Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER) by Laura M. Spring, Lauren Scarpetti, Arielle J. Medford, Andrzej Niemierko, Amy Comander, Therese Mulvey, Lowell Schnipper, Steven J. Isakoff, Beverly Moy, Seth A. Wander, Jennifer Shin, Zanta Ephrem, Anneke R. Laposta, Elyssa Denault, Elizabeth Abraham, Gayle Calistro, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu, Alexey Aleshin, Jeffrey Peppercorn, Leif W. Ellisen, Aditya Bardia

“…This prospective phase II clinical trial investigated tolerability and safety of two ribociclib dosing schedules. Patients with stage I–III hormone receptor-positive (HR+)/HER2– breast cancer on adjuvant endocrine therapy (ET) were randomized to two ribociclib dosing schedules: 400 mg continuous vs 600 mg intermittent, with initiation in early (prior ET < 2 years) vs delayed (prior ET ≥ 2 years) setting. …”
Get full text

Cost-effectiveness of watchful waiting versus immediate emergency department transfer after epinephrine autoinjector use in Canada by Yiwei Yin, Moshe Ben Shoshan, Marcus Shaker, Matthew Greenhawt, Kate M. Johnson

“…Methods We developed a probabilistic Markov model of individuals starting at age of one year who are at risk of severe food-related allergic reactions requiring epinephrine. …”
Get full text

Peculiarities of determining the circle of recipients of one-time financial assistance in case of death of a serviceman, person liable for military service or reservist under marti... by О. V. Dzhafarova, S. O. Shatrava, О. V. Pohorilets

“…It has been stressed that the issue of determining the list of persons who should be considered family members entitled to this social payment remains controversial. …”
Get full text

Traumatic Ulceration of the Vestibular Mucous Membrane After Insertion of Four Mini-Implants in the Atrophied Mandible: A Case Report by Domagoj Kilić, Sanja Peršić-Kiršić, Asja Čelebić

“…This clinical report describes how a decubital ulcer arose from the direct contact of the vestibular movable mucous membrane against mini-implant balled-type heads after the mini-implant insertion in the edentulous atrophic mandible of a 78-year-old patient who was not wearing a conventional mandibular complete denture for more than 10 years. …”
Get full text

The Uncoupling of Disease Activity from Joint Structural Progression in Patients with Rheumatoid Arthritis Treated with Filgotinib by Yoshiya Tanaka, Tatsuya Atsumi, Daniel Aletaha, Hendrik Schulze-Koops, Haruhiko Fukada, Chris Watson, Tsutomu Takeuchi

“…Results At week 24, the least squares (LS) mean CFB in mTSS was similarly low across treatments among patients who achieved CDAI remission (range 0.00–0.11) or LDA (n = 285 and 575, respectively). …”
Get full text

The system of subjects of intellectual property law in the conditions of the cyberspace formation by O. Ye. Avramova

“…Derivative subjects of intellectual property rights are persons who acquire property rights to the already created, existing result of creative, intellectual, scientific work in a material and/or virtual environment. …”
Get full text

Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome by Linghui Zhu, Linghui Zhu, Yuan Xia, Yuan Xia, Hao Ding, Tong Zhang, Jun Li, Baomin Li, Baomin Li

“…Patients administered adrenocorticotropic hormone (ACTH) exhibited a higher likelihood of attaining seizure control, and those who responded favorably to the medication saw improved results.ConclusionThe predominant etiology of IESS is structural, succeeded by genetic factors, with significant pathogenic genes comprising TSC2, NF1, SCN8A, and KCNQ2. …”
Get full text

Functional Improvement Trajectories After Surgery (FIT After Surgery) study: protocol for a multicentre prospective cohort study to evaluate significant new disability after major... by E Jacobsohn, Duminda N Wijeysundera, Gerald Lebovic, M Davis, Martine T E Puts, Shabbir M H Alibhai, Karim S Ladha, C Wong, Daniel I McIsaac, C Hanley, T Barnes, G Lorello, N Siddiqui, P Serrano, Tyler R Chesney, S Choi, J Van Vlymen, D Sussman, D Macdonald, P Jüni, Emily Hladkowicz, C David Mazer, M Bosch, CD Mazer, A Jerath, J Pazmino-Canizares, E Kennedy, R Spence, V Lyon, Alice C Wei, Julian F Daza, Sahar Ehtesham, Janet M van Vlymen, DN Wijeysundera, KS Ladha, JF Daza, G Mattina, E Hladkowicz, M Tessier, S Ehtesham, S Nnorom, SMH Alibhai, M Puts, G Lebovic, TR Chesney, AC Wei, S Drozdz, M Louridas, RH Breau, M Lalu, S Abdellatif, S Gagne, E Duceppe, K Zarnke, D Dumerton, M Karizhenskaia, H El Beheiry, F Bonazza, A Zahavich, M Thorleifson, S L Russell, H Bagry, SY MacDonell, J Dale-Gandar, L Kaustov, A Fleet, E Al Azazi, M Parotto, S A McCluskey, H Poonawala, D Dillane, Di McIsaac, S Avramescu, S Shabeen

“…Disability is assessed using WHO Disability Assessment Schedule (WHODAS) 2.0 instrument and participants’ level-of-care needs. …”
Get full text

HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…The study will recruit 90 participants who will undergo serial clinical assessment over 12 months with advanced cardiovascular imaging (CMR scans with automated analysis at baseline, 6 and 12 months), cardiac biomarker measurement (six time points over 12 months), plus complete heart failure QoL and medication disutility questionnaires. …”
Get full text

Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients by Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Dario Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, for the SIAARTI Study Group

Subjects: “…Arterial partial pressure of oxygen to inspired fraction of oxygen ratio (PaO2/FiO2)…”
Get full text

Trauma as a Public Health Moment: Addressing Vaccine Uptake in Trauma Patients by Grace E. Keegan, BS, Rachel Alexander, BS, Simi Ogunnowo, BS, Isaiah Brown, BS, Tanya L. Zakrison, MD, MPH, Lea E. Hoefer, MD

“…Conclusions:. Trauma patients who have experienced more discrimination in medical settings have lower rates of COVID-19 vaccination. …”
Get full text

The Relationship Between the Modified Glasgow Prognostic and SYNTAX Scores in Patients with Non-ST Elevation Myocardial Infarction by Ahmet KARADUMAN, Cemalettin YILMAZ, Mustafa Ferhat KETEN, Ismail BALABAN, Zeynep Esra GUNER, Mehmet CELIK

“…Results: There were 295 patients (23.1% female, 76.9% male) included in the research, with an average age being 61.2+-10.9 years, and the mean SYNTAX score being 7.3+-10.4 (range: 0-40). …”
Get full text

Transformations in the police organization in the early 1920s by V. A. Grechenko

“…In the first of the named documents, it was stated that persons who joined the police and investigation service are considered civil servants. …”
Get full text

Stress and Coping Strategies among Nurses and Midwives during Assisted Vaginal Delivery in Pregnant Women with COVID-19: A Cross-sectional Study by R Bagavathi, Binu Mathew, Shivangi Mudgal, Ranjana Kumari, Sapna Chopra

“…During the pandemic, nurses and midwives were the pillars of health-care sector where they provide care to the patients, assist vaginal delivery, and provide emotional support too. However, psychological well-being of health-care professionals was somewhere lost. …”
Get full text

Enablers of and barriers to ART adherence among female sex workers in mid-western Uganda: a qualitative study by David Friday Apuulison, Brenda Nabawanuka, Michael Muhoozi, Julian Aryampa, Pauline Irumba, Edson Katsomyo, Moses Asiimwe, Joshua Epuitai, Pardon Akugizibwe, Wasswa George, John Rubaihayo

“…Materials and methods A descriptive qualitative study was conducted in Fort portal City. We conducted 30 in-depth interviews among FSWs who had been taking ART for at least six months. …”
Get full text

A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…Conclusion. In this study, we were able to compare multiple variables between 47 circumcised patients diagnosed with LSc and a control group. …”
Get full text

Heterogeneous association of health with patient and general practice characteristics by region, age and chronic condition: pooled cross-sectional study of patient-level data from... by Hugh Gravelle, Yan Feng, Vladimir Sergeevich Gordeev

“…One index has a much weaker correlation relationship with the other two indices in the region-specific samples.Conclusion Income-related health inequality and the associations of health with patient and practice characteristics are heterogeneous by patients’ chronic condition, age and region.…”
Get full text

KNOWLEDGE AND USE OF MODERN CONTRACEPTIVES AMONG MOTHERS OF REPRODUCTIVE AGE IN ENUGU STATE; SOUTHEASTERN NIGERIA by UCHENNA TERESA OKONKWO, HELEN NNADI, CHIOMA AKAEBE

“…Qualitative data indicated that the majority of married mothers of reproductive age who used any other modern contraceptive aside from the male condom often do so without the knowledge or consent of their spouses due to male dominance and some patriarchal values/beliefs. …”
Get full text

Advancing Objective Mobile Device Use Measurement in Children Ages 6–11 Through Built-In Device Sensors: A Proof-of-Concept Study by Olivia L. Finnegan, R. Glenn Weaver, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal, Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart, Michael W. Beets, Bridget Armstrong

“…Passive sensing applications objectively monitor time spent on a given device but are unable to identify who is using the device, a significant limitation in child screen time research. …”
Get full text

Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience by Xiaoru Li, Xiaoru Li, Xiaoru Li, Yu Zhu, Yu Zhu, Yu Zhu, Hongwei Wan, Hongwei Wan, Hongwei Wan

“…The aim of the present study was to investigate the relationship between perceived stress and family adaptability in patients with head and neck tumors and to analyze whether social support and family resilience play a mediating role in this relationship.MethodsThe convenience sample approach was utilized to recruit 316 patients with head and neck tumors who received radiation. Self-developed general information questionnaires, the Chinese Perceived Stress Scales, Social Support Rating Scale, the Shortened Chinese Version of the Family Resilience Assessment Scale, and Family Adaptability Scale were used to collect data. …”
Get full text