Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating by Shiwei Niu, Fan Li, Zhi Lin, Bo Chen, Lechun Lyu, Yongliang Jiang, Wanting Li, Jianlin Jiao, Yi Han, Di Lu, Lin Sun

“…The synthesis process was characterized, its biocompatibility, hierarchically cell induction capacity, anticoagulant effect and the ability to promote neovascularization were evaluated. In such way, we hope to prepare a biodegradable small-diameter artificial vascular for the clinical application.…”
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A survey of knowledge about health education and self-management behavior in 118 patients with early diabetic nephropathy (118例早期糖尿病肾病患者健康教育知识水平及自我管理行为现状调查)... by CHEN Furong (陈芙蓉), ZHOU Jianping (周建平), MAO Dandan (毛丹旦), BO Jing (薄静), ZHUANG Ji (庄姬)

“…There were 39(33. 05%)smokers who consumed averaged 19. 01 cigarettes per day. …”
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Effects of Carbonate Alkalinity on Antioxidants, Immunity and Intestinal Flora of <i>Penaeus vannamei</i> by Chuang Gao, Zhonghong Li, Bo Ma, Rantao Zuo, Xudong Shen, Mingkang Chen, Chuanqi Ren, Wenjun Zheng, Zhonglu Cai, Jiaxing Li, Shuang Li

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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…Background and objectiveThe diagnosis of thyroblastoma initially identified as a thyroid malignant teratoma was subsequently classified as a distinct entity by the World Health Organization (WHO) in 2022. This classification was based on the observation that the tumor presents with independent primitive multilineage elements and is frequently associated with DICER1 hotspot mutations.The objective of this study was to explore and investigate the clinicopathologic characteristics, molecular features and treatment strategies of patients with thyroblastoma, followed by a review of the previous relevant literature.MethodsThe clinical manifestations, pathological characteristics, molecular features and treatment strategies of the initial case of thyroblastoma pathologically confirmed in China were analyzed.ResultsThe tumor was revealed to have high invasive potential, rapid disease progression, and primitive multilineage elements of pathology, including immature thyroid epithelium, spindled mesenchymal proliferations, and neuroepithelial blastema. …”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…However, safety concerns over hBM-MSCs limit their clinical application. In this study, we observed that hBM-MSC-conditioned medium (hBM-MSC-CM) promotes gastric cancer development via upregulation of c-Myc. …”
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Effect of Mesenchymal Stem Cells and Platelet-Rich Plasma on the Bone Healing of Ovariectomized Rats by Bo Wei, Chengshuo Huang, Mingyan Zhao, Peng Li, Xiang Gao, Junchao Kong, Yanru Niu, Rui Huang, Juanhua Quan, Jinsong Wei, Jiaqi Chu

“…In ovariectomized rats treated with PRP or with a combination of PRP and BMSCs, the trabecular connectivity densities (Conn.D), bone volume ratios (BV/TV), and numbers (Tb.N) in the defect areas increased significantly from day 7 to day 42. …”
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Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy by Rui-Bo Guo, Lu Zhang, Yang Liu, Liang Kong, Yang Yu, Bin Yang, Zuo-Jun Wang, Jing-Yi Zhang, Xue-Tao Li

“…The in vivo and in vitro evaluation showed that micelles precisely targeted the inflammatory site, thus inhibiting the expression of pro-inflammatory cytokines, reversing the polarization of M1 macrophages, inhibiting the invasion and migration of proliferative FLSs, and, at the same time, regulating the seeds and soils of RA. …”
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Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma by Lin Fu, Jiang-Tao Lou, Yue Guo, Pei-Juan Wang, Rong-Rong Le, Shu-Xia Xu, Guo-Xing Li, Yuan-Bo Liang

“…METHODS: This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for 12mo. …”
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Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…This study evaluates changes in participant quality of life (QoL), unmet needs and mental health over time based on their genetic variant status.Methods and analysis This prospective cohort study will recruit 1435 patients with suspected hereditary cancer who have undergone BRCA1/2 or next-generation sequencing (NGS) testing. …”
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Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults by Bo Wu, Huachao Zheng, Caixiang Zhuang, Jiesheng Mao, Luo Yuncheng, Lidong Huang, Min Li, Zhao Feiyang, Sisi Lin, Pengwei Wang, Yiren Hu

“…BackgroundResearch indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. …”
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Clinical Findings in Diabetes Mellitus Patients with COVID-19 by Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Jinhua Li, Wenlong He, Bo Yu, Chenfang Wu, Zhiguo Zhou, Hong Luo, Hong Peng

“…On admission, the mean level of glycated hemoglobin A1c (HbA1c) was higher in the ICU DM patients than that in the non-ICU DM patients (8.5% vs. 7.1%). …”
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Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive B... by Ming Zhai, Peipei Luan, Yefei Shi, Bo Li, Jianhua Kang, Fan Hu, Mingjie Li, Lei Du, Donglei Zhou, Weixia Jian, Wenhui Peng

“…Gene Expression Omnibus (GEO) datasets (GSE27951, GSE55200, and GSE26637) of insulin-resistant individuals or type 2 diabetes patients and normal controls were downloaded to get differently expressed genes (DEGs), and GO and KEGG pathway analyses were performed. …”
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Fully automated segmentation and classification of renal tumors on CT scans via machine learning by Jang Hee Han, Byung Woo Kim, Taek Min Kim, Ji Yeon Ko, Seung Jae Choi, Minho Kang, Sang Youn Kim, Jeong Yeon Cho, Ja Hyeon Ku, Cheol Kwak, Young-Gon Kim, Chang Wook Jeong

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Multifractal characteristics of pore structure in the terrestrial shale reservoirs of the Lianggaoshan formation in northeast sichuan basin and its geological significance by Jiping Wang, Jiping Wang, Hongmei Shao, Hongmei Shao, Yuanhao Zhang, Yuanhao Zhang, Zhenxue Jiang, Zhenxue Jiang, Bo Gao, Bo Gao, Lingling Li, Lingling Li, Huifang Pan, Huifang Pan, Haonan Wang, Haonan Wang, Xi Lu, Xi Lu, Hengyuan Qiu, Hengyuan Qiu, Xiaobiao He, Xiaobiao He, Chengju Zhang, Chengju Zhang

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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA. Here, we constructed a functionally enhanced FVIII variant, F309S/E1984V-mutated B domain-deleted (BDD)-FVIII (FE-FVIII), with increased activity and stability. …”
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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…Abstract The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in Drosophila. …”
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Imaging of Myocardial Ischemia–Reperfusion Injury Using Sodium [F]Fluoride Positron Emission Tomography/Computed Tomography in Rats and Humans by Hongyoon Choi MD, PhD, Jeong Hee Han PhD, Sue Yeon Lim MS, Inki Lee MD, Young-Seok Cho MD, PhD, Eun Ju Chun MD, PhD, Won Woo Lee MD, PhD

“…Positron emission tomography (PET)/computed tomography (CT) using sodium [ 18 F]fluoride (Na[ 18 F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[ 18 F]F uptake in ischemia–reperfusion injury (IRI) of rats and humans. …”
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Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human by JooYeon Jhun, Jennifer Lee, Jae-Kyeong Byun, Eun-Kyung Kim, Jung-Won Woo, Jae-Ho Lee, Seung-Ki Kwok, Ji-Hyeon Ju, Kyung-Su Park, Ho-Youn Kim, Sung Hwan Park, Mi-La Cho

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A Promising Approach to Ultra‐Flexible 1 Ah Lithium–Sulfur Batteries Using Oxygen‐Functionalized Single‐Walled Carbon Nanotubes by Junyoung Heo, Jeong‐Won Hong, Ha Won Gu, Junghwan Sung, Dong‐Hee Kim, Jung Hoon Kim, Sung Kang, You‐Jin Lee, Hye Young Choi, Doohun Kim, Kang‐Jun Baeg, Joong Tark Han, Jun‐Woo Park

“…Abstract Lithium–sulfur (Li‐S) batteries represent a promising solution for achieving high energy densities exceeding 500 Wh kg−1, leveraging cathode materials with theoretical energy densities up to 2600 Wh kg−1. …”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…Background The REpeated ASSEssment of SurvivorS (REASSESS) study will conduct long-term cognitive, functional and neuropsychiatric performance assessments to determine whether evacuation of spontaneous intracerebral haemorrhage (ICH) reduces the risk of later cognitive decline in the ageing brain.Methods and analysis This study will compare rates of cognitive decline under two treatment strategies for ICH. The first strategy is the use of minimally invasive surgery (MIS) with similar techniques as performed in (1) the Minimally Invasive Surgery plus rt-PA in the Treatment of Intracerebral haemorrhage Evacuation phase III (MISTIE III) trial, (2) the Early MiNimally-invasive Removal of IntraCerebral Haemorrhage (ENRICH) trial and (3) a single-centre cohort of consecutively treated patients with MIS. …”
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