Mihai Dudaș, Marius Stupariu, Maria Maxim

“…At the same time, compared to the territory of Western Europe, in Transylvania, heat waves and droughts were more frequent in the first half of the 16th century, while in Western Europe, these climatic phenomena were more sporadic and less intense. Finally, the manuscript emphasizes the significant role of the climate in shaping the historical and socio-economic landscape of Transylvania in the 16th century, offering perspectives on the complex interactions between the climate and the human component.…”
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CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis by Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang

“…We report here that calcium dependent protein kinase 1 (CPK1) directly activates CNGC5/6/9 to promote Arabidopsis RH growth. …”
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Study on the Fractal Characteristics of Coal Body Fissure Development and the Law of Coalbed Methane Migration of around the Stope by He Yang, Zhen Liu, Danliang Zhu, Wenzhi Yang, Dawei Zhao, Wendi Wang

“…Further, with the help of the fractal theory and box counting method, the fracture development characteristics of the overlying strata are quantitatively described on the basis of experimental images. Finally, by building a model for calculating the penetrability coefficient of coal seam based on fractal dimension of mining fissure and analyzing the relationship between fissure development and fractal dimension, the gas migration law and the fissure development areas of #7 and #8 overburden strata where CBM concentrates can be revealed and determined. …”
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Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging by Anqin Wang, Hongli Wu, Chunsheng Xu, Lanfeng Tang, Jaeyoun Lee, Min Wang, Man Jiang, Chuanfu Li, Qi Lu, Chunyun Zhang

“…Besides, lesions in the basal ganglia, thalamus, and cerebellum might disconnect the basal ganglia-thalamo-cortical circuits or dentato-rubro-thalamic (DRT) track and disrupt cerebello-thalamo-cortical network finally, which may cause clinical extrapyramidal symptoms.…”
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Integrating Explainable Artificial Intelligence With Advanced Deep Learning Model for Crowd Density Estimation in Real-World Surveillance Systems by Sultan Refa Alotaibi, Hanan Abdullah Mengash, Mohammed Maray, Faiz Abdullah Alotaibi, Abdulwhab Alkharashi, Ahmad A. Alzahrani, Moneerah Alotaibi, Mrim M. Alnfiai

“…The OOADL-CDDC technique utilizes an advanced DL method, employing the SE-DenseNet model for feature extraction, while the hyperparameter selection is performed by using the OOA model. Finally, the detection and classification of the crowd density is accomplished by using the attention bidirectional gated recurrent unit (ABiGRU) model. …”
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Benidipine Protects Kidney through Inhibiting ROCK1 Activity and Reducing the Epithelium-Mesenchymal Transdifferentiation in Type 1 Diabetic Rats by Ganlin Wu, Meirong Xu, Kui Xu, Yilan Hu

“…We investigated the protective effect of benidipine, by testing the changes of the activity of Rho kinase and transdifferentiation of renal tubular epithelium cells in vivo. …”
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Analysis and Application of the Mechanical Properties of the Karst Collapse Column Fillings by Zhibin Lin, Boyang Zhang, Xiaofei Gong, Limin Sun, Wenzhen Wang, Dafang Yang, Yanlin Yang, Ming Guo, Xia-Hui Pan

“…The larger the consolidation pressure or the smaller the moisture content, the larger the ratio. (2) With the increase of consolidation pressure or the decrease of moisture content, the uniaxial compressive strength, elastic modulus, splitting tensile strength, cohesive stress, and internal friction angle of the filling material of the KCC increase linearly, while its permeability increases exponentially. (3) When the crack field of the surrounding rocks of the stope is connected with the KCC, its filling material will continue to yield, activate, and migrate under the fluid-solid coupling effect and finally result in the lagging water inrush from the KCC.…”
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Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…The role of shPSMB8 in LPS-induced apoptosis was detected by flow cytometry. Finally, western blot was performed to assess the NF-κB signaling pathway related proteins, and the nuclear translocation of NF-kB P65 was detected by immunofluorescence microscopy. …”
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Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls by Alex P. Lange, Reza Sadjadi, Jameelah Saeedi, Janette Lindley, Fiona Costello, Anthony L. Traboulsee

“…Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…We further find that HDACs are involved in the regulation of lipogenic genes and HDAC6 is particularly important for the regulation of FASN in IDH1 MT glioma. Finally, we show that FASN knockdown alone and VPA in combination with FASN knockdown significantly improved the survival of mice in an IDH1 MT primary orthotopic xenograft model in vivo. …”
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A Parallel Approach to Generate Sports Highlights from Match Videos Using Artificial Intelligence by Arjun Sivaraman, Tarun Kannuchamy, Anmol Anand, Shivam Dheer, Devansh Mishra, Narayanan Prasanth, S. P. Raja

“…The approach involves creating a list of words (wordnet) that indicate a highlight and comparing it with the commentary audio’s transcript to find a similarity, making use of a speech-to-text conversion, followed by some pre-processing of the extracted text, vectorization and finally measurement of the cosine similarity metric between the text and the wordnet. …”
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Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria by Teresa Krakauer

“…Phagocytosis and toll-like receptor (TLR) signaling induce reactive oxygen species (ROS), type I IFN, NFκB activation of proinflammatory cytokines, and the mitogen-activated protein kinase cascade. ROS and IFNγ are also prominent inducers of autophagy. …”
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The optimization of consensus decision-making for a multi-microwave source system based on composite leader-follower clustering for intelligent agent-based joint heating temperatur... by Biao Yang, Baowei Song, Cheng Cheng, Youpeng Zhao, Haiqin Yang, Yuchen Li, Zhongyi He

“…Then, on the basis of the composite leader decision information, the feeding power of the microwave source cluster was coordinated via a consensus algorithm, achieving dynamic coordination and complementarity between the leader cluster and the follower cluster. Finally, the simulation results revealed that after adopting this strategy, the temperature control error rate ranged from 0.25% to 1.43%. …”
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Histological, physiological and transcriptomic analysis in hepatopancreas of Procambarus clarkii under heat stress by Yongfeng Zou, Panhui Cao, Zhiming Bao, Yu Xu, Zhiqiang Xu, Hui Guo

“…Significant fluctuations were observed in the malondialdehyde (MDA) content, reactive oxygen species (ROS) production, total antioxidant capacity (T-AOC), and activities of pyruvate kinase (PK), hexokinase (HK), alkaline phosphatase (ALP), lysozyme (LYS), acid phosphatase (ACP), fatty acid synthase (FAS), as well as lipoprotein lipase (LPL) in response to different stress conditions (P < 0.05). …”
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Promising horizons in achondroplasia along with the development of new drugs by Keiichi Ozono, Takuo Kubota, Toshimi Michigami

“…Additionally in development are a tyrosine kinase inhibitor, a soluble FGFR3, an antibody against FGFR3, meclizine, and the FGF2-aptamer. …”
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Attitude towards research and self-study in Cuban medical science students during COVID-19 by Juan Arturo Berenguer Gouarnaluses, Margarita Montes de Oca Carmenaty, Adrián Alejandro Vitón-Castillo, Elizabeth Melissa Tablada Podio, Maritza del Carmen Berenguer Gouarnaluses

“…<br /><strong>Results:</strong> It was found a predominance of female students (66.5%), aged between 18 and 20 years (56.5%), of the medical career (92.5%) and of the third year (25.5 %). 34.5% of those surveyed came from the medical universities of Holguín and Pinar del Río. 87.5% of the surveyed students reported having joined the active investigations, in 87.0% of the cases the relatives did not present any objection. 66.0% of the surveyed students found this task useful. 79.5% affirmed that their incorporation into conducting active investigations in times of the COVID-19 pandemic had a great influence on their professional and humanistic training. 68.5% of the students expressed feeling support from the different health institutions. …”
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Thermodynamic Properties of γ- and δ-Lactones: Exploring Alkyl Chain Length Effect and Ring-Opening Reactions for Green Chemistry Applications by Ana L. R. Silva, Gastón P. León, Vladimír Lukeš, Erik Klein, Maria D. M. C. Ribeiro da Silva

“…The experimental results are discussed in terms of structural contributions to the energetic properties of the lactones studied, as well as to other alkylated γ- and δ-lactones, and empirical correlations are suggested for the estimation of the standard molar enthalpies of formation, at <i>T</i> = 298.15 K, for other alkylated γ- and δ-lactones, both in the liquid and gaseous phases, as well as for the respective enthalpies of vaporization. Finally, the thermochemistry of individual steps of lactone ring opening and successive decarboxylation mechanism, including the identification of transition states, was studied using the M06-2X/6-311++G(d,p) approach.…”
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