Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation by Douglas W. Barrett, Christopher G. Beevers, F. Gonzalez-Lima

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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Exogenous Interleukin-37 Alleviates Hepatitis with Reduced Dendritic Cells and Induced Regulatory T Cells in Acute Murine Cytomegalovirus Infection by Yufei Ruan, Zhengwang Wen, Ke Chen, Jianan Xi, Bo Wu, Zhiyong Xu, Minzhi Jiang, Junling Zhang, Yiping Chen, Qi Liu

“…The present study suggested that exogenous IL-37 can alleviate MCMV-infected hepatitis, likely through reduced DCs and induced Tregs with a weaker cytokine storm, demonstrating its potential value in clinical management for HCMV-infected hepatitis.…”
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Influences of Different Preparation Conditions on Catalytic Activity of Ag2O-Co3O4/γ-Al2O3 for Hydrogenation of Coal Pyrolysis by Lei Zhang, Sha Xiang-ling, Lei Zhang, Wang Rui, Zhang Lixin, Shu Xinqian

“…The results showed the following: (1) at the same preparation condition, when silver loading was 8%, the Ag2O-Co3O4/γ-Al2O3 showed higher catalyst activity, (2) the catalyst activity had obviously improved when the cobalt loading was 8%, while it was weaker at loadings 5% and 10%, (3) the catalyst activity was influenced by different calcination temperatures of silver, but the influences were not marked, (4) the catalyst activity can be influenced by calcination time of silver, (5) different calcination times of cobalt can also influence the catalyst activity of Ag2O-Co3O4/γ-Al2O3, and (6) the best preparation conditions of the Ag2O-Co3O4/γ-Al2O3 were silver loading of 8%, calcination temperature of silver of 450°C, and calcinations time of silver of 4 h, while at the same time the cobalt loading was 8%, the calcination temperature of cobalt was 450°C, and calcination time of cobalt was 4 h.…”
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Bulgarian tourism and the problem of poverty alleviation in Bulgaria by Preslav Mihaylov Dimitrov, Rouska Kraseta, Boiko Dimitrov

“…These two sub-questions, these two issues, have been chosen deliberately as the usual excuse of the representatives of the Bulgarian tourism industry for the much weaker results in comparison to the neighboring competing countries is that the tourists who come usually to Bulgaria from Western Europe are poorer. …”
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A Novel Fuzzy Structure: Infra-Fuzzy Topological Spaces by Zanyar A. Ameen, Tareq M. Al-shami, A. A. Azzam, Abdelwaheb Mhemdi

“…Obtaining a weaker condition that preserves some inspired topological properties is always desirable. …”
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Financial contagion in the US, European and Chinese stock markets during global shocks by Marina Yu. Malkina

“…During the 2021 energy crisis and SMO, there was strong and relatively long-lasting contagion of the S&P 500 from the STOXX 600 and their much weaker contagion from the SSE Composite Index. The findings may be useful for stock market players in managing investment portfolios, and for the state in formulating financial stabilisation policies during the impact of global shocks.…”
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Posterior reversible encephalopathy syndrome related to severe hypomagnesaemia by Martín Naya Rosato, María Luisa Núñez Calvo, Lucía Barrera López

“…It is suggested that rapid increases in blood pressure are thought to overwhelm the self-regulatory capability of cerebral blood flow, especially in the posterior brain regions where the regulatory flow capacity may be weaker. This might result in increased cerebral perfusion leading to oedema due to capillary leakage. …”
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Dual Jet Interaction, Magnetically Arrested Flows, and Flares in Accreting Binary Black Holes by Sean M. Ressler, Luciano Combi, Bart Ripperda, Elias R. Most

“…However, simulations with black hole spins misaligned with the orbital plane and simulations with larger Bondi radii saturate at lower values of horizon-penetrating magnetic flux than standard magnetically arrested disks, leading to weaker, intermittent jets owing to feedback from the weak jets or equatorial flux tubes ejected by reconnecting field lines near the horizon.…”
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PYROSEQUENCING: ITS POTENTIAL AND LIMITATIONS IN DIAGNOSIS OF INHERITED DISEASES IN CATTLE by Н. A. Kirsanova, A. V. Sukhoedova, M. A. Pleskacheva, I. V. Soltynskaya, I. A. Timofeeva, О. V. Prasolova, E. V. Krylova

“…Such mutations are associated with leukocyte adhesion defi ciency, complex vertebral malformation, uridine monophosphate synthetase defi ciency, citrullinemia, spinal muscular atrophy, spinal cord demyelination, Brown Swiss haplotype 2, Weaver syndrome, developmental duplications, α-mannosidosis, dwarfi sm, bovine male subfertility, trombocytopathya, arachnomelia syndrome, hypozincemia-like syndrome. …”
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Dark Galactic Subhalos and the Gaia Snail by Daniel Gilman, Jo Bovy, Neige Frankel, Andrew Benson

“…Perturbations caused by dark subhalos are, on average, orders of magnitude weaker than those caused by luminous satellite galaxies, but the ubiquity of dark halos predicted by cold dark matter makes them a more probable source of strong perturbation to the dynamics of the solar neighborhood. …”
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Calibration of Swarm Plasma Densities Overestimation Using Neural Networks by Artem Smirnov, Yuri Shprits, Hermann Lühr, Alessio Pignalberi, Chao Xiong

“…During solstices, the crests are more pronounced in the local winter hemispheres, while during equinoxes the crests are weaker and exhibit hemispheric symmetry. This morphology aligns with the presence of light ions diffusing downward from the plasmasphere. …”
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Impact Angle Control of Local Intense dB/dt Variations During Shock‐Induced Substorms by Denny M. Oliveira, James M. Weygand, Eftyhia Zesta, Chigomezyo M. Ngwira, Michael D. Hartinger, Zhonghua Xu, Barbara L. Giles, Daniel J. Gershman, Marcos V. D. Silveira, Vítor M. Souza

“…Strong field‐aligned currents computed with the spherical elementary current system (SECS) technique occur in both cases, but the current variations resulting from the inclined shock impact are weaker and slower compared to the nearly frontal case. …”
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Real‐Time Detection, Location, and Measurement of Geoeffective Stellar Flares From Global Navigation Satellite System Data: New Technique and Case Studies by Manuel Hernández‐Pajares, David Moreno‐Borràs

“…In this work we generalize GSFLAI for the very challenging scenario of stellar superflares, with a much weaker expected geoeffectiveness on the Earth ionosphere, making it difficult to distinguish its potential footprint regarding conventional ionospheric variability sources. …”
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Contradiction in the Poems of Mikhail Lermontov by Marzieh Yahyapour, Janolah Karimi Motahhar, Masoumeh Mirzaie

“…They represent and express the spirit of the seeker, the religious beliefs and the true form of worship of a religious person, and the mystical spirit of the poet is expressed in them. …”
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Transient Characteristics and Operation Regulation of Grid‐Connected Variable Speed Pumped Storage‐Wind‐Solar Hybrid Power System by Yanhao Li, Fanchao Song, Wencheng Guo

“…The effect of the parameters for the control links of frequency converter on the regulation quality of grid‐connected VSPS‐wind‐solar HPS is weaker than that of governor.…”
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Dry eye disease in keratoconus: etiology and medical treatment by V.V. Averich

“…In the lack of the effect of tear substitutes or in rigid gas permeable contact lens wearers, gel-based dexpanthenol in high concentrations is recommended. …”
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Historical-pedagogical perspective of intellectual disability across the world and in Serbia by Đurić Zdravković Aleksandra A.

“…Teodor Janković Mirijevski was the first Serbian pedagogist whose school reform legally enabled students categorized as "weaker learners" to participate in school activities on an equal basis with other students. …”
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Molecular simulation study of CO2 and O2 adsorption characteristics and diffusion pattern in coal body at atmospheric pressure by JIA Tinggui, WU Xingyu, QU Guona

“…With increasing pressure, the adsorption selectivity coefficient of CO2 decreases from 7.67 to 3.69. ③ The adsorption of O2 is weaker than that of CO2, and the diffusion of O2 shows a decreasing trend, while the diffusion of CO2 shows an increasing trend. …”
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The opportunities and risks of mobile phones for refugees' experience: A scoping review. by Tiziana Mancini, Federica Sibilla, Dimitris Argiropoulos, Michele Rossi, Marina Everri

“…The results showed that modern devices, such as mobile phones, bring both risks and opportunities for refugees' experience, thereby both favouring and threatening asylum seekers' and refugees' human rights. Recommendations to policymaking and services and associations for advancing the use of MPs for the protection of the rights of migrants have been proposed.…”
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