Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…Recent improved mechanistic understanding of MND heralds a new translational era with many potential targets being identified that are ripe for clinical trials. …”
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A Fortified Method to Screen and Detect Left Ventricular Hypertrophy in Asymptomatic Hypertensive Adults: A Korean Retrospective, Cross-Sectional Study by Hyo Eun Park, Sung-Bin Chon, Sang Hoon Na, Heesun Lee, Su-Yeon Choi

“…This retrospective cross-sectional study included asymptomatic hypertensive individuals aged ≥40 y who underwent voluntary checkups including echocardiography. …”
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Implementation and improvement of policies for building healthy cities in China by Quansheng Wang, Guoqing Han, Lansong Huang

“…This paper adopts the policy tool analysis method to design a two-dimensional analysis framework of the “policy tool-construction domain.” …”
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Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? by Ajami Gikandi, BA, Zhi Ven Fong, MD, MPH, DrPH, Motaz Qadan, MD, PhD, Raja R. Narayan, MD, MPH, Thinzar Lwin, MD, MS, Carlos Fernández-del Castillo, MD, Keith D. Lillemoe, MD, Cristina R. Ferrone, MD

“…Our aim was to assess whether complications after pancreatoduodenectomy (PD) impact long-term quality of life (QoL) and functional outcomes. Background:. There is an increasing number of long-term post-PD survivors, but few studies have evaluated long-term QoL outcomes. …”
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Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction by Waiel Abusnina, Ilan Merdler, Matteo Cellamare, Kalyan R. Chitturi, Abhishek Chaturvedi, Irwin M. Feuerstein, Cheng Zhang, Sevket Tolga Ozturk, Teshome Deksissa, Vaishnavi Sawant, Kassandra Lopez, Lior Lupu, Dan Haberman, Itsik Ben‐Dor, Lowell F. Satler, Ron Waksman, Hayder D. Hashim, Brian C. Case

“…However, a direct correlation remains unclear. We aimed to investigate this association. Methods and Results The CMDR (Coronary Microvascular Disease Registry) is a prospective, 2‐center registry that is enrolling patients with angina and nonobstructive coronary artery disease who underwent invasive hemodynamic assessment of the coronary microvasculature. …”
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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study by Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

“…Patients with high EASIX-pre also had worse 2 years overall survival (51.6% vs 70.9%; p=0.002). We were able to validate the cut-off and found that EASIX ≥3 was associated with more than twofold increased risk for NRM in multivariate analysis (HR=2.18, 95% CI 1.2 to 3.94; p=0.01). …”
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Sex Difference in the Association of Osteoporosis and Osteopenia Prevalence in Patients with Adrenal Adenoma and Different Degrees of Cortisol Excess by Shoichiro Izawa, Kazuhisa Matsumoto, Kazuhiko Matsuzawa, Takuyuki Katabami, Takanobu Yoshimoto, Michio Otsuki, Masakatsu Sone, Yoshiyu Takeda, Shintaro Okamura, Takamasa Ichijo, Mika Tsuiki, Tomoko Suzuki, Mitsuhide Naruse, Akiyo Tanabe

“…In total, 112 of 237 patients, who were predominantly female (P<0.001) and had lower BMI (P=0.013), had OS/OP. …”
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ASSOCIATION BETWEEN POLYMORPHISMS IN GENES ENCODING 2′-5′-OLIGOADENYLATE SYNTHETASES AND THE HUMORAL IMMUNE RESPONSE UPON VACCINATION AGAINST TICK-BORNE ENCEPHALITIS by N. S. Yudin, A. V. Igoshin, S. L. Lutova, Ya. Gon, M. I. Voevoda, V. A. Belyavskaya

“…Vaccination forms active immunity and represents an effective way of preventing tick-borne encephalitis (TBE). …”
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Assessment Of Awareness Level and Perception In Usage Of Plastic Bags And Its Hazards Among Secondary School Students by Mohi Ud Din, Zain Arif, Hafiz Usama Naveed, Maryam Tauseef, Nouman Yaseen, Talha Mahboob

“…Inclusion criteria were students of the 8th to 10th class and those who gave consent and filled out the questionnaire. …”
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Clinical depression prevalence and associated factors among adolescents with sickle cell anemia in dar es salaam, tanzania: a cross-sectional study by Linda Paul Athman, Agnes Jonathan, Fatima Musa, Honesta John Kipasika, Isihaka Mahawi, Florence Urio, Mwashungi Ally, Ritah Mutagonda, Lulu Chirande, Julie Makani, Emmanuel Balandya

“…Abstract Background Depression commonly arises among adolescents who have experienced long-standing psychosocial difficulties, especially those facing chronic illnesses such as sickle cell anemia (SCA). …”
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Initial Rotational Instability of the Tapered Wedge-Shaped Type Cementless Stem by Yosuke Iwamoto, Hiroaki Kijima, Hiroshi Tazawa, Natsuo Konishi, Hitoshi Kubota, Shin Yamada, Takayuki Tani, Keiji Kamo, Norio Suzuki, Yoshihiko Okudera, Masashi Fujii, Ken Sasaki, Tetsuya Kawano, Itsuki Nagahata, Naohisa Miyakoshi, Yoichi Shimada

“…A total of 61 primary total hip arthroplasties with the tapered wedge-shaped type cementless stem Accolade® TMZF (11 males, 50 females; mean age 60 years) from January 2012 to June 2015 who underwent computed tomography before surgery and within 4 weeks and 1 year after surgery were evaluated. …”
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Mortality and Morbidity of Beef Calves in Free-Range Farms in Alentejo, Portugal—A Preliminary Study by Rute Santos, Ana Cachapa, Graça P. Carvalho, Carolina B. Silva, Laura Hernández, Lina Costa, Luísa S. Pereira, Miguel Minas, Helena Vala

“…As expected, farmers that assessed a higher impact of calf losses on their annual economic revenue were also those who reported higher incidences of calf diarrhea, respiratory disease, and sudden, unexplained deaths. …”
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Perception of the organization's safety culture by medical staff in Germany and Russia by K. N. Tsaranov

“…In the study carried out in Germany (Bohmann F. O. et al.), the original Safety Attitudes Questionnaire (SAQ), was used. …”
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Predictors of Hospital Length of Stay among Patients with Low-risk Pulmonary Embolism by Li Wang, Onur Baser, Phil Wells, W. Frank Peacock, Craig I. Coleman, Gregory J. Fermann, Jeff Schein, Concetta Crivera

“…**Background:** Increased hospital length of stay is an important cost driver in hospitalized low-risk pulmonary embolism (LRPE) patients, who benefit from abbreviated hospital stays. We sought to measure length-of-stay associated predictors among Veterans Health Administration LRPE patients. …”
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Barriers and facilitators to facility-based delivery in rural Zambia: a qualitative study of women’s perceptions after implementation of an improved maternity waiting homes interve... by Peter C Rockers, Godfrey Biemba, Davidson H Hamer, Nancy A Scott, Jeanette L Kaiser, Taryn Vian, Rachel M Fong, Thandiwe Ngoma, Jody R Lori, Michelle Munro-Kramer, Misheck Bwalya, Gertrude Musonda, Eden Ahmed Mdluli, Viviane Rutagwera Sakanga, Kayla J Kuhfeldt

“…An improved maternity waiting homes (MWH) model was implemented in rural Zambia to bring pregnant women closer to facilities for delivery. We qualitatively assessed whether MWHs changed perceived barriers to facility delivery among remote-living women.Design We administered in-depth interviews (IDIs) to a randomly selected subsample of women in intervention (n=78) and control (n=80) groups who participated in the primary quasi-experimental evaluation of an improved MWH model. …”
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Risk Factors and Timing of Additional Surgery after Noncurative ESD for Early Gastric Cancer by Kaipeng Duan, Dongbao Li, Dongtao Shi, Jie Pei, Jiayu Ren, Weikang Li, Anqi Dong, Tao Chen, Jin Zhou

“…The clinicopathological characteristics of 30 early gastric cancer patients who received noncurative ESD and additional surgery were studied retrospectively. …”
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High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele by Margarita Y. Pervakova, Alexandra V. Mazing, Sergey V. Lapin, Olga Y. Tkachenko, Anna I. Budkova, Elena A. Surkova, Vladimir L. Emanuel, Olga N. Titova

“…Serum samples and clinical data were obtained from 44 COPD patients, who included 6 PiZZ, 8 PiMZ, and 30 PiMM A1AT phenotype carriers. …”
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Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis by Shifan Zhou, Shifan Zhou, Lu Liu, Xiaochuang Jin, Daniel Dorikun, Songfeng Ma

“…Sensitivity analysis investigated heterogeneity, and Egger's test assessed publication bias.ResultsSeventeen eligible articles were included, the biomarkers involved include serum lactate, NT-Pro BNP, PaO2, serum creatinine, C1-INH activity, ST2, serum chloride concentration, GH, glycemia, cTOI, NLR, serum albumin, and glucose levels, with 2,888 patients who underwent surgery(modified Norwood procedure, arterial switch procedure, biventricular repair etc.). …”
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Men care too: a qualitative study examining women’s perceptions of fathers’ engagement in early childhood development (ECD) during an ECD program for HIV-positive mothers in Malawi by Linda Richter, Thomas J Coates, Tijana Temelkovska, Pericles Kalande, Evelyn Udedi, Laurie Bruns, Siyenunu Mulungu, Julie Hubbard, Sundeep Gupta, Kathryn Dovel

“…Objectives Integrated early childhood development (ECD) and prevention of mother-to-child transmission (PMTCT) interventions rarely target fathers, a missed opportunity given existing research demonstrating that father involvement improves maternal and child outcomes. We aimed to explore mother’s perceptions of fathers’ buy-in to an integrated PMTCT-ECD programme, any impact the programme had on couple dynamics, and perceived barriers to fathers’ involvement in ECD activities.Design Qualitative study using individual in-depth interviews with mothers participating in a PMTCT–ECD programme. …”
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Multilevel determinants of racial/ethnic disparities in severe maternal morbidity and mortality in the context of the COVID-19 pandemic in the USA: protocol for a concurrent triang... by Bankole Olatosi, Jiajia Zhang, Xiaoming Li, Chen Liang, Jihong Liu, Peiyin Hung, Shan Qiao, Berry A Campbell, Myriam E Torres, Neset Hikmet

“…We will also conduct similar analyses using EHR data from the National COVID-19 Cohort Collaborative including &gt;270 000 women who had a childbirth between 2018 and 2021 in the USA. …”
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