Harnessing Big Heterogeneous Data to Evaluate the Potential Impact of HIV Responses Among Key Populations in Sub-Saharan Africa: Protocol for the Boloka Data Repository Initiative by Refilwe Nancy Phaswana Mafuya, Edith Phalane, Amrita Rao, Kalai Willis, Katherine Rucinski, K Alida Voet, Amal Abdulrahman, Claris Siyamayambo, Betty Sebati, Mohlago Seloka, Musa Jaiteh, Lerato Lucia Olifant, Katharine Journeay, Haley Sisel, Xiaoming Li, Bankole Olatosi, Neset Hikmet, Prashant Duhoon, Francois Wolmarans, Yegnanew A Shiferaw, Lifutso Motsieloa, Mashudu Rampilo, Stefan Baral

“…There will be engagement of a wide range of stakeholders to facilitate the acquisition of data (stage 1). …”
Get full text

The Role of Immunohistochemistry for AMACR/p504s and p63 in Distinguishing Prostate Cancer from Benign Prostate Tissue Samples in Botswana by Ramatlho P, Rugemalila MM, Tawe L, Pain D, Choga OT, Ndlovu AK, Koobotse MO, Lal P, Rebbeck TR, Paganotti GM, Narasimhamurthy M, Kyokunda LT

“…PSA levels showed significant positive correlation with AMACR/p504s expression (P < 0.00001).Discussion: In this study, we have demonstrated the diagnostic utility of AMACR/p504s and p63 due to their high sensitivity and specificity in detecting CaP in Botswana, where these biomarkers are not yet widely used. Furthermore, utilizing these markers in conjunction with other diagnostic tools, such as PSA levels and morphological evaluation, could improve the diagnostic accuracy, especially in challenging cases where histopathological examination alone may be inconclusive.Keywords: prostate cancer, AMACR/p504s, p63, benign prostatic hyperplasia, Botswana…”
Get full text

Repetitive Transcranial Magnetic Stimulation for the Treatment of Complex Regional Pain Syndrome: A Pilot Study by Foglia SD, Drapeau CC, Ramdeo KR, Adams FC, Soppitt DB, Rehsi RS, Shanthanna H, Nelson AJ

“…Stevie D Foglia,1 Chloe C Drapeau,2 Karishma R Ramdeo,2 Faith C Adams,2 Daniel B Soppitt,2 Ravjot S Rehsi,2 Harsha Shanthanna,1,3 Aimee J Nelson1,2 1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; 2Department of Kinesiology, McMaster University, Hamilton, ON, Canada; 3Department of Anesthesia, McMaster University, Hamilton, ON, CanadaCorrespondence: Aimee J Nelson, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, Tel +1 905-525-9140 x28053, Fax +1 905-523-6011, Email nelsonaj@mcmaster.caPurpose: Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition characterized by sensory, motor, and autonomic dysfunction with a world-wide prevalence of 26.2 per 100,000 people per year and is 3 to 4 times more prevalent in females. …”
Get full text

Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review by Pan J, Li Z, Ye C, Zhang X, Yang Q, Zhang X, Zhou Y, Zhang J

“…Juan Pan,1,&ast; Zuyi Li,1,&ast; Chao Ye,2 Xiaojuan Zhang,1 Qiongliang Yang,1 Xu Zhang,1 Ya Zhou,3 Jianjun Zhang2 1Department of Pharmacy, Liuyang Hospital of Traditional Chinese Medicine, Changsha, Hunan, 410300, People’s Republic of China; 2Department of Pharmacy, Guangdong Provincial second Hospital of Traditional Chinese Medicine (Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, Guangdong, 510095, People’s Republic of China; 3Department of Pharmacy, People’s Hospital of Ningxiang City Affiliated to Hunan University of Chinese Medicine, Changsha, Hunan, 410600, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chao Ye, Department of Pharmacy, Guangdong Provincial second Hospital of Traditional Chinese Medicine (Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine), No. 60, Hengfu Road, Guangzhou, Guangdong, 510095, People’s Republic of China, Email yechao1234256@163.comObjective: Mesalazine is a widely used medication for treating mild to moderate inflammatory bowel disease (IBD). …”
Get full text

Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. …”
Get full text

OPTIMALISASI VISIBILITAS MENGGUNAKAN SPACE SYNTAX: STUDI KASUS GEDUNG GALERI NUSANTARA SEMARANG by Alifiano Rezka Adi, Muhammad Rizqi

“…The low R2 values are more common in panel board arrangements because there are areas with low visibility within a fairly wide coverage area. It results in overall low R2 value in the gallery. …”
Get full text

Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polariza... by Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song

“…Abstract Introduction Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. …”
Get full text

A novel nomogram for predicting mortality risk in young and middle-aged patients undergoing maintenance hemodialysis: a retrospective study by Lei Sun, Lei Sun, Yue Zhang, Yue Zhang, Xinliang Zuo, Xinliang Zuo, Yongmei Liu

“…Additionally, the DCA indicated that the model provides a net benefit across a wide range of decision thresholds from 0 to 0.99, underscoring its clinical utility.ConclusionThe nomogram developed from variables including age, HB levels, serum Mg, NLR, and PAR exhibits high levels of discrimination and calibration. …”
Get full text

AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist by Rahul Brahma, Sunghyun Moon, Jae-Min Shin, Kwang-Hwi Cho

“…Moreover, our first-in-class multi-tasking model can predict agonist and antagonist activities across a wide range of GPCRs, offering a comprehensive perspective on ligand bioactivity within this diverse superfamily. …”
Get full text

Visualization analysis of knowledge graph of domestic self-regulated learning researches based on CiteSpace (基于CiteSpace的国内自我调节学习研究知识图谱可视化分析)... by CHEN Qiannan (陈倩楠), QIAN Zhigang (钱志刚), WANG Beibei (王贝贝), JIN Guifang (金桂芳), ZHANG Xueru (张雪茹)

“…Conclusion The research population of self-regulated learning is more and more wide, the research content and the research field are more and more detailed, but the cross research of self-regulated learning and medical discipline needs to be strengthened. …”
Get full text

IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…Furthermore, we found that SOCS1 restrained the expression of the key proteins p65 and p-P65 in the NF-κB pathway. Causing, the wide range of cross-species activities of IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula>, therefore we established a pregnant mouse model for the future confirmation of the above mechanism. …”
Get full text

Danggui-Shaoyao-San Can Ameliorate Alzheimer&rsquo;s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology by Zhang KX, Zhang JW, Jiang YH, Wang YR, Liu ZL, Ding PL, Wang XY, Cui WQ, Xu XQ, Wang YH

“…Kai-Xin Zhang,1 Ji-Wei Zhang,2 Yan-Hong Jiang,1 Yi-Ran Wang,1 Zhen-Ling Liu,1 Peng-Li Ding,1 Xiang-Ying Wang,1 Wen-Qiang Cui,3 Xiang-Qing Xu,3,&ast; Ya-Han Wang3,&ast; 1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 2College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 3Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiang-Qing Xu, Ya-Han Wang; Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China, Email happyxiangqing@163.com; sdwangyahan@sina.comBackground: Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine prescription with a history of nearly 2000 years, originally widely used for gynecological diseases, and in recent years research has found that DSS also has a good therapeutic effect on Alzheimer’s disease (AD).Purpose: The objective is to investigate the metabolic components of the DSS in the blood and the potential mechanisms for AD.Materials and Methods: Liquid chromatography‒mass spectrometry (LC-MS) combined with gas chromatography‒mass spectrometry (GC-MS) based non-targeted metabolomics were used to conduct in-depth research. …”
Get full text

Le site antique de la clinique des Dames Blanches à Tours (Indre-et-Loire) : aménagements d’un embarcadère romain sur la Loire et évolution du trait de rive by Nicolas Fouillet, Philippe Gardère

“…The excavation made it possible to uncover a Roman landing stage 8 m wide, probably connected to the riverbank road. The development is marked by a multitude of oak piles deeply driven into the alluvial deposits. …”
Get full text

An efficient method for predicting the morphology of proppant packs based on a surrogate model by Tao ZHANG, Hangyu ZHOU, Yifan ZHANG, Jianchun GUO, Haoran GOU, Tang TANG

“…The model and approach proposed in this study accelerated the speed of proppant transport simulation and greatly shortened the prediction time of the proppant placement patterns, which could be widely applied in fracturing in the field after further improvement.…”
Get full text

Knowledge and Perception of Eponyms in Chemistry by University Students in Belarus and the United States by U. K. Slabin

“…A positive example is considered a widely recognised and effective method of education and upbringing. …”
Get full text

Re-examining the Division of Candi Borobudur into Kāmadhātu, Rūpadhātu, and Arūpadhātu by So Tju Shinta LEE, Agus Aris Munandar, Lilawati Kurnia

“… The interpretation that Candi Borobudur is divided into kāmadhātu, rūpadhātu, and arūpadhātu is widely adopted in many writings about Borobudur, despite being questioned by some scholars. …”
Get full text

The application of allelopathy in integrated pest management systems to control temperate European crop pests: a systematic map by Charlotte Kiely, Nicola Randall, Magda Kaczorowska-Dolowry

“…Allyl isothiocyanate was the most studied allelochemical and of the 99 identified chemical groups, flavonoids and glucosinolates were the most frequent. A wide range of pest and plant species were identified. …”
Get full text

Behavioral Study of Parkinson's Disease Rats Model with DigiGait^TM Imaging System by LIU Xinhao, MA Shujie, DING Daofang, LUO Kailiang, MA Xinran, JIANG Wenling, HU Jun

“…But stride length of right paws and overlap distance of left and right paws in the model group had no significant changes (<italic>P</italic>&gt;0.05). 3) Postural subcomponent: compared with the normal group and the sham operation group, the contact area of left front paw, left hind paw and right hind paw with running belt in the model group significantly decreased (<italic>P</italic>&lt;0.05), there was no significant difference in paw area, paw angle and gait angle between the right front paw and the running belt (<italic>P</italic>&gt;0.05).ConclusionDigiGait^TM Imaging System can objectively evaluate walking, balance and coordination functions of PD rats, which has the potential to be widely applied in PD related basic research.…”
Get full text

Efficacy of Moringa oleifera Seed Husk as Adsorptive Agent for Trihalomethanes from a Water Treatment Plant in Southwestern, Nigeria by Aderonke Adetutu Okoya, Olasunkanmi Olalekan Olaiya, Abimbola Bankole Akinyele, Nnenneh Oruada Ochor

“…Moringa oleifera (MO) has found wide acceptance by many people in Nigeria who have used it for food for both humans and fauna, for health purposes, and as a coagulant for water treatment. …”
Get full text

A China dataset of soil properties for land surface modelling (version 2, CSDLv2) by G. Shi, W. Sun, W. Shangguan, Z. Wei, H. Yuan, L. Li, X. Sun, Y. Zhang, H. Liang, D. Li, F. Huang, Q. Li, Q. Li, Y. Dai

“…The prediction accuracy of soil properties at all depth intervals ranged from good to moderate, with median model efficiency coefficients for most soil properties ranging from 0.29 to 0.70 during data-splitting validation and from 0.25 to 0.84 during independent-sample validation. The wide range between the 5 % lower and 95 % upper prediction limits may indicate substantial room for improvement in current predictions. …”
Get full text