Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with increasing incidence worldwide. Growing evidence highlights the pivotal role of nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into the subtype-specific molecular underpinnings and diagnostic potential of NAD+ metabolism-related genes (NMRGs).MethodsTranscriptome data from UC patients and healthy controls were downloaded from the GEO database, specifically GSE75214 and GSE87466. …”
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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma by Ga Ram Ahn, Hyung-Joon Park, Yu Jin Kim, Min Gyo Song, Hye Sung Han, Woo Geon Lee, Hyuck Ki Hong, Kwang Ho Yoo, Joon Seok, Kyu Back Lee, Beom Joon Kim

“…Recent studies have provided evidence that CAP can facilitate the delivery of large, hydrophilic molecules through the epidermis to the dermis. …”
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Interventions promoting recovery from depression for patients transitioning from outpatient mental health services to primary care: A scoping review. by Anne Sofie Aggestrup, Frederik Martiny, Line Lund Henriksen, Annette Sofie Davidsen, Klaus Martiny

“…This scoping review aimed to systematically map the evidence and identify knowledge gaps in interventions that aimed to promote recovery from MDD for patients transitioning from outpatient mental health services to primary care.…”
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Isokinetic Assessment of Knee Flexor and Extensor Strength and Lower Extremity Flexibility Assessment of an NCAA Division III Men’s Soccer Team by Savanna Perkins, Paul Canavan

“…The benefits of this research have direct implications, as participants received both their screening data and a set of exercises aimed to help decrease their injury risk, in addition to the offering data that is useful for determining what normative values for flexibility and strength profiles might look like for Division III male soccer players. # Level of Evidence Level 3…”
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The quality of judicial decisions in cases of bullying in professional educational institutions by O. G. Yushkevych

“…It has been highlighted that most judicial decisions contain an exhaustive list of evidence in the case; the courts comply with the requirement to find out whether an administrative offence has been committed, whether the person is guilty of committing it, whether he or she is subject to administrative liability, etc..…”
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Point of Care Ultrasound Guided Management of Lateral Ankle Sprains: A Case Series by Matthew Bush, Jon Umlauf, Bryan Pickens

“…The observations from this case series suggest that functional bracing strategies focused on ligamentous protection to promote healing and reduce re-injury rates does not delay improvement in functional outcomes. # Level of Evidence Level IV, Case Series…”
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Transjugular Intrahepatic Portosystemic Shunt Placement for Portal Hypertension: Meta-Analysis of Safety and Efficacy of 8 mm vs. 10 mm Stents by Jiangtao Liu, Eric Paul Wehrenberg-Klee, Emily D. Bethea, Raul N. Uppot, Kei Yamada, Suvranu Ganguli

“…We aim to provide meta-analysis-based evidence regarding the safety and efficacy of 8 mm vs. 10 mm stents during TIPS placement. …”
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Analyzing Land Use/Land Cover Changes Using Google Earth Engine and Random Forest Algorithm and Their Implications to the Management of Land Degradation in the Upper Tekeze Basin,... by Alemu Eshetu Fentaw, Assefa Abegaz

“…The observed changes showed the existing land degradation and the future vulnerability of the basin which would serve as an evidence to mitigate land degradation by avoiding the future conversion of forest, bushland, and shrubland to farmland, on the one hand, and by scaling up sustainable farmland management, and afforestation practices on degraded and vulnerable areas, on the other hand.…”
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Is it Time to Normalize Scapular Dyskinesis? The Incidence of Scapular Dyskinesis in Those With and Without Symptoms: a Systematic Review of the Literature by Paul A. Salamh, William J. Hanney, Trey Boles, Daniel Holmes, Alex McMillan, Austin Wagner, Morey J. Kolber

“…More revealing is the number of asymptomatic individuals who do present with SD, suggesting that SD may be a normal finding among nearly half of the asymptomatic population. # Level of Evidence 2a…”
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Your period and your pregnancy, a cohort study of pregnant patients investigating the associations between menstruation and birth outcomes in Australia: study protocol by Miranda Davies-Tuck, Billie Bradford, Adrienne Gordon, Beverley Vollenhoven, Kirsten Rebecca Palmer, Kirstin Tindal, Caroline E Gargett, Fiona Cousins, Stacey Ellery

“…Most stillbirths and approximately two-thirds of preterm births, however, occur in the absence of evident risk factors. The majority of stillbirths occur in the preterm period, yet there are few interventions targeting this period, and progress to reduce stillbirth rates remains slow. …”
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Development and assessment of a mortality risk prediction nomogram model for pneumocystis disease in ICU within 28 days by Yiru Weng, Tingting Zhou, Honghua Ye

“…Demonstrating robust discrimination and calibration, this tool provides clinicians with a valuable resource for assessing prognosis and making evidence-based treatment decisions.…”
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Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

“…This is particularly evident in low and middle-income countries (LMICs) where healthcare disparities exacerbate distress. …”
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Healthcare Resource Utilization and Cost Comparisons of High-Protein Enteral Nutrition Formulas Used in Critically Ill Patients by Matthew C. Bozeman, Laura L. Schott, Amarsinh M. Desai, Mary K. Miranowski, Dorothy L. Baumer, Cynthia C. Lowen, Zhun Cao, Krysmaru Araujo Torres

“…**Objective:** The study goal was to compare healthcare resource utilization (HCRU) and cost between immunonutrition and StdHP using real-world evidence from a large US administrative database. …”
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Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…Discussion This evaluation will contribute robust evidence on the impact, implementation experience, political economy and gendered implications of PCNs in a LMIC setting, as well as guide the refining of PCN implementation in Kenya and other LMICs implementing or planning to implement PCNs to enhance their effectiveness.…”
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An Upper Bound for Locating Strings with High Probability Within Consecutive Bits of Pi by Víctor Manuel Silva-García, Manuel Alejandro Cardona-López, Rolando Flores-Carapia

“…To support the hypotheses, we present experimental evidence about the equiprobable and independent properties of bits of <inline-formula><math display="inline"><semantics><mi>π</mi></semantics></math></inline-formula>, analyzing their distribution, and measuring correlations between bit strings. …”
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Comparing the Effects of Integrative Neuromuscular Training and Traditional Physical Fitness Training on Physical Performance Outcomes in Young Athletes: A Systematic Review and Me... by Ke-wen Wan, Zi-han Dai, Po-san Wong, Robin Sze-tak Ho, Bjorn T. Tam

“…Physical performance-related outcomes were analyzed using standardized mean differences (SMDs) and mean differences (MDs) with 95% confidence intervals (CIs). The certainty of evidence and quality of the included studies were rated using the GRADE scale and the revised Cochrane risk-of-bias tool respectively. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Dehong Wu,1,&ast; Mengdi Yin,2,&ast; Dandan Cao,2,&ast; Xiafeng Zhang,2 Yichun Zhu,2 Ying Wei,2 Yiling Li,2 Chengping Wen,2 Jia Zhou2 1Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jia Zhou; Chengping Wen, Email zhoujia@zcmu.edu.cn; chengpw2010@126.comBackground: Rheumatoid arthritis (RA) is a chronic autoimmune disease and increasing evidence suggests that disturbances in the composition and function of gut microbiota are potentially implicated in the progression of RA. …”
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«Talgenism» in the Digital Age: A Domestic History of cMOOC by M. A. Babaeva, E. B. Golubev

“…The article traces the historical milestones of the development of the method of collective mutual learning in Russia and adduces the documentary evidence of experiments on the creation of a fundamentally different pedagogical system. …”
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Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…Abstract Background Individuals with neurofibromatosis type 1 (NF1) frequently report psychosocial problems, among which internalizing and externalizing symptoms are the most poorly understood due to limited research and inconsistent evidence. This hinders the overall attendance of their psychosocial needs and has a major impact on their quality of life. …”
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Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy by Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

“…Conclusions: Our study provides the first evidence for the pathogenicity of a gain-of-function mutation in FGFR3 (G382D) using mouse and cell models, and it underscores the potential of targeting the HSPB6-ERK-Drp1-FDX1 axis as a novel therapeutic approach for HCH. …”
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