Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…There is increasing evidence for involvement of the immune system in this disease. …”
Get full text

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Genetic and other preclinical evidence suggest a relationship between retinal degeneration and inflammation. …”
Get full text

The analgesic effects of quadratus lumborum block versus caudal block for pediatric patients undergoing abdominal surgery: a systematic review and meta-analysis by Yu Zhu, Jin Wu, Shenglong Qu, Peng Jiang, Chetan Bohara, Chetan Bohara, Yi Li

“…Other secondary outcome measures were the time of first rescue analgesia, the incidence of PONV, and the incidence of postoperative complications, such as post-block infection, anaphylaxis to local anesthesia and hematoma.Evidence reviewWe systematically reviewed Pubmed, Central, EMBASE, Google Scholar, Web of Science citation index, the US clinical trials register, and abstracts for randomized controlled trials that compared these blocks and reported the rate of postoperative rescue analgesia.FindingsSeven RCTs (444 patients) were included in the final analysis. …”
Get full text

Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions by J.A. Fischer, W. Born, R. Muff

“…Some cross-reaction between the CGRP receptor and AM was evident whereas amylin and CT were only recognized at over 10-7 M. …”
Get full text

Evaluation of an Interdisciplinary Educational Program to Foster Learning Health Systems: Education Evaluation by Sathana Dushyanthen, Nadia Izzati Zamri, Wendy Chapman, Daniel Capurro, Kayley Lyons

“…Further, they undertook voluntary weekly surveys to provide feedback on which aspects to continue and recommendations for improvements, via free-text responses. ResultsFrom the evaluation, it was evident that participants found the teaching model engaging, useful, valuable, and applicable to their work. …”
Get full text

Community disaster exposure and first onset of depression: A panel analysis of nationally representative South African data, 2008-2017. by Andrew Tomita, Busisiwe P Ncama, Yoshan Moodley, Rashieda Davids, Jonathan K Burns, Tafadzwanashe Mabhaudhi, Albert T Modi, Rob Slotow

“…Despite the potential danger of such cumulative community disaster exposure on mental health (e.g. depression), large-scale population-level evidence for the region is limited. We investigated the association between exposure to cumulative disaster and the first onset of depression in a nationally representative survey in South Africa. …”
Get full text

Comparing Optimal Portfolio Performance Based on Skew-Normal Distribution and Skew-Laplace-Normal Distribution: A Mean-Absolute Deviation-Entropy Approach by Hila Rezaei, Gholamhossien Golarzi, Omid Karimi

“…Additionally, upon analyzing the descriptive statistics of the symbols, it's evident that the kurtosis of most stock symbols is substantial. …”
Get full text

Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

“…Regardless, research on endometrial carcinoma tumorigenesis is scarce and no uniform, evidence-based gynaecological management guidelines exist. …”
Get full text

AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…However, chemotherapy resistance typically develops after an initial period of therapeutic efficacy. Increasing evidence indicates that cancer stem cells confer chemotherapy resistance via exosomes. …”
Get full text

Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…Through a comprehensive analysis of a polyherbal prescription dataset, we identified 18 key herbs and 16 significant combination rules, further supported by relevant preclinical evidence. These herbs and synergistic herbal combinations were anticipated to be the most pharmacologically influential in contributing to the meta-analysis outcomes, as substantiated by analytical metrics including network topology and intricate association pattern evaluations. …”
Get full text

Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

“…This current study’s results highlighted the significance of wildlife sanctuaries, which not only aid in wildlife preservation but also provide compelling evidence supporting forest management practices that promote the planting of multiple vegetation layers in landscape restoration as a means to enhance biodiversity and increase resilience to climate change. …”
Get full text

Guideline: Neurorehabilitation in patients with disorder of consciousness. Recommendations from the Spanish Society of Neurorehabilitation by E. Noé, M.D. Navarro, B. Moliner, M. O’Valle, J. Olaya, A. Maza, R. Llorens, J. Ferri, R. Rodríguez, T. Pérez, M. Bernabéu, C. Colomer, A. Gómez, C. González, A. Juárez-Belaúnde, C. López, S. Laxe, R. Pelayo, M. Ríos, I. Quemada, Enrique Noé Sebastián, María Dolores Navarro Pérez, Belén Moliner Muñoz, Myrtha O’Valle Rodríguez, José Olaya Sanchez, Roberto Llorens Rodríguez, Anny Maza Pino, Joan Ferri Campos, Rubén Rodríguez Duarte, Teresa Pérez Nieves, Montserrat Bernabeu, Carolina Colomer Font, Antonio Gómez Blanco, Carlos González Alted, Alan Juárez Belaúnde, Cristina López Pascua, Sara Laxe García, Raúl Pelayo Vergara, Marcos Ríos Lago, Ignacio Quemada

“…Conclusions: This document presents 40 recommendations categorised according to the level of evidence provided by the reviewed studies. These recommendations represent a consensus among experts and pertain to various aspects related to: 1) clinical assessment, 2) complementary diagnostic tests, 3) prognosis, and 4) treatment in this specific population. …”
Get full text

Electromyographic Characteristics of a Single Motion Shoulder Exercise: A Pilot Study Investigating a Novel Shoulder Exercise by Michael J Henehan, Tamar Brand-Perez, Jeffrey C Peng, Masaaki Tsuruike

“…Further evaluation of the clinical effectiveness of the single motion shoulder exercise is needed. # Level of Evidence Level 3b…”
Get full text

The global impact of COVID-19 on tuberculosis: A thematic scoping review, 2020-2023. by Michael H Marco, Sevim Ahmedov, Kenneth G Castro

“…The impact and lessons learned from the themed analysis propelled us to draft public health policy recommendations to direct evidence-informed guidance that strengthens comprehensive global responses, recovery for TB, and future airborne pandemic preparedness.…”
Get full text

Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing by Xinjian Jia, Hai Lei, Xuemei Jiang, Ying Yi, Xue Luo, Junyan Li, Yu Chen, Sha Liu, Chengcheng Yang

“…The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. …”
Get full text

Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…Additionally, triglyceride-lowering benefits were evident, particularly in metabolically compromised individuals (Cohorts 2 and 3), where these effects were statistically significant. …”
Get full text

Construction land transition in Qinghai-Tibet Plateau and its eco-environmental effects during 2000-2020 by ZHANG Zining, LUO Junqiang, ZHANG Peilei, RONG Han, LIU Haiyang, AN Shuang, CHANG Genying

“…Regional differences in land-use transitions were evident: the Northern Tibet Plateau and Qaidam Basin showed higher proportions of transitions to water bodies, water conservancy land, and unused land, while the expansion mainly occupied grasslands and unused land; in other regions, construction land predominantly shifted between cropland and grassland. (3) The <i>IRSEI</i> values of construction land in the regions of Qinghai-Tibet Plateau were ranked as follows: Sichuan-Tibet alpine canyon region &gt; Qilian Mountains region &gt; Southern Tibet valley region &gt; Qinghai Plateau &gt; Qaidam Basin &gt; Northern Tibet Plateau. (4) Overall, construction land transition demonstrated negative ecological effects. …”
Get full text

Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…In the low PD-L1 (TS &lt;50%) cohort, TMB &lt;20 muts/Mb showed a more favorable rwPFS (HR: 0.56 (95% CI: 0.40 to 0.79)) and rwOS (HR 0.74 (95% CI: 0.58 to 0.96)) on chemoICPI when compared with ICPI alone while the point estimate in rwPFS favored monoICPI in the TMB ≥20 muts/Mb cohort, the CI is wide and does not reach statistical significance (HR: 1.68 (95% CI: 0.52 to 5.48)).Conclusion This study provides evidence that higher TMB cut-offs, such as 20 muts/Mb, can identify patients with prolonged benefit from ICPI. …”
Get full text

Medical Arbitration (Arbitration Court) as an Alternative to Civil Courts in Medical Disputes by I. I. Bozhuk, I. V. Chekhovskaya

“…These include: simplified procedure and lack of evidence; lack of formal rules of conduct; free choice of mediator (arbitrator, mediator, consultant, etc.); confidentiality and secrecy in resolving the dispute; possibility of personal control of the course of the procedure; infinity in time; private (non-state) nature. …”
Get full text

Comprehensive approach to predictive analysis and anomaly detection for road crash fatalities by Chopparapu Gowthami, S. Kavitha

“…The findings open the door for evidence-based initiatives to lessen the effects of traffic accidents and save lives on our roads by utilizing data analytics and predictive modeling.…”
Get full text