An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) by Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem

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Fertigation with alpha-tocopherol enhances morphological, physiological, and antioxidant responses in radish (Raphanus sativus L.) under drought stress by Muhammad Shahbaz Chishti, Muhammad Shahbaz, Muhammad Kaleem, Saba Shafi, Anam Mehmood, Zhang Qingzhu, Musarat Mansha, Nimra Shehzadi, Shamsa Rana, Hina Shahid, Abeer Hashem, Alanoud Alfagham, Elsayed Fathi Abd-Allah

“…The present work was designed to explore the potential role of alpha-tocopherol (α-Toc), a form of vitamin E, on the morphological, physio-biochemical, and cellular antioxidant responses of two radish genotypes grown under drought conditions (38 ± 3% of field capacity). …”
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Quality of Life of Palestinian Patients on Hemodialysis: Cross-Sectional Observational Study by Hani H. Naseef, Nadin Haj Ali, Arin Arafat, Sawsan Khraishi, Abdallah Damin AbuKhalil, Ni’meh Al-Shami, Hosniyeh Ladadweh, Mohammad Alsheikh, Abdullah K. Rabba, Imad T. Asmar, Yousef Sahoury

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Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review by Taoufik Alsaadi, AbuBakar Al Madani, Mohammed Alhatou, Mona Nada, Abdulrazaq Albilali, Ahmed Al-Qassabi, Hegab Mohamed, Haytham Mohamed, Rowan El Masry, Ghaidaa Ahmed Saifuddin, Suhail Abdullah AlRukn

“…Thus, a systematic literature review (SLR) was conducted to examine epidemiological data, treatment patterns, QoL, and unmet needs regarding migraines in the ME region. …”
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Prepancreatic postduodenal portal vein discovered in a pediatric patient undergoing total pancreatectomy with islet autotransplantation: a case report and review of literature by Muhammed Ali Colak, Andrew T. Trout, Christie Heinzman, A Jay Freeman, A Jay Freeman, Sara K. Rasmussen, Sara K. Rasmussen, Maisam Abu-El-Haija, Jaimie D. Nathan, Jaimie D. Nathan

“…Only 20 cases of PPPV, all in adults, have been reported in literature. We report the first case of PPPV in a pediatric patient discovered intraoperatively during total pancreatectomy with islet autotransplantation (TPIAT) and the third known case in which the PPPV could be isolated intraoperatively.CaseA 10-year-old girl with debilitating acute recurrent pancreatitis requiring daily pain medication was admitted for elective TPIAT operation. …”
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Length-weight relationships of Indian squid, Uroteuthis duvaucelii and Bigfin reef squid, Sepioteuthis lessoniana from the coastal waters of Langkawi Island, Malaysia by Rohizad Maidin Mohd Samsul, Mastura Mustapha, Atikah Harun Nadiayatul, Wahab Abdullah Abdul, Luqman Wan Rosdi Wan Muhammad, Asyraf Raja Omar Raja Hanif, Faizah Ismail, Haryati Abd. Wahab, Bakri Miswan

“…E3S Web of Conferences…”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Abstract Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent stem cells to generate an atlas of multilineage differentiation from pluripotency, encompassing an eight-day time course with modulation of WNT, BMP, and VEGF signalling pathways. …”
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Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident Is a Cause of Diabetes: Results from the Fukushima Health Management Survey by Hiroaki Satoh, Tetsuya Ohira, Mitsuaki Hosoya, Akira Sakai, Tsuyoshi Watanabe, Akira Ohtsuru, Yukihiko Kawasaki, Hitoshi Suzuki, Atsushi Takahashi, Gen Kobashi, Kotaro Ozasa, Seiji Yasumura, Shunichi Yamashita, Kenji Kamiya, Masafumi Abe

“…Using the Comprehensive Health Check survey, we analyzed changes in the glucose metabolism before and after the disaster. …”
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Corrigendum to “Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident Is a Cause of Diabetes: Results from the Fukushima Health Management Survey” by Hiroaki Satoh, Tetsuya Ohira, Mitsuaki Hosoya, Akira Sakai, Tsuyoshi Watanabe, Akira Ohtsuru, Yukihiko Kawasaki, Hitoshi Suzuki, Atsushi Takahashi, Gen Kobashi, Kotaro Ozasa, Seiji Yasumura, Shunichi Yamashita, Kenji Kamiya, Masafumi Abe

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CytoSorb hemoadsorption of apixaban during cardio-pulmonary bypass for heart transplantation by Anouk Frering, MD, Antoine Abi Lutfallah, MD, Aude Carillion, MD, PhD, Daniel Wendt, MD, Pascal Leprince, MD, PhD, Adrien Bougle, MD, PhD, Guillaume Lebreton, MD, PhD

“…Patients on the transplant waiting list often have multiple reasons for being anticoagulated. Intraoperative removal of apixaban using CytoSorb seems to be an interesting solution for patients on DOACs requiring an emergency CPB intervention. …”
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The Addis Declaration on Immunization: Assessing the Effectiveness and Efficiency of Immunization Service Delivery Systems in Africa as of the End of 2023 by Franck Mboussou, Charles Shey Wiysonge, Bridget Farham, Ado Bwaka, Sarah Wanyoike, Amos Petu, Sidy Ndiaye, Andre Bita Fouda, Johnson Muluh Ticha, Adidja Amani, Regis Obiang, Magaran Monzon Bagayoko, Benido Impouma

“…<b>Methods</b>: To analyze African countries’ performance in achieving the fourth ADI commitment, a cross-sectional retrospective study was conducted including the 54 African Member States of the World Health Organization (WHO) out of 55 African Union (AU) Member States. …”
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Evidence of organizational support in hospitals in the context of the COVID-19 pandemic: scoping review by Renata Santos Tito, Patricia Campos Pavan Baptista, Daniela Campos de Andrade Lourenção, Chennyfer Dobbins Abi Rached, Juliana Pereira Tavares de Melo, Edson José da Silva Junior, Cristiane Maria Talala Zogheib

“…ABSTRACT Objective: To map evidence of organizational support for healthcare professionals who worked in hospitals during the pandemic. Method: This is a scoping review, based on the framework established by Joanna Briggs Institute and the PRISMA-ScR protocol, registered in the Open Science Framework, under DOI: 10.17605/OSF.IO/2P7B4. …”
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Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies by Zhenzhen Shi, Adquate Mhlanga, Yuji Ishida, Ari Josephson, Nicholson T. Collier, Hiromi Abe-Chayama, Chise Tateno-Mukaidani, Scott J. Cotler, Jonathan Ozik, Marian Major, Jordan J. Feld, Kazuaki Chayama, Harel Dahari

“…Humanized mouse models lack adaptive immune responses but provide a unique opportunity to obtain quantitative understanding of early HCV kinetics and develop mathematical models to further understand viral and innate immune response dynamics during acute HCV infection. We show that the models reproduce the measured HCV kinetics in humanized mice, which are consistent with early acute HCV-host dynamics in immunocompetent chimpanzees. …”
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Effect of Autoclave Sterilization on the Number of Uses and Resistance to Cyclic Fatigue of WaveOne Gold and Four Replica-Like Endodontic Instruments by Gustavo Ragozzini, Amjad Abu Hasna, Fernando Antonio Siano dos Reis, Felipe Bernardo de Moura, Tiago Moreira Bastos Campos, Carlos Eduardo Silveira Bueno, Cláudio Antonio Talge Carvalho, Alexandre Sigrist de Martin

“…This study aimed to evaluate the effect of autoclave sterilization on the integrity and instruments’ fracture number after multiple uses and cyclic fatigue of the original WaveOne Gold (Dentsply Sirona Endodontics) compared to four replica-like instruments (TF4-Gold, Roll-Wave-Gold, W-File, and Micro-Gold). The instruments were analyzed by scanning electron microscope (SEM) before being used in root canal instrumentation (baseline). …”
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Factors determining primary or delayed surgery for unilateral, non-metastatic Wilms tumor: a multicentric Egyptian study by Ahmed Elgendy, Amr Abdelhamid AbouZeid, Mohamed El-Debeiky, Shaimaa Abdelsattar Mohammad, Marwa Romeih, Ahmed Ebeed, Mohamed Abouheba, Mohammed Hamada Takrouney, Mahmoud Mostafa, Ahmed Khairi, Osama El-Naggar, Sameh Shehata

“…A retrospective analysis was conducted on all patients with unilateral, non-metastatic WT treated at four major Egyptian institutions from January 2019 to January 2024. …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…Edoxaban, the latest DOAC, also has proven efficacy and safety for those diseases in two large clinical trials; the ENGAGE-AF trial and HOKUSAI-VTE trial. …”
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Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress by Abdulrahman H. Laftah, Nawfal Alhelfi, Sadeq K. Al Salait, Ammar B. Altemimi, Mohammad Reza Tabandeh, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Additionally, the herbal treatment lowered pro-inflammatory cytokine levels and regulated apoptosis-related gene expression, lowering BAX and increasing BCL2, promoting cell survival, and reducing inflammation. …”
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Genome sequencing reveals novel variants in a diverse population with congenital anterior segment anomalies by Ashraf Hussain, Maria Fernanda Villalba, Dayna Morel Swols, Rayan Abou Khzam, Brittney Keira Johnson, LéShon Peart, Sarha D’Haiti, Alana L. Grajewski, Mustafa Tekin, Ta Chen Chang, Guney Bademci

“…These variants included single nucleotide variants CPAMD8:c.4825 C > T, c.534 G > A, CRYBB1:c.683 C > A, NHS:c.1180 C > T, GJA3:c.176 C > T, CRYGC:c.470 G > A, COL2A1:c.2819 G > A, c.1693 C > T, EPHA2:c.2864 A > C, a splice donor variant in COL11A1:c.933 + 1del, and a copy number variant in FBN1. The observed inheritance patterns were predominantly dominant, with a few recessive cases and a single instance of X-linked inheritance. …”
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Endoscopic ultrasound-guided drainage of postoperative pancreatic fluid collections by Shigeru Nishiyama, Takeshi Hisa, Aki Ego, Shogo Sakata, Yui Ito, Akiharu Kudo, Takahiro Yamada, Shozo Osera, Hideki Fukushima, Shunta Ishizaki, Ryoga Hamura, Masashi Tsunematsu, Kyohei Abe, Yoshihiro Shirai, Shinji Onda

“…Methods : This retrospective, single-center study focused on EUSD of POPFCs performed at our hospital. We examined the rates of technical success, clinical success, adverse events, and recurrence. …”
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Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications by Md. Mahamudul Hasan Rumon, Md. Sohanur Rahman, Anwarul Azim Akib, Md. Shafiuzzaman Sohag, Md. Rakibul Alam Rakib, Md. Abu Rayhan Khan, Farzana Yesmin, Md Salman Shakil, Mohammad Mizanur Rahman Khan

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