Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold by Wei Zhang, Zhe Peng, ShuKui Yu, Qing-Ling Song, Teng-Fei Qu, Lu He, Ke Liu, Shu-Sheng Gong

“…Tinnitus was confirmed in the treated rats via Behaviour Testing of Acoustic Startle Response (ASR) and Gap Prepulse Inhibition Test of Acoustic Startle Reflex (GPIAS). A immunostaining study showed that there is significant loss of anti-CtBP2 puncta (a marker of cochlear inner hair cell (HC) ribbon synapses) in treated animals in apical, middle, and basal turns (all p<0.05). …”
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Comparison of Canal Transportation by Two Rotary Systems, Neoniti vs. Wave One, Both Used with Reciprocal Motion by Mohsen Aminsobhani, Arvin Rezaei Avval, Fatemeh Hamidzadeh

“…However, no significant differences were observed in the coronal or apical thirds. Conclusion: While the manufacturer of Neoniti recommends using this system with continuous rotational motion, it can also be effectively utilized with reciprocal motion, yielding satisfactory results while respecting the canal anatomy. …”
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Takotsubo Cardiomyopathy in the Setting of Tension Pneumothorax by Michael Gale, Pablo Loarte, Brooks Mirrer, Thierry Mallet, Louis Salciccioli, Alison Petrie, Ronny Cohen

“…Initial echocardiogram showed apical ballooning with a LVEF of 10–15%. A cardiac angiography revealed normal coronary arteries with no coronary disease. …”
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Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats by Esther Castillo-Gómez, Emilio Varea, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher

“…Both treatments decreased spine density in apical dendrites of pyramidal neurons without affecting their inhibitory innervation. …”
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Indocyanine green nebulization visualizes the pulmonary bronchus during video-assisted thoracoscopic surgery by Hao Xu, Xun Wu, Songjing Zhao, Zhenfan Wang, Guanchao Jiang, Yun Li, Jian Zhou

“…We dissected the bronchi with the assistance of fluorescence imaging and were surprised to find that the bifurcation of the anterior and apical bronchi could be clearly identified by navigation via the inhaled ICG and NIF system. …”
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Cotton aphid (Aphis gossypii Glover: Aphididae) influence associated to water hyacinth nutrient (Pontederia crassipes Mart.: Pontederiaceae) in lath house conditions in Great Rift... by Tatek Kassu, Emana Getu, Diriba Muleta

“…The water hyacinth treated with a high nutrient level had the highest (295.0) mean aphids on apical leaves followed by the middle (178.3) and basal (104.7) leaves. …”
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EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway by Pengcheng Wang, Huan Tian, Zheng Zhang, Zuomin Wang

“…Modulation of the NF-κB pathway through the inhibition of EZH2 may offer a new perspective on the treatment of chronic apical periodontitis.…”
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Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway. by Yael Litvak, Shir Sharon, Meirav Hyams, Li Zhang, Simi Kobi, Naama Katsowich, Shira Dishon, Gabriel Nussbaum, Na Dong, Feng Shao, Ilan Rosenshine

“…The primary niche of infecting EPEC is the apical surface of intestinal epithelial cells. EPEC employs a type three secretion system (TTSS) to inject the host cells with dozens of effector proteins, which facilitate attachment to these cells and successful colonization. …”
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Surgical Repair of Late Complications in Patients Having Undergone Primary Hypospadias Repair during Childhood: A New Perspective by Guido Barbagli, Salvatore Sansalone, Rados Djinovic, Massimo Lazzeri

“…Success was defined as a normal functional urethra, with apical meatus, no residual penile curvature or esthetic deformity of the genitalia. …”
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Flow optimization in vascular networks by Radu C. Cascaval, Ciro D'Apice, Maria Pia D'Arienzo, Rosanna Manzo

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Real-Time Control System for Model Railway Based on SIMIS W Interlocking System by Dávid Macko, Ľubomír Hrmo, Jozef Hrbček, Peter Nagy

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An Efficient In Vitro Propagation Protocol of Cocoyam [Xanthosoma sagittifolium (L) Schott] by Anne E. Sama, Harrison G. Hughes, Mohamed S. Abbas, Mohamed A. Shahba

“…Shoot tips of 3–5 mm comprising the apical meristem with 4–6 leaf primordial, and approximately 0.5 mm of corm tissue at the base. …”
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Evaluation of cortical limitation of the mandibular second molar distalization with cone beam computed tomography by CHENG Ye, ZENG Weihao, LI Huang, LEI Lang

“…The lingual distance was smaller in levels at the crown side than that in the apical level. There was a positive correlation between the distal distance and the lingual distal distance. …”
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Coronary Embolism despite CHA₂DS₂-VASc Score of Zero: Should We Reconsider Anticoagulation? by Ammar Ahmed, Andrew Assaf, Aditi Shankar, Marcel Zughaib

“…Coronary angiography revealed a distal left anterior descending artery occlusion with apical wall akinesis without any evidence of atherosclerotic coronary artery disease. …”
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Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes by Tamara Lechon, Nicholas A. Kent, James A. H. Murray, Simon Scofield

“…Abstract The Arabidopsis Knotted1-like homeobox (KNOX) gene SHOOT MERISTEMLESS (STM) encodes a homeodomain transcription factor that operates as a central component of the gene regulatory network (GRN) controlling shoot apical meristem formation and maintenance. It regulates the expression of target genes that include transcriptional regulators associated with meristem function, particularly those involved in pluripotency and cellular differentiation, as well as genes involved in hormone metabolism and signaling. …”
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COVID-19 Induced Cardiomyopathy Successfully Treated with Tocilizumab by Ariyon Schreiber, Kalaimani Elango, Christoph Sossou, Sadaf Fakhra, Shabada Asad, Chowdhury Ahsan

“…Her initial Transthoracic echocardiography demonstrated an Left ventricular ejection fraction (LVEF) of 20-25% with apical akinesis. After administration of tocilizumab and corticosteroids, patient demonstrated interval improvement with LVEF improving to 50-55% within days. …”
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Chemotaxonomic studies on <i>Schwenckia americana</i> LINN by C Wahua, SM Sam

“…The leaves are simple, entire, elliptic to ovate in shape, smooth, variable, petiolate and larger at the lower region of stem and narrowing to smaller almost sessile and oblanceolate towards the apical regions which are alternately arranged and acrescently structured from the top to the base up to 3.7 ± 1.5cm long and 2.4±0.6cm wide. …”
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Evaluation of the Canal Transportation Following Glide Path Preparation with Different Rotary Systems: A Comparative Study by Mohsen Aminsobhani, Fatemeh Hamidzadeh, Arvin Rezaei Avval, Farid Merrikhi, Ehsan Sadri

“…Although K file led to significantly more transportation in the apical and middle thirds (p<0.001), rotary groups were not statistically different. …”
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Histological Changes of the Mucosal Epithelium in the Chicken Intestine during Pre- and Post-Hatching Stages by Md. Al amin, Md Badiul Alam, Kohzy Hiramatsu

“…Both villin and β-actin immunoreactivities were detected at the apical surface of the villous epithelium in all intestinal regions, and villin immunopositivity was stronger in the jejunum and ileum after hatching. …”
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Invasion of Chicken Intestinal Cells Is Higher for <i>Enterococcus cecorum</i> Lesion Strains Compared to Cloacal Strains in an Organoid Model by Lonneke Vervelde, Thijs T. M. Manders, Samira Kammourieh, Jeanine Wiegel

“…Floating chicken intestinal organoids combine the complex cell system of the gut with an easily accessible apical-out orientation. The organoids were treated with four <i>E. cecorum</i> strains that differ in original isolation, lesion, or cloacal, and bacterial load was determined after 3 and 6 h by quantitative PCR and bacterial plating. …”
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