miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…We demonstrated that hypertension exacerbated Pb-induced neuroinflammation in the prefrontal cortex (PFC), hippocampus, and hypothalamus, as evidenced by increased levels of proinflammatory cytokines (IL-6 and TNF-α) and decreased levels of anti-inflammatory cytokines (CD206 and IL-10). …”
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Altered spontaneous brain activity in children with deprivation amblyopia: a resting-state functional magnetic resonance imaging study by Yadong Li, Guangying Zheng, Baohong Wen, Xiaopan Zhang

“…Results Compared to healthy controls, children with binocular deprivation amblyopia presented increased fALFF values in the left medial superior frontal gyrus, left middle frontal gyrus, left anterior cingulate cortex, left postcentral gyrus and bilateral precentral gyrus, and decreased fALFF values in the right fusiform gyrus. …”
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Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis by Yao Zhang, Nan Mu, Shun Qi, Chuanzhu Sun, Yang Rao, Xinyi Yang, Jianying Guo, Yunfeng Mu

“…Individual target-transcranial magnetic stimulation (IT-TMS) using Stanford Neuromodulation Therapy over individualized left dorsolateral prefrontal cortex was performed to treat MDD/SI+ with the ethical approval (KY20212218-C-1). …”
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Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats by Essia Hamdi, Slah Hidouri, Ana-Belén Muniz-Gonzalez, Marwa Kechnebbou, Salem Amara

“…Notably, malondialdehyde (MDA) levels, a marker of lipid peroxidation, were significantly reestablished in the frontal cortex and hippocampus following SiO2-NPs@AA. Overall, the study revealed that SiO2-NPs@AA corrected effectively nitric oxide (NO) and monoamine oxidase activities, which confirm their role to preserve neuronal function and mitigate neurotoxicity.…”
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Reorganization of gray matter networks in patients with Moyamoya disease by Huan Zhu, Peijiong Wang, Wenjie Li, Qihang Zhang, Chenyu Zhu, Tong Liu, Tao Yu, Xingju Liu, Qian Zhang, Jizong Zhao, Yan Zhang

“…MMD patients had significant regional abnormalities, including decreased degree centrality (DC) in the left medial orbital superior frontal gyrus, left orbital inferior frontal gyrus, and right calcarine fissure and surrounding cortex (P < 0.05, FDR corrected). Increased DC was found in bilateral olfactory regions, with higher betweenness centrality (BC) in the right median cingulate, paracingulate fusiform gyrus, and left pallidum (P < 0.05, FDR corrected). …”
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Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography by Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian

“…We demonstrate DS on various human cerebral cortex samples, achieving consistent staining quality and enhancing contrast across cortical layer boundaries. …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…Using MetaboAnalyst 5.0 and the KEGG database was used to depict the 12 key metabolic pathways.Results: Compared with the control group, the Corilagin induced 20, 9, 11, 7, 16, 19, 14, 15, and 16 differential metabolites in the intestine, lung, kidney, stomach, heart, liver, hippocampus, cerebral cortex, and serum, respectively. And 12 key pathways involving glucose metabolism, lipid metabolism, and amino acid metabolism were identified following Corilagin treatment.Conclusion: This research provides insight into the action mechanism of Corilagin’s anti-oxidative, anti-inflammatory, anti-atherosclerotic, hepatoprotective, anti-tumor, and neuroprotective properties. …”
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Evaluation of Comparative Efficacy of Ashwagandha (Withania somnifera) vs Brahmi (Bacopa monnieri Linn) on Stress Level and Quality of Sleep in the Subjects Experiencing Mental Str... by Mohnish Vijay Gokhale, Vaishali Kuchewar, Pankaj Yadav, Bhishmani Tarare

“…Sleep deprivation causes loss of sleep-dependent processes in the hippocampus and pyriform cortex, which are responsible for memory and perception. …”
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Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging by Tania Alexandra Couto, Shiyang Xu, Paulo Armada da Silva, Chenggang Wu, Karl Neergaard, Meng-Yun Wang, Juan Zhang, Yutao Xiang, Zhen Yuan

“…Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. …”
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Accurate Spatial Heterogeneity Dissection and Gene Regulation Interpretation for Spatial Transcriptomics using Dual Graph Contrastive Learning by Zhuohan Yu, Yuning Yang, Xingjian Chen, Ka‐Chun Wong, Zhaolei Zhang, Yuming Zhao, Xiangtao Li

“…Benchmarking stDCL against other state‐of‐the‐art clustering methods using complex cortex datasets demonstrates its superior accuracy and effectiveness in identifying spatial domains. …”
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Event segmentation in ADHD: neglect of social information and deviant theta activity point to a mechanism underlying ADHD by Christian Beste, Veit Roessner, Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Bernhard Hommel

“…For the ADHD group, the inferior frontal cortex associated with attentional sampling served as a hub instead, indicating problems in the deployment of attentional control.Conclusions This study shows that adolescents with ADHD perceive events differently from their NT peers, in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental information. …”
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Microscopy and spatial-metabolomics identify tissue-specific metabolic pathways uncovering salinity and drought tolerance mechanisms in Avicennia marina and Phoenix dactylifera roo... by Paula Oyarce, Ting Ting Xiao, Corinna Henkel, Signe Frost Frederiksen, Jose Kenyi Gonzalez-Kise, Wouter Smet, Jian You Wang, Salim Al-Babili, Ikram Blilou

“…We identified common osmoprotectants accumulating in the exodermis/epidermis of date palm and mangrove root meristems, along with a unique metabolite highly abundant in the inner cortex of date palm roots. These findings provide valuable insights into stress adaptation pathways and highlight key tissue types involved in root stress response.…”
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Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model by Musaad A. Alshammari, Mohammad R. Khan, Fawaz Alasmari, Abdulaziz O. Alshehri, Rizwan Ali, Mohamed Boudjelal, Khalid A. Alhosaini, Abdurahman A. Niazy, Tahani K. Alshammari

“…Using Western blot studies and high-resolution confocal microscopy in the prefrontal frontal cortex (PFC), our data indicate disrupted expression of different isoforms of the voltage-gated sodium channels (NaV) at the AIS, whereas other components of AIS such as ankyrin-G and fibroblast growth factor 14 (FGF14) and contactin-associated protein 1 (Caspr) in BTBR were comparable to those in wild-type control mice. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…Twelve anodal-left/cathodal-right 2 mA tDCS sessions over the dorsolateral prefrontal cortex will be performed in 6 weeks. Results. In the pilot phase, five patients received active tDCS and were double-blindly assessed, two presenting clinical response. …”
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Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment by Qiongling Li, Xinwei Li, Xuetong Wang, Yuxia Li, Kuncheng Li, Yang Yu, Changhao Yin, Shuyu Li, Ying Han

“…., sulcal depth, curvature, and metric distortion) change in aMCI patients compared with normal controls because these geometric features of cerebral cortex may be related to its intrinsic connectivity. …”
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Phenotypic stability of spring bread wheat regenerant lines by V. Yu. Stupko, A. V. Sidorov

“…The GGE-biplot analysis shows that they belong to the same “environment” (sector) with the vertex genotype ‘Novosibirskaya 15’ with bi being close to 1. …”
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Rapid Identification of the Chemical Components of Ilex rotunda Thunb Using UPLC-Q-TOF-MS/MS by Xinxin Chen, Junmao Li, Renyikun Yuan, Youqiong Zhuo, Yangling Chen, Chenwei Zhang, Ming Chen, Hong-Wei Gao, Zhenjie Liu, Yulin Feng, Zheng-Tao Wang, Shilin Yang

“…Ilicis Rotundae Cortex (IRC) consists of the bark of Ilex rotunda Thunb, and its chemical constituents mainly include flavonoid glycosides, phenols, and triterpenoid saponins. …”
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Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives by Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant

“…Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins. …”
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Impact of electrical muscle stimulation-induced muscle contractions on endogenous pain modulatory system: a quantitative sensory testing evaluation by Satoshi Ohga, Takafumi Hattori, Kazuhiro Shimo, Hajime Maeda, Takako Matsubara

“…This study investigated the contribution of EMS-induced muscle contractions to systemic analgesia, independent of motor cortex activity. We aimed to explore the underlying mechanisms of EIH by analyzing the influence of skeletal muscle mass (SMM), skeletal muscle mass index (SMI), and conditioned pain modulation (CPM). …”
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Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder by Marina Ivanova, Ksenia Germanova, Dmitry S. Petelin, Aynur Ragimova, Grigory Kopytin, Beatrice A. Volel, Vadim V. Nikulin, Maria Herrojo Ruiz

“…Additionally, we examined if this increased expectation speeds up belief updating in decision-making, associated with modulation of rhythmic neural activity within the prefrontal, orbitofrontal, and anterior cingulate cortex (PFC, OFC, ACC). Twenty-two euthymic BD and 27 healthy control (HC) participants completed a reward-based motor decision-making task in a volatile setting. …”
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