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  1. 4461
  2. 4462

    Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

    Published 2025-01-01
    “…A total of six key genes related to amino acid metabolism were identified, including ALDH18A1, CENPF, CSAD, CTH, CYP27B1, HBB. Results: All six genes exhibited promising diagnostic capabilities (AUC:0.7 to 0.9). …”
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  3. 4463

    Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution St... by Bo Li, Min Lu, Lei Jin, Maoen Zheng, Peilu Sun, Shanshan Lei, Shan Xiong, Suhong Chen

    Published 2019-01-01
    “…The simple and sensitive LC-MS/MS method was successfully applied to the pharmacokinetic and brain distribution studies following a single oral administration of brigatinib and brigatinib-analog to rats. The above studies would lay a good foundation for the further applications of brigatinib and brigatinib-analog.…”
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  4. 4464

    Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation by Jing Wang, Bo Wang, Qibin Zhao, Jinnan Cao, Xiao Xiao, Di Zhao, Zhenya Chen, Di Wu

    Published 2025-01-01
    “…The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.16 mg/kg, chromium (Cr) at 75.23 mg/kg, nickel (Ni) at 30.38 mg/kg, arsenic (As) at 22.53 mg/kg, cadmium (Cd) at 0.76 mg/kg, and mercury (Hg) at 0.14 mg/kg; (2) The distribution of heavy metal concentrations exhibits significant regional variations, with the spatial pattern of pollution indicating that TLS is more affected than JLS, as evidenced by the Pollution Load Index (PLI) values; (3) Three potential sources of heavy metals were identified: natural sources, anthropogenic activities (including industrial production and agricultural practices), and atmospheric deposition (both dry and wet); (4) While severe contamination levels of specific metals such as copper and cadmium are observed in JLS and TLS soils, the overall contamination is mild, suggesting complex contamination dynamics; (5) Cadmium poses a moderate to high ecological risk, being the most sensitive factor in the comprehensive ecological risk assessment with a contribution rate of 65.2 %; (6) The concentrations of heavy metals in the soil present certain health risks, with children being more vulnerable than adults. …”
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  5. 4465

    Production Data Analysis and Practical Applications in the Sulige Tight Gas Reservoir, Ordos Basin, China by Minhua Cheng, Wen Xue, Meng Zhao, Guoting Wang, Bo Ning, Guang Ji, Lihua Cheng, Yingying Tian

    Published 2021-01-01
    “…Successful exploitation of tight sandstone gas is one of the important means to ensure the “increasing reserves and production” of the oil and gas initiative and also one of the important ways to ensure national energy security. To further improve the accuracy of historical matching of field data such as gas production and bottom-hole pressure during the production process of this type of gas reservoir, in this study, a new expression of wellbore pressure for the uniform flow of vertical fractured wells in Laplace space based on the point sink function model of vertical fractures in tight sandstone gas reservoirs is constructed. …”
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  9. 4469

    Effect of Low-Frequency Vibration on Muscle Response under Different Neurointact Conditions by Chaofei Zhang, Wenjun Wang, Dennis Anderson, Sishu Guan, Guofa Li, Hongyi Xiang, Hui Zhao, Bo Cheng

    Published 2019-01-01
    “…Variables including dynamic muscle force, vibration acceleration, and displacement were recorded in two conditions, with and without the stretch reflex. …”
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  13. 4473

    Digital Twin-Empowered Robotic Arm Control: An Integrated PPO and Fuzzy PID Approach by Yuhao Cen, Jianjue Deng, Ye Chen, Haoxian Liu, Zetao Zhong, Bo Fan, Le Chang, Li Jiang

    Published 2025-01-01
    “…However, the control and error management of robotic arms in digital twin systems pose challenges. In this paper, we present a digital twin-empowered robotic arm system and propose a control policy using deep reinforcement learning, specifically the proximal policy optimization approach. …”
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  14. 4474

    Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats by Jiawei Wang, Yunxiao Zhao, Fengque Zheng, Nana Ma, Rongyan Qin, Weili Qin, Bo Liu, Aiping Qin

    Published 2021-01-01
    “…The combined transplantation of HucMSCs and ucPRP resulted in more stem cells being retained in the ovaries of POF rats, the estrus cycle of the POF rats being restored, the levels of serum E2, AMH, and FSH improving, and damaged follicles beginning to grow. …”
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  18. 4478

    Female Gender Remains a Significant Barrier to Access Cataract Surgery in South Asia: A Systematic Review and Meta-Analysis by Qunru Ye, Yanxian Chen, William Yan, Wei Wang, Jingxian Zhong, Cong Tang, Andreas Müller, Bo Qiu

    Published 2020-01-01
    “…To determine whether the female gender is a barrier for the access to cataract surgery services in South Asia in the last two decades. Methods. Eligible cross-sectional studies were identified via computer searches and reviewing the reference lists of the obtained articles. …”
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