Sungai Batu Archaeological Complex (SBAC) in Kedah, Malaysia, as a sustainable heritage tourism product by Mohd Hasfarisham Abd Halim, Shyeh Sahibul Karamah Masnan, Mokhtar Saidin

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Prenatal exposure to bisphenol A causes reproductive damage in F1 male rabbits due to inflammation and oxidative stress by Qianhui Zhao, Jialu Pan, Yongzhan Bao, Xiao Wang, Wanyu Shi

“…By modulation of the Nrf2 and NF-κB axes, BPA could influence the expression of antioxidant enzymes and inflammatory mediators in the rabbit reproductive system, leading to cell apoptosis and tissue damage. …”
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Asini Corii Colla (Ejiao) as a health-care food and traditional Chinese medicine: A review of its chemical composition, pharmacological activity, quality control, modern applicatio... by Xiao-jun Yu, Ling-mei Kong, Bin Wang, Chang-qi Zhai, Yong-zhen Lao, Long-jian Zhang, Yan Gao, Bo-Nian Zhao

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Mutant glycosidases for labeling sialoglycans with high specificity and affinity by Shuyu Liang, Qi Tang, Xunzi Guo, Zi’an Li, Yilan Guo, Jinghan Chang, Bo Cheng, Qitao Song, Jiayu Sun, Peng Dai, Xing Chen

“…However, affinity probes recognizing glycans with high specificity remain scarce. Here we report the development of glycan recombinant affinity binders (GRABs) based on mutant bacterial sialidases, which are enzymatically inactive but preserve stringent specificity for sialoglycan substrates. …”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…Epsin3 (EPN3), a member of the endocytic adaptor protein family, is essential for the endocytosis of multiple receptors. In this study, we aimed to investigate the role of EPN3 in modulating EGFR function, its effects on NSCLC progression, and its potential involvement in tyrosine kinase inhibitor (TKI) resistance, which remains a significant hurdle in NSCLC treatment. …”
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Identification of natural and anthropogenic factors in the spatial pattern of Pb in the surface soil of the Nanliu River Basin by Xu Liu, Zhongfang Yang, Huading Shi, Tiansheng Wu, Tao Yu, Bo Li, Lei Wang, Yuxiang Shao, Zexin He, Minghui Xie, Chenning Deng

“…Soil samples were collected and analyzed for Pb concentrations, revealing that granite and urban development significantly control Pb occurrence. …”
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Association between advanced lung cancer inflammation index and all-cause and cause-specific mortality among asthma patients: a cohort study by Tu-Lei Tian, Xiang-Kun Qu, Hong-Bo Zhang, Cun-Cun Wang, Qing-Qing Yuan, Jing Xia, Li-Fang Cao, Kui Liu

“…This study aimed to evaluate the association between ALI and mortality from all causes, as well as specific causes including cardiovascular disease (CVD) and cancer-related mortality, among individuals with asthma.MethodsWe analyzed data from 4,829 asthma patients who participated in the U.S. …”
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Nonlinear responses of ecosystem carbon fluxes to precipitation change in a semiarid grassland by Hua Chai, Hua Chai, Jianying Ma, Jinwei Zhang, Junqin Li, Bo Meng, Chengliang Wang, Duofeng Pan, Jie Li, Wei Sun, Xuhui Zhou

“…However, how ecosystem C fluxes respond to variability in precipitation (both decreases and increases precipitation along a gradient) remains unclear. In this study, we conducted a three-year field experiment in a semiarid grassland, with six precipitation treatments (precipitation decreased by 70%, 50%, and 30% [P–70%, P–50%, and P–30%], natural precipitation [P+0%], and precipitation increased by 30% and 50% [P+30% and P+50%]) to examine how variations in precipitation influence ecosystem C fluxes, specifically focusing on gross ecosystem productivity (GEP), ecosystem respiration (ER), and net ecosystem CO2 exchange (NEE). …”
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Peptide P2 targeting Vibrio parahaemolyticus PirB toxins blocks the cytotoxic effects to shrimp Litopenaeus vannamei by Xin Zhang, Ting Chen, Chunhua Ren, Yanhong Wang, Xiao Jiang, Jiasheng Huang, Bo Ma, Boxiang Zhu, Jiayue Yin, Chaoqun Hu, Peng Luo

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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…Background and objectiveThe diagnosis of thyroblastoma initially identified as a thyroid malignant teratoma was subsequently classified as a distinct entity by the World Health Organization (WHO) in 2022. This classification was based on the observation that the tumor presents with independent primitive multilineage elements and is frequently associated with DICER1 hotspot mutations.The objective of this study was to explore and investigate the clinicopathologic characteristics, molecular features and treatment strategies of patients with thyroblastoma, followed by a review of the previous relevant literature.MethodsThe clinical manifestations, pathological characteristics, molecular features and treatment strategies of the initial case of thyroblastoma pathologically confirmed in China were analyzed.ResultsThe tumor was revealed to have high invasive potential, rapid disease progression, and primitive multilineage elements of pathology, including immature thyroid epithelium, spindled mesenchymal proliferations, and neuroepithelial blastema. …”
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Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…This study evaluates changes in participant quality of life (QoL), unmet needs and mental health over time based on their genetic variant status.Methods and analysis This prospective cohort study will recruit 1435 patients with suspected hereditary cancer who have undergone BRCA1/2 or next-generation sequencing (NGS) testing. …”
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Celebración de los 25 años de Cinde en Manizales Ceremonia de graduación del Doctorado en Ciencias Sociales, Niñez y Juventud, Cinde - Universidad de Manizales.... by Sara Victoria Alvarado

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Multifractal characteristics of pore structure in the terrestrial shale reservoirs of the Lianggaoshan formation in northeast sichuan basin and its geological significance by Jiping Wang, Jiping Wang, Hongmei Shao, Hongmei Shao, Yuanhao Zhang, Yuanhao Zhang, Zhenxue Jiang, Zhenxue Jiang, Bo Gao, Bo Gao, Lingling Li, Lingling Li, Huifang Pan, Huifang Pan, Haonan Wang, Haonan Wang, Xi Lu, Xi Lu, Hengyuan Qiu, Hengyuan Qiu, Xiaobiao He, Xiaobiao He, Chengju Zhang, Chengju Zhang

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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA. Here, we constructed a functionally enhanced FVIII variant, F309S/E1984V-mutated B domain-deleted (BDD)-FVIII (FE-FVIII), with increased activity and stability. …”
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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…Abstract The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in Drosophila. …”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…Background The REpeated ASSEssment of SurvivorS (REASSESS) study will conduct long-term cognitive, functional and neuropsychiatric performance assessments to determine whether evacuation of spontaneous intracerebral haemorrhage (ICH) reduces the risk of later cognitive decline in the ageing brain.Methods and analysis This study will compare rates of cognitive decline under two treatment strategies for ICH. The first strategy is the use of minimally invasive surgery (MIS) with similar techniques as performed in (1) the Minimally Invasive Surgery plus rt-PA in the Treatment of Intracerebral haemorrhage Evacuation phase III (MISTIE III) trial, (2) the Early MiNimally-invasive Removal of IntraCerebral Haemorrhage (ENRICH) trial and (3) a single-centre cohort of consecutively treated patients with MIS. …”
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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae by Qian Qin, Yanjing Dong, Jialong Chen, Bo Wang, Yuxin Peng, XinPeng Zhang, Xiaoyun Wang, Jinxiang Zeng, Guoyue Zhong, Shouwen Zhang, Xiaolang Du

“…The lengths of the cpDNAs of 18 species range from 121,190 bp to 158,539 bp, and they contain between 107 and 112 unique genes. …”
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High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…Objective To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).Design A systematic review and meta-analysis.Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).Outcome measure Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.Results A total of six RCTs with 10 993 adult patients with CKD were included. …”
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Differential expression of “A Disintegrin and Metalloproteinase 10” in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogene... by Amal Abd El Hafez, Basem H. Elesawy, Heba S. E. I. Hany

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