The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications by Carlos Andrés Coy-Barrera, Laura Galvis, Maria Juliana Rueda, Sergio Alejandro Torres-Cortés

“…This demonstrates that species of this genus possess potential for various medicinal applications and serve as a source of chemical compounds that could become active principles of phytotherapeutics with significant results.It is evident that this type of compound has variety concerning oxygen substituents, which may provide information of interest for future studies on structure-activity relationships and offer alternatives of natural origin that can be evaluated against related organisms to demonstrate the pharmacological potential found in the literature. …”
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Patellofemoral Joint Loading During the Performance of the Forward and Side Lunge with Step Height Variations by Rafael Escamilla, Naiquan Zheng, Toran D MacLeod, Rodney Imamura, Kevin E. Wilk, Shangcheng Wang, Irv Rubenstein, Kyle Yamashiro, Glenn S. Fleisig

“… # Hypothesis/Purpose The purpose was to quantify, via calculated estimates, patellofemoral force and stress between two lunge type variations (forward lunge versus side lunge) and between two step height variations (ground level versus 10 cm platform). …”
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Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis by Haoyuan Lyu, Na Fan, Hao Wen, Xin Zhang, Herong Mao, Qinglai Bian, Jiaxu Chen

“…Conclusions Our study presents strong evidence of the complex interconnection between BMI, neutrophils, triglyceride, and UA, revealing complex causal links and highlighting potential inflammatory states as key mediators. …”
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Entrepreneurial Budgeting in the Iranian Government Budget: Obstacles and Solutions by Seyyed Mohammad Moghimi, Alireza Salmanian

“…In return for this significant trust in government managers, it is expected that they provide evidence of success in their achievements based on their performance outcomes. …”
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IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells by Li Cheng, Yang Jiao, Wei Jiang, Xin Zhang, Liping Zhang, Gongwei Jia

“…Dendritic cells (DCs) can regulate the differentiation of CD4+ T cells, including Th17 and Treg cells. Recent evidence revealed that interleukin-33 (IL-33) signaling could activate and mature DCs. …”
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5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus by Nisreen O. Mohammed, Ibtisam A. Ali, Bahaelddin K. Elamin, Bakri Osman Saeed

“…We enrolled 226 Sudanese patients with T2DM, age range 25-60 years, recruited from Alshaab and Omdurman teaching hospitals in Khartoum State. 113 patients had CAD confirmed by angiography and electrocardiography (ECG) and 113 had no evidence of CAD. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), using Hinf1 restriction enzyme, were used to determine MTHFR genotypes. …”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…This meta-analysis provides evidence for further exploration and application of NIT in non-metastatic pMMR/MSS RC and highlights the potential for organ preservation with this approach. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Yue Wang,1– 5 Jiang Fang,1– 5 Qiang Yuan,1– 5 Jian Yu,1– 5 Jin Hu1– 5 1Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 2National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 3Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 4Neurosurgical Institute of Fudan University, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 5Shanghai Clinical Medical Center of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of ChinaCorrespondence: Jian Yu; Jin Hu, Department of Neurosurgery, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, People’s Republic of China, Tel +86 21 52889999, Email hujin@fudan.edu.cn; lance2000@hotmail.comBackground: Traumatic brain injury (TBI) is a prevalent neurological disorder associated with significant public health burdens and long-term risks, including neurodegenerative diseases such as Parkinson’s disease (PD). Emerging evidence suggests a strong link between moderate to severe TBI and an elevated risk of PD, though the underlying mechanisms remain poorly understood.Materials and Methods: Common differentially expressed genes (DEGs) were identified in GEO datasets of patients with traumatic brain injury (TBI) and Parkinson’s disease (PD). …”
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Regional Differences of Digital Rural Construction in China and Driving Factors by Zeng Yongming, Zhong Zikang

“…In addition, the four sub-dimensional indexes—rural digital infrastructure, rural economic digitalization, rural governance digitalization, and rural life digitalization—show evident spatial differentiation characteristics, with the "Hu Huanyong Line" as the boundary. 3) Regarding mechanism, the spatial panel model was used to verify that government functions, economic foundations, digital foundations, and human capital were important driving factors for the construction of county-level digital rural areas. …”
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Understanding Human Papillomavirus Vaccination Hesitancy in Japan Using Social Media: Content Analysis by Junyu Liu, Qian Niu, Momoko Nagai-Tanima, Tomoki Aoyama

“…Addressing misinformation, reducing complacency, and enhancing vaccine accessibility are key strategies for improving vaccine uptake. Some evidence suggests that confidence in one vaccine may positively influence perceptions of other vaccines. …”
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Posteromedial opening wedge high tibial osteotomy has favourable outcomes in simultaneous medial meniscus posterior root repair and varus medial knee osteoarthritis patients withou... by Ali Engin Dastan, Elcil Kaya Bicer, Huseyin Kaya, Mehmet Argin, Emin Taskiran

“…Conclusions PMOWHTO has favourable clinical and radiological outcomes and prevents PTS increase in simultaneous MMPRT repair and varus medial knee osteoarthritis patients without concomitant root tear. Level of evidence Level IV, case series.…”
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Patterns of Comorbidity and Multimorbidity Among Patients With Multiple Sclerosis in a Large US Commercially Insured and Medicare Advantage Population by Dingwei Dai, Ajay Sharma, Amy L. Phillips, Carroline Lobo

“…**Background:** Comorbidities are common in patients with multiple sclerosis (MS), thus increasing the complexity of disease management and economic burden and worsening their prognosis and quality of life. Real-world evidence comparing comorbidities and multimorbidity patterns of commercially insured vs Medicare enrollees with MS is lacking. …”
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Assessing the Impact of a Virtual Reality Cognitive Intervention on Tennis Performance in Junior Tennis Players: Pilot Study by Joaquin A Anguera, Aleem Choudhry, Michael Seaman, Dominick Fedele

“… BackgroundThere is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. …”
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Aproximación al manejo del ureterocele y los desenlaces clínicos en la población pediátrica: una revisión sistemática by Ana Ma. Ortiz-Zableh, Diana L. Garzón-Correa, Andrés F. Quiñones-Roa, Ana I. López, Camila Pérez, Eliana Calderón, Víctor H. Figueroa-Arenas, Paul A. Camacho

“…Los pacientes con reflujo vesicoureteral (RVU) postoperatorio mostraron una mejoría posterior al tratamiento con una odds ratio de 0,24; se evidenció una gran heterogeneidad entre los estudios (I2: 85%; p < 0,001). …”
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Digital health interventions for improving access to primary care in India: A scoping review. by Lenny Vasanthan, Sindhu Kulandaipalayam Natarajan, Andrew Babu, Mohan S Kamath, Sureshkumar Kamalakannan

“…Such a strategy could address the paucity of evidence in public health interventions and provide sustainable strategies to strengthen health systems in India. …”
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The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis by Melsew Setegn Alie, Getayeneh Antehunegn Tesema, Getayeneh Antehunegn Tesema, Gossa Fetene Abebe, Desalegn Girma

“…While numerous studies have been conducted on the long-term effects of COVID-19, our systematic review, and meta-analysis, is the first of its kind in sub-Saharan Africa, providing a comprehensive understanding of the situation in the region and highlighting the necessity for continuous clinical management.ObjectiveThis study aimed to systematically synthesize evidence on the persistent sequelae of COVID-19 and their predictors in sub-Saharan Africa.MethodsA thorough search was conducted across multiple databases, including PubMed/MEDLINE, Web of Science, Google/Google Scholar, African online journals, and selected reference lists, from the inception of these databases until January 12, 2024. …”
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Assessment in education: Current trends, problems and contradictions (review of scientific publications) by I. B. Shmigirilova, A. S. Rvanova, O. V. Grigorenko

“…This process is accompanied by a rapid increase in the volume of scientific and methodological publications on this issue, reducing the ability of scientists and practising educators to comprehend the cumulative evidence in this area of research, which is important at the stage of reform. …”
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Significance of Heparin-Binding Protein and D-dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis by Tomasz Mikuła, Mariusz Sapuła, Joanna Jabłońska, Joanna Kozłowska, Wojciech Stańczak, Dagny Krankowska, Alicja Wiercińska-Drapało

“…After the peritoneal tap, 31 patients were determined to have SBP (defined as an ascitic fluid polymorphonuclear count > 250 cells/μL) and 32 patients had no evidence of SBP on peritoneal tap. A very weak, but statistically significant, correlation of HBP, WBC, and D-dimer levels with the peritoneal fluid polymorphonuclear (PMN) count was observed in the simple regression model, but multivariable analysis using the multiple regression model showed that only D-dimers correlated with peritoneal fluid PMNs independently from other inflammation biomarkers. …”
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OPTIMIZATION PROBLEM FOR NUMBER OF LOGIC GATES NEEDED TO IMPLEMENT MULTIPLE BOOLEAN FUNCTIONS USING DECODER by M. Onai, H. Skopyk

“…This way, LE outputs can be used in more than one function, which results in reduction of total number of LEs. It becomes evident that the problem can be restated in terms of sets. …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Interpretation: We found evidence of racial and ethnic disparities in mortality for children diagnosed with community-acquired pneumonia. …”
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