Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). We report the largest integrated safety analysis of tofacitinib, as of March 2017, using data from phase I, II, III, IIIb/IV and long-term extension studies in adult patients with RA.Methods Data were pooled for patients with RA who received ≥1 tofacitinib dose. …”
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Evaluation of clinical, laboratory, radiographical and histopathological characteristics in patients with spinal tuberculosis in the context of HIV infection: An analysis of 52 pat... by J Scherer, M Locketz, S Castelein, R Dunn, M Held, F Thienemann

“…To assess correlations between continuous data groups, the Pearson correlation coefficient was used. Results. We assessed 52 patients with STB (mean (standard deviation (SD) age 38 (15.2) years, range 17 - 80 years), of whom 55.8% were female, and 59.6% HIV infected. …”
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Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0... by Alena S. Ovchinnikova, Dmitrii A. Odnoshevsky, Alexey S. Kabanov, Sergey A. Bodnev, Oleg V. Pyankov, Oksana P. Os'kina, Maria V. Sivay, Andrey V. Bespalov, Tatyana V. Tregubchak, Larisa N. Shishkina, Oleg S. Taranov, Vladimir V. Zolin, Artemiy A. Sergeev, Alexander P. Agafonov

“…A diagnostic study of the biological samples of a patient who returned from a tourist trip to European countries with complaints of skin rashes all over the body revealed MPXV DNA. …”
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Analisis Klasifikasi Sentimen Ulasan pada E-Commerce Shopee Berbasis Word Cloud dengan Metode Naive Bayes dan K-Nearest Neighbor by Josua Josen Alexander Limbong, Irwan Sembiring, kristoko dwi hartomo

“…Therefore the need for sentiment analysis to classify such a large dataset so that you can easily find out what customer sentiments are. …”
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Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastase... by Xuxiazi Zou, Hong-Liang Zou, Xuan Luo, Xu-Wei Chen, Wei-Ling Huang, Chao Zhang, Ge Ren, Jin-Hua Huang, Xue Han, Yi-Quan Jiang

“…Materials and methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA patients had fewer male patients(62.5% vs. 79.7%, P < 0.001), later onset age(33.8 years vs. 22.0 years, P < 0.001), shorter diagnostic delays(6.0 months vs. 14.2 months, P=0.004), more associated peripheral arthritis(71.7% vs. 9.3%, P < 0.001) and dactylitis(6.5% vs. 0.3%, P < 0.001), more cases of psoriasis(52.7% vs. 1.1%, P < 0.001) and a more common family history of psoriasis(11.4% vs. 3.4%, P < 0.001). pSpA patients had higher levels of inflammatory markers but a lower positive rate of human leukocyte antigen(HLA)-B27(43.5% vs. 87.4%, P < 0.001). A positive HLA-B27 was associated with an earlier onset age, fewer cases of psoriasis, and a family history of ankylosing spondylitis. pSpA patients had a higher proportion of using conventional synthetic disease-modifying antirheumatic drugs(csDMARDs), biologic disease-modifying antirheumatic drugs(bDMARDs), and oral glucocorticoids, and they also more frequently used a combination of bDMARDs and csDMARDs(19.0% vs. 12.2%, P=0.009) or multiple csDMARDs(65.8% vs. 12.5%, P < 0.001). …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…One of the main treatment goals is improving quality of life (QoL), particularly for patients with lower-risk MDS (LR-MDS) who may live longer with compromised QoL. …”
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Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…Both Asian and non-Asian patients who received NOAC at enrolment experienced lower all-cause mortality and non-haemorrhagic stroke/SE compared with patients on other treatments or none.All-cause mortality, non-cardiovascular mortality and major bleeding were less frequent in patients from Asia versus non-Asia (HR (95% CI): 0.62 (0.39 to 0.99), 0.52 (0.28 to 0.97), 0.58 (0.36 to 0.96), respectively). …”
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Dietary and lifestyle patterns identified through reduced rank regression and their association with insulin-related disorders: a prospective analysis from the Tehran Lipid and Glu... by Ebrahim Mokhtari, Hossein Farhadnejad, Farshad Teymoori, Mitra Kazemi Jahromi, Mehrnaz Nikkhah, Parvin Mirmiran, Fereidoun Azizi

“…Also, RRR derived a lifestyle pattern based on the above-mentioned dietary pattern and high BMI as response variables. …”
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The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 by Huanhuan Yan, Huanhuan Yan, Huanhuan Yan, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Huer Yan, Xiaoying Zhang, Xiaoying Zhang, Xiaoying Zhang, Jie Bai, Jie Bai, Jie Bai, Chong Gao, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Caihong Wang, Caihong Wang, Caihong Wang

“…The absolute numbers of peripheral blood lymphocyte subsets were detected by flow cytometry (FCM) and serum cytokine levels were detected by flow cytometry bead array (CBA).ResultsThe absolute number of T, CD4+ T, and Treg cells in the D2T RA group was lower than that in the HC, new, and treated RA groups. …”
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Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination by Chia-Yi Chou, Chung-Yi Cheng, Chih-Hsin Lee, Makoto Kuro-O, Tso-Hsiao Chen, San-Yuan Wang, Yung-Kun Chuang, Yun-Jung Yang, Yun-Hsuan Lin, I-Lin Tsai

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First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan by Khalid Salman, Sittna Hayder El Nagar, Abdel Rahim M. El Hussein, Mohammed A. El Hussein, Hadi M. Yassine, Hebah A. Al Khatib, Mashael Ali Al- Badr, Ibrahim Farah, Khalid A. Enan

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Strategi Penanganan Imbalance Class Pada Model Klasifikasi Penerima Kartu Indonesia Pintar Kuliah Berbasis Neural Network Menggunakan Kombinasi SMOTE dan ENN by Zaqiatud Darojah, Ronny Susetyoko, Nana Ramadijanti

“…To solve the imbalanced KIP Kuliah recipients data, we propose a hybrid sampling technique that combines the Synthetic Minority Over-Sampling Technique (SMOTE) and the Edited Nearest Neighbor (ENN) and also samples selected deletion method with a new scheme. …”
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Evaluating the surgical and oncological outcomes of hepatic artery variations in minimally invasive pancreaticoduodenectomy: insights from 2023 data at a high-volume pancreatic cen... by Tianyu Li, Liangbo Dong, Dongming Zhang, Jiashu Han, Menghua Dai, Junchao Guo, Qiang Xu, Weibin Wang, Xianlin Han, Chen Lin

“…This study aims to explore the differences in surgical and oncological outcomes of MIPD with or without HAV and CR-HAV. Methods We enrolled 267 consecutive patients who underwent MIPD at Peking Union Medical College Hospital between January and December 2023. …”
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Digitalisasi Model Sistem Akuntansi Terintegrasi Bagi Usaha Bersama Simpan Pinjam di Kota Kupang by Yustina Alfira Nay, Selfiana Goetha, Maria Goreti Malut

“…Joint Savings and Loans Business (UBSP) has an important role as an investor, especially for housewives who do not have a fixed income. UBSP operates in the savings and loans, credit, and trading business sectors but does not yet have an accounting information system that is capable of integrating all parts. …”
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Carcinoembryonic antigen trajectory predicts pathological complete response in advanced gastric cancer after neoadjuvant chemotherapy by Yonghe Chen, Yonghe Chen, Yonghe Chen, Dan Liu, Kaikai Wei, Yi Lin, Yi Lin, Yi Lin, Zhong Wang, Qian Sun, Huashe Wang, Huashe Wang, Huashe Wang, Junsheng Peng, Junsheng Peng, Junsheng Peng, Lei Lian, Lei Lian, Lei Lian

“…AimsThis study aims to develop a simple, clinically applicable classification system to predict pCR based on carcinoembryonic antigen (CEA) trajectory during NAC.MethodsThis study included 366 AGC patients who received NAC followed by radical gastrectomy. …”
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Implementasi Metode Naive Bayes untuk Mendeteksi Stres Siswa Berdasarkan Tweet pada Sistem Monitoring Stres by Diva Fardiana Risa, Fajar Pradana, Fitra Abdurrachman Bachtiar

“…Stress has a huge impact on the health of sufferers, but there are still many people who underestimate the existence of the stress disease. …”
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Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation by Yoshihisa Matsushima, Tatsuhiro Shibata, Kodai Shibao, Rei Yamakawa, Miyu Hayashida, Toshiyuki Yanai, Takashi Ishimatsu, Takehiro Homma, Shoichiro Nohara, Maki Otsuka, Yoshihiro Fukumoto

“…This study investigated the relationship between mechanical CPR and severe intrathoracic hemorrhage during ECPR compared to manual CPR. Methods: We conducted a single-center retrospective study of consecutive patients who underwent ECPR from April 2017 to March 2024 according to a standard institutional protocol. …”
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Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…Abscopal effects were observed in 6 patients (23.08%); four of whom achieved a partial response. Patients who achieved a partial response were significantly more likely to have an abscopal effect( P = 0.025). …”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases by Tesson, Florian, Planel, Rémi, Egorov, Artyom A, Georjon, Héloïse, Vaysset, Hugo, Brancotte, Bryan, Néron, Bertrand, Mordret, Ernest, Atkinson, Gemma Catherine, Bernheim, Aude, Cury, Jean

“…These pages can be freely accessed for users as a starting point on their journey to better understand a given system. We anticipate that these resources will foster the use of bioinformatics in the study of antiphage systems and will serve the community of researchers who study antiphage systems. …”
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