Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention by Zhen-Gang Liu, Zhen-Gang Liu, Lai-Yang Zhou, Lai-Yang Zhou, Lai-Yang Zhou, Lai-Yang Zhou, Yong-Quan Sun, Yong-Quan Sun, Yong-Quan Sun, Yong-Quan Sun, Yi-Hang Ma, Chang-Mei Liu, Chang-Mei Liu, Chang-Mei Liu, Chang-Mei Liu, Bo-Yin Zhang

“…These strategies are crucial not only for optic nerve regeneration but also for broader applications in central nervous system repair. In this review, we discuss multifactors therapeutic strategies for optic nerve regeneration, offering insights into advancing nerve regeneration research.…”
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Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia by Yu-Ting Ling, Qian-Qian Guo, Si-Min Wang, Li-Nan Zhang, Jin-Hua Chen, Yi Liu, Ruo-Heng Xuan, Bo Qu, Li-Ge Liu, Zhi-Shuang Wen, Jia-Kun Xu, Lu-Lu Jiang, Wen-Biao Xian, Bin Wu, Chang-Ming Zhang, Ling Chen, Jin-Long Liu, Nan Jiang

“…The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. Methods. We conducted a retrospective observational cohort study on the data of 240 patients with Parkinson’s disease who underwent deep brain stimulation of the subthalamic nucleus under general anesthesia. …”
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Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics by James Wang, Jai Woong Seo, Aris J. Kare, Martin Schneider, Mallesh Pandrala, Spencer K. Tumbale, Marina N. Raie, Gokce Engudar, Nisi Zhang, Yutong Guo, Xiaoxu Zhong, Sofia Ferreira, Bo Wu, Laura D. Attardi, Guillem Pratx, Andrei Iagaru, Ryan L. Brunsing, Gregory W. Charville, Walter G. Park, Katherine W. Ferrara

“…Claudin-4 expression increases ~16 fold in cancer as compared with normal pancreas, and tight junction localization confers low background for imaging in normal tissue. We develop a peptide-based molecular imaging agent targeted to claudin-4 with accumulation to ~25% injected activity per cubic centimeter (IA/cc) in metastases and ~18% IA/cc in tumors. …”
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Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle by Bo Shao, Yuan-Guo Xie, Long Zhang, Yang Ruan, Bin Liang, Ruochen Zhang, Xijun Xu, Wei Wang, Zhengda Lin, Xuanyuan Pei, Xueting Wang, Lei Zhao, Xu Zhou, Xiaohui Wu, Defeng Xing, Aijie Wang, Duu-Jong Lee, Nanqi Ren, Donald E. Canfield, Brian P. Hedlund, Zheng-Shuang Hua, Chuan Chen

“…However, their inability to oxidize sulfide renders them vulnerable to this toxic molecule, which inhibits the key enzymatic reaction responsible for reducing nitrous oxide (N2O), thereby raising greenhouse gas emissions. Here, we applied microcosm incubations, community-isotope-corrected DNA stable-isotope probing, and metagenomics to characterize a cohort of heterotrophic denitrifiers in estuarine sediments that thrive by coupling sulfur oxidation with denitrification through chemolithoheterotrophic metabolism. …”
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Random resistive memory-based deep extreme point learning machine for unified visual processing by Shaocong Wang, Yizhao Gao, Yi Li, Woyu Zhang, Yifei Yu, Bo Wang, Ning Lin, Hegan Chen, Yue Zhang, Yang Jiang, Dingchen Wang, Jia Chen, Peng Dai, Hao Jiang, Peng Lin, Xumeng Zhang, Xiaojuan Qi, Xiaoxin Xu, Hayden So, Zhongrui Wang, Dashan Shang, Qi Liu, Kwang-Ting Cheng, Ming Liu

“…The computational demands of training ever-growing models further exacerbate these challenges. We propose a hardware-software co-designed random resistive memory-based deep extreme point learning machine. …”
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Implementing deep learning-based disruption prediction in a drifting data environment of new tokamak: HL-3 by Zongyu Yang, Wulyu Zhong, Fan Xia, Zhe Gao, Xiaobo Zhu, Jiyuan Li, Liwen Hu, Zhaohe Xu, Da Li, Guohui Zheng, Yihang Chen, Junzhao Zhang, Bo Li, Xiaolong Zhang, Yiren Zhu, Ruihai Tong, Yunbo Dong, Yipo Zhang, Boda Yuan, Xin Yu, Zongyuhui He, Wenjing Tian, Xinwen Gong, Min Xu

“…An Area Under receiver-operator characteristic Curve of 0.940 has been realized offline over a test campaign involving 72 disruptive and 240 non-disruptive shots, despite the limited training data available from the initial two campaigns. In addition to the well-documented challenge of insufficient training data, a previously unanticipated issue is addressed that the data distribution of a new device is continuously drifting. …”
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Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities by Muhammad Hussnain Siddique, Maimona Sadia, Saima Muzammil, Muhammad Saqalein, Asma Ashraf, Sumreen Hayat, Saba Saba, Arif Muhammad Khan, Abeer Hashem, Graciela Dolores Avila-Qezada, Elsayed Fathi Abd-Allah

“…In the current investigation, copper oxide nanoparticles (CuO NPs) were fabricated by green method using Dalbergia sissoo leaf extract. …”
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Omeprazole and Ranitidine in the Prevention of Relapse in Patients with Duodenal Ulcer Disease by K Lauritsen, K Rutgersson, E Bolling, G Brunner, S Eriksson, JP Galmiche, A Walan, AP Archambault, H Gudjónsson, RJ Bailey, G Bianchi Porro, L Frison, N Havu, ABR Thompson

“…BACKGROUND: Although the eradication of Helicobacter pylori is of primary importance when initiating treatment, it is also important to have a strategy for patients who are H pylori-negative, fail to demonstrate eradication or have a tendency to become re-infected or relapse.…”
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Flow Mediated Dilatation Is Reduced with the Progressive Stages of Glomerular Filtration Rate and Albuminuria in Type 2 Diabetic Patients without Coronary Heart Disease by Hiroyuki Ito, Mina Nakashima, Kentaro Meguro, Haruki Furukawa, Hitomi Yamashita, Akifusa Takaki, Chizuko Yukawa, Takashi Omoto, Masahiro Shinozaki, Shinya Nishio, Mariko Abe, Shinichi Antoku, Mizuo Mifune, Michiko Togane

“…We aimed to clarify the usefulness of measuring the flow mediated dilatation (FMD) in patients with type 2 diabetes mellitus without and with coronary heart disease (CHD). …”
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Advancing Sustainable Development Goals through Character Education and Social Studies in Japanese Schools by Andhy Surya Hapsara, Charlotte Adams, Mark Vencint Tapia Lubi, Nhung Thi-Cam Nguyen, Siti Muti’ah, Thy Visal, Fui Byn Liew, Abd-Asit Hayeekhade, Chandy Xaiyalath, Yusuke Nakashima

“… Character education is increasingly recognized as a critical component in developing individuals who are not only academically proficient but also possess strong moral and ethical values. …”
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Midwife-led birthing centre in the humanitarian setup: An experience from the Rohingya camp, Bangladesh. by Abdul Halim, Abu Sayeed Md Abdullah, Fazlur Rahman, Oliva Bazirete, Sabera Turkmani, Kirsty Hughes, Sofia Castro Lopes, Andrea Nove, Mandy Forrester, Vanessa Scarf, Emily Callander, Caroline S E Homer

“…Qualitative data included two key informant interviews (KIIs) with policy makers, one focus group discussion (FGD) with 7 midwives and ten in-depth interviews (IDIs) with Rohingya women who gave birth in this MLBC. …”
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ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

“…The protease, a disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 (ADAMTS13), known to cleave only the von Willebrand factor (VWF), has powerful regulatory effects on microvascular platelet adhesion, thrombosis, inflammation, and endothelial dysfunction. We study the protection against diabetes-induced retinal injury in experimental rats by supplementation with recombinant ADAMTS13. …”
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Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor by Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein

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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton by Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood

“…To investigate further, we examined the actin cytoskeleton following treatment with TGFβ1 and/or cytochalasin D. …”
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The Combination Effect of <i>Purpureocillium lilacinum</i> Strain (AUMC 10620) and Avermectin (B1a and B1b) on Control Citrus Nematode <i>Tylenchulus semipenetrans</i> (Cobb) Under Laboratory and Field Conditions by Amr M. El-Marzoky, Mohamed A. M. S. Ali, Ahmed S. M. Elnahal, Dalia A. Abuljadayel, Wafa A. H. Alkherb, Mahmoud Moustafa, Mohammed O. Alshaharni, Elsayed M. Abd El-Aal

“…This study investigates the nematicidal efficacy of <i>Purpureocillium lilacinum</i> strain (AUMC 10620) combined with avermectin (B1a and B1b) against the citrus nematode <i>Tylenchulus semipenetrans</i>, both in vitro and in vivo. …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…Moreover, treatment with S. deserti hydroethanolic extract relieved oxidative stress (reduction of MDA and H2O2) and the activity of antioxidant enzymes SOD, CAT and GPx. …”
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Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy by Keita Saito, Eiki Nomura, Yu Sasaki, Yasuhiko Abe, Nana Kanno, Naoko Mizumoto, Rika Shibuya, Kazuhiro Sakuta, Makoto Yagi, Kazuya Yoshizawa, Daisuke Iwano, Takeshi Sato, Shoichi Nishise, Yoshiyuki Ueno

“…Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum. …”
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The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients by Mohamed Adel Abd Elaziz, Asmaa Mustafa Gouda Elewa, Dina Zaki Mohamed Zaki Abdel Hamid, Nohier Essam Soliman Ahmed Hassan, Éva Csongrádi, Emad Hamdy Hamouda Mohammed, Mohammed Abdel Gawad

“…Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. …”
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The role of morphological adaptability in Vibrio cholerae’s motility by Jun Xu, Keigo Abe, Toshio Kodama, Marzia Sultana, Denise Chac, Susan M. Markiewicz, Hideyuki Matsunami, Erika Kuba, Shiyu Tsunoda, Munirul Alam, Ana A. Weil, Shuichi Nakamura, Tetsu Yamashiro

“…mBio…”
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In-vitro comparative thermo-chemical aging and penetration analyses of bioactive glass-based dental resin infiltrates by Syed Zubairuddin Ahmed, Abdul Samad Khan, Maram Alshehri, Fatimah Alsebaa, Fadak Almutawah, Moayad Mohammed Aljeshi, Asma Tufail Shah, Budi Aslinie Md Sabri, Sultan Akhtar, Mohamed Ibrahim Abu Hassan

“…This prepared resin, called “PURE RESIN” was then further incorporated with three different types of bioactive glasses, i.e., Bioglass (45S5), boron-substituted (B-BG), and fluoride-substituted (F-BG). Initial manual mixing for 1 h, followed by ultrasonic mixing for 3 min and then proceeded for the final mixing on a magnetic stirrer for 24 h in a dark room at ambient temperature. …”
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