RETRACTED ARTICLE: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Sna... by Yaodong Zhu, Yanqing Liu, Yayun Qian, Xiaojun Dai, Ling Yang, Jue Chen, Shiyu Guo, Tadashi Hisamitsu

“…In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cells has not been investigated so far. …”
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Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy by Defa Huang, Fangfang Xie, Shengpeng Xiao, Minyang Cai, Die Hu, Baodian Ling, Fangsheng Wang, Xuan Lin, Fangli Song, Qi Wang, Tianyu Zhong

“…Abstract Warfarin is the most widely used oral anticoagulant in clinical practice. …”
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Mixed Comparative Evaluation of a Training Program Dedicated to Cystic Fibrosis Reference Centers: Protocol for the Pilot Implementation of Shared Decision-Making in the Treatment... by Nora Moumjid, Constance Gotte, Sophie Hommey, Stéphanie Poupon Bourdy, Julie Haesebaert, Isabelle Durieu, Quitterie Reynaud

“…ConclusionsOur study will give us keys to adapt, improve, and disseminate SDM more widely in the context of cystic fibrosis therapy. …”
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Kelainan Hati akibat Penggunaan Antipiretik by Yusri Dianne Jurnalis, Yorva Sayoeti, Marlia Moriska

“…Recently, the use of combination acetaminophen-ibuprofen was widely use in child. The objective of this artikel was to learn more about how about antipyretics induced hepatotoxicity. …”
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Role and contribution of the nurse in caring for patients with palliative care needs: A scoping review. by Sue Moran, Maria E Bailey, Owen Doody

“…<h4>Conclusion</h4>Nurses in palliative care engage in a wide range of roles and responsibilities in caring for patients and their families with palliative care needs. …”
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Validity and reliability International Classification of Diseases-10 codes for all forms of injury: A systematic review. by Sarah Paleczny, Nosakhare Osagie, Jai Sethi, Michael Cusimano

“…International Classification of Diseases (ICD), Tenth Revision (ICD-10) codes are used to classify injuries in administrative health data and are widely used for health care planning and delivery, research, and policy. …”
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Performance of Sisal Fabre as Natural Geotextile to Reinforce Soil Layers on Unpaved Road. by Kyomugasho, Lilian

“…And sisal fibre is the one of the most widely used natural fibre and is very easily cultivated. …”
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Investigating a Suitable Ratio of Iron Ore Tailings and Quarry Dust in Concrete Production. by Kasozi, Mark

“…Concrete is the most widely used construction material, man consumes no material except water in such a tremendous quantity. …”
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¬¬Effect of Soil and Moisture Conservation Technologies on Growth and Grain Yields of Climbing Beans in Lake Mulehe Sub-catchment South-Western Uganda. by Kushaba, Laban Katende

“…Given the high adoption of mulching as a soil and moisture conservation technology and its significant benefits in improving soil pH, organic matter, and phosphorus availability, should be widely promoted in the production of climbing beans.…”
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Gamified Web-Delivered Attentional Bias Modification Training for Adults With Chronic Pain: Randomized, Double-Blind, Placebo-Controlled Trial by Julie F Vermeir, Melanie J White, Daniel Johnson, Geert Crombez, Dimitri M L Van Ryckeghem

“…MethodsA final sample of 129 adults with chronic musculoskeletal pain, recruited from clinical (hospital outpatient waiting list) and nonclinical (wider community) settings, were included in this randomized, double-blind, placebo-controlled, 3-arm trial. …”
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Application of Kansei Engineering in Various Train Compartment Designs to Determine the User's Affective Response by Dinda Karina Yohanny, Lu'Lu' Purwaningrum, Ambar Mulyono

“…This research is expected to be helpful for the wider community and the development of the interior design of train compartments. …”
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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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GravIS: mass anomaly products from satellite gravimetry by C. Dahle, E. Boergens, I. Sasgen, I. Sasgen, T. Döhne, S. Reißland, H. Dobslaw, V. Klemann, M. Murböck, M. Murböck, R. König, R. König, R. Dill, M. Sips, U. Sylla, A. Groh, M. Horwath, F. Flechtner, F. Flechtner

“…Together with GFZ's complementary information portal <span class="uri">https://www.globalwaterstorage.info/</span> (last access: 21 January 2025), GravIS supports widening the dissemination of knowledge about satellite gravimetry in science and society and highlights the significance and contributions of the GRACE/-FO missions for understanding changes in the climate system.…”
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Reims/Durocortorum, ville gauloise ? Hypothèses pour une nouvelle problématique des origines de l’agglomération by Robert Neiss

“…The layout of the most important one, with its much wider and deeper outline, would not have been polygonal, but rather circular and would have belonged to a Gallic period rampart. …”
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Une pompe hydraulique romaine en bois en contexte d’incendie à Reims/Durocortorum by Cyril Driard

“…The largest is oriented northeast/southeast and is 5 m wide. It runs perpendicular to a lane heading towards the decumanus maximus. …”
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Scrutinizing Generation Z's Interpretation of Social Justice: A Case Study in Khomeinishahr, Iran by Akbar Zareshahabadi, Alireza Asgari, Reza Javadian

“…Discussion of Results & Conclusion The findings revealed that Generation Z faced a wide range of discriminatory experiences across various contexts. …”
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Progress in phase field research of dead lithium in lithium batteries by Jing LIU, Huiyi CHEN, Huiyu LIU, Shu LI

“…These problems considerably reduce the Coulomb efficiency and service life of lithium metal batteries and constitute a substantial obstacle to the development and wide application of lithium metal batteries. Lithium dendrites are tree-like structures formed by uneven lithium deposition during the charging of lithium metal. …”
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A Mindfulness-Based App Intervention for Pregnant Women: Qualitative Evaluation of a Prototype Using Multiple Case Studies by Silvia Rizzi, Maria Chiara Pavesi, Alessia Moser, Francesca Paolazzi, Michele Marchesoni, Stefania Poggianella, Erik Gadotti, Stefano Forti

“…ObjectiveThis study aimed to develop a mindfulness-based well-being intervention for all pregnant women that can be delivered electronically and guided by an online assistant with wide reach and dissemination. This paper aimed to describe a prototype technology-based mindfulness intervention’s design and development process for pregnant women, including the exploration phase, intervention content development, and iterative software development (including design, development, and formative evaluation of paper and low-fidelity prototypes). …”
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Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study by Yaqin Peng, Ruijie Xie, Yifeng Luo, Yifeng Luo, Yifeng Luo, Penghao Guo, Zhongwen Wu, Yili Chen, Pingjuan Liu, Jiankai Deng, Bin Huang, Kang Liao

“…BackgroundThough droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with discrepant diagnostic performance. …”
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Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Cont... by Myriam Rahmouni, Sigrid Le Clerc, Jean-Louis Spadoni, Taoufik Labib, Maxime Tison, Raissa Medina-Santos, Armand Bensussan, Ryad Tamouza, Jean-François Deleuze, Jean-François Zagury

“…Abstract Introduction We have reanalyzed the genomic data from the International Collaboration for the Genomics of HIV (ICGH), focusing on HIV-1 Elite Controllers (EC). Methods A genome-wide association study (GWAS) was performed, comparing 543 HIV-1 EC individuals with 3,272 uninfected controls (CTR) of European ancestry. 8 million single nucleotide polymorphisms (SNPs) and HLA class I and class II gene alleles were imputed to compare EC and CTR. …”
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