Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation by Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Victoria J. Nicolini, Coline Savy, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickael Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pages, Frederic Luciano

“…USP39 knockdown inhibits clonogenic capacity, induces cell cycle arrest, triggers apoptosis, and overcomes BTZ resistance. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…Cognitive function was evaluated using the Kaufman Assessment Battery for Children (KABC-II), with additional tools measuring executive function, literacy, numeracy, fine motor skills, and socioemotional function. Physical function was assessed using standing broad jump and handgrip for strength, and the shuttle-run test for cardiovascular fitness. …”
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Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data by Meghan B. Mitchell, Cynthia R. Cimino, Andreana Benitez, Cassandra L. Brown, Laura E. Gibbons, Robert F. Kennison, Steven D. Shirk, Alireza Atri, Annie Robitaille, Stuart W. S. MacDonald, Magnus Lindwall, Elizabeth M. Zelinski, Sherry L. Willis, K. Warner Schaie, Boo Johansson, Roger A. Dixon, Dan M. Mungas, Scott M. Hofer, Andrea M. Piccinin

“…Engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills, thereby minimizing age-related cognitive decline. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Summary: Background: Leptospirosis is a globally neglected re-emerging zoonosis affecting all mammals, albeit with variable outcomes. Humans are susceptible to leptospirosis; infection with Leptospira interrogans species can cause severe disease in humans, with multi-organ failure, mainly affecting kidney, lung and liver function, leading to death in 10% of cases. …”
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Application of probiotic microcapsules Bacillus cereus BR2 with different doses for the prevention of Aeromonas hydrophila NFC1 infection in catfish Clarias sp. by Nurul Faoziyatunnisa, Munti Yuhana, Dinamella Wahjuningrum, Sri Nuryati, Usamah Afiff

“…All treatments of P1, P2, and P3 were intramuscularly injected with A. hydrophila NFC1 cell suspension. …”
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Protein digestibility and ammonia excretion in catfish Clarias gariepinus culture by Bambang Gunadi, Enang Harris, Eddy Supriyono, . Sukenda, Tatag Budiardi

“…In the ammonia excretion experiment, catfish with an individual size of 111.6±9.5 and 40.6±3.4 g, respectively,  were placed into a 10 L chamber filled with 8 L of water. Total ammonia nitrogen (TAN) in the chambers were monitored every hour for six consecutive hours. …”
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Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort by Charles Dupuy, Thibault Martinez, Olivier Duranteau, Tobias Gauss, Natacha Kapandji, Jean Pasqueron, Mathilde Holleville, Georges Abi Abdallah, Anatole Harrois, Véronique Ramonda, Delphine Huet-Garrigue, Théophane Doublet, Marc Leone, Vincent Legros, Julien Pottecher, Gérard Audibert, Ingrid Millot, Benjamin Popoff, Benjamin Cohen, Fanny Vardon-Bounes, Mathieu Willig, Pierre Gosset, Emilie Angles, Nouchan Mellati, Nicolas Higel, Mathieu Boutonnet, Pierre Pasquier, and the TraumaBase Group®

“…The patients included in this study were all trauma patients who had received transfusions of at least 1 unit of red blood cells (RBCs) within the first 6 h of hospital admission and for whom ionized calcium measurements were available. …”
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Characteristics of Traditional Human Settlement Landscapes on Bedrock Islands in Guangdong Based on the “Ao” Unit by Ying PAN, Linxi CHEN, Ying SHI

“…The Ao unit has the following basic characteristics, backed by hills and facing the bay, with a certain area of flat land between the mountains and the sea, where a large number of island villages and towns are gathered, with complete production and living space. 2) At the island-wide level, the Ao unit has been the preferred area for human settlement on Nan’ao Island, with settlements primarily established around these units. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen 4 (CTLA4), we hypothesized that biomarkers of immune dysregulationpreviously defined in patients with congenital CTLA4 deficiency, including elevated soluble interleukin-2 receptor alpha (sIL-2R) and flow cytometric cell-based markers of B and T cell dysregulation in peripheral blood may aid the diagnosis of ICI-nephritis.Methods A retrospective cohort of patients diagnosed with ICI-nephritis was compared with three prospectively enrolled control cohorts: ICI-treated controls without immune-related adverse events, patients not on ICIs with hemodynamic acute kidney injury (hemodynamic AKI), and patients not on ICIs with biopsy proven acute interstitial nephritis from other causes (non-ICI-nephritis). sIL-2R level and flow cytometric parameters were compared between groups using Wilcoxon rank sum test or Kruskal-Wallis test. …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…In addition, over 550 water, rock and gas samples collected during borehole drilling and testing underwent diverse geochemical, isotopic and microbiological analysis. …”
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Direct measurement of three different deformations near the ground state in an atomic nucleus by Adrian Montes Plaza, Janne Pakarinen, Philippos Papadakis, Rolf-Dietmar Herzberg, Rauno Julin, Tomás R. Rodríguez, Andrew D. Briscoe, Andrés Illana, Joonas Ojala, Panu Ruotsalainen, Eetu Uusikylä, Betool Alayed, Ahmed Alharbi, Odette Alonso-Sañudo, Kalle Auranen, Ville Bogdanoff, Jamie Chadderton, Arwin Esmaylzadeh, Christoph Fransen, Tuomas Grahn, Paul T. Greenlees, Jan Jolie, Henna Joukainen, Henri Jutila, Casper-David Lakenbrink, Matti Leino, Jussi Louko, Minna Luoma, Adam McCarter, Bondili Sreenivasa Nara Singh, Panu Rahkila, Andrea Raggio, Jorge Romero, Jan Sarén, Maria-Magdalini Satrazani, Marek Stryjczyk, Conor M. Sullivan, Álvaro Tolosa-Delgado, Juha Uusitalo, Franziskus von Spee, Jessica Warbinek, George L. Zimba

“…Contrary to earlier interpretations, we associate the collective yrast band as predominantly oblate, while the non-yrast band with higher collectivity follows characteristics of more deformed, predominantly prolate bands. …”
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Investigation on health behavior of middle-aged and elderly patients with ischemic stroke and analysis of its influencing factors (中老年缺血性脑卒中患者健康行为现状调查及影响因素分析)... by LONG XinLing (龙鑫伶), YANG Mingchun (杨鸣春), ZOU Airong (邹爱容)

“…The questionnaire of health behavior, health knowledge, self-efficacy and general data were collected by self-filling questionnaire and enquiry methods. Results A total of 201(99. 01%) valid questionnaires were collected. …”
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Prevalence of pulmonary hypertension and associated factors among rheumatic heart disease patients in Ethiopia by Asmamaw Gedefaw, Yihealem Yabebal Ayele, Gebeyaw Wudie, Abiyot Tefera, Agerye Kassa Yirdaw, Tadele Demilew

“…Severe mitral valve stenosis (AOR 7.8, 95% CI 2.4–25.7), duration of illness ≥ 3 years (AOR 7.7, 95% CI 2.1–28.5), and diuretics use (AOR 5.6, 95% CI 2.2–14.3) were factors associated with PH. …”
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Poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia: a comparative cross-sectional study by Milen Mihertabe, Alehegn Bishaw Geremew, Alehegn Bishaw Geremew, Elsa Awoke Fentie, Gidey Rtbey

“…Being HIV-positive [AOR = 2.38, 95% CI (1.31, 4.32)], being divorced [AOR = 4.5, 95% CI (1.55, 13)], and having a family history of mental illness [AOR = 1.89, 95% CI (1.16, 3.1)], depression [AOR = 1.93 (1.11, 3.3)], and anxiety [AOR = 2.76, 95% CI (1.8, 4.2)] among postpartum women and poor social support [AOR = 6, 95% CI (1.63, 22.4)] among HIV-positive women were significantly associated with poor sleep quality.Conclusion and recommendationThis study revealed that the prevalence of poor sleep quality was higher among HIV-positive postpartum women compared to HIV-negative women. …”
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Catastrophic health expenditure associated with non-inpatient costs among middle-aged and older individuals in China by Xiaojuan Zhang, Kun Zhu

“…BackgroundSince their establishment, the two predominant social health insurance schemes in China, Urban Employee Medical Insurance (UEMIS) and Urban and Rural Residents’ Medical Insurance (URRMS), have primarily focused on covering non-inpatient expenditure, while costs associated with outpatient care and pharmaceutical purchases have been largely excluded from the insurance benefit package. …”
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Factors Associated with Maternal Near Miss among Women Admitted in West Arsi Zone Public Hospitals, Ethiopia: Unmatched Case-Control Study by Fikadu Nugusu Dessalegn, Feleke Hailemichael Astawesegn, Nana Chea Hankalo

“…Maternal near miss refers to a very ill pregnant or delivered woman who nearly died but survived a complication during pregnancy, childbirth, or within 42 days of termination of pregnancy. …”
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Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review by Mariana Herrera, Cristian Vera, Yoav Keynan, Zulma Vanessa Rueda

“…We found 24 parameters that were increased only in active TB (TGF-α, CSF3, CSF2, CCL1 [I-309], IL-7, TGF-β1, CCL3 [MIP-1α], sIL-2R, TNF-β, CCL7 [MCP-3], IFN-α, fractalkine, I-TAG, CCL8 [MCP-2], CCL21 [6Ckine], PDGF, IL-22, VEGF-A, LXA4, PGE2, PGF2α, sCD163, sCD14, and 15-Epi-LXA4), five were elevated in LTBI (IL-5, IL-17F, IL-1, CCL20 [MIP-3α], and ICAM-1), and two substances were increased among uninfected individuals (IL-23 and basic FGF). …”
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Employment status and information needs of patients with breast cancer: a multicentre cross-sectional study of first oncology consultations by Lidia Del Piccolo, Maria Angela Mazzi, Cinzia Perlini, Giuseppe Deledda, Alberto Ghilardi, Chiara Buizza, Alessandro Bottacini, Claudia Goss

“…When age and education were included in the statistical model, the significance of employment status was rearranged among all the variables and was no more significant (b=1.2, p=0.44). …”
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Clinical course, management and outcomes of COVID-19 in HIV-infected renal transplant recipients: A case series by L Bertels, K Manning, A Redd, T du Toit, Z Barday, E Muller

“…HIV‐infected kidney transplant recipients with COVID‐19 are at increased risk of acute illness and death owing to their underlying comorbidities and chronic immunosuppression. …”
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The prevalence of optrA-carrying Enterococci in the vaginal micro-ecology of pregnant women in late pregnancy by Yanjun Xie, Fangyi Xu, Huali Dong, Jianfeng Mao, Chuanling Zhang

“…Fifty-four optrA-carrying Enterococcus strains were obtained, the proportion of the whole vagina of late pregnant women was 15.88% (54 out of 340), and Enterococcus faecalis account the highest proportion. All optrA-carrying Enterococcus were resistant to at least three drugs. …”
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