Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient by Nedal Bukhari, Faisal Azam, Mohammed Alfawaz, Mohammed Zahrani

“…Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy. …”
Get full text

As memórias do que aconteceu: religiosidade, tecnologias e traduções nos meios populares by José Rogério Lopes, André Luiz da Silva, Régis de Toledo Souza

“…The analysis of these references considers two possibilities of objectification: the resulting projections of the subjects on goods and objects, unveiled since the interaction processes laid down in religious events, and another on the way designed for the goods and objects, that extrapolate their relational values when moving mediations that operate to objectifications in another order of interactions, or produce hybridisms between orders of different interactions. …”
Get full text

Use of Diagnostic Laparoscopy for Identification of Bilateral Noncommunicating Hydroceles in an Infant with Right-Sided Abdominoscrotal Mass and Left-Sided Scrotal Mass by Kian Asanad, Pooya Banapour, Monica Metzdorf

“…Infantile abdominoscrotal hydrocele (ASH) is a rare condition characterized by a dumbbell-shaped cystic mass extending from the scrotum to the abdomen. We present the case of a 4-month-old infant who presented with progressively enlarging bilateral scrotal swelling and a tense, ballotable right-sided abdominal mass with extension into the scrotum. …”
Get full text

Les Fils de Bas-de-Cuir. Sauvagisme, franc trappeur et « lutte des traces » dans le roman d’aventures français (1850-1880) by Luca Di Gregorio

“…The analysis deals with the heroism embodied by the recurring figure of the coureur des bois, a French variety of mountain man who is the main protagonist of these novels. …”
Get full text

Heroic Deeds and Heroic Failure by Carol Sweetenham

“…Robert himself was depicted as a flawed hero, whose bravery on crusade was celebrated, but who failed in his ultimate duty by refusing the crown of Jerusalem. …”
Get full text

Severe Malaria in an Adult Patient from Low-Endemic Area in Flores Island, East Nusa Tenggara by Maria Teressa, Asep Purnama, Joshua Henrina, Agustinus Wiraatmadja, Angela M. B. Boro, Candida I. L. Sam, Tersila A. D. Dedang, Alius Cahyadi

“…This case describes a 26-year-old man who suffered cerebral malaria with multiple organ dysfunction and successfully recovered despite poor initial prognosis. …”
Get full text

From the Firing at Yeonpyeong Island to a Comprehensive Solution to the Problems of Division and War in Korea by Wada Haruki

Subjects: Get full text

Validating Factorial Survey Experiments: Response to Comment by Andrea G. Forster, Martin Neugebauer

“…In addition to exploring the conditions under which FSs provide valid behavioral predictions, we varied the topic sensitivity and tested whether behavioral predictions were more accurate after filtering out respondents who provided socially desirable answers or did not exert sufficient effort in responding to FS vignettes. …”
Get full text

Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone by Robin Paudel, Prerna Dogra, Saurav Suman, Saurav Acharya, Jyoti Matta

“…The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form.…”
Get full text

Implementation of digital competencies in higher education educational programs in Russia by G. P. Sorokina, T. A. Pershina, E. A. Dolgikh

“…The descriptors (knowledge, skills and abilities) of graduates in various fields who, in the era of digitalisation, must have the necessary digital competencies are identified. …”
Get full text

Iatrogenic Ascending Aorta Dissection during Diagnostic Coronary Angiography: Rare but Life-Threatening by Marc Lambelin, Luc Janssens, Luc Haenen

“…Dissection of the ascending aorta is a very rare but life-threatening complication during diagnostic angiography. We present a case of an elderly woman who underwent an elective diagnostic coronary angiography, complicated with an iatrogenic ascending aorta dissection that did not involve the coronary arteries but originated 4 cm distal of the aortic valve. …”
Get full text

Introduction by Jean-Claude Yon

“…Written by a historian of the performing arts who once worked at the Musée d'Orsay, this introduction aims to put the fifteen or so texts in this dossier into perspective. …”
Get full text

SOCIAL IMPACT OF IMMIGRATION TO THE UNITED STATES by N. E. Petrovskaya

“…The first time in Gallup’s trend that the percentage wanting increased immigration has exceeded the percentage who want decreased immigration.…”
Get full text

Accidental Overdosing in Patients with Take-Home Methadone – A Case Series by Anshul Sharma, Sidharth Arya, Gunjan Chadha, Rajiv Gupta

“…During the COVID-19 pandemic, guidelines were relaxed, and take-home methadone was allowed for 5–7 days. We discuss three cases of accidental methadone overdose among the patients who were on take-home dispensing. …”
Get full text

Biotechnological tools boost the functional diversity of DNA-based data storage systems by Xiaoyuan Xu, Wen Wang, Zhi Ping

“…It is attracting many researchers’ attention, who are implementing functions such as random access, searching, and data operations apart from the existing capabilities, including reading and writing. …”
Get full text

Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature by José C. De La Flor, Marina Alonso, Edna Sandoval, Alexander Marschall, Miguel Rodeles

“…We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. …”
Get full text

Le discours antinobiliaire en Espagne à la fin du XVIIIe et dans la première moitié du XIXe siècle by Arnaud Pierre

“…Since the end of the 18th-century at least, there were many in Spain who strongly criticized some hidalgos, although they did not question the existence of gentry. …”
Get full text

Clinical practice guidelines. Advantages and disadvantages. by Alfredo Darío Espinosa Brito, Luis Gustavo Del Sol Padrón, Alfredo Alberto Espinosa Roca, José Luis Garriga Valdés, Brandy Viera Valdés

“…Better informed patients, health systems who see to keep control of sanitary expenditures and a growing professional competence, are very efficient factors that will keep a process of improvement and efficiency in motion, which will inevitably lead to an objective assessment of the services we provide to patients, mainly for the sake of the ill and the professionals.…”
Get full text

Perfect Meals with Pressure Cooking by Paula G. Harris-Swiatko, Karla P. Shelnutt, Amy Simonne

“…Preparing great tasting, healthy meals can be a time-consuming task, but pressure cooking is a great way to prepare them in just minutes. Although they may seem old fashioned, pressure cookers are making a comeback, especially with today's busy families who are trying to save both time and money. …”
Get full text

Diagnosis and Treatment of Gastroesophageal Reflux Disease in Infants and Children by Yvan Vandenplas

“…In life-threatening situations, or in patients who are resistant to or dependent on acid suppressive medication, a surgical procedure such as laparoscopic Nissen should be considered.…”
Get full text