Real-World Experience of Clascoterone Cream 1% in Acne Management: Case Series and Canadian Experience by Tay E, Loo WJ

“…Elena Tay,1 Wei Jing Loo1– 3 1Western University, London, ON, Canada; 2DermEffects, London, ON, Canada; 3Probity Medical Research, Waterloo, ON, CanadaCorrespondence: Wei Jing Loo, DermEffects, 1560 Hyde Park Road, London, ON N6H 5L5, Canada, Tel +1 519 472 2929, Email dermeffects@gmail.comAbstract: Acne vulgaris is a globally prevalent dermatological condition associated with substantial physical and psychological burden. …”
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HAPLOIDENTICAL TRANSPLANT WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASTIC SYNDROMES PATIENTS: THE ROLE OF PREVIOUS LINES OF THERAPY. by Daniele Avenoso, Fabio Serpenti, Liron Barnea Slonim, Styliani Bouziana, Francesco Dazzi, Guy Hannah, Michelle Kenyon, Varun Mehra, Austin Kulasekararaj, Pramila Krishnamurthy, Mili Naresh Shah, Sharon Lionel, Antonio Pagliuca, Victoria Potter

“…Post-transplant cyclophosphamide administration allows for selection of haploidentical donors in patients who are eligible for the procedure, but do not have a fully matched donor, since it can overcome the HLA barrier. …”
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The Effect of an Educational Intervention Based on the Health Belief Model on the Level of Breastfeeding Self-efficacy in Mothers Referring to Qazvin Health Centers: A Randomized C... by fatemeh mohammadi, mahdi ranjbaran, hamed bigdeli, zinat jourabchi

“…Results: Following the intervention, a statistically significant difference was noted in the mean values between the two cohorts with regard to the components of the health belief model (p<0.05). …”
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Blood Borne Viral Infections in Transplantation: Hepatitis Viruses and Retroviruses by RP Bryce Larke

“…Hepatitis viruses B (HBV), C (HCV) and D (HDV) and the retroviruses human immunodeficiency virus (HIV-1) and human T celllymphotropic virus type I (HTLV-1) and type ll (HTLV-11) have been transmitted from infected organ and tissue donors to allograft recipients. …”
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Estradiol and progesterone levels in early pregnancy after natural, estradiol + progesterone or gonadotrophin stimulated frozen embryo transfer cycle: a randomised controlled trial... by Nina Freiesleben Mørch, Mette Petri Lauritsen, Pernille Fog Svendsen

“…Knowledge on fetal exposure to estradiol in early pregnancy is very limited, but studies on mice and rats have shown hormonal and metabolic disturbances in cubs born from estradiol-exposed mothers. We aim to investigate serum estradiol and progesterone levels in women who conceived after natural, estradiol and progesterone, or gonadotrophin stimulated frozen embryo transfer.Methods and analysis The study is an open-label, randomised controlled trial with normo-ovulatory women being randomised to natural cycle or estradiol and progesterone substitution and anovulatory women being randomised to estradiol and progesterone substitution or gonadotrophin stimulation. …”
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Safe Implementation of Treatments in Stroke: a study on intravenous thrombolysis in patients over 80 years of age with acute ischaemic stroke by Manju Krishnan, Danilo Toni, Niaz Ahmed, Anand Dixit, Ana Paiva Nunes, Marius Matusevicius, Jose Egido, Letizia Concari, Monica Reggiani, Alain Pagès, Thierry Danays

“…There were no statistically significant differences in outcomes between pre- and post-approval patients for SICH (2.5% vs 2.3%, risk ratio (RR) 1.064, 95% CI 0.345–1.784), death (25.3% vs 28.4%, RR 0.889, 0.699–1.08) and functional independency at 90 days (40.3% vs 37%, RR 1.089, 0.942–1.237).Conclusions In this observational study of IVT treatment in patients &gt;80 years of age with AIS before and after formal approval for this treatment, we did not find any difference in outcomes between the pre- and post-approval periods.…”
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Risk factors for moderate disturbance of consciousness in patients with unilateral chronic subdural hematoma by Adrian Liebert, Thomas Eibl, Thomas Bertsch, Hans-Herbert Steiner, Karl-Michael Schebesch, Leonard Ritter

“…Methods: We retrospectively analyzed consecutive unilateral CSDH patients, who were surgically treated in our department from 2018 to 2023. …”
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Evaluation of Prevalence and Risk Factors for Postpartum Depression Using the Edinburgh Postpartum Depression Scale: A Cross-Sectional Analytic Study by Gaye Kahveci, Bekir Kahveci, Hamza Aslanhan, Pakize Gamze Erten Bucaktepe

“…Study design: The population of this cross-sectional analytic study consisted of 311 women who were admitted to our hospital at 4-6 weeks after birth. …”
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TEICHI and the Tools Paradox by Sebastian Pape, Christof Schöch, Lutz Wegner

“…Our findings suggest that tool development has to address two aims which seem to be mutually exclusive, that of “keeping it simple” and that of “going generic”. …”
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A PROBLEM OF OPENING OF THE SECOND FRONT IS IN EUROPE: LOOK AFTER SEVEN DECADES by A. A. Paderin

“…The author associate himself with those historians, who support the origin of idea about the efficient strategy of attack against enemy simultaneously from different directions by the defeat of Germany, against which in the years of world war first two-front war was going: Russian army - from the east and Anglo-Franco-American soldiers from the west. …”
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Determination of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) Reference Intervals in Healthy Adult and Pediatric Individuals Using a Particle-Enhanced Turbidimetric I... by Tabari M. Baker, Christopher A. Bird, Dennis L. Broyles, Ursula Klause

“…A multisite, cross-sectional study was conducted to establish reference intervals for uNGAL in apparently healthy individuals. <b>Methods</b>: Urine samples were collected from apparently healthy individuals aged ≥3 months who met all inclusion criteria and no exclusion criteria. …”
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The validity of serum autotaxin as a predictor of hepatic fibrosis in patients with nonalcoholic fatty liver disease by Muhammad Abdel-Gawad, Hamdiy Mahfouz, Mona Abdelmeguid, Gehad M.A.-A. Hassan, Marwa Khalaf, Hani S. Aboalam

“…This study aims to evaluate the diagnostic validity of using s.autotaxin (ATX) as a noninvasive bio-marker of fibrosis in NAFLD cases as compared with Controlled Attenuation Parameter and scoring systems of hepatic steatosis. …”
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Treatment preferences of patients with muscle invasive bladder cancer: A discrete choice experiment by Liam Mannion, Verity Watson, Vinod Mullassery, Rajesh Nair, Thomas Charlton, Margaret Northover, Deborah Enting, Mieke Van Hemelrijck, Muhammad Shamim Khan, Ramesh Thurairaja, Suzanne Amery, Kathryn Chatterton, Kate Smith, Simon Hughes

“…Results We recruited patients with MIBC who had either already completed, were undergoing or had yet to commence radical treatment for MIBC (n = 60). …”
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Borrowing, loss of income and related sociodemographic factors in post-traumatic stress disorder in COVID-19 patients: A cross-sectional study from a government hospital in Mumbai,... by Amit Bhondve, Shruti Vijay Tilak, Nived G. Sudarson, Shermeen Rajesh More, Prashant Harish Saraf, Shreyansh Dinesh Singh, Eeshwari Vinay Lele, Ritu Mohit Shah, Kavya Amitabh Shah, Diya Padam Mehra

“…On bivariate analyses, being unmarried or divorced or separated (P = 0. 037), having children who were minors (P = 0. 002), traveling from outside the state for hospitalization (P < 0.001), borrowing (P = 0.002), or loss of income (P = 0.028) due to hospitalization were significantly associated with subthreshold PTSD. …”
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LETERMOVIR PRIMARY CYTOMEGALOVIRUS PROPHYLAXIS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS: COULD INFECTION AND DISEASE NO LONGER BE A SIGNIFICANT PROBLEM? by Fabian Herrera

“…Blips can occur during prophylaxis and do not require LET discontinuation. Keywords: letermovir; cytomegalovirus; hematopoietic cell transplantation. …”
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Augmentation versus No Augmentation for Immediate Postextraction Implants by Huda Hamed Basher Mohamed, Asma M. Serag Eldien, Amr Zahran

“…Materials and methods. We searched the Cochrane Oral Health Group Trial Register, Cochrane Central Register of Controlled Trials, MEDLINE, and the WHO International Clinical Trial Registry Platform (22 March 2017). …”
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Genotype 3 is linked to worse liver disease progression in hepatitis C patients even after SVR following DAA therapy by Xiping Ran, Xiping Ran, Yang Xu, Ying Wang, Cheng Zeng, Chen Gong, Ni Wang, Dachuan Cai, Dachuan Cai

“…However, the liver disease progression and its risk factors in patients with HCV GT 3 infection after sustained virological response (SVR) following direct-acting antivirals (DAAs) remain unclear. Therefore, we aimed to investigate the liver disease progression of patients with GT 3 after SVR.MethodsThis was a retrospective cohort study of patients with HCV infection who achieved SVR by DAAs. …”
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Microvascular disease and heart failure with reduced and preserved ejection fraction in type 2 diabetes by Ify R. Mordi, Aaron Tee, Colin N. Palmer, Rory J. McCrimmon, Alexander S.F. Doney, Chim C. Lang

“…Abstract Aims Identification of patients with type 2 diabetes (T2D) at increased risk of incident heart failure (HF) beyond traditional risk factors such as prior myocardial infarction (MI) might allow selection of patients who would benefit from preventative treatment. Microvascular disease (MiVD) is thought to play a pathophysiological role in the development of HF in T2D; however, its association with new‐onset HF with reduced or preserved ejection fraction has not been specifically defined. …”
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Evaluation of the Desire to Avoid Pregnancy Scale in the UK: a psychometric analysis including predictive validity by Geraldine Barrett, Jennifer Hall, Corinne Rocca

“…Objectives To evaluate the psychometric performance, including predictive validity, of a UK version of the Desire to Avoid Pregnancy (DAP) scale.Design Prospective cohort study for psychometric evaluation.Setting UK.Participants Women in the UK aged 15 years to menopause, who were not pregnant at the time of recruitment in October 2018, were eligible. 994 women completed the baseline survey and 90.2% of women eligible for the 12-month survey participated.Primary and secondary outcome measures The DAP scale was assessed according to key measurement properties of validity (construct (structural and hypothesis testing) and criterion (predictive)), reliability (internal consistency using Cronbach’s alpha and test–retest using intraclass correlation coefficients, ICC) and differential item functioning. …”
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Carbidopa/levodopa dose elevation and safety concerns in Parkinson's patients: a cross-sectional and cohort design by Michael S Okun, Peter Schmidt, David W Brodell, Nicole T Stanford, Charles E Jacobson

“…In PD patients who crossed the 800 mg threshold between two consecutive clinic visits, a significant improvement in depressive symptoms and quality-of-life measures was demonstrated, and in these patients there was no worsening of motor fluctuations or dyskinesia.Conclusions The data suggest that PD patients have the potential for enhanced clinical benefits when eclipsing the 800 mg carbidopa/levodopa threshold. …”
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