Transformations in the police organization in the early 1920s by V. A. Grechenko

“…In the first of the named documents, it was stated that persons who joined the police and investigation service are considered civil servants. …”
Get full text

Combination of functional dyspepsia syndrome and irritable bowel syndrome by V. T. Ivashkin, Ye. A. Poluektova

“…The factor determining quite low efficacy of pharmacotherapy at combined functional disorders is the personality features of the patient, that determine relationship with society, and development of symptoms as the adaptive mechanism protecting from necessity to be socially active.…”
Get full text

Global research trends on gastrointestinal cancer and mental health (2004–2024): a bibliographic study by Wenjin Han, Tianmeng Wang, Zhiqiang He, Caihua Wang, Zhaozhao Hui, Shuangyan Lei, Nan Hao, Ning Li, Xiaoqin Wang, Xiaoqin Wang

“…The research direction is mainly focused on personalized mental health interventions to improve QoL, as well as preoperative mental healthcare and ongoing care through internet-based multidisciplinary collaboration to reduce postoperative complications. …”
Get full text

Conversational Therapy through Semi-Immersive Virtual Reality Environments for Language Recovery and Psychological Well-Being in Post Stroke Aphasia by A. Giachero, M. Calati, L. Pia, L. La Vista, M. Molo, C. Rugiero, C. Fornaro, P. Marangolo

“…In the present study, thirty-six chronic persons with aphasia (PWA) were randomly assigned to two groups. …”
Get full text

Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retro... by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…Nonetheless, if there are any signs of decreased growth velocity or hypopituitarism, the presence of GHD should be assessed before GH therapy, and personalized therapy based on the results is required.…”
Get full text

Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Abstract Although the efficacy of pharmacy in the treatment of attention deficit/hyperactivity disorder (ADHD) has been well established, the lack of predictors of treatment response poses great challenges for personalized treatment. The current study employed a comprehensive approach, combining genome-wide association analyses (GWAS) and deep learning (DL) methods, to elucidate the genetic underpinnings of pharmacological treatment response in ADHD. …”
Get full text

Socioeconomic disparity in stage at cancer diagnosis among patients with type 2 diabetes in Dutch primary care: a cross-sectional study by Geertruida H De Bock, Gijs W D Landman, Nanne Kleefstra, Bert van der Vegt, Sabine Siesling, Klaas H Groenier, Jing de Haan-Du

“…We evaluated the association of SES and cancer stage among patients with type 2 diabetes (T2DM) treated in primary care.Research design and methods This cross-sectional study linked data from the primary care Zwolle Outpatient Diabetes Project Integrating Available Care database for T2DM (n=71 648, 1998–2019) to a cancer registry and personal records database in the Netherlands. Only cancers (excluding all skin cancers) diagnosed after the onset of diabetes were included and grouped by stages (III–IV or 0–II). …”
Get full text

Research on the Correlation between Multisource Big Data Virtual Assisted Preschool Education and the Development of Children’s Innovative Ability by Tuo Meimei, Long Baoxin

“…As one of the important contents of scientific literacy, innovation ability is the key ability of young children to make informed decisions when facing scientific problems in social and personal life. In order to adapt to the future life, it is very important for children to have the ability to innovate. …”
Get full text

Comunicación de la verdad en oncología desde la visión de la bioética médica by Edeny Fando Couso, Alexander Reyes de la Paz, Liuba Luisa Arteche Hidalgo, Yinett Hernández León

“…La comunicación de la verdad, particularmente cuando se trata de informar malas noticias, es una situación estresante, difícil y que demanda la adecuada preparación del personal de la salud. Objetivo: Comentar sobre los fundamentos de la comunicación de la verdad en las enfermedades oncológicas y los puntos relevantes en la relación médico paciente. …”
Get full text

A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies by Lucie Perillat, Lucie Perillat, Andrew McFadyen, Andrew McFadyen, Andrew McFadyen, Patricia Furlong, James Anderson, James Anderson, James Anderson

“…A significant unresolved question is determining where personalized interventions fall on the research-care continuum and understanding the institutional, regulatory, and ethical implications when custom therapies are classified as research, care, or a mix of both. …”
Get full text

Effectiveness of Fewer Falls, an online group-based self-management fall prevention programme for people with multiple sclerosis: protocol of a randomised controlled trial by Maria Flink, Charlotte Ytterberg, Kristina Gottberg, Marie Kierkegaard, Susanna Tuvemo Johnson, Elizabeth Walker Peterson, Ulrika Meijer, Johanna Bylinder

“…The primary outcome is fall frequency (falls/person/year). Secondary outcomes include injurious falls, falls control, fear of falling, falls self-efficacy, activity curtailment, perceived effect of MS, self-rated health and cost-effectiveness.Ethics and dissemination Ethical approval has been obtained from the Swedish Ethical Review Authority (registration numbers 2022-06667-01 and 2023-07723-02). …”
Get full text

Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

“…Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. …”
Get full text

Examining different measures of multimorbidity, using a large prospective cross-sectional study in Australian general practice by Christopher Harrison, Helena Britt, Graeme Miller, Joan Henderson

“…The proposed concept of “complex multimorbidity”, the co-occurrence of three or more chronic conditions affecting three or more different body systems within one person without defining an index chronic condition, may be useful in identifying high-need individuals.…”
Get full text

Guía para la enseñanza del apoyo vital avanzado ante múltiples víctimas. Consenso para el proyecto de formación e investigación en apoyo vital. Cienfuegos, 2018 by Víctor René Navarro Machado, Alexis Lorenzo Ruiz, Julio Betancourt Cervantes, Irayma Cazull Imbert, Rosario Gutiérrez Castro, Bárbara Hilaria Padrón Novales, Grupo Fiaved-Aviamuv

“…<strong>Fundamento:</strong> en situaciones de desastres, cuando el número de enfermos o lesionados es alto y los recursos limitados, la atención médica precisa de cambios de estructura y procesos si se quiere salvar un número elevado de personas. El personal de salud debe estar entrenado para enfrentar esta situación cada vez más frecuente. …”
Get full text

Enhancing road safety of PLEVs by novel vehicle concepts: A comprehensive investigation on regulations, accident statistics, and perception of riders in Europe by Michelangelo-Santo Gulino, Susanna Papini, Giovanni Zonfrillo, Peter Miklis, Thomas Unger, Dario Vangi

“…The rise of Personal Light Electric Vehicles (PLEVs), including electric bicycles and electric kick scooters, represents a relevant trend in current urban mobility. …”
Get full text

A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Identifying molecular signatures associated with this interaction could yield critical prognostic insights and inform personalized therapeutic approaches. Methods: We conducted an in silico study integrating single-cell RNA sequencing and bulk transcriptome data to characterize the cellular heterogeneity of CRC. …”
Get full text

The value of FDG-PET/CT metabolic parameters and treatment metabolic response in predicting long-term survival of patients with diffuse large B-cell lymphoma by Abbas Yousefikoma, Mohamad Mehdi Karimy Taha

“…At the end of 2 years of follow-up, in all groups, five people (14.2%) experienced disease relapse, and one person (2.9%) died. Comparing metabolic parameters of PET/CT between survived and non-survived groups showed no difference between the two groups. …”
Get full text

Blood pressure variation and hypertension rates in a pre-modernized Bedouin population: data from tribes of the Sinai Peninsula (Egypt) by Hani Monk-Vitelson, Israel Hershkovitz, Eugene Kobyliansky

“…The overall rates of hypertension (HTN, defined as the percent of persons with systolic BP >/= 140 and/or diastolic BP >/= 90 mmHg) are 12% for males and 4% for females. …”
Get full text

Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…The current lack of reliable predictive biomarkers hinders early diagnosis and personalized therapy.MethodsTranscriptomic profiles of DN samples and controls were extracted from GEO databases. …”
Get full text

Mesothelial cell responses to acute appendicitis or small bowel obstruction reactive ascites: Insights into immunoregulation of abdominal adhesion. by Melissa A Hausburg, Kaysie L Banton, Christopher D Cassidy, Robert M Madayag, Carlos H Palacio, Jason S Williams, Raphael Bar-Or, Rebecca J Ryznar, David Bar-Or

“…Further, quantifying immunomodulators in peritoneal rA may lead to the development a personalized approach to post-surgical adhesion treatment and prevention.…”
Get full text