Efficacy of ceftazidime-avibactam with or without polymyxin for carbapenem-resistant Klebsiella pneumoniae infections after initial treatment with polymyxin by Jingli Lu, Yani Ma, Zhe Cao, Baoling Zhu, Luna Fan, Haiyang Meng

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Clinical Analysis of the Patients with Isolated Low-Velocity Penetrating Neck Injury by Junepill Seok, Hyun Min Cho

“…However, there has not been a report which is reflecting Korean medical present. We retrospectively analyzed the penetrating neck injury patients based on the Korean Trauma Data Base. …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…By using aggregate level, routinely collected data for the coprimary outcomes, we removed the need to recruit individual participants.Setting Primary care.Participants Baseline data from general practitioner practices and interviews with individuals from Clinical Research Networks (CRNs) in England who helped recruit practices and Clinical Commission Groups (CCGs) who collected outcome data.Intervention The intervention included: (1) explicit elicitation of parental concerns, (2) a prognostic algorithm to identify children at low risk of hospitalisation and (3) provision of a printout for carers including safety-netting advice.Coprimary outcomes For 0–9 years old—(1) Dispensing data for amoxicillin and macrolide antibiotics and (2) hospital admission rate for RTI.Results We recruited 294 of the intended 310 practices (95%) representing 336 496 registered 0–9 years old (5% of all 0–9 years old children). …”
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The role of diet therapy in insulin resistance in women with polycystic ovary syndrome by H.B. Semenyna, T.V. Fartushok, N.V. Fartushok, N.Ya. Dumanchuk, O.M. Yurchyshyn

“…At the beginning of the study patients had HOMA-IR above 2.5, which confirms insulin resistance. After using ketogenic diet, a significant decrease in the level of glucose, insulin, and, therefore, the HOMA index was observed. …”
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Efficacy and safety of hemoporfin photodynamic therapy in treating port-wine stains in Chinese children: a systematic review and meta-analysis by Jing Xu, Hongxin Li

“…Regardless of whether the outcome variable was efficacy I or efficacy II, the therapeutic efficacy in children with PWS aged 0–3 years was superior to those aged 3–6 and 6–18 years, and children who underwent a treatment course of ≥3 sessions showed better outcomes compared to those who have only 1 or 2 sessions. …”
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Comparison of the Efficacy and Safety of Two Cryotherapy Protocols in the Treatment of Common Viral Warts: A Prospective Observational Study by Jihan M. Muhaidat, Firas A. Al-qarqaz, Diala M. Alshiyab, Hadeel S. Alkofahi, Yousef Khader, Mawaddah Y. Ababneh

“…A prospective observational study was conducted; it involved 80 patients with common warts on the hands and feet who were treated with cryotherapy done by two dermatologists who use different protocols; group 1 (45 patients) were treated by a single cycle of 10 seconds of freezing at 2 weekly intervals, and group 2 (35 patients) received a single cycle of 20 seconds of freezing at 4-weeks intervals. …”
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HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients by Floran Begue, Bryan Veeren, Philippe Rondeau, Aline-Marie Florence, Simon Jamard, Philippe Montravers, Sébastien Tanaka, Olivier Meilhac, on behalf of French COVID Study Group

“…Results Plasma apolipoproteins, including Apo A-II, Apo Cs (I, II, III), Apo H, Apo J, Apo M, and LCAT, were decreased in patients who did not survive COVID-19. …”
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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…Here we present a 74-year-old woman who developed fatal cerebral toxoplasmosis after anti-tumor necrosis factor-α (TNF-α). …”
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Interrelationship between altered metabolites and the gut microbiota in people living with HIV with different immune responses to antiretroviral therapy by Xuebin Tian, Zhongyao Gao, Yiwen Xie, Xiangyun Lu, Yulong Zhao, Peng Yao, Mingqing Dong, Lifeng Yu, Nanping Wu

“…This study explores the connections among immune responses, metabolites, and the gut microbiota in PLWH with differing reactions to ART. Methods: We analyzed the gut microbiota composition, metabolites, and immune markers in 38 PLWH who showed an immunological response (IR) and 32 who did not (INR), as classified according to CD4+ T-cell levels after 24 months of ART. …”
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Prevalence of digestive diseases in patients with excessive body weight and obesity (<i>according to data of polyclinic department of versatile clinic</i>) by I. R. Popova

“…Retrospective study of diseases of digestive organs prevalence included 1504 patients, who have visited polyclinic department in 2010 : 659 with excessive body weight – body mass index (BMI) 25,0 to 29,9 kg/m2), 610 with obesity (BMI ≥30 кг/м2) and 235 with normal weight (BMI 18,5 to 24,9 kg/m2), the latter made control group. …”
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Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study by Qiuping Liao, Qiuping Liao, Qiuping Liao, Tiantian Yu, Tiantian Yu, Tiantian Yu, Jiajia Chen, Jiajia Chen, Jiajia Chen, Xiuqiong Zheng, Xiuqiong Zheng, Xiuqiong Zheng, Lianghui Zheng, Lianghui Zheng, Lianghui Zheng, Jianying Yan, Jianying Yan, Jianying Yan

“…Neonatal birth weight displayed a significantly increasing trend with increasing maternal pre-pregnancy BMI when maternal pre-pregnancy BMI was less than 27.78 kg/m2 [β = 0.03, 95% CI (0.01, 0.04); p = 0.0052 &lt; 0.05] when maternal pre-pregnancy BMI was greater than 27.78 kg/m2, neonatal birth weight decreased as maternal pre-pregnancy BMI increased [β = −0.01, 95% CI (−0.04, 0.01); p = 0.3555].ConclusionThe incidence of SGA and LGA babies was higher in the women with GDM who were overweight or obese before pregnancy. The data suggest that different management strategies should be implemented for pregnant women with a pre-pregnancy BMI below 27.78 kg/m2 and above 27.78 kg/m2, particularly in cases of GDM. …”
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The Old Woman’s Farcical Rejuvenation in The Rejuvenation of Miss Semaphore (1897) by Somi Ahn

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Clinical Profile and Outcome of Esophageal Button Battery Ingestion in Children: An 8-Year Retrospective Case Series by Mustafa Erman Dörterler

“…Median age was 29 months (range, 2–99 months). Boys comprised (n=11, 64.7%) of the study population. …”
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Navigating DR-TB Treatment care: a qualitative exploration of barriers and facilitators to retention in care among people with history of early disengagement from drug-resistant tuberculosis treatment in Johannesburg, South Africa by Ndiviwe Mphothulo, Sindisiwe Hlangu, Jennifer Furin, Mosa Moshabela, Marian Loveday

Subjects: “…DR-TB…”
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Real life experience of a screening strategy for latent tuberculosis before treatment with biologicals in indian patients with rheumatic diseases by Anand N Malaviya, Ravita Thakaran, Roopa Rawat, Sanjiv Kapoor, Shriram Garg, Sadhana S Baghel, Christy Messi, Vivekanand, Qamar Zaheer

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The Impact of Insulin Degludec on Glucocorticoid-Induced Hyperglycemia in Patients with Diabetes and COVID-19 Infection by Varun Prasanna, Ravindranath Venketesan

“…Conclusion: IDeg is an effective and safe insulin for managing hyperglycemia in PWD who developed SIH during hospitalization for moderate-to-severe COVID-19.…”
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CLINICAL PROFILES OF FROSTBITE IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL: A CASE SERIES by Thomas Eduardus Sudrajat Wahyu Nugroho, Beta Subakti Nata’atmadja

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Prediction-based prompt levothyroxine replacement to prevent a hypothyroid state after immune-related adverse events involving the thyroid gland by Ichiro Yamauchi, Takuro Hakata, Taku Sugawa, Daisuke Kosugi, Haruka Fujita, Kentaro Okamoto, Yohei Ueda, Toshihito Fujii, Daisuke Taura, Norio Harada, Nobuya Inagaki

“…The Toxic-Hypo group developed severe hypothyroidism and required larger levothyroxine (LT4) doses than the Hypo group (75 vs. 25 μg/day; p = 0.007). We predicted that patients with positive TgAbs who developed severe thyrotoxicosis within 4 weeks after the first ICI administration would develop subsequent hypothyroidism. …”
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Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS by Richard E. K. Russell, Darush Attar-Zadeh, Natalie Harper, Fiona Mosgrove, Laura Rush, Dave Singh

“…Lack of clarity exists regarding who should prescribe ICS/LABA/LAMA and in which patients, and this is compounded by a lack of consistency among guidelines. …”
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Exploring the heterogeneity of HER2 gene status and expression in non-positive breast cancer patients: insights from immunohistochemistry and fluorescence in situ hybridization by Jingmin Zhong, Beibei Gao, Qingjie Wang, Jun He, Danjv Luo, Chen Zhang, Jun Fan, Xiu Nie

“…Of the 349 cases, IHC was ultimately evaluated in 327, the antibodies demonstrated only 64.22% (95% CI: 58.76–69.42%) agreement between clone 4B5 and clone EP3. Pathologist 1, who had more extensive working experience, demonstrated higher consistency (94.19%) with the gold standard when using clone EP3, compared to Pathologist 2 (74.31%). …”
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