Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…<b>Background/Objectives</b>: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. …”
Get full text

Identifying the determining factors of detonation properties for linear nitroaliphatics with high-throughput computation and machine learning by Wen Qian, Jing Huang, Shi-tai Guo, Bo-wen Duan, Wei-yu Xie, Jian Liu, Chao-yang Zhang

“…In this work, a high-throughput computation (HTC) and machine learning (ML) combined method was applied to identify the determining factors of the detonation velocity (vd) and detonation pressure (pd) of energetic molecules and screen potential high-energy molecules with acceptable stability in a high-throughput way. The HTC was performed based on 1725 sample molecules abstracted from a dataset of over 106 linear nitroaliphatics with 1- to 6-membered C backbones and three types of substituents, namely single nitro group (-NO2), nitroamine (-NNO2), and nitrate ester (-ONO2). …”
Get full text

Relationship between Particle Size Distribution and Pollutant Content during the Transport of Storm Runoff by GAO Aiping, HUANG Tinglin, MA Xu, ZHANG Guorong, FAN Wenwei, QI Yunzhi, ZHANG Bo, DU Juanjuan, CUI Hongjun

“…The inflow on October 3 is three times larger than that on April 4 and 2.6 times larger than that on June 3, while the TP content is five times higher than that on June 3, and the COD_Mn is 1.8 times and 1.7 times higher than that on these two days, respectively, indicating that the TP and COD_Mn in the inflow are related to its volume. …”
Get full text

Research on integrated 3D geological modeling of vector grid ——taking the core area of Tianfu New Area as an example by Ming Hao, Peiyao Xie, Huan Liu, Bo Wang, Fang Zhou, Xianglong Zeng, Yang Lei, Deng Pan, Guokun Liao

Get full text

Association between impaired brachial flow-mediated dilation and early neurological deterioration in acute ischemic stroke: a retrospective analysis by Sang Hee Ha, Bo Hye Yoon, Bon Gook Koo, Dong Hoon Shin, Yeong-Bae Lee, Bum Joon Kim

“…Methods We retrospectively reviewed patients who had experienced AIS within 7 days of stroke onset and underwent FMD assessments during their hospitalization (%FMD = Peak diameter − baseline diameter)/baseline diameter x 100). …”
Get full text

Reliability Design and Experimental Development for High-Power Electric Driving Wheel Gearbox by Zhang Lei, Zhao Juan, Zhang Bin, Li Hongbiao, Shan Hongbo, Ge Kai, Yang Bo, Li Zhaochuan, Zhang Hongtao

Get full text

RESEARCH AND OPTIMIZATION OF FORMING PATH OF ELECTRON BEAM FUSE ADDITIVE MANUFACTURING——A CASE OF 304 STAINLESS STEEL by SUN BaoFu, XU BoHan, ZHANG LiPing, LI XiaoFeng, ZHANG JianFei, CHEN DongXue

Subjects: “…Electron beam freeform fabrication（EBF3）…”
Get full text

An Overview: PAH and Nitro-PAH Emission from the Stationary Sources and their Transformations in the Atmosphere by Yen-Yi Lee, Yen-Kung Hsieh, Bo-Wun Huang, Justus Kavita Mutuku, Guo-Ping Chang-Chien, Shiwei Huang

Get full text

Study of Wind Loads and Wind Speed Amplifications on High-Rise Building with Opening by Numerical Simulation and Wind Tunnel Test by Fu-Bin Chen, Xiao-Lu Wang, Yun Zhao, Yuan-Bo Li, Qiu-Sheng Li, Ping Xiang, Yi Li

Get full text

Рrevention of contrast-induced nephropathy during interventional treatment of acute coronary syndrome by L.O. Miakinkova, T.I. Yarmola, G.L. Pustovoit, Iu.A. Kostrikova, B.O. Pysana, V.V. Talash

“…According to the stages of chronic kidney disease: I stage – 8.1%, II stage – 46.8%, III A stage – 30.6%, III B stage – 14.5% of patients. The control group consisted of 32 patients with acute coronary syndrome without kidney pathology. …”
Get full text

Preparation of Ginsenoside Rg3 and Protection against H2O2-Induced Oxidative Stress in Human Neuroblastoma SK-N-SH Cells by Gang Li, Xiao-xiao Zhang, Lin Lin, Xiao-ning Liu, Cheng-jun Ma, Ji Li, Chi-bo Wang

“…MTT assay and LDH leakage assay were used to determine the cell viability and the oxidative stress cellular model was established by means of H2O2 (600 μM for 4 h). We also investigated the changes of intracellular MDA content, SOD activity, and ROS formation after the treatment of ginsenoside Rg3 for 20 h. …”
Get full text

Quantitative Prediction of Natural Fractures in Shale Oil Reservoirs by Lei Gong, Shuai Gao, Bo Liu, Jianguo Yang, Xiaofei Fu, Fei Xiao, Xiaocen Su, Rongzhi Fu, Qi Lu

“…Finally, the fracture distribution is evaluated comprehensively based on above prediction. The prediction results in this work are consistent with the core measurements.…”
Get full text

Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis by Ping Li, Cheng-xun Han, Cui-li Ma, Jia-long Guo, Bo Liu, Juan Du, Li-qi Bi

“…To investigate the relationship between Brachial-ankle pulse wave velocity (baPWV), and its associated risk factors in Chinese patients with RA. …”
Get full text

Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies by Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li

“…mAbs…”
Get full text

The role of BATF in immune cell differentiation and autoimmune diseases by Xiaomeng Wang, Yue Hong, Jinmei Zou, Bo Zhu, Chao Jiang, Liwei Lu, Jie Tian, Jing Yang, Ke Rui

Get full text

Comparison of radiation esophagitis associated with daytime versus evening radiotherapy in patients with esophageal carcinoma by Yun Xing, Yutian Yin, Liang Yu, Cong Zhang, Guangjin Chai, Bo Lyu, Bin Wang, Lina Zhao, Geng Xiang

“…The grades of radiation esophagitis (Common Terminology Criteria for Adverse Events version 5.0) and survival outcomes were compared in the two groups. Analyses were performed by using ordinal logistic regression and Cox proportional hazard regression. …”
Get full text

Deep-Learning Prediction Model with Serial Two-Level Decomposition Based on Bayesian Optimization by Xue-Bo Jin, Hong-Xing Wang, Xiao-Yi Wang, Yu-Ting Bai, Ting-Li Su, Jian-Lei Kong

“…This paper presents a deep hybrid model with a serial two‐level decomposition structure. First, the power load data are decomposed into components; then, the gated recurrent unit (GRU) network, with the Bayesian optimization parameters, is used as the subpredictor for each component. …”
Get full text

Advances in Object Detection and Localization Techniques for Fruit Harvesting Robots by Xiaojie Shi, Shaowei Wang, Bo Zhang, Xinbing Ding, Peng Qi, Huixing Qu, Ning Li, Jie Wu, Huawei Yang

“…The increasingly evolving and powerful deep learning technology can effectively solve the above problems and has been widely used in the last few years. …”
Get full text

Accurate localization of indoor high similarity scenes using visual slam combined with loop closure detection algorithm. by Zhuoheng Xiang, Jiaxi Guo, Jin Meng, Xin Meng, Yan Li, Jonghyuk Kim, Shifeng Wang, Bo Lu, Yu Chen

“…PLoS ONE…”
Get full text

Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

Get full text