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6001
Highly efficient construction of monkey blastoid capsules from aged somatic cells
Published 2025-01-01“…We also introduce a hydrogel-based microfluidics platform for the scalable and reproducible production of size-adjustable, biodegradable blastoid capsules, providing a stable 3D structure and mechanical protection. …”
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Rapid and accurate multi-phenotype imputation for millions of individuals
Published 2025-01-01“…We demonstrate by extensive simulations that PIXANT is reliable, robust and highly resource-efficient. …”
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6004
Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis
Published 2025-01-01“…Conclusions These findings demonstrate that the combination of CeO2 and siCTGF has a beneficial curative effect on cardiac fibrosis, with significant translational potential.…”
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Self-driving lab for the photochemical synthesis of plasmonic nanoparticles with targeted structural and optical properties
Published 2025-02-01“…Finding reaction conditions for the synthesis of nanoparticles with targeted characteristics is a time-consuming and resource-intensive trial-and-error process, however closed-loop nanoparticle synthesis enables the accelerated exploration of large chemical spaces without human intervention. Here, we introduce the Autonomous Fluidic Identification and Optimization Nanochemistry (AFION) self-driving lab that integrates a microfluidic reactor, in-flow spectroscopic nanoparticle characterization, and machine learning for the exploration and optimization of the multidimensional chemical space for the photochemical synthesis of plasmonic nanoparticles. …”
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6006
Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats
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PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation
Published 2025-01-01“…After downregulating PRAF2 in two BC cell lines, we tested cell proliferation by CCK-8 and Wound healing assays. …”
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Digital light processing three-dimensional printing with acrylic–titanium composite powders for multiscale porous scaffolds
Published 2025-01-01“…However, dense internal structures produced by the powder bed fusion technique fails to meet the feature of porous materials in scenarios that demand large specific surface areas. Herein, we propose a strategy for 3D printing of titanium scaffolds featuring multiscale porous internal structures via powder modification and digital light processing (DLP). …”
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Template-Free Synthesis of Star-Like ZrO2 Nanostructures and Their Application in Photocatalysis
Published 2018-01-01“…The results showed that CH3COO− and NO3− had great effects on the formation of star-like ZrO2 nanostructures. …”
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Serpina3k lactylation protects from cardiac ischemia reperfusion injury
Published 2025-01-01“…By analyzing the lactylomes and proteomes of mouse myocardium during ischemia-reperfusion injury using mass spectrometry, we show that both Serpina3k protein expression and its lactylation at lysine 351 are increased upon reperfusion. …”
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Review and Evaluation of European National Clinical Practice Guidelines for the Treatment and Management of Active Charcot Neuro-Osteoarthropathy in Diabetes Using the AGREE-II Too...
Published 2024-01-01“…Conclusions: European national CPGs for diabetes provide limited recommendations on active CNO. All guidelines showcased deficits in their methodology, suggesting that more rigorous methods should be employed for diabetes CPG development across Europe.…”
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Global, regional, and national incidence and mortality for enteric infections from 1990 to 2019
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Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder
Published 2019-01-01“…Here we examine the effects of extracts of Poria cocos mycelium fermented with freeze-dried plum powder (PPE) on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells), relative to the effects of Prunus extract. …”
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Identification of Nontuberculous Mycobacteria in Patients with Pulmonary Diseases in Gyeongnam, Korea, Using Multiplex PCR and Multigene Sequence-Based Analysis
Published 2021-01-01“…Variable regions of the genes 16S rRNA, rpoB, hsp65, and 16S-23S rRNA internal transcribed spacer were included in the analysis. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans
Published 2009-01-01“…We tested the hypothesis that the TUSC5 gene is a bona fide PPARγ target and evaluated whether its WAT expression or single-nucleotide polymorphisms (SNPs) in the TUSC5 coding region are associated with human obesity. …”
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