Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework. by Máté Mohácsi, Márk Patrik Török, Sára Sáray, Luca Tar, Gábor Farkas, Szabolcs Káli

“…To address these issues, we developed a generic platform (called Neuroptimus) that allows users to set up neural parameter optimization tasks via a graphical interface, and to solve these tasks using a wide selection of state-of-the-art parameter search methods implemented by five different Python packages. …”
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The Mediation of Circulating Inflammatory Proteins in the Causal Pathway from Immune Cells to COPD by Yan K, Wang Y, Xin P

“…The objective of this study was to ascertain the causal relationship between immune cells and COPD and to quantify the potential role of circulating inflammatory proteins as mediators.Methods: A two-sample Mendelian randomisation analysis was conducted involving 731 immune cells, 91 inflammatory proteins and COPD, utilising summary-level data from genome-wide association studies. The causal relationships between immune cells, inflammatory proteins and COPD were sequentially analysed by multivariate Mendelian randomisation and validated using Bayesian weighted Mendelian randomisation. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Ethnopharmacological studies revealed that the leaves and stems of Mimosa pudica L. (Fabaceae) are widely used for the treatment of epilepsy. This study sought to investigate the effects of the aqueous extract of Mimosa pudica leaves and stems against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy in mice and its implication on oxidative/nitrosative stress, GABAergic/cholinergic signalling, and brain-derived neurotrophic factor (BDNF) expression. …”
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Towards implementing new payment models for the reimbursement of high-cost, curative therapies in Europe: insights from semi-structured interviews by Thomas Desmet, Thomas Desmet, Sissel Michelsen, Sissel Michelsen, Elena Van den Brande, Walter Van Dyck, Steven Simoens, Isabelle Huys

“…Due to the complex nature of ATMPs, new payment models and reimbursement modalities are proposed yet not widely applied across Europe.ObjectivesThis study aimed to elicit opinions on and insights into the governance aspect of implementing outcome-based spread payments (OBSP) in Belgium for the reimbursement of innovative therapies. …”
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Plant genetic resources in India: management and utilization by K. Singh, K. Gupta, V. Tyagi, S. Rajkumar

“…Presently, our focus is on characterization of ex situ conserved germplasm and detailed evaluation of prioritized crops for enhanced utilization; assessment of impact of on-farm conservation practices on genetic diversity; genome-wide association mapping for identification of novel genes and alleles for enhanced utilization of PGR; identification and deployment of germplasm/landraces using climate analog data; validation of trait-specific introduced germplasm for enhanced utilization.…”
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Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction by Chilukuri Balaji, Mahendran Bhuvanesh, Chinnadurai Saranya, Ramamoorthy Ramesh, Mayilsamy Saravanan, Sankaralingam Rajeswari

“…However, the role of H. pylori in SSc has not been widely reported. The objective of the study was to estimate the prevalence of H. pylori infection in SSc patients and analyze its clinical associations. …”
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Medicinal plants used to treat human ailments in Wadla District, Northern Ethiopia: An ethnobotanical approach by Sara Yosef, Ermias Lulekal, Asfaw Debela, Muhidin Tahir

“…Conclusion: This study revealed that the study area has a considerable number of traditional medicinal plants that are used to address a wide range of health problems. Although community members rely on medicinal plant species to manage various health problems, they threaten medicinal plants in the country, and indigenous knowledge is rapidly vanishing from communities; thus, conservation measures should be taken to protect these plants in their natural sites, agricultural areas and villages.…”
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SUGGESTOPEDIA AS THE METHOD OF THE MUSIC EXPERIENCE FORMATION OF PRE-SCHOOL CHILDREN by Natalya T. Таgiltseva, Filip D. Shavov

“…The research findings and developed diagnostic tasks can become widely used in practical activities of starting schools.…”
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Response characteristics and particle contributions of epoxy resin composite embedded with Al particles under different loading modes by Zhenhui He, Enling Tang, Wenjin Yao, Ruizhi Wang

“…Particle reinforced epoxy resin composites are widely used in aerospace, military defense, electronics industry and other fields because their mechanical strength, electromagnetic shielding effect and thermal stability can be controlled by adding different forms of particles. …”
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The outcome of trachomatous trichiasis surgery in Ethiopia: risk factors for recurrence. by Saul N Rajak, Esmael Habtamu, Helen A Weiss, Amir B Kello, Bayeh Abera, Mulat Zerihun, Teshome Gebre, Clare E Gilbert, Peng T Khaw, Paul M Emerson, Matthew J Burton

“…We investigated the outcomes (recurrence rates and other complications) of posterior lamellar tarsal rotation (PLTR) surgery, one of the two most widely practised TT procedures in endemic settings.…”
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The role of the KIBRA and APOE genes in developing spatial abilities in humans by A. V. Kazantseva, R. F. Enikeeva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, M. M. Lobaskova, T. N. Tikhomirova, E. K. Khusnutdinova

“…According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. …”
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Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity by Stefanie Hoffmann, Philip Hewitt, Isabel Koscielski, Dorota Kurek, Wouter Strijker, Kinga Kosim

“…These connections are responsible for the maintenance of intestinal homeostasis and can be used as a specific safety endpoint, by measuring the Trans Epithelial Electrical Resistance (TEER), for the investigation of drug-induced GI toxicity. Compared to a widely used Caco-2 cell 2D Transwell model, the advanced MPS model (Mimetas OrganoPlate®) allows for the recapitulation of the enterocyte cell layer of the intestinal barrier as the Caco-2 cells grow in a tubular structure through which the medium continuously flows.MethodsThe OrganoPlate® intestinal model was qualified to be implemented as a routine test system for the early prediction of drug-induced GI toxicity based on the measurement of the tightness of the cell layer by measuring changes in the TEER. …”
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APPLICATION OF OPTICAL CHARACTER RECOGNITION AND MACHINE LEARNING TECHNOLOGIES TO CREATE AN INFORMATION SYSTEM FOR AUTOMATIC VERIFICATION OF OFFLINE TESTING by Vadym Ziuziun, Nikita Petrenko

“…The scientific novelty lies in integrating machine learning algorithms with modified image processing algorithms to create a system capable of analyzing and grading a wide range of offline test tasks, including open-ended, closed-ended, sequence identification, and multiple-correct-answer questions. …”
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Combination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel,... by Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang, Jie Li

“…Compound Kushen injection (CKI) is one of the representative drugs of anti-cancer Chinese herbal injection drugs, which has been widely used in the adjunct treatment of cancer in China. …”
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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

“…IntroductionInterleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as a therapeutic agent for diseases, including myocardial infarction (MI). …”
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Can the botanical azadirachtin replace phased-out soil insecticides in suppressing the soil insect pest Diabrotica virgifera virgifera? by Stefan Toepfer, Szabolcs Toth, Mark Szalai

“…We investigated whether the less problematic botanical azadirachtin, widely used against above-ground insects, could become an option for the control of this soil insect pest. …”
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Association between nutritional inflammation index and diabetic foot ulcers: a population-based study by Zhou Lin, Wanli Zhuang, Lei Wang, Weifeng Lan

“…Given the components of ANLR were widely used and readily available in clinical settings, their future clinical applications hold great potential.…”
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Are We Overlooking Anatomical Contributions to Dynamic Knee Valgus? by Matt Dewald, Madison Andersen, Laura Higgins, Emma Porter, Alex Wickersham

“…# Background Dynamic knee valgus (DKV) is widely considered a risk factor for injuries, despite contradictory research. …”
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Analytical and diagnostic performance characteristics of reverse-transcriptase loop-mediated isothermal amplification assays for dengue virus serotypes 1-4: A scoping review to inf... by Paul Arkell, Dumrong Mairiang, Adisak Songjaeng, Kenny Malpartida-Cardenas, Kerri Hill-Cawthorne, Panisadee Avirutnan, Pantelis Georgiou, Alison Holmes, Jesus Rodriguez-Manzano

“…When evaluated, diagnostic performance was also high, though reference diagnostic criteria varied widely, prohibiting comparison between assays. Fourteen studies using previously described assays were identified, including those where reagents were lyophilised or 'printed' into microfluidic channels and where several novel detection methods were used. …”
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Genomic signatures of selection in Brangus cattle revealing the genetic foundations of adaptability and production traits using a breed of origin approach by Gabriel A. Zayas, Raluca G. Mateescu

“…BOA was estimated in these herds using LAMP-LD, followed by a signature of selection analysis utilizing a median-based Z-score approach and Fst analyses to detect genomic regions under selection.ResultsThe analysis revealed a genome-wide increase in Angus ancestry in both Brangus populations (71.46%, 68.7%), reflecting intense selection for traits associated with this lineage. …”
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