A Case of Reverse Takotsubo Cardiomyopathy Incited by a Spinal Subdural Hematoma by Kyle Sanchez, Steven Glener, Nathan E. Esplin, Okorie N. Okorie, Amay Parikh

“…It mimics myocardial infarction clinically and includes elevated cardiac enzymes, but echocardiography reveals apical ballooning and basal hyperkinesis. Infrequently, midventricular or even reverse Takotsubo patterns have been described, involving ballooning of the basal heart without the characteristic ‘Takotsubo’ appearance. …”
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Effect of Anatomical Customization of the Fiber Post on the Bond Strength of a Self-Adhesive Resin Cement by Adricyla Teixeira Rocha, Leticia Machado Gonçalves, Ana Júlia de Carvalho Vasconcelos, Etevaldo Matos Maia Filho, Ceci Nunes Carvalho, Rudys Rodolfo De Jesus Tavarez

“…The roots were sectioned into three slices, cervical, middle, and apical, and photographed with a digital camera attached to a stereomicroscopic loupe. …”
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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…In all epithelial cells, the adherent junctions (AJs) with cadherin as the core play an important role in the maintenance of the connection and the formation of apical-basal polarity. The ependymal cells close to the ventricular system rely on AJs with N-cadherin at the core to maintain their normal morphology and function. …”
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Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer by Hesong Shen, Qian Xu, Chunrong Tu, Yangling Peng, Yuhang Xie, Zhiming Miao, Rui Yang, Jiuquan Zhang

“…The C‐indices of LVTFD‐based score integrating age, hypertension, previous cardiovascular disease, and maximal apical fractal dimension were higher than those of HFA‐ICOS score for stratifying CTRCD (0.834 vs. 0.642 and 0.834 vs. 0.633, respectively, in derivation and validation cohort). …”
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Claudin-4 Undergoes Age-Dependent Change in Cellular Localization on Pig Jejunal Villous Epithelial Cells, Independent of Bacterial Colonization by J. Alex Pasternak, Coral Kent-Dennis, Andrew G. Van Kessel, Heather L. Wilson

“…Claudin-4 was strongly localized to the apical aspect of jejunal epithelial cells for the first 2 days of life after which it was redistributed to the lateral surface between adjacent enterocytes. …”
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Alimentary Canal of the Adult Blow Fly, Chrysomya megacephala (F.) (Diptera: Calliphoridae)—Part I: Ultrastructure of Salivary Glands by Worachote Boonsriwong, Kabkaew L. Sukontason, Tarinee Chaiwong, Urai Chaisri, Roy C. Vogtsberger, Kom Sukontason

“…Thick cuticle, which was well-delineated and electron dense, apically lined the gland compartments, with discontinuity of the double-layer cuticle revealing a trace of secretion discharged into the lumen. …”
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Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature by William W. Wu, Mai Gu, Di Lu

“…On immunohistochemical staining, the neoplastic cells demonstrated staining for CK7, CA 19-9, polyclonal CEA, CD10 (apical), CD56 (focal), and vimentin. Ki-67 highlighted less than 2% of tumor cell nuclei. …”
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Establishing a CRISPR/Cas9 genome editing framework in pigeonpea (Cajanus cajan L.) by targeting phytoene desaturase (PDS) gene disruption by Kameshwaran Senthil, Maniraj Rathinam, Manisha Parashar, Narasimham Dokka, Shaily Tyagi, Vandana Mathur, Sandhya Sharma, Kishor Gaikwad, Ramcharan Bhattacharya, Rohini Sreevathsa

“…The system was validated by Agrobacterium tumefaciens-mediated apical meristem-targeted in planta and in vitro embryonic axis explant transformations, with gene knockout confirmed by albino/bleached phenotypes. …”
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Inverted Pyramid Nanostructures Coupled with a Sandwich Immunoassay for SERS Biomarker Detection by Wen-Huei Chang, Shao-Quan Zhang, Zi-Yi Yang, Chun-Hung Lin

“…These substrates, characterized by sharp apices and edges, are further functionalized with (3-aminopropyl)triethoxysilane (APTES), enabling the uniform self-assembly of AuNPs to create a highly favorable configuration for enhanced SERS analysis. …”
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METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation by Xiao Han, Guoyue Li, Haoqing Yang, Chen Zhang, Yangyang Cao, Ning Wang, Lihua Ge, Zhipeng Fan

“…In the present study, our data discovered that the knockdown of miR-196b-5p promoted alkaline phosphatase (ALP) activity assay, mineralization in vitro, and expressions of osteo/odontogenic differentiation markers DSPP and OCN and enhanced in vivo osteo/odontogenic differentiation of stem cells of the apical papilla (SCAPs). Mechanistically, the results indicated that METTL3-dependent N6-methyladenosine (m6A) methylation inhibited miR-196b-5p maturation by the microprocessor protein DGCR8. …”
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Neurons with larval synaptic targets pioneer the later nervous system in the annelid Malacoceros fuliginosus by Anna Seybold, Anna Seybold, Suman Kumar, Suman Kumar, Sharat Chandra Tumu, Harald Hausen, Harald Hausen

“…With volume EM, we followed the neuronal targets of the very first pioneer neurons at the apical and posterior ends of the larva of the annelid Malacoceros fuliginosus. …”
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DA ORIGEM DO CINEMA À INTELIGÊNCIA ARTIFICIAL by Thais Mendes Rocha, Anderson Pedro Laurindo, Josie Agatha Parrilha da Silva

“…A metodologia compreendeu apresentações teóricas, a exibição do filme “Um Truque de Luz” (1995), explorando a história do cinema, análises críticas e debates coletivos. O ápice da oficina concentrou-se na reflexão sobre o papel do educador frente aos avanços da inteligência artificial. …”
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Functions of BCL-XL at the Interface between Cell Death and Metabolism by Judith Michels, Oliver Kepp, Laura Senovilla, Delphine Lissa, Maria Castedo, Guido Kroemer, Lorenzo Galluzzi

“…Similar to BCL-2, BCL-XL binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the formation of lethal pores in the mitochondrial outer membrane, as well as to multiple BH3-only proteins, thus interrupting apical proapoptotic signals. In addition, BCL-XL has been suggested to exert cytoprotective functions by sequestering a cytosolic pool of the pro-apoptotic transcription factor p53 and by binding to the voltage-dependent anion channel 1 (VDAC1), thereby inhibiting the so-called mitochondrial permeability transition (MPT). …”
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Aquaporin 12 Is Expressed in the Stomach and Liver of the Spiny Dogfish (<i>Squalus acanthias</i>) by Christopher P. Cutler, Jade Bender, Sarah Conner, Esosa Omoregie

“…High-magnification imaging showed that the AQP12 staining was located in the membrane of secretory granules in the apical pole of the cells. This localization is reminiscent of the AQP12 localization in pancreatic acinar cells, where it is found in the membrane of zymogen granules containing digestive enzymes.…”
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Cardiogenic Shock due to Kounis Syndrome following Cobra Bite by W. D. D. Priyankara, E. M. Manoj, A. Gunapala, A. G. R. M. A. Ranaweera, K. S. Vithanage, M. Sivasubramanium, E. Snajeeva

“…Serum IgE levels were significantly high (19155IU/ml, baseline 100). 2-Dimensional echocardiogram showed anterior and apical-septal hypokinesia with left ventricular ejection fraction of 30-35%. …”
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Saikosaponin D improves nonalcoholic fatty liver disease via gut microbiota-bile acid metabolism pathway by Lan Li, Shengye Yang, Xinyu Liang, Yameng Liu, Hualing Xu, Xiaozhen Guo, Cen Xie, Xiaojun Xu

“…Further exploration found that SSD inhibited the mRNA expression levels of farnesoid X receptor (Fxr), small heterodimer partner (Shp), recombinant fibroblast growth factor 15 (Fgf15) and apical sodium dependent bile acid transporter (Asbt) in the intestine, suggesting that SSD improved liver lipid metabolism by inhibiting intestinal FXR signaling. …”
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Asymptomatic lung abscess of aspergillus in a female without previous lung diseases or immunocompromise: a case report by Hanxue Xiang, Ling Zhang, Liu Yang, Miaotian Cai, Yingmin Ma, Yulin Zhang

“…Case presentation A 43-year-old female was found a mass shadow with central liquid anechoic area in the apical posterior segment of the left upper lung lobe by chest computerized tomography for 1 month, but had no any systematic or respiratory complaints. …”
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections by Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin

“…The dental pulp, includes a few immune cells surrounded by rigid mineralized tissue, and opens to the outside through the apical foramen. Owing to this special organization, the dental pulp generates a directional immune response to bacterial infection. …”
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Lipid and Bile Acid Dysmetabolism in Crohn’s Disease by Koji Uchiyama, Hisashi Kishi, Wataru Komatsu, Masanori Nagao, Shuji Ohhira, Gen Kobashi

“…The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. …”
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Life historytraits of Sirex Noctilio F. (Hymenoptera: Siricidae) canexplain outbreaks independently of environmental factors by Juan Pablo Aparicio, Juan Carlos Corley, Jorge Eduardo Rabinovich

“…To understand whatdetermines outbreaks dynamics in this species, we developed anindividual based model for a wasp population developing within apine plantation. We show that outbreaks may be the result of theinsect's life history. …”
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