Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus by S. N. Shchelkunov, T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, S. A. Pyankov

“…In this research, the effect of the introduction of two point mutations into the A34R gene of attenuated strain LIVP-GFP (ТК–), which increase the yield of extracellular enveloped virions (EEV), on the pathogenicity and immunogenicity of VACV LIVP-GFP-A34R administered intranasally to laboratory mice were studied. …”
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Serum Magnesium Levels in Patients Admitted to Intensive Care Unit and its Association with Sequential Organ Failure Assessment Score – A Cross-sectional Observational Study by Medha Gayatri Tiruvuri, K. Varsha Reddy, Merugu Satya Pratik, Krishna Chaitanya Alam

“…This difference was found to be statistically significant (P < 0.05). The odds of being diabetic in those with hypomagnesemia were 2.746 times more than those without hypomagnesemia. …”
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Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study by Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

“…The patients were predominantly males (70.6%), and more than half were above 55 years old (56%), with a mean age of 58 (SD ± 14.8) years. 56.6% developed CRBSI and were predominantly gram‐positive (69.7%). …”
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The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind,... by Mehran Noori, Zainab Shateri, Siavash Babajafari, Mohammad Hadi Eskandari, Karim Parastouei, Mohammad Ghasemi, Hoseein Afshari, Mohammad Samadi

“…Methods This study was a double-blind, randomized, and placebo-controlled clinical trial conducted on 67 elderly men aged over 65, who were randomly divided into two groups. One group (n = 35) received one bottle (240 cc) of regular kefir as a placebo, while the intervention group (n = 32) received one bottle of probiotic-fortified kefir for eight weeks. …”
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THE IMPACT OF NEUROSCIENCE-BASED MINDFULNESS TRAINING ON MENTAL HEALTH IN FUTURE PSYCHOLOGISTS by Olha Lazorko

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INVESTIGATING RISKS IN DEPENDENCE PRODUCING DRUGS USERS AMONGSUB-POPULATION OF HIGHER EDUCATION INSTITUTES IN KARACHI;.A CROSS-SECTIONAL STUDY by Shamsul Arfin Qasmi et al

“…Methods: This cross – sectional study was performed at four medical colleges (two public and two private) across Karachi, Pakistan from July 2018 to January 2019. …”
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The role of mycobacteremia screening in enhancing non-tuberculous mycobacteria detection in hospitalized persons with HIV by Mengjiao Miao, Hongyan Zhu, Ziyao Liu, Jinjin Yang, Yiting Zhang, Chenyu Ma, Jiamin Qin, Yaling Chen, Hongxia Wei, Wei Chen, Yongfeng Yang, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu

“…The sensitivity of mycobacterial blood cultures (MBC) in diagnosing all culture-proven NTM infections was 63.9% (95% CI, 54.0–72.8%), increasing to 75.7% (95% CI, 64.8–84.0%) in patients with CD4 counts &lt;50 cells/μL. …”
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Brazilian criminal organizations as subjects of non-classical wars in the form of criminal rebellion by K. S. Strigunov

“…The specific of the situation in Brazil is that such an insurgency is carried out by non-state violent actors who formally do not pursue any political/ideological goals. …”
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Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…However, this is less apparent in older, less fit patients, who are ineligible for stem cell transplant. Research is required in this patient group, taking into account frailty and aiming to improve: treatment tolerability, clinical outcomes and quality of life.Methods and analysis Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma is a national, phase III, multicentre, randomised controlled trial comparing standard (reactive) and frailty-adjusted (adaptive) induction therapy delivery with ixazomib, lenalidomide and dexamethasone (IRD), and to compare maintenance lenalidomide to lenalidomide+ixazomib, in patients with newly diagnosed multiple myeloma not suitable for stem cell transplant. …”
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Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation by Yoshihisa Matsushima, Tatsuhiro Shibata, Kodai Shibao, Rei Yamakawa, Miyu Hayashida, Toshiyuki Yanai, Takashi Ishimatsu, Takehiro Homma, Shoichiro Nohara, Maki Otsuka, Yoshihiro Fukumoto

“…This study investigated the relationship between mechanical CPR and severe intrathoracic hemorrhage during ECPR compared to manual CPR. Methods: We conducted a single-center retrospective study of consecutive patients who underwent ECPR from April 2017 to March 2024 according to a standard institutional protocol. …”
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Systematic review of infant and young child feeding practices in conflict areas: what the evidence advocates by Jai K Das, Zulfiqar Bhutta, Amna Rabbani, Zahra A Padhani, Faareha A Siddiqui

“…Studies were included if they discussed IYCF practices, barriers, programmes and guidelines to promote and improve IYCF practices. Two review authors independently evaluated and screened studies for eligibility and extracted data; followed by a descriptive and thematic analysis.Results We included 56 studies in our review including 11 published articles and 45 reports from grey literature and broadly classified into four predetermined sections: epidemiology (n=24), barriers/enablers (n=18), programmes/interventions (n=15) and implementation guidelines (n=30). …”
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Scaling up computational thinking skills in computer-assisted language learning (CTsCALL) and its fitness with language learners’ intentions to use virtual exchange: A bi-symmetric approach by Amir Reza Rahimi, Ana Sevilla-Pavón

“…Thus, we developed the conceptual framework that integrated CTsCALL and Individual-technology-task-environment Fit (ITTEF). …”
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Tocilizumab, an Exploratory Treatment for Severe COVID-19 Patients by Yong Wang, Yongfeng Chen, Xiangdong Zhou

“…A persistent and dramatic increase of IL-6 was observed in 2 patients who were finally dead. The CRP levels of 76.92% (10/13) of the patients were above the normal range before the start of TCZ therapy and gradually declined after the TCZ treatment. …”
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Outcome of therapy in biopsy proven lupus nephritis with cyclophosphamide or mycophenolate: Registry data from a South Indian tertiary care center by Keerthi Talari, Rajendra Varaprasad Irlapati, Megha Uppin, Liza Rajasekhar

“…Background: Cyclophosphamide and mycophenolate are the currently proposed first-line agents for induction in lupus nephritis (LN). In this study, we analysed the response rates with the three different induction regimens currently available for LN. …”
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Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis by Kamal AmirAshjei Asalemi, Alia Saberi, Amirreza Ghayeghran, Sima Fallah Arzpeyma, Sharareh Eskandarieh, Mohammad Ali Sahraian, Hamidreza Hatamian, Kasra Sarlak, Negin Ashoori, Nima Broomand Lomer

“…Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. …”
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The effect of calf muscular vein thrombosis on the prognosis within one year postoperatively of geriatric hip fracture patients: a propensity score-matched analysis by Jiabao Jiang, Fei Xing, Rong Luo, Zhao Chen, Hao Liu, Zhou Xiang, Xin Duan

“…Registered March 15, 2023, https://www.chictr.org.cn/showproj.html?proj=192079 .…”
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Novel MRI Signs in Atlantodental Space Predict Reduction Degree of Atlantoaxial Dislocation by Xia‐Qing Sheng, Yi‐Fei Deng, Cheng‐Yi Huang, Nan‐Fang Pan, You‐Jin Zhao, Qi‐Yong Gong, Quan Gong, Yue‐Ming Song, Hao Liu, Yang Meng

“…Methods Preoperative T2‐weighted MRIs and dynamic digital radiographs of patients who underwent posterior reduction and fixation surgery for congenital AAD between September 2012 and February 2023 were collected. …”
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CHATGPT: ATTITUDES AND EXPERIENCES OF TECHNICAL UNIVERSITY STUDENTS IN UKRAINE by Oksana Chugai, Kateryna Havrylenko

“…This study explores the attitudes and experiences of students at a technical university in Ukraine who utilize ChatGPT. Employing a mixed-method research design, a comprehensive array of quantitative and qualitative data was collected through Google Form surveys from a cohort of 208 student volunteers, ensuring anonymity and voluntary participation. …”
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The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty by Lotte M. C. Jacobs, Veerle Bijkerk, Lucas T. van Eijk, Leo A. B. Joosten, Christiaan Keijzer, Jetze Visser, Michiel C. Warlé

“…Methods This comparative matched cohort study used data from two single-center randomized-controlled trials. …”
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Clinical Burden of Chronic Obstructive Pulmonary Disease in Patients with Suboptimal Peak Inspiratory Flow by Jill A. Ohar, Donald A. Mahler, Gabrielle N. Davis, David A. Lombardi, Edmund J. Moran, Glenn D. Crater

“…To assess the clinical burden of COPD by characterizing the clinical characteristics of participants with sPIF against medium-low resistance DPIs versus those with optimal PIF (oPIF) from two phase 3 clinical trials. Methods. …”
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